An experimental model of cerebral venous hypertension in the rat.

Abstract:

:Several means of establishing a useful experimental model of cerebral venous hypertension were examined in rats. Retrograde embolization with an autologous blood clot passed through a catheter inserted in an external jugular vein, combined with ligation of the contralateral external jugular vein, was found to produce consistent, sustained cerebral venous hypertension. This model has the advantages of being technically easy to prepare, well tolerated by the animals, and suitable for autoradiographic and/or histochemical assessment of regional circulation and metabolism.

authors

Kurokawa Y,Hashi K,Okuyama T,Sasaki S

doi

10.2176/nmc.29.175

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

175-80

issue

3

eissn

0470-8105

issn

1349-8029

pii

JST.Journalarchive/nmc1959/29.175

journal_volume

29

pub_type

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