An evaluation of factors affecting activated coagulation time.

Abstract:

OBJECTIVE:Although failure to achieve an adequate activated coagulation time (ACT) after full heparinization before cardiopulmonary bypass often is attributed to antithrombin (AT) deficiency, it remains unclear if this is a causative mechanism of decreased heparin responsiveness. Therefore, the authors determined the relationship between AT and other coagulation-related factors that affect the ACT measurement and heparin sensitivity index before the establishment of cardiopulmonary bypass. DESIGN:Observational study. SETTING:University medical center. PARTICIPANTS:Adult elective cardiac surgical patients. INTERVENTIONS:Preoperative data collection included demographics, type of preoperative medical therapy, hemoglobin, platelet count, and AT. Intraoperative measurements included ACT and anti-Xa activity. RESULTS:Of the 203 patients enrolled in this study, 10% (n = 21) did not achieve an adequate ACT (≥400 seconds) after full heparinization. Subnormal AT activity (55%-79%) was not related to a low ACT and a low heparin sensitivity index. Preoperative low-molecular-weight heparin therapy did not cause a decreased ACT response. However, preoperative low hemoglobin levels and high platelet counts were associated with a decreased ACT. CONCLUSIONS:All these observations suggest that failure to achieve an adequate ACT is, in general, not an indicator of AT deficiency but could be affected by high platelet counts and low hemoglobin levels.

authors

Bosch YP,Weerwind PW,Nelemans PJ,Maessen JG,Mochtar B

doi

10.1053/j.jvca.2012.03.011

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

563-8

issue

4

eissn

1053-0770

issn

1532-8422

pii

S1053-0770(12)00137-1

journal_volume

26

pub_type

杂志文章
  • Prognosis of Prolonged Intensive Care Unit Stay After Aortic Valve Replacement for Severe Aortic Stenosis in Octogenarians.

    abstract:OBJECTIVES:Octogenarians considered for cardiac surgery encounter more complications than other patients. Postoperative complications raise the question of continuation of high-cost care for patients with limited life expectancy. Duration of hospitalization in intensive care after cardiac surgery may differ between oct...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章

    doi:10.1053/j.jvca.2016.07.029

    authors: Augustin P,Tanaka S,Chhor V,Provenchère S,Arnaudovski D,Ibrahim H,Dilly MP,Allou N,Montravers P,Philip I

    更新日期:2016-12-01 00:00:00

  • Right Ventricular Systolic Performance Determined by 2D Speckle-Tracking Echocardiography and Acute Kidney Injury After Cardiac Surgery.

    abstract:OBJECTIVE:An association between central venous pressure and acute kidney injury (AKI) has been observed following cardiac surgery, but it is unknown whether this reflects intravascular volume status or impaired right ventricular (RV) myocardial performance. This study was performed to test the hypothesis that decrease...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章

    doi:10.1053/j.jvca.2018.09.012

    authors: Yockelson SR,Heitner SB,Click S,Geleto G,Treggiari MM,Hutchens MP

    更新日期:2019-03-01 00:00:00

  • Markers of splanchnic perfusion and intestinal translocation of endotoxins during cardiopulmonary bypass: effects of dopamine and milrinone.

    abstract:OBJECTIVES:To investigate markers of splanchnic perfusion and the extent of endotoxemia during cardiopulmonary bypass (CPB) and to compare the effects of dopamine and milrinone on both splanchnic perfusion and endotoxemia. DESIGN:Prospective, randomized, blinded study. SETTING:University teaching hospital. PARTICIPA...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s1053-0770(99)90266-5

    authors: McNicol L,Andersen LW,Liu G,Doolan L,Baek L

    更新日期:1999-06-01 00:00:00

  • Echocardiographic Assessment of Left Ventricular Assist Device Outflow Velocity During Percutaneous Decommissioning.

    abstract::Left ventricular assist devices (LVADs) have been used as an effective therapeutic option in patients with advanced heart failure, either as a bridge to transplantation or, in some patients, as a bridge to recovery. LVAD withdrawal with ventricular recovery represents the optimal outcome for patients previously implan...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章

    doi:10.1053/j.jvca.2020.12.043

    authors: Liu X,Kimmelstiel C,Couper GS,Brovman EY

    更新日期:2021-01-05 00:00:00

  • Coagulation Derangements in Patients With Refractory Cardiac Arrest Treated With Extracorporeal Cardiopulmonary Resuscitation.

    abstract:OBJECTIVE:Extracorporeal cardiopulmonary resuscitation (eCPR) with venoarterial extracorporeal membrane oxygenation (VA-ECMO) is gaining importance as a rescue therapy for refractory cardiac arrest. VA-ECMO, especially in the setting of eCPR, is plagued by hemorrhagic and thromboembolic complications. The authors' aims...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章

    doi:10.1053/j.jvca.2018.11.014

    authors: Ruggeri L,Franco A,Alba AC,Lembo R,Frassoni S,Scandroglio AM,Calabrò MG,Zangrillo A,Pappalardo F

    更新日期:2019-07-01 00:00:00

  • Epidural versus ON-Q local anesthetic-infiltrating catheter for post-thoracotomy pain control.

    abstract:OBJECTIVE:The authors compared thoracic epidural with ON-Q infiltrating catheters in patients having open thoracotomy to determine whether one method better relieves postoperative pain and would allow earlier discharge from the hospital and, hence, cost savings. DESIGN:Retrospective chart review. SETTING:University h...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章

    doi:10.1053/j.jvca.2013.02.017

    authors: Gebhardt R,Mehran RJ,Soliz J,Cata JP,Smallwood AK,Feeley TW

    更新日期:2013-06-01 00:00:00

  • Does aprotinin influence endothelial-associated coagulation in cardiac surgery?

    abstract::Aprotinin has been reported to reduce bleeding in cardiac surgery patients. Its mechanisms of action on coagulation have not been fully elucidated. In a prospectively randomized study of 40 patients undergoing elective aortocoronary bypass grafting, the influence of high-dose aprotinin (2 million IU of aprotinin befor...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/1053-0770(94)90164-3

    authors: Boldt J,Schindler E,Knothe C,Hammermann H,Stertmann WA,Hempelmann G

    更新日期:1994-10-01 00:00:00

  • Perioperative management and outcome of patients having cardiac surgery combined with abdominal aortic aneurysm resection.

    abstract::Patients with abdominal aortic aneurysms (AAA) have a high incidence of associated cardiac disease. If a patient presents with both severe coronary artery disease and a large AAA, a staged procedure of cardiac surgery (CS) followed by AAA resection may present too great a risk of aneurysm rupture and death. A combined...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章

    doi:10.1016/1053-0770(94)90163-5

    authors: O'Connor MS,Licina MG,Kraenzler EJ,Savage RM,Padua-Shannon N,Starr NJ

    更新日期:1994-10-01 00:00:00

  • Propofol inhibits desflurane-induced preconditioning in rabbits.

    abstract:OBJECTIVES:The authors tested the hypothesis that ischemic and desflurane-induced preconditioning are blocked by propofol. DESIGN:A prospective, randomized, vehicle-controlled study. SETTING:A university research laboratory. SUBJECTS:New Zealand white rabbits (n = 52). METHODS:Pentobarbital-anesthetized rabbits wer...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章

    doi:10.1053/j.jvca.2010.07.018

    authors: Smul TM,Stumpner J,Blomeyer C,Lotz C,Redel A,Lange M,Roewer N,Kehl F

    更新日期:2011-04-01 00:00:00

  • A randomized trial of outcomes of anesthetic management directed to very early extubation after cardiac surgery in children.

    abstract:OBJECTIVES:Intraoperative management directed to early extubation of children undergoing cardiac surgery has been suggested as a viable alternative to prolonged postoperative mechanical ventilation. The authors evaluated the safety and efficacy of this approach in a randomized prospective trial. DESIGN:A prospective r...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1053/j.jvca.2008.11.011

    authors: Preisman S,Lembersky H,Yusim Y,Raviv-Zilka L,Perel A,Keidan I,Mishaly D

    更新日期:2009-06-01 00:00:00

  • Cardiorespiratory changes in patients undergoing pulmonary resection using different anesthetic management techniques.

    abstract:OBJECTIVE:Pulmonary resection may be associated with considerable alterations of the cardiorespiratory system. The ideal anesthetic regimen for these patients is not yet definitely determined. DESIGN:Prospective, randomized study. SETTING:Single-institutional, clinical investigation in a thoracic anesthesia departmen...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s1053-0770(96)80045-0

    authors: Boldt J,Müller M,Uphus D,Padberg W,Hempelmann G

    更新日期:1996-12-01 00:00:00

  • Intravenous Iron Versus Placebo in the Management of Postoperative Functional Iron Deficiency Anemia in Patients Undergoing Cardiac Valvular Surgery: A Prospective, Single-Blinded, Randomized Controlled Trial.

    abstract:OBJECTIVE:To compare the efficacy of intravenous iron versus placebo to correct postoperative functional iron deficiency anemia in patients undergoing cardiac valvular surgery. DESIGN:A prospective, single-blinded, randomized controlled study. SETTING:National Center for Cardiovascular Diseases and a university hospi...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1053/j.jvca.2019.01.063

    authors: Xu H,Duan Y,Yuan X,Wu H,Sun H,Ji H

    更新日期:2019-11-01 00:00:00

  • Comparison Between Intraoperative Two-Space Injection Thoracic Paravertebral Block and Wound Infiltration as a Component of Multimodal Analgesia for Postoperative Pain Management After Video-Assisted Thoracoscopic Lobectomy: A Randomized Controlled Trial.

    abstract:OBJECTIVE:To compare paravertebral block under thoracoscopy with wound infiltration at an early stage after video-assisted thoracic lobectomy surgery. DESIGN:A prospective, randomized, triple-blinded, placebo-controlled trial. SETTING:A single-center university hospital. PARTICIPANTS:Patients scheduled for video-ass...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1053/j.jvca.2015.06.013

    authors: Zhang X,Shu L,Lin C,Yang P,Zhou Y,Wang Q,Wu Y,Xu X,Cui X,Lin X,Jin L,Li T

    更新日期:2015-12-01 00:00:00

  • Postoperative hypoalbuminemia is associated with outcome in patients undergoing off-pump coronary artery bypass graft surgery.

    abstract:OBJECTIVE:The authors aimed to investigate whether immediate postoperative hypoalbuminemia could be associated with outcomes after off-pump coronary artery bypass graft (OPCAB) surgery. DESIGN:A retrospective analysis of the medical data. SETTING:Cardiac operating room and adult cardiovascular intensive care unit at ...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章

    doi:10.1053/j.jvca.2010.09.008

    authors: Lee EH,Chin JH,Choi DK,Hwang BY,Choo SJ,Song JG,Kim TY,Choi IC

    更新日期:2011-06-01 00:00:00

  • Anesthesia for percutaneous transcatheter closure of perimembranous ventricular septal defect.

    abstract:OBJECTIVE:To review the anesthetic management for percutaneous transcatheter closure of perimembranous ventricular septal defect (VSD) with an Amplatzer asymmetric occluder device and to highlight the hemodynamic effects and potential complications associated with its delivery. DESIGN:Retrospective review of prospecti...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章

    doi:10.1053/j.jvca.2005.05.023

    authors: Kapoor MC,Sharma S,Sharma VK,Dugal JS,Singh C

    更新日期:2006-04-01 00:00:00

  • Prospective observational study of hemostatic alterations during adult extracorporeal membrane oxygenation (ECMO) using point-of-care thromboelastometry and platelet aggregometry.

    abstract:OBJECTIVES:To characterize the longitudinal hemostatic profile during adult ECMO using point-of-care tests (POCT) for coagulation and to compare these parameters to standard laboratory tests. In addition, the clinicians' responses during bleeding episodes using available information were compared to a POCT-based respon...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章

    doi:10.1053/j.jvca.2014.06.006

    authors: Nair P,Hoechter DJ,Buscher H,Venkatesh K,Whittam S,Joseph J,Jansz P

    更新日期:2015-04-01 00:00:00

  • Palliative Care for Patients With Advanced Heart Disease.

    abstract::Over the past 2 decades, the discipline of palliative care has evolved and expanded such that it is now the standard of care for a variety of acute and chronic processes. Although there are recommendations encouraging incorporation of palliative care into the routine management of patients with chronic cardiac process...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章,评审

    doi:10.1053/j.jvca.2018.04.047

    authors: Klinedinst R,Kornfield ZN,Hadler RA

    更新日期:2019-03-01 00:00:00

  • Perioperative myocardial ischemia in carotid endarterectomy under cervical plexus block and prophylactic nitroglycerin infusion.

    abstract::Perioperative myocardial ischemia was evaluated in 36 consecutive carotid endarterectomy procedures carried out on patients with a high (72.2%) prevalence of ischemic heart disease. The procedures were performed under cervical plexus block plus a prophylactic intravenous nitroglycerin infusion. Findings of myocardial ...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章

    doi:10.1016/1053-0770(93)90002-3

    authors: Landesberg G,Erel J,Anner H,Eidelman LA,Weinmann E,Luria MH,Admon D,Assaf J,Sapoznikov D,Berlatzky Y

    更新日期:1993-06-01 00:00:00

  • Pro: early extubation after cardiac surgery decreases intensive care unit stay and cost.

    abstract::The recurrent or new trends of early extubation after cardiac surgery are here to stay in the 1990s. The preoperative status does not necessarily predict the postoperative course and prolonged mechanical ventilation following cardiac surgery should not be uncritically considered as routine. All patients should be asse...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章,评审

    doi:10.1016/s1053-0770(05)80105-3

    authors: Cheng DC

    更新日期:1995-08-01 00:00:00

  • Efficacy of Bilateral Erector Spinae Plane Block in Management of Acute Postoperative Surgical Pain After Pediatric Cardiac Surgeries Through a Midline Sternotomy.

    abstract:OBJECTIVE:Regional analgesia continues to evolve with the introduction of ultrasound-guided fascial plane blocks. Erector spinae plane block (ESPB) is a novel technique gaining recent acceptability as a perioperative modality of analgesia in various thoracic and abdominal surgeries. However, literature on the use of ES...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章

    doi:10.1053/j.jvca.2019.08.009

    authors: Kaushal B,Chauhan S,Magoon R,Krishna NS,Saini K,Bhoi D,Bisoi AK

    更新日期:2020-04-01 00:00:00

  • Supraglottic Airway Use for Transfemoral-Transcatheter Aortic Valve Replacement.

    abstract:OBJECTIVE:Examine outcome differences in patients managed either with a supraglottic airway or an endotracheal tube for general anesthesia during transcatheter aortic valve replacement. The authors hypothesized that patients managed with a supraglottic airway would have shorter post-anesthesia care unit and hospital st...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章

    doi:10.1053/j.jvca.2020.04.059

    authors: Azad SS,Cobey FC,Price LL,Schumann R,Shapeton AD

    更新日期:2020-12-01 00:00:00

  • Propofol-fentanyl versus isoflurane-fentanyl anesthesia for coronary artery bypass grafting: effect on myocardial contractility and peripheral hemodynamics.

    abstract::To avoid intraoperative awareness and postoperative respiratory depression from high-dose opioid anesthesia, propofol (P), or isoflurane (I) has been combined with moderate-dose opioid with varying results. However, the effects of both P and I on myocardial contractility and left ventricular afterload have not been co...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s1053-0770(05)80050-3

    authors: Sorbara C,Pittarello D,Rizzoli G,Pasini L,Armellin G,Bonato R,Giron GP

    更新日期:1995-02-01 00:00:00

  • Protective ventilation attenuates postoperative pulmonary dysfunction in patients undergoing cardiopulmonary bypass.

    abstract:OBJECTIVE:To ascertain if protective ventilation can attenuate the damaging postoperative pulmonary effects of cardiopulmonary bypass (increases in airway pressure, decreases in lung compliance, and increases in shunt). DESIGN:Prospective, randomized clinical trial. SETTING:Single university hospital. PARTICIPANTS:T...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1053/jcan.2000.9487

    authors: Chaney MA,Nikolov MP,Blakeman BP,Bakhos M

    更新日期:2000-10-01 00:00:00

  • The influence of propofol and midazolam/halothane anesthesia on hepatic SvO2 and gastric mucosal pH during cardiopulmonary bypass.

    abstract:OBJECTIVE:Because propofol is known to reduce vascular resistance, the objective of this study was to compare the indices of hepatosplanchnic circulation and oxygenation during cardiopulmonary bypass (CPB) in patients anesthetized with either propofol or midazolam/halothane. DESIGN:A prospective, randomized, nonblinde...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s1053-0770(98)90195-1

    authors: Christiansen CL,Ahlburg P,Jakobsen CJ,Andresen EB,Paulsen PK

    更新日期:1998-08-01 00:00:00

  • Effects of a thromboxane receptor antagonist (NT-126) and a thromboxane synthase inhibitor (OKY-O46) on protamine-induced circulatory changes in dogs.

    abstract:OBJECTIVE:To examine whether a thromboxane receptor antagonist, NT-126, or a thromboxane synthase inhibitor, OKY-046, prevents circulatory changes caused by protamine reversal of heparin and to evaluate the significance of thromboxane generation in the phenomena. DESIGN:Prospective, randomized, controlled, animal stud...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章

    doi:10.1053/jcan.2000.18449

    authors: Mizutani T,Takahashi S,Kihara S,Toyooka H

    更新日期:2000-12-01 00:00:00

  • Whole-lung Lavage and Pulmonary Alveolar Proteinosis: Review of Clinical and Patient-centered Outcomes.

    abstract:OBJECTIVE:The objective of this retrospective review was to evaluate the perioperative and procedural management of patients with pulmonary alveolar proteinosis (PAP) who presented for whole-lung lavage (WLL). DESIGN:The records of all adult patients with PAP who underwent WLL between January 1, 1988 and August 20, 20...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章

    doi:10.1053/j.jvca.2019.03.047

    authors: Smith BB,Torres NE,Hyder JA,Barbara DW,Gillespie SM,Wylam ME,Smith MM

    更新日期:2019-09-01 00:00:00

  • Atrial fibrillation after cardiac surgery: incidence, risk factors, and economic burden.

    abstract:OBJECTIVE:To evaluate the incidence of postoperative atrial fibrillation (POAF), the predisposing factors, the results of treatment before discharge, and the impact on duration and costs of hospitalization. DESIGN:A prospective observational study. METHODS:Patients who underwent cardiac surgery from January 1, 2007 t...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章

    doi:10.1053/j.jvca.2010.03.009

    authors: Rostagno C,La Meir M,Gelsomino S,Ghilli L,Rossi A,Carone E,Braconi L,Rosso G,Puggelli F,Mattesini A,Stefàno PL,Padeletti L,Maessen J,Gensini GF

    更新日期:2010-12-01 00:00:00

  • Is clinical assessment of the circulation reliable in postoperative cardiac surgical patients?

    abstract:OBJECTIVE:To study adult patients in the immediate postoperative period after cardiac surgery and determine whether cardiac output (CO) and systemic vascular resistance (SVR) are generally within normal limits and whether clinical assessment of CO provides an adequate approximation to guide treatment. DESIGN:Prospecti...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章

    doi:10.1053/jcan.2002.29631

    authors: Linton RA,Linton NW,Kelly F

    更新日期:2002-02-01 00:00:00

  • Liver transplantation without venovenous bypass: morbidity and mortality in patients with greater than 50% reduction in cardiac output after vena cava clamping.

    abstract:OBJECTIVE:To investigate whether a decrease in cardiac output of >or=50% after vena cava clamping is associated with an increase in perioperative morbidity or mortality in patients undergoing orthotopic liver transplantation without venovenous bypass. DESIGN:Retrospective, clinical study. PARTICIPANTS:Patients underg...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章

    doi:10.1053/jcan.2001.24982

    authors: Schwarz B,Pomaroli A,Hoermann C,Margreiter R,Mair P

    更新日期:2001-08-01 00:00:00

  • Cardiac interventions in pregnancy and peripartum - a narrative review of the literature.

    abstract::In the UK, mortality rate during pregnancy/in the peripartal period is 14.1 per 100,000 maternities with heart disease being the leading cause of non-obstetric maternal mortality (10% to 15% of all maternal deaths). Owing to the advances in the treatment of congenital heart disease (CHD), an increasing percentage of w...

    journal_title:Journal of cardiothoracic and vascular anesthesia

    pub_type: 杂志文章,评审

    doi:10.1053/j.jvca.2019.12.021

    authors: Carlier L,Devroe S,Budts W,Van Calsteren K,Rega F,Van de Velde M,Rex S

    更新日期:2020-12-01 00:00:00