Rat brain adenosine deaminase after 2'-deoxycoformycin administration: biochemical properties and evidence for reduced enzyme levels detected by 2'-[3H]deoxycoformycin ligand binding.

abstract：:Sphingosine 1-phosphate (S1P) is accumulated in lipoproteins, especially high-density lipoprotein (HDL), in plasma. However, it remains uncharacterized how extracellular S1P is produced in the CNS. The treatment of rat astrocytes with retinoic acid and dibutyryl cAMP, which induce apolipoprotein E (apoE) synthesis and...

journal_title：Journal of neurochemistry

authors： Sato K,Malchinkhuu E,Horiuchi Y,Mogi C,Tomura H,Tosaka M,Yoshimoto Y,Kuwabara A,Okajima F

更新日期：2007-12-01 00:00:00

abstract：:Female mice are more susceptible to apolipoprotein E (apoE4)-induced cognitive deficits than male mice. These deficits can be antagonized by stimulating androgen receptors (ARs). To determine the role of AR in the cognitive effects of apoE4, we backcrossed mutant mice with a naturally occurring defect in the AR [testi...

journal_title：Journal of neurochemistry

authors： Rizk-Jackson A,Robertson J,Raber J

更新日期：2008-04-01 00:00:00

abstract：:Elemental (Na, Cl, K) and water contents of leech (Macrobdella decora) neurons and glial cells were determined under steady-state exposure to 4, 10, and 20 mM KCl concentrations (bathing media) using x-ray microanalysis for quantitative digital imaging of frozen hydrated and dried cryosections. Effects of furosemide, ...

journal_title：Journal of neurochemistry

authors： Saubermann AJ,Stockton JD

更新日期：1988-12-01 00:00:00

abstract：:In the present study we have used perfused hippocampal slices to examine the hypothesis that nitric oxide (NO) can evoke the release of adenosine from nervous tissue. ATP stores were labeled by incubation with [3H]adenine. Electrical field stimulation at 5 Hz for 5 min evoked the release of 3H-purines, and this was en...

journal_title：Journal of neurochemistry

authors： Fallahi N,Broad RM,Jin S,Fredholm BB

更新日期：1996-07-01 00:00:00

abstract：:Properties so far studied of the 125-kDa 14C-arginylated protein from rat brain show remarkable similarities with those of the STOP (stable tubule only polypeptide) protein. On sodium dodecyl sulfate-polyacrylamide gel electrophoresis the 125-kDa 14C-arginylated protein moves to the same position as the STOP protein. ...

journal_title：Journal of neurochemistry

authors： Bongiovanni G,Barra HS,Hallak ME

更新日期：1994-12-01 00:00:00

abstract：:Previous work has demonstrated that there is a selective increase in extracellular taurine in the brain during acute water intoxication. One aim of the present study was to investigate whether plasma taurine contributes to this increase. To this end, the concentrations of taurine, other amino acids, and ethanolamine (...

journal_title：Journal of neurochemistry

authors： Lehmann A,Carlström C,Nagelhus EA,Ottersen OP

更新日期：1991-02-01 00:00:00

abstract：:alpha-Conotoxins interact with nicotinic acetylcholine receptors (nAChRs) and acetylcholine-binding proteins (AChBPs) at the sites for agonists/competitive antagonists. alpha-Conotoxins blocking muscle-type or alpha7 nAChRs compete with alpha-bungarotoxin. However, alpha-conotoxin ImII, a close homolog of the alpha7 n...

journal_title：Journal of neurochemistry

authors： Kasheverov IE,Zhmak MN,Fish A,Rucktooa P,Khruschov AY,Osipov AV,Ziganshin RH,D'hoedt D,Bertrand D,Sixma TK,Smit AB,Tsetlin VI

更新日期：2009-11-01 00:00:00

abstract：:Prolonged seizures activate members of the Bcl-2 homology domain 3-only sub-group of the Bcl-2 protein family, which are essential for initiation of apoptosis signaling. Bid is a potent pro-apoptotic Bcl-2 homology domain 3-only protein, which upon proteolytic activation translocates to mitochondria to promote activat...

journal_title：Journal of neurochemistry

authors： Engel T,Caballero-Caballero A,Schindler CK,Plesnila N,Strasser A,Prehn JH,Henshall DC

更新日期：2010-10-01 00:00:00

abstract：:In brain, the precursor of imidazoleacetic acid (IAA), a GABAA agonist but a GABAC antagonist, is not known. In the periphery, IAA derives from oxidation of histamine. But in brain, histamine is thought to be metabolized solely by histamine methyltransferase (HMT), forming tele-methylhistamine (t-MH) and tele-methylim...

journal_title：Journal of neurochemistry

authors： Prell GD,Morrishow AM,Duoyon E,Lee WS

更新日期：1997-01-01 00:00:00

abstract：:Vinpocetine is a neuroprotective drug that exerts beneficial effects on neurological symptoms and cerebrovascular disease. 3-nitropropionic acid (3-NPA) is a toxin that irreversibly inhibits succinate dehydrogenase, the mitochondrial enzyme that acts in the electron transport chain at complex II. In previous studies i...

journal_title：Journal of neurochemistry

authors： Herrera-Mundo N,Sitges M

更新日期：2013-01-01 00:00:00

abstract：:To further analyze the action of copper on brain synaptic mechanisms, the brain dipeptide carnosine (beta-alanyl-L-histidine) was tested in Xenopus laevis oocytes expressing the rat P2X4 or P2X7 receptors. Ten micromolar copper halved the currents evoked by ATP in both receptors; co-application of carnosine plus coppe...

journal_title：Journal of neurochemistry

authors： Coddou C,Villalobos C,González J,Acuña-Castillo C,Loeb B,Huidobro-Toro JP

更新日期：2002-02-01 00:00:00

abstract：:Retinoid-related orphan receptor alpha1 (RORalpha1) is a member of the nuclear receptor superfamily. It is highly expressed in CNS particularly in the cerebellum. Absence of this transcription factor in mice leads to several abnormalities, such as cerebellar atrophy linked to Purkinje cell death and impaired different...

journal_title：Journal of neurochemistry

authors： Duplus E,Gras C,Soubeyre V,Vodjdani G,Lemaigre-Dubreuil Y,Brugg B

更新日期：2008-03-01 00:00:00

abstract：:Huntington's disease is a progressive neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the huntingtin gene. This expansion produces a mutant form of the huntingtin protein, which contains an elongated polyglutamine stretch at its amino-terminus. Mutant huntingtin may adopt an aberrant, aggr...

journal_title：Journal of neurochemistry

authors： Roscic A,Baldo B,Crochemore C,Marcellin D,Paganetti P

更新日期：2011-10-01 00:00:00

abstract：:Dual-probe microdialysis was used to study interstitial diffusion in the rat brain. A radiolabelled tracer, (3H]mannitol, was continuously infused at different concentrations via a probe acutely implanted into the striatum of an anaesthetized male rat or into a dilute agar gel. Samples were collected by a second probe...

journal_title：Journal of neurochemistry

authors： Höistad M,Chen KC,Nicholson C,Fuxe K,Kehr J

更新日期：2002-04-01 00:00:00

abstract：:Manganese is an essential nutrient, integral to proper metabolism of amino acids, proteins and lipids. Excessive environmental exposure to manganese can produce extrapyramidal symptoms similar to those observed in Parkinson's disease (PD). We used in vivo and in vitro models to examine cellular and circuitry alteratio...

journal_title：Journal of neurochemistry

authors： Stanwood GD,Leitch DB,Savchenko V,Wu J,Fitsanakis VA,Anderson DJ,Stankowski JN,Aschner M,McLaughlin B

更新日期：2009-07-01 00:00:00

abstract：:Microglial activation by blood-borne factors following blood-brain barrier damage may play a significant role in subsequent neuropathogenesis of several neurodegenerative diseases. Exposure of primary cultured rat brain microglia to pure, fatty acid- and lipid-deficient rat serum albumin or fraction V, (fatty acid and...

journal_title：Journal of neurochemistry

authors： Hooper C,Pinteaux-Jones F,Fry VA,Sevastou IG,Baker D,Heales SJ,Pocock JM

更新日期：2009-05-01 00:00:00

abstract：:The neurotransmitter glutamate, once released into the synaptic cleft, is largely recycled by the glutamate-glutamine cycle, which involves uptake into astrocytes, conversion into glutamine and subsequent release of glutamine from astrocytes as a precursor for neuroneal glutamate synthesis. We analysed glutamine efflu...

journal_title：Journal of neurochemistry

authors： Deitmer JW,Bröer A,Bröer S

更新日期：2003-10-01 00:00:00

abstract：:Axonal transport of glycoconjugates was studied in the motoneurons of rat sciatic nerve following injection of [3H]glucosamine into the lumbosacral spinal cord. After varying time intervals, the sciatic nerve was exposed, and two ligatures were tied for collection of materials undergoing anterograde and retrograde tra...

journal_title：Journal of neurochemistry

authors： Aquino DA,Bisby MA,Ledeen RW

更新日期：1985-10-01 00:00:00

abstract：:The possibility that the mechanism of lead neurotoxicity may be at the level of transcription was investigated in PC12 cells. In electrophoretic mobility gel shift assays Pb2+ was found to increase activator protein-1 complex (AP-1) DNA binding activity in PC12 cells; the increase was time- and concentration-dependent...

journal_title：Journal of neurochemistry

authors： Chakraborti T,Kim KA,Goldstein GG,Bressler JP

更新日期：1999-07-01 00:00:00

abstract：:We examined the effects of chronic (2 weeks) treatment with a typical neuroleptic, haloperidol (1 mg/kg, s.c.), and an atypical neuroleptic, clozapine (20 mg/kg, s.c.), on neurotensin receptor (NTR) mRNA levels by in situ hybridization histochemistry. Quantitative OD analysis showed haloperidol-induced NTR mRNA levels...

journal_title：Journal of neurochemistry

authors： Bolden-Watson C,Watson MA,Murray KD,Isackson PJ,Richelson E

更新日期：1993-09-01 00:00:00

abstract：:Conversion of the cellular prion protein (PrP(C)) into the abnormal scrapie isoform (PrP(Sc)) is the hallmark of prion diseases, which are fatal and transmissible neurodegenerative disorders. ER-retained anti-prion recombinant single-chain Fv fragments have been proved to be an effective tool for inhibition of PrP(C) ...

journal_title：Journal of neurochemistry

authors： Filesi I,Cardinale A,Mattei S,Biocca S

更新日期：2007-06-01 00:00:00

abstract：:Fingolimod, a sphingosine-1-phosphate receptor (S1PR) agonist, is clinically available to treat multiple sclerosis and is showing promise in treating stroke. We investigated if fingolimod provides long-term protection from experimental neonatal germinal matrix hemorrhage (GMH), aiming to support a potential mechanism ...

journal_title：Journal of neurochemistry

authors： Rolland WB,Krafft PR,Lekic T,Klebe D,LeGrand J,Weldon AJ,Xu L,Zhang JH

更新日期：2017-03-01 00:00:00

abstract：:Brain homogenate, cerebral microvessels, and endothelial cells (ECs) were prepared from 15-18-week-old human fetuses and analyzed biochemically for the presence of elements of the cholinergic system [acetylcholinesterase (AChE), choline acetyltransferase (ChAT), and butyrylcholinesterase]. The ECs were cultured, and t...

journal_title：Journal of neurochemistry

authors： Kasa P,Pakaski M,Joó F,Lajtha A

更新日期：1991-06-01 00:00:00

abstract：:GN11 and GT1-7 are immortalized gonadotropin-releasing hormone-positive murine cell lines exhibiting the features of immature olfactory neurons and differentiated hypothalamic neurons, respectively. Using electron microscopy and biochemical assays (RT-PCR and immunoblotting) we determined the presence of numerous cave...

journal_title：Journal of neurochemistry

authors： D'Orlando C,Guzzi F,Gravati M,Biella G,Toselli M,Meneveri R,Barisani D,Parenti M

更新日期：2008-03-01 00:00:00

abstract：:Hydrogen sulfide (H(2)S), a gasotransmitter, induces neuronal differentiation characterized by neuritogenesis and functional up-regulation of high voltage-activated Ca(2+) channels, via activation of T-type Ca(2+) channels in NG108-15 cells. We thus analyzed signaling mechanisms for the H(2)S-evoked neuronal different...

journal_title：Journal of neurochemistry

authors： Tarui T,Fukami K,Nagasawa K,Yoshida S,Sekiguchi F,Kawabata A

更新日期：2010-07-01 00:00:00

abstract：:We describe here two types of apoptotic cell death observed in the rat CNS-derived neuroblastoma B50 and B104 cells. One type was induced by dibutyryl cyclic AMP (DBcAMP) after differentiation, and the other was induced by treatment of proliferating cells with cycloheximide. When B50 and B104 cells were treated with 1...

journal_title：Journal of neurochemistry

authors： Honma N,Uchida A,Hirose H,Srsen V,Kishimoto T,Hisanaga S

更新日期：1996-11-01 00:00:00

abstract：:beta-Amyloid peptides (Abeta40 and Abeta42) are the major constituents of amyloid plaques, which are one of the hallmarks of Alzheimer's disease (AD). The Abeta is derived from sequential cleavages of amyloid precursor protein (APP) by beta- and gamma-secretases. gamma-Secretase consists of at least four proteins wher...

journal_title：Journal of neurochemistry

authors： Lai MT,Crouthamel MC,DiMuzio J,Pietrak BL,Donoviel DB,Bernstein A,Gardell SJ,Li YM,Hazuda D

更新日期：2006-01-01 00:00:00

abstract：:The aim of this study was to investigate the effect of long-term treatment with interferon (IFN)-alpha on the noradrenaline transporter of bovine adrenal medullary cells. Treatment of cultured adrenal medullary cells with IFN-alpha caused a decrease in uptake of [3H]noradrenaline by the cells in time (4-48 h)- and con...

journal_title：Journal of neurochemistry

authors： Toyohira Y,Yanagihara N,Minami K,Ueno S,Uezono Y,Tachikawa E,Kondo Y,Kashimoto T,Izumi F

更新日期：1998-04-01 00:00:00

abstract：:Tissue plasminogen activator (tPA) is necessary for hippocampal long-term potentiation. Synaptically released zinc also contributes to long-term potentiation, especially in the hippocampal CA3 region. Using cortical cultures, we examined whether zinc increased the concentration and/or activity of tPA. Two hours after ...

journal_title：Journal of neurochemistry

authors： Hwang IY,Sun ES,An JH,Im H,Lee SH,Lee JY,Han PL,Koh JY,Kim YH

更新日期：2011-09-01 00:00:00

abstract：:We have developed a novel competitive method to select from a phage display library a single chain Fv which is able to mimic the alpha-bungarotoxin binding site of the muscle nicotinic receptor. The single chain Fv was selected from a large synthetic library using alpha-bungarotoxin-coated magnetic beads. Toxin-bound ...

journal_title：Journal of neurochemistry

authors： Bracci L,Pini A,Lozzi L,Lelli B,Battestin P,Spreafico A,Bernini A,Niccolai N,Neri P

更新日期：2001-07-01 00:00:00