Abstract:
:Many traits including shapes and colors of flowers, fruits and seeds in plants, as well as coat colors and some behavioral properties in animals, are recorded in discrete categories. If categories are ordered, genetic analyses of the categorical traits are often performed using the threshold model, which considers a latent continuous variable, called the liability, underlying a trait and assumes the monotonic relationship between the phenotype and the liability. In some categorical traits, however, descriptions of phenotypes are purely nominal and the phenotypic scores cannot be ordered. The threshold model is unreasonable for the analyses of such unordered categorical traits. In this study, we developed a method for interval mapping of loci affecting unordered categorical traits with more than two categories. The probability of the phenotype of an individual falling in each of the categories was expressed by a polychotomous logistic model, in which the log-odds for each category relative to the reference category were assumed to follow a linear model including genotype at a locus affecting a trait as covariate. Based on the model, the interval mapping using a maximum likelihood method was devised for the analysis of complex categorical traits described with unordered categories. We confined ourselves to the case of F2 populations derived from a cross between two inbred lines, although this approach can easily be extended to the analyses for other populations of general structures. As results of analyses of simulated data show, the method showed high efficiency in detecting the loci affecting unordered categorical traits.
journal_name
Heredity (Edinb)journal_title
Heredityauthors
Hayashi T,Awata Tdoi
10.1038/sj.hdy.6800783keywords:
subject
Has Abstractpub_date
2006-02-01 00:00:00pages
185-94issue
2eissn
0018-067Xissn
1365-2540pii
6800783journal_volume
96pub_type
杂志文章相关文献
HEREDITY文献大全abstract::There are only few studies of dominance effects in non-inbred aquaculture species, since commonly used mating designs often have low power to separate dominance, maternal and common environmental effects. Here, a factorial design with reciprocal cross, common rearing of eggs and subsequent lifecycle stages and pedigre...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-017-0046-x
更新日期:2018-05-01 00:00:00
abstract::Colonizing events may expose organisms to physical and ecological environments found nowhere else in their range. Novel selection pressures can then influence subsequent rapid evolutionary changes. Here, I investigate the genetics of one such rapid change in the sexual signal of Polynesian field crickets, Teleogryllus...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/sj.hdy.6801069
更新日期:2008-03-01 00:00:00
abstract::Genetic diversity is a fundamental requirement for evolution and adaptation. Nonetheless, the forces that maintain patterns of genetic variation in wild populations are not completely understood. Neutral theory posits that genetic diversity will increase with a larger effective population size and the decreasing effec...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.2015.76
更新日期:2016-01-01 00:00:00
abstract::Although allelic variants at a locus usually are expressed either dominantly or co-dominantly, there are many cases when a gene is dominantly expressed in some individuals and co-dominantly in others. We present a maximum-likelihood procedure for allele frequency estimation in such situations of "incomplete" co-domina...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.1990.114
更新日期:1990-12-01 00:00:00
abstract::We review and discuss the importance of correlational selection (selection for optimal character combinations) in natural populations. If two or more traits subject to multivariate selection are heritable, correlational selection builds favourable genetic correlations through the formation of linkage disequilibrium at...
journal_title:Heredity
pub_type: 杂志文章,评审
doi:10.1038/sj.hdy.6800148
更新日期:2002-11-01 00:00:00
abstract::Paternity analysis based on eight microsatellite loci was used to investigate pollen and seed dispersal patterns of the dioecious wind-pollinated tree, Araucaria angustifolia. The study sites were a 5.4 ha isolated forest fragment and a small tree group situated 1.7 km away, located in Paranalpha State, Brazil. In the...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/sj.hdy.6801019
更新日期:2007-12-01 00:00:00
abstract::We dissected the relationship between genetic differentiation (Q(ST)) for a trait and its underlying genes (G(STq), differentiation for a quantitative locus) in an evolutionary context, with the aim of identifying the conditions in which these two measurements are decoupled. We used two parameters (θ(B) and θ(W)) scal...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.2011.81
更新日期:2012-04-01 00:00:00
abstract::The 'Hill-Robertson (HR) effect' describes that linkage between sites under selection will reduce the overall effectiveness of selection in finite populations. Here we discuss the major concepts associated with the HR effect and present results of computer simulations focusing on the linkage effects generated by multi...
journal_title:Heredity
pub_type: 杂志文章,评审
doi:10.1038/sj.hdy.6801059
更新日期:2008-01-01 00:00:00
abstract::There is great uncertainty about how Ireland attained its current fauna and flora. Long-distance human-mediated colonization from southwestern Europe has been seen as a possible way that Ireland obtained many of its species; however, Britain has (surprisingly) been neglected as a source area for Ireland. The pygmy shr...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.2011.41
更新日期:2011-12-01 00:00:00
abstract::In the mosquito Culex pipiens, over-production of esterases is a common insecticide resistance mechanism. Different alleles at the esterase A and B loci are known to occur in natural populations, as shown by enzyme electrophoresis and RFLP studies on the esterase B locus. Here we analyse the variability of the esteras...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.1996.181
更新日期:1996-11-01 00:00:00
abstract::The mechanisms by which paternal inheritance of mitochondrial DNA (mtDNA) (paternal leakage) and, subsequently, recombination of mtDNA are prevented vary in a species-specific manner with one mechanism in common: paternally derived mtDNA is assumed to be vastly outnumbered by maternal mtDNA in the zygote. To date, thi...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.2008.74
更新日期:2008-11-01 00:00:00
abstract::Gene flow was investigated in Anopheles gambiae from eight localities that span the ecological zones of Nigeria (arid savanna zones in the north gradually turn into humid forest zones in the south). Genetic differentiation was measured over 10 microsatellite loci and, to determine any effects of selection, five loci w...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1046/j.1365-2540.2001.00957.x
更新日期:2001-12-01 00:00:00
abstract::When individuals interact, their phenotypes may be affected not only by their own genes but also by genes in their social partners. This phenomenon is known as Indirect Genetic Effects (IGEs). In aquaculture species and some plants, however, competition not only affects trait levels of individuals, but also inflates v...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-018-0068-z
更新日期:2018-12-01 00:00:00
abstract::Pigmentation is one of the most variable traits within and between Drosophila species. Much of this diversity appears to be adaptive, with environmental factors often invoked as selective forces. Here, we describe the geographic structure of pigmentation in Drosophila americana and evaluate the hypothesis that it is a...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.2010.90
更新日期:2011-04-01 00:00:00
abstract::We have studied in Drosophila melanogaster the effects of allozyme variation at the alpha Gpdh and Adh loci on the following fitness components: female fecundity, egg hatchability, egg-to-adult survival under near-optimal and competitive conditions, rate of development under near-optimal and competitive conditions, an...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.1989.108
更新日期:1989-12-01 00:00:00
abstract::Chicken growth traits are economically important, but the relevant genetic mechanisms have not yet been elucidated. Herein, we performed a genome-wide association study to identify the variants associated with growth traits. In total, 860 chickens from a Gushi-Anka F2 resource population were phenotyped for 68 growth ...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-020-00365-x
更新日期:2020-09-28 00:00:00
abstract::Patterns of pollen dispersal were investigated in a small, isolated, relict population of Pinus sylvestris L., consisting of 36 trees. A total-exclusion battery comprising four chloroplast and two nuclear microsatellites (theoretical paternity exclusion probability EP=0.996) was used to assign paternity to 813 seeds, ...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/sj.hdy.6800542
更新日期:2005-01-01 00:00:00
abstract::At treeline, selection by harsh environmental conditions sets an upward limit to arboreal vegetation. Increasing temperatures and the decline of traditional animal raising have favoured an upward shift of treeline in the last decades. These circumstances create a unique opportunity to study the balance of the main for...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.2009.42
更新日期:2009-08-01 00:00:00
abstract::In the context of frequency-dependent selection, the effect of conditioning the medium, by the previous culture of larvae of a given strain, on the survival of subsequent larvae of the same or different strains was measured. Six strains were sued, some inbred and some lines selected for low or high sternopleural brist...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.1975.102
更新日期:1975-12-01 00:00:00
abstract::Effective population size over a generation (Ne) or over a reproductive cycle (Nb) and the adult census size (Nc) are important parameters in both conservation and evolutionary biology. Ne provides information regarding the rate of loss of genetic diversity and can be tracked back in time to infer demographic history ...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.2016.62
更新日期:2016-10-01 00:00:00
abstract::Competition experiments between several Drosophila pseudoobscura strains that were previously subjected to periodic bottlenecks of different sizes and D. willistoni have been carried out. Contrary to previous results with these two species, where stable coexistence was detected, populations of D. pseudoobscura displac...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.1993.8
更新日期:1993-01-01 00:00:00
abstract::A model is described for the biometrical analysis of interaction behavioural characteristics. The model is illustrated by analysis of the mating speed of Drosophila pseudoobscura derived from crosses of fast and of slow mating strains generated through artificial selection. ...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.1975.1
更新日期:1975-02-01 00:00:00
abstract::The sibling species Anopheles atroparvus and Anopheles labranchiae are cytogenetically almost indistinguishable. The chromosome complement (2n = 6) consists of two pairs of autosomes and two heteromorphic sex chromosomes with largely homologous heterochromatic long arms. Treatment of chromosome preparations with the r...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.1990.80
更新日期:1990-08-01 00:00:00
abstract::Atlantic Coast striped bass exhibit exceptionally low levels of genetic variation. The ability of the randomly amplified polymorphic DNA (RAPD) method to uncover genetic variation in this highly conserved species was investigated. Sufficient levels of variation were detected to allow a population genetic analysis of t...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.1997.4
更新日期:1997-01-01 00:00:00
abstract::Many lepidopteran insects exhibit body colour variations, where the high phenotypic diversity observed in the wings and bodies of adults provides opportunities for studying adaptive morphological evolution. In the silkworm Bombyx mori, two genes responsible for moth colour mutation, Bm and Ws, have been mapped to 0.0 ...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.2015.69
更新日期:2016-01-01 00:00:00
abstract::Comprehensive long-term studies of isolated populations provide valuable comparative data that may be used to evaluate different methods for quantifying the relationship between genetic diversity and fitness. Here, we report on data collected from large and well-characterized cohorts of the two numerically dominant sp...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/sj.hdy.6800409
更新日期:2004-04-01 00:00:00
abstract::Many first-generation interspecific hybrids between the five species of the Drosophila virilis subgroup are fertile. Fertile hybrids can be utilized in the analysis of sterile hybrids, by creating new combinations of genetic elements to identify cross-incompatible chromosomes or chromosome segments. Here, crosses star...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1046/j.1365-2540.1998.00422.x
更新日期:1998-11-01 00:00:00
abstract::The European bison (Bison bonasus) has recovered successfully after a severe bottleneck about 90 years ago but has been left with low genetic variability that may substantially hinder parentage and identity analysis. According to pedigree analysis, over 80% of the genes in the contemporary population descend from just...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.2009.73
更新日期:2009-10-01 00:00:00
abstract::Invasive species are believed to spread through a process of stratified dispersal consisting of short-distance diffusive spread around established foci and human mediated long-distance jumps. Brazilian peppertree (Schinus terebinthifolius), native to South America, was introduced twice as an ornamental plant into Flor...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/sj.hdy.6800936
更新日期:2007-05-01 00:00:00
abstract::Genomic resources developed for domesticated species provide powerful tools for studying the evolutionary history of their wild relatives. Here we use 61K single-nucleotide polymorphisms (SNPs) evenly spaced throughout the canine nuclear genome to analyse evolutionary relationships among the three largest European pop...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.2013.122
更新日期:2014-04-01 00:00:00