Abstract:
:Over the last 8 years, the National Cancer Institute (NCI) has launched a major effort to integrate molecular and clinical cancer-related information within a unified biomedical informatics framework, with controlled terminology as its foundational layer. The NCI Thesaurus is the reference terminology underpinning these efforts. It is designed to meet the growing need for accurate, comprehensive, and shared terminology, covering topics including: cancers, findings, drugs, therapies, anatomy, genes, pathways, cellular and subcellular processes, proteins, and experimental organisms. The NCI Thesaurus provides a partial model of how these things relate to each other, responding to actual user needs and implemented in a deductive logic framework that can help maintain the integrity and extend the informational power of what is provided. This paper presents the semantic model for cancer diseases and its uses in integrating clinical and molecular knowledge, more briefly examines the models and uses for drug, biochemical pathway, and mouse terminology, and discusses limits of the current approach and directions for future work.
journal_name
J Biomed Informjournal_title
Journal of biomedical informaticsauthors
Sioutos N,de Coronado S,Haber MW,Hartel FW,Shaiu WL,Wright LWdoi
10.1016/j.jbi.2006.02.013subject
Has Abstractpub_date
2007-02-01 00:00:00pages
30-43issue
1eissn
1532-0464issn
1532-0480pii
S1532-0464(06)00031-1journal_volume
40pub_type
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