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Arocalciferols: synthesis and biological evaluation of aromatic side-chain analogues of 1 alpha,25-dihydroxyvitamin D3(1a).

Abstract：

:Aromatic side-chain analogues (arocalciferols 6-9) of the steroid hormone 1 alpha,25-dihydroxyvitamin D3 (1) were synthesized and biologically evaluated. The analogues were prepared by coupling the vitamin D A-ring enyne 14 with the appropriate enol triflate of a modified CD steroid fragment of the type 22. The resulting dienyne 23 was then transformed in three steps to the vitamin D analogues 6-9. Biological evaluation of these analogues have provided information concerning side-chain topographical effects on in vivo and in vitro activity.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Figadère B,Norman AW,Henry HL,Koeffler HP,Zhou JY,Okamura WH

doi

10.1021/jm00112a021

keywords:

subject

Has Abstract

pub_date

1991-08-01 00:00:00

pages

2452-63

issue

8

eissn

0022-2623

issn

1520-4804

journal_volume

34

pub_type

杂志文章

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