Am5-HT7: molecular and pharmacological characterization of the first serotonin receptor of the honeybee (Apis mellifera).

abstract：:Converging lines of evidence implicate the beta-amyloid peptide (Ass) as causative in Alzheimer's disease. We describe a novel class of compounds that reduce A beta production by functionally inhibiting gamma-secretase, the activity responsible for the carboxy-terminal cleavage required for A beta production. These mo...

journal_title：Journal of neurochemistry

authors： Dovey HF,John V,Anderson JP,Chen LZ,de Saint Andrieu P,Fang LY,Freedman SB,Folmer B,Goldbach E,Holsztynska EJ,Hu KL,Johnson-Wood KL,Kennedy SL,Kholodenko D,Knops JE,Latimer LH,Lee M,Liao Z,Lieberburg IM,Motter RN,

更新日期：2001-01-01 00:00:00

abstract：:Deep hypothermia protects the brain from ischemic damage and is therefore used during major cardiovascular surgeries requiring cardiopulmonary bypass and a period of circulatory arrest. Here, we demonstrated that small ubiquitin-like modifier (SUMO1-3) conjugation is markedly activated in the brain during deep to mode...

journal_title：Journal of neurochemistry

authors： Wang L,Ma Q,Yang W,Mackensen GB,Paschen W

更新日期：2012-11-01 00:00:00

abstract：:Adrenal chromaffin cells release neurotransmitters in response to stress and may be involved in conditions such as post-traumatic stress and anxiety disorders. Neurotransmitter release is triggered, in part, by activation of nicotinic acetylcholine receptors (nAChRs). However, despite decades of use as a model system ...

journal_title：Journal of neurochemistry

authors： Hone AJ,Rueda-Ruzafa L,Gordon TJ,Gajewiak J,Christensen S,Dyhring T,Albillos A,McIntosh JM

更新日期：2020-07-01 00:00:00

abstract：:Kainate receptors (KARs) modulate synaptic transmission at both pre-synaptic and post-synaptic sites. The overlap in the distribution of KA-2 and GluR6/7 subunits in several brain regions suggests the co-assembly of these subunits in native KARs. The molecular mechanisms that control the assembly and surface expressio...

journal_title：Journal of neurochemistry

authors： Gallyas F Jr,Ball SM,Molnar E

更新日期：2003-09-01 00:00:00

abstract：:Post-traumatic immune suppression renders individuals with spinal cord injury (SCI) susceptible to infection. Normally, proper immune function is regulated by collaboration between the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis and involves the controlled release of glucocorticoids ...

journal_title：Journal of neurochemistry

authors： Lucin KM,Sanders VM,Popovich PG

更新日期：2009-09-01 00:00:00

abstract：:Female mice are more susceptible to apolipoprotein E (apoE4)-induced cognitive deficits than male mice. These deficits can be antagonized by stimulating androgen receptors (ARs). To determine the role of AR in the cognitive effects of apoE4, we backcrossed mutant mice with a naturally occurring defect in the AR [testi...

journal_title：Journal of neurochemistry

authors： Rizk-Jackson A,Robertson J,Raber J

更新日期：2008-04-01 00:00:00

abstract：:Knowledge of the relative contributions of mast cells and neurons to the overall pool of histamine in the brain is a prerequisite to determining the significance and role of this amine in brain function. Consequently, we analyzed the levels of brain histamine in four genotypes (+/+, W/+, Wv/+, and W/Wv) of WBB6F1 mice...

journal_title：Journal of neurochemistry

authors： Orr EL,Pace KR

更新日期：1984-03-01 00:00:00

abstract：:From immunizations of mice with a glutathione S-transferase fusion protein containing residues 724-781 of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR1-flop, two monoclonal antibodies (mAbs) were developed that differed widely in their ranges of specificity. In immunocytochemical ...

journal_title：Journal of neurochemistry

authors： Tönnes J,Stierli B,Cerletti C,Behrmann JT,Molnár E,Streit P

更新日期：1999-11-01 00:00:00

abstract：:GABAA receptors are activated via low-affinity binding sites for the agonists GABA or muscimol. Evidence has been provided that the amino acid residue alpha 1F64 located at the beta2(+)/alpha1(-) subunit interface forms part of this binding site. In radioactive ligand binding studies the agonist [3H]muscimol has been ...

journal_title：Journal of neurochemistry

authors： Baur R,Sigel E

更新日期：2003-10-01 00:00:00

abstract：:The antisense strategy was used to unravel the functional contribution of the mRNAs encoding dopamine (DA) receptors to the multiple transduction mechanisms operated by DA in rat pituitary cells. An antisense oligonucleotide was designed to recognize seven nucleotides upstream and 11 nucleotides downstream from the in...

journal_title：Journal of neurochemistry

authors： Valerio A,Alberici A,Tinti C,Spano P,Memo M

更新日期：1994-04-01 00:00:00

abstract：:Near total inhibition of brain adenosine deaminase (ADA) activity in rats injected with the potent ADA inhibitor 2'-deoxycoformycin (DCF) was previously shown to reduce enzyme activity for up to 50 days during which time the enzyme exhibited reduced sensitivity to in vivo inhibition by DCF. Here, we investigated the b...

journal_title：Journal of neurochemistry

authors： Padua RA,Geiger JD,Delaney SM,Nagy JI

更新日期：1992-02-01 00:00:00

abstract：:The origin of afferent somatostatin-containing fibers terminating in medial and ventral parts of the striatum has been investigated by performing various neurochemical and surgical lesions in the rat. Lesions of the anterior hypothalamus, amygdala, and the hippocampal commissure as well as lesions with 6-hydroxydopami...

journal_title：Journal of neurochemistry

authors： Widmann R,Mensdorff-Pouilly N,Pfaller K,Sperk G

更新日期：1987-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative pathology characterized by aggregates of amyloid-β (Aβ) and phosphorylated tau protein, synaptic dysfunction, and spatial memory impairment. The Wnt signaling pathway has several key functions in the adult brain and has been associated with AD, mainly as a neuroprotectiv...

journal_title：Journal of neurochemistry

authors： Tapia-Rojas C,Inestrosa NC

更新日期：2018-02-01 00:00:00

abstract：:Rat cerebral cortex synaptosomes were exposed in superfusion to various depolarizing stimuli and the release of somatostatin-like immunoreactivity (SRIF-LI) was measured by means of a radioimmunoassay procedure. High KCl (9-50 mM) concentration dependently evoked SRIF-LI release; the evoked overflow reached a plateau ...

journal_title：Journal of neurochemistry

authors： Bonanno G,Parodi B,Cafaggi S,Raiteri M

更新日期：1991-10-01 00:00:00

abstract：:Microsomal fractions isolated from rat corpus striatum catalyze the oxidation of thiobenzamide to the sulfoxide. The rate of thiobenzamide sulfoxidation is 6.9 +/- 4.8 nmol(min)-1 (mg microsomal protein)-1. The reaction is inhibited by an excess of sulfur- and nitrogen-containing substrates for the microsomal flavin-c...

journal_title：Journal of neurochemistry

authors： Duffel MW,Gillespie SG

更新日期：1984-05-01 00:00:00

abstract：:The release of gamma-aminobutyric acid (GABA) was studied in slices of the head of the rabbit caudate nucleus. The slices were preincubated with [3H]GABA and then superfused. Aminooxyacetic acid was present throughout. Both the tritium in the slices and that in the superfusate consisted practically entirely of [3H]GAB...

journal_title：Journal of neurochemistry

authors： Limberger N,Späth L,Starke K

更新日期：1986-04-01 00:00:00

abstract：:IMP-GMP 5'-nucleotidase has been purified to homogeneity from total rat brain extracts. This preparation showed a unique band (Mr 54,000 +/- 1,509) in sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The enzyme presented the following properties: optimal pH value, 6.5-6.8; relative velocity measured in the p...

journal_title：Journal of neurochemistry

authors： Marques AF,Teixeira NA,Gambaretto C,Sillero A,Sillero MA

更新日期：1998-09-01 00:00:00

abstract：:Receptors for the nerve growth factor protein (NGF) have been isolated from three cell types [embryonic chicken sensory neurons (dorsal root sensory ganglia; DRG), rat pheochromocytoma (PC12) and human neuroblastoma (LAN-1) cells] and have been shown to be similar with respect to equilibrium dissociation constants. Th...

journal_title：Journal of neurochemistry

authors： Stach RW,Lyons CR,Perez-Polo JR

更新日期：1987-10-01 00:00:00

abstract：:beta-nerve growth factor (NGF) was modified by biotinylation via carboxyl group substitution (C-bio-NGF) using biotin hydrazide and the coupling reagent 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide, under reaction conditions that yielded an average of 3 biotin additions per NGF subunit. NGF was also biotinylated thr...

journal_title：Journal of neurochemistry

authors： Rosenberg MB,Hawrot E,Breakefield XO

更新日期：1986-02-01 00:00:00

abstract：:Neurodegenerative diseases are a worldwide health problem and are a major cause of death and disability. A progressive loss of defined neuronal populations is triggered by a diverse array of stimuli that converge in deficient neurotrophic signaling. Therefore, much effort has been placed in recent years in the charact...

journal_title：Journal of neurochemistry

authors： Hernández-Kelly LC,Ortega A

更新日期：2020-10-19 00:00:00

abstract：:In this work, we have studied (a) the contents of gangliosides, glycoproteins, and phospholipids of the vesicle and plasma membrane fractions from brains of anesthetized and control rats and chickens and (b) the labeling of gangliosides and glycoproteins in the retina ganglion cell layer and optic tectum of urethane-a...

journal_title：Journal of neurochemistry

authors： Domowicz MS,Kivatinitz SC,Caputto BL,Caputto R

更新日期：1988-05-01 00:00:00

abstract：:Exposure of neurones in culture to excitotoxic levels of glutamate results in an initial transient spike in [Ca2+]i followed by a delayed, irreversible [Ca2+]i rise governed by rapid kinetics, with Ca2+ originating from the extracellular medium. The molecular mechanism responsible for the secondary Ca2+ rise is unknow...

journal_title：Journal of neurochemistry

authors： Chinopoulos C,Gerencser AA,Doczi J,Fiskum G,Adam-Vizi V

更新日期：2004-10-01 00:00:00

abstract：:Pretreatment of rats with the excitatory amino acid antagonist 2-amino-7-phosphonoheptanoic acid (2-APH; 0.5 mmol/kg, i.p.) protected against insulin-induced clonic seizures. Complete protection was observed in 38% of the rats and partial protection in an additional 50%. Lesioning of the corticostriatal pathway by fro...

journal_title：Journal of neurochemistry

authors： Chapman AG,Engelsen B,Meldrum BS

更新日期：1987-07-01 00:00:00

abstract：:Free radicals have been implicated in the etiology of many neurodegenerative conditions. Yet, because these species are highly reactive and thus short-lived it has been difficult to test these hypotheses. We adapted a method in which hydroxyl radicals are trapped by salicylate in vivo, resulting in the stable and quan...

journal_title：Journal of neurochemistry

authors： Giovanni A,Liang LP,Hastings TG,Zigmond MJ

更新日期：1995-04-01 00:00:00

abstract：:It has been established that neurosteroids can either inhibit or enhance GABA(A) receptor activity. Although GABA is the main inhibitory neurotransmitter in the mammalian retina, the effects of neurosteroids on retinal GABAergic activity have not been investigated. The aim of this work was to study the neurochemical a...

journal_title：Journal of neurochemistry

authors： Jaliffa CO,Howard S,Hoijman E,Salido E,Sarmiento MI,Arias P,Rosenstein RE

更新日期：2005-09-01 00:00:00

abstract：:Leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) share common components in their multimeric receptors. Both cytokine receptors contain gp130/interleukin-6-receptor transducer as well as gp190/low affinity LIF receptor. For CNTF, addition of a third subunit, or alpha subunit, defines the high-af...

journal_title：Journal of neurochemistry

authors： Robledo O,Auguste P,Coupey L,Praloran V,Chevalier S,Pouplard A,Gascan H

更新日期：1996-04-01 00:00:00

abstract：:Cl(-)-ATPase in the CNS is a candidate for an outwardly directed neuronal Cl(-) transporter requiring phosphatidylinositol-4-phosphate (PI4P) for its optimal activity. To test its pathophysiological changes in a phosphatidylinositol (PI) metabolism disorder, the effects of neurotoxic factors in Alzheimer's disease (AD...

journal_title：Journal of neurochemistry

authors： Yagyu K,Kitagawa K,Irie T,Wu B,Zeng XT,Hattori N,Inagaki C

更新日期：2001-08-01 00:00:00

abstract：:Epinephrine (Epi) mediates various physiological effects via alpha2A-adrenergic receptors (alpha2A-ARs). Studies in mice with a point mutation in the gene for alpha2A-AR have shown that these receptors are responsible for the centrally mediated depressor effects of alpha2-AR agonists. These studies underscore the impo...

journal_title：Journal of neurochemistry

authors： Reutter MA,Richards EM,Sumners C

更新日期：1998-01-01 00:00:00

abstract：:Aggregate-prone mutant proteins, such as α-synuclein and huntingtin, play a prominent role in the pathogenesis of various neurodegenerative disorders; thus, it has been hypothesized that reducing the aggregate-prone proteins may be a beneficial therapeutic strategy for these neurodegenerative disorders. Here, we ident...

journal_title：Journal of neurochemistry

authors： Shen W,Henry AG,Paumier KL,Li L,Mou K,Dunlop J,Berger Z,Hirst WD

更新日期：2014-06-01 00:00:00

abstract：:The degeneration of nigral dopamine neurons in Parkinson's disease (PD) reportedly involves a defect in brain mitochondrial complex I in association with the activation of nuclear factor-kappaB (NF-kappaB) and caspase-3. To elucidate molecular mechanisms possibly linking these events, as well as to evaluate the neurop...

journal_title：Journal of neurochemistry

authors： Wang X,Qin ZH,Leng Y,Wang Y,Jin X,Chase TN,Bennett MC

更新日期：2002-12-01 00:00:00