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Effects of antioxidants on auditory nerve function and survival in deafened guinea pigs.

Abstract：

:Based on in vitro studies, it is hypothesized that neurotrophic factor deprivation following deafferentation elicits an oxidative state change in the deafferented neuron and the formation of free radicals that then signal cell death pathways. This pathway to cell death was tested in vivo by assessing the efficacy of antioxidants (AOs) to prevent degeneration of deafferented CNVIII spiral ganglion cells (SGCs) in deafened guinea pigs. Following destruction of sensory cells, guinea pigs were treated immediately with Trolox (a water soluble vitamin E analogue)+ascorbic acid (vitamin C) administered either locally, directly in the inner ear, or systemically. Electrical auditory brainstem response (EABR) thresholds were recorded to assess nerve function and showed a large increase following deafness. In treated animals EABR thresholds decreased and surviving SGCs were increased significantly compared to untreated animals. These results indicate that a change in oxidative state following deafferentation plays a role in nerve cell death and antioxidant therapy may rescue SGCs from deafferentation-induced degeneration.

journal_name

Neurobiol Dis

journal_title

Neurobiology of disease

authors

Maruyama J,Yamagata T,Ulfendahl M,Bredberg G,Altschuler RA,Miller JM

doi

10.1016/j.nbd.2006.09.012

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

309-18

issue

2

eissn

0969-9961

issn

1095-953X

pii

S0969-9961(06)00242-7

journal_volume

25

pub_type

杂志文章

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