Evaluation of the Production and Absorption of Cerebrospinal Fluid.

Abstract:

:The traditional hypothesis of cerebrospinal fluid (CSF) hydrodynamics presumes that CSF is primarily produced in the choroid plexus (CP), then flows from the ventricles into the subarachnoid spaces, and mainly reabsorbed in the arachnoid granulations. This hypothesis is necessary to reconsider in view of recent research and clinical observations. This literature review presents numerous evidence for a new hypothesis of CSF hydrodynamics-(1) A significantly strong relationship exists between the CSF and interstitial fluid (IF), (2) CSF and IF are mainly produced and absorbed in the parenchymal capillaries of the brain and spinal cord. A considerable amount of CSF and IF are also absorbed by the lymphatic system, and (3) CSF movement is not unidirectional flow. It is only local mixing and diffusion.

authors

Miyajima M,Arai H

doi

10.2176/nmc.ra.2015-0003

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

647-56

issue

8

eissn

0470-8105

issn

1349-8029

journal_volume

55

pub_type

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