Abstract：
OBJECTIVES:The prognostic impact of risk factors for ovarian cancer development is sparsely explored, but previous sterilisation has been shown to have a negative impact on survival. METHODS:Ovarian cancer cases were from the Danish MALOVA study. Information on previous pelvic surgery as well as reproductive variables was obtained from a personal interview conducted closely after primary surgery. Cox regression models were used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (95% CI) for ovarian cancer specific death in relation to previous pelvic surgery and reproductive variables including lifetime number of ovulation years. RESULTS:A total of 295 women with Stage III ovarian carcinomas were identified and followed to death or for a median of 7.3 years (range 5.4-9.5 years). Previously sterilised or hysterectomised women seemed to have a slightly decreased risk of ovarian cancer death (HR = 0.62; 95% CI: 0.36-1.08 and HR = 0.82; 95% CI: 0.55-1.21), although none of these associations reached statistical significance. The prognostic impacts of the individual reproductive variables followed the same pattern as the impact of the variables on ovarian cancer development, although significance was only reached for age at menarche (HR = 0.91 per year; 95% CI: 0.84-0.99). By accumulation of the possible minor effects of the reproductive variables in calculation of the total lifetime number of ovulation years, we found that survival decreased significantly with increasing number of ovulations (HR = 1.53 per 10 years; 95% CI: 1.09-2.14). CONCLUSION:Increasing lifetime number of ovulations was a negative prognostic factor for ovarian cancer specific survival. Previous sterilisation or hysterectomy seemed to be associated with improved survival.
journal_name
Eur J Gynaecol Oncoljournal_title
European journal of gynaecological oncologyauthors
Kjaerbye-Thygesen A,Frederiksen K,Høgdall EV,Høgdall CK,Blaakaer J,Kjaer SKsubject
Has Abstractpub_date
2006-01-01 00:00:00pages
467-72issue
5eissn
0392-2936issn
2709-0086journal_volume
27pub_type
杂志文章abstract：INTRODUCTION:Methylation of genomic DNA is one of the major mechanisms that deactivates genes and regulates their tissue-specific transcription levels. Its patterns are based on clonal inheritance that occurs in the early stages of embryogenesis. All changes in the DNA methylation levels occurring especially in the pro...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章,评审
doi：
更新日期：2004-01-01 00:00:00
abstract：:Six patients with vulvar malignant melanoma are reported. They accounted for 5.2% of all females with vulvar malignancies diagnosed in the south of Israel between 1961 and 1997. Age ranged from 25 to 66 years. Presenting symptoms were pruritus, bleeding and ulcer. Lesion originated in the labia minora in four patients...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Cervical cancer is the most common cancer among women in South India. More than 70% of the cases present in stage IIB and IIIB and of these more than 50% fail conventional treatment. The purpose of the present study was to determine the prognostic significance of Bcl-2 and p53 expression in squamous cell carcinomas of...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVE:The objective was to improve the design of the indwelling-intrauterine tube (IIUT) for brachy-radiotherapy of cervical cancer or sleeve, specifically one that would not require stitching to retain it properly in the uterus for periods of one to two weeks and to ensure hygiene by making them disposable, thinne...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVE:Three cases of pelvic actinomycosis initially diagnosed as pelvic malignancy and treated surgically are reported. CASES:The first case was a 38-year-old multiparous woman who was referred to our clinic because of bilateral ovarian solid masses. With the impression of ovarian carcinoma, a laparotomy was perfo...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:It is well recognized that genetic alterations within oncogenes, tumor suppressor genes, DNA mismatch repair and excision repair genes contribute to tumorigenesis within the human ovary. This study was undertaken to screen for the existence of K-ras gene point mutations in paraffin-embedded slides randomly selected fr...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Correlates of HPV amongst a cohort of women with a CIN I detected by a screening Pap test were investigated. Co-incident CIN II/III lesions were identified and their influence on the HPV status and HPV determinants of screening detected CIN I was assessed. Based on both the colposcopic impression and repeat Pap test, ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:This is a case report of a 57-year-old man who had primary angiosarcoma of the left breast. Five months after detecting a mass in his breast, he underwent mastectomy with biopsy of the ipsilateral axillary lymph nodes. Three years later, he is still alive without any recurrence. Angiosarcoma of the female breast is ra...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:Fertility sparing surgery might be a benefit for young patients with early-stage cervical cancer. The authors herein describe a case of adenocarcinoma of cervix Stage IA2 treated with laparoscopic radical trachelectomy (LRT) with round ligament and uterine artery preservation. ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:Ovarian cancer is not the most frequent malignancy of female reproductive system, but it causes many deaths in women with this diagnosis. Mostly of the patients with ovarian cancer will have recurrence after first-line standard treatment containing surgery and chemotherapy. This article presents two cases with late re...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章,评审
doi：
更新日期：2015-01-01 00:00:00
abstract：:The aim of our study was to describe the expression of c-erbB-1, c-erbB-2, c-erbB-3 and c-erbB-4 in endometrial cancer tissue and its correlation with clinicopathologic features and prognosis of the patients. One hundred and six cases of endometrial cancer were identified from the archives of the Department of Obstetr...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：PURPOSE OF INVESTIGATION:Mortality and morbidity rates of cervical, breast, and colorectal cancers (CRC) can be decreased via effective screening strategies. Developing countries are to be expected to establish and implement their own programs. MATERIALS AND METHODS:To evaluate regional awareness and status of cervica...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2017-01-01 00:00:00
abstract：:This paper reports an investigation of the mechanism involved in the response of endometrial adenocarcinoma to MPA. The following protocol was used for a period of 8 years: 1 g/day MPA per os for 30 days and 60 days after surgery, following by 500 mg/day for 1 year. Adenocarcinoma glycolytic activity, G-6-P cycle, pol...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Transudative ascites are a rare entity in cancer which may sometimes make their diagnosis difficult. Here, the authors report an unusual case of transudative ascites in a 50-year-old woman with ovarian cancer. The patient first presented with progressive painless gross transudative ascites for the past five months wit...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2017-01-01 00:00:00
abstract：:Class II HLA antigen expression was investigated in biopsy material from patients with preclinical cervical carcinoma. Class II molecules were determined immunohistochemically by MoAb against HLA-DR antigens. A significant reduction of class II positive cells was established in the tumor tissue compared to the normal ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Cancer of the endometrium is a neoplasm which essentially strikes postmenopausal women and in which the predominant risk factors are recognized as an excessive imbalance of estrogen and obesity. The survival rate is good in the first stage and is acceptable in the second, while in the third and especially the fourth s...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:The purpose was to evaluate the usefulness of serum Cyfra 21.1 assay for the monitoring of patients with uterine cervix cancer. METHODS:Pre-treatment sera and complete follow-up of the patients were available for SCC and Cyfra 21.1 for 79 patients Another group of 50 patients was studied to evaluate the specif...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:A prospective, randomized study comparing single dose intravenous antibiotic prophylaxis with multiple-dose regimen in patients undergoing radical surgery for gynecologic malignancy was carried out. The majority of patients had cervical cancer. Thirty-seven patients in group A received one dose of 4 g piperacillin and...
journal_title：European journal of gynaecological oncology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1993-01-01 00:00:00
abstract：:402 radical hysterectomies (17 ultraradical) were performed with lymphadenectomy. Positive metastatic nodes (N+) rate was 23.6% with an arithmetic mean of 22 excised lymph nodes. Single N+ belonged mostly to the obturatory group, double N+ to obturatory and external iliac groups, while multiple N+ (24 cases) had no pa...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：PURPOSE OF INVESTIGATION:Invasive squamous cell cancer of the vulva (ISCC) is a rare disease in young patients and in pregnant women. The purpose of this paper was to investigate this type of cancer in women less than 40 years old and to present three cases, one which was diagnosed in the third trimester of pregnancy. ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:To establish the accuracy of endometrial biopsy with the Cornier pipelle in the diagnosis of endometrial cancer and atypical endometrial hyperplasia in our milieu. MATERIAL AND METHOD:We reviewed 1,535 anatomopathologic reports on endometrial biopsies taken from outpatients using the Cornier pipelle between ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:The optimal treatment of patients with "high risk" cancer involving the uterine cervix has not been defined. These patients include those with "bulky" or barrel shaped cervical tumors, individuals with adenocarcinomas or sarcomas, and those who respond poorly to radiation. As these patients are at high risk ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND:Vulvar dermatofibrosarcoma is a rare fibrous tumor of intermediate grade malignancy, with a tendency for local recurrence, and rarely metastasizes. Management should be multidisciplinary. This is a report of an apparently benign vulvar mass with delayed diagnosis of vulvar dermatofibrosarcoma. CASE REPORT:A...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:All malignant cells appear to have increased needs for glucose in vitro as well as in vivo. The enhanced glucose uptake is mediated through transporters (Gluts), whose action and expression are regulated by oncogenes and growth factors. Cyclin D1 is a nuclear protein that plays an important role in regulating the cell...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:256 patients of the years 1965-1979 who suffered from collum carcinoma stage T1b were reviewed. Most of the neoplasmas were squamous cell carcinoma (81%). By tumor screening only 21% of the carcinomas were detected. The treatment was in most of the cases a radical hysterectomy (Wertheim-Meigs). Postoperative radiother...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Breast cancer is a common disease in Western societies, with an incidence of 46.31/100,000 women/year in Brazil. The tumor suppressor gene TP53 is one of the most studied genes regarding the presence of mutations. Indeed, 50% of all tumors are known to exhibit changes in the TP53 nucleotide sequence due to carcinogeni...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:To investigate prognostic factors in patients with recurrent cervical cancer after treatment of early-stage disease in order to identify high-risk patients who might benefit from alternative treatment strategies. STUDY DESIGN:The authors retrospectively analyzed clinical and pathology data from 130 recurrent...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2017-01-01 00:00:00
abstract：:The incidence of invasive cervical cancer and consequently mortality decreased due to adequate screening programmes in Canada from 1969 to 2003. Systematic cervical screening programmes similar to those in Europe should be implemented throughout Canada. The new techniques, including a liquid-based cytology, associated...
journal_title：European journal of gynaecological oncology
pub_type： 社论
doi：
更新日期：2004-01-01 00:00:00
abstract：:Nineteen women with a mean age of 62 were treated for primary adenocarcinoma of the fallopian tube from 1960 to 1980. Common presentations were bleeding or discharge, pelvic mass, and pain. Cervical cytology was positive in five of eleven cases; endometrial curettings revealed adenocarcinoma in three of nine cases. St...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章,评审
doi：
更新日期：1989-01-01 00:00:00
abstract：:According to the present guidelines for advanced epithelial ovarian cancer (EOC), bulky lymph nodes should be removed as part of the routine surgical staging and the primary goal being removal of all macroscopic tumor residuals. Furthermore, EOC-patients with bulky lymph node relapse seem to benefit from lymphadenecto...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
