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Clinical Update in Pediatric Sepsis: Focus on Children With Pre-Existing Heart Disease.

Abstract：

:SEPSIS REMAINS one of the most common causes of childhood morbidity, mortality, and higher healthcare costs, with over 75,000 hospital admissions in the United States and an estimated 4 million cases worldwide per year. While standardized criteria to define sepsis are in flux, the general concept of sepsis is a severe infection that results in organ dysfunction. Although sepsis can affect previously healthy children, those with certain pre-existing comorbid conditions, including congenital and acquired heart disease, are at higher risk for both developing sepsis and having a poor outcome after sepsis. Multiple specialists including intensivists, cardiologists, surgeons, and anesthesiologists commonly contribute to the management and outcome of sepsis in children. In this article, the authors examine the evolving epidemiology of pediatric sepsis, including the subset of patients with underlying heart disease; contrast pediatric and adult sepsis; review the latest hemodynamic guidelines for management of pediatric septic shock and their application to children with heart disease; discuss the role of mechanical circulatory support; and review key aspects of anesthetic management for children with sepsis.

journal_name

J Cardiothorac Vasc Anesth

journal_title

Journal of cardiothoracic and vascular anesthesia

authors

Weiss SL,Nicolson SC,Naim MY

doi

10.1053/j.jvca.2019.10.029

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

1324-1332

issue

5

eissn

1053-0770

issn

1532-8422

pii

S1053-0770(19)31103-6

journal_volume

34

pub_type

杂志文章,评审

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