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SNP@Domain: a web resource of single nucleotide polymorphisms (SNPs) within protein domain structures and sequences.

Abstract：

:The single nucleotide polymorphisms (SNPs) in conserved protein regions have been thought to be strong candidates that alter protein functions. Thus, we have developed SNP@Domain, a web resource, to identify SNPs within human protein domains. We annotated SNPs from dbSNP with protein structure-based as well as sequence-based domains: (i) structure-based using SCOP and (ii) sequence-based using Pfam to avoid conflicts from two domain assignment methodologies. Users can investigate SNPs within protein domains with 2D and 3D maps. We expect this visual annotation of SNPs within protein domains will help scientists select and interpret SNPs associated with diseases. A web interface for the SNP@Domain is freely available at http://snpnavigator.net/ and from http://bioportal.net/.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Han A,Kang HJ,Cho Y,Lee S,Kim YJ,Gong S

doi

10.1093/nar/gkl323

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

W642-4

issue

Web Server issue

eissn

0305-1048

issn

1362-4962

pii

34/suppl_2/W642

journal_volume

34

pub_type

杂志文章

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