[Amplification of L-myc oncogene in malignant meningioma. Case report].

Abstract:

:Amplification of L-myc oncogene was noticed in a malignant meningioma originating from the right sphenoidal wing of a 54-year-old female. The patient underwent three surgical resections plus radiotherapy over a period of 11 years and then the growth rate of the tumor became much greater with a severely invasive appearance. Using Southern blot hybridization, L-myc amplification was examined on the specimen resected at the fourth operation. As a result, approximately five-fold amplification was confirmed, which has not been previously reported except for that in a small cell carcinoma of the lung. This result may suggest that L-myc amplification is responsible to some extent for the malignant transformation in this meningioma.

authors

Jimbo T,Tsuboi K,Iwamura Y,Kaneko M,Nakagawa K,Nose T

doi

10.2176/nmc.31.1040

subject

Has Abstract

pub_date

1991-12-01 00:00:00

pages

1040-4

issue

13

eissn

0470-8105

issn

1349-8029

pii

JST.Journalarchive/nmc1959/31.1040

journal_volume

31

pub_type

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