Neuroprotective effects of the agonist of metabotropic glutamate receptors ABHxD-I in two animal models of cerebral ischaemia.


:The neuroprotective efficacy of 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I (ABHxD-I), a rigid agonist of metabotropic glutamate receptors, was studied using a 3-min global cerebral ischaemia model in Mongolian gerbils and the hypoxia/ischaemia model in 7-day-old rats. The effects on brain damage of ABHxD-I (30 mg/kg, intraperitoneally or 7.5 microg intracerebroventricularly) administered 30 min before global ischaemia or 30 min after hypoxia/ischaemia was evaluated 14 days after the insults. Treatment of adult gerbils with ABHxD-I injected i.c.v. but not systemically, prevented post-ischaemic hyperthermia and substantially reduced brain damage. These effects may reflect low permeability of the adult blood-brain barrier to ABHxD-I, and the role of reduced body and brain temperature in neuroprotection after its i.c.v. administration. ABHxD-I given either i.p. or i.c.v. to developing rats reduced brain damage by 55 and 37%, respectively, without affecting the body temperature. Due to immaturity and increased post-ischaemic permeability of the blood-brain barrier in developing rats, ABHxD-I may induce neuroprotection by direct interference with brain metabotropic glutamate receptors.






Makarewicz D,Gadamski R,Ziembowicz A,Kozikowski AP,Wroblewski JT,Lazarewicz JW





Has Abstract


2006-01-01 00:00:00














  • Bystander automated external defibrillator use and clinical outcomes after out-of-hospital cardiac arrest: A systematic review and meta-analysis.

    abstract:AIM:To systematically review studies comparing bystander automated external defibrillator (AED) use to no AED use in regard to clinical outcomes in out-of-hospital cardiac arrest (OHCA), and to provide a descriptive summary of studies on the cost-effectiveness of bystander AED use. METHODS:We searched Medline, Embase,...


    pub_type: 杂志文章,meta分析,评审


    authors: Holmberg MJ,Vognsen M,Andersen MS,Donnino MW,Andersen LW

    更新日期:2017-11-01 00:00:00

  • Chest wall injuries following cardiopulmonary resuscitation.

    abstract::The forensic records were reviewed of 1823 deaths referred to Edinburgh City Mortuary for autopsy over a 15-month period, 2000-2001; 499 cases (343 males, 156 females) that received CPR prior to death were studied. Rib fractures were found in 29%, sternal fracture in 14%, and 11% of cases showed external chest wall br...


    pub_type: 杂志文章


    authors: Black CJ,Busuttil A,Robertson C

    更新日期:2004-12-01 00:00:00

  • A comparison of major trauma patients transported to trauma centres vs. non-trauma centres in metropolitan Perth.

    abstract:INTRODUCTION:Some major trauma patients in metropolitan Perth (area 5000 km(2)) are initially transported to a secondary hospital (non-trauma centre), rather than directly to a tertiary hospital (trauma centre). They are subsequently transferred to a tertiary hospital. We compared outcomes from these different systems ...


    pub_type: 杂志文章,多中心研究


    authors: Fatovich DM,Phillips M,Jacobs IG

    更新日期:2011-05-01 00:00:00

  • Tracheal intubation in an urban emergency department in Scotland: a prospective, observational study of 3738 intubations.

    abstract:AIM:The emergency department (ED) is an area where major airway difficulties can occur, often as complications of rapid sequence induction (RSI). We undertook a prospective, observational study of tracheal intubation performed in a large, urban UK ED to study this further. METHODS:We reviewed data on every intubation ...


    pub_type: 杂志文章


    authors: Kerslake D,Oglesby AJ,Di Rollo N,James E,McKeown DW,Ray DC,EDIR investigators.

    更新日期:2015-04-01 00:00:00

  • Open chest cardiopulmonary resuscitation in out-of-hospital cardiac arrest.

    abstract::Because closed chest cardiopulmonary resuscitation (CCCPR) achieve restoration of spontaneous circulation (ROSC) in less than 50% of cases, and because of the apparent physiological superiority of open-chest cardiopulmonary resuscitation (OCCPR), we evaluated OCCPR in out-of hospital cardiac arrest in cases who did no...


    pub_type: 杂志文章


    authors: Hachimi-Idrissi S,Leeman J,Hubloue Y,Huyghens L,Corne L

    更新日期:1997-10-01 00:00:00

  • Post-resuscitation arterial oxygen and carbon dioxide and outcomes after out-of-hospital cardiac arrest.

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    pub_type: 杂志文章,多中心研究


    authors: Wang HE,Prince DK,Drennan IR,Grunau B,Carlbom DJ,Johnson N,Hansen M,Elmer J,Christenson J,Kudenchuk P,Aufderheide T,Weisfeldt M,Idris A,Trzeciak S,Kurz M,Rittenberger JC,Griffiths D,Jasti J,May S,Resuscitation Outco

    更新日期:2017-11-01 00:00:00

  • Cerebellar Purkinje cell neurodegeneration after cardiac arrest: effect of therapeutic hypothermia.

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    pub_type: 杂志文章


    authors: Paine MG,Che D,Li L,Neumar RW

    更新日期:2012-12-01 00:00:00

  • Evidence-based educational pathway for the integration of first aid training in school curricula.

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    pub_type: 杂志文章,评审


    authors: De Buck E,Van Remoortel H,Dieltjens T,Verstraeten H,Clarysse M,Moens O,Vandekerckhove P

    更新日期:2015-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Kusunoki S,Tanigawa K,Kondo T,Kawamoto M,Yuge O

    更新日期:2009-10-01 00:00:00

  • Glucose, insulin and potassium (GIK) during reperfusion mediates improved myocardial bioenergetics.

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    pub_type: 杂志文章


    authors: Angelos MG,Murray HN,Gorsline RT,Klawitter PF

    更新日期:2002-12-01 00:00:00

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    pub_type: 杂志文章,随机对照试验


    authors: Gong J,Guo S,Li HB,Yuan SY,Shang Y,Yao SL

    更新日期:2012-07-01 00:00:00

  • The epidemiology of defibrillation in a medical school complex.

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    pub_type: 杂志文章


    authors: Shiner SL,Gold MI

    更新日期:1984-02-01 00:00:00

  • CPR variability during ground ambulance transport of patients in cardiac arrest.

    abstract:AIM OF STUDY:High-quality CPR is associated with improved outcomes from out-of-hospital cardiac arrest (OHCA). The purpose of this investigation was to compare the quality of CPR provided at the prehospital scene, during ambulance transport, and during the early minutes in the emergency department (ED). METHODS:A pros...


    pub_type: 杂志文章


    authors: Roosa JR,Vadeboncoeur TF,Dommer PB,Panchal AR,Venuti M,Smith G,Silver A,Mullins M,Spaite D,Bobrow BJ

    更新日期:2013-05-01 00:00:00

  • Arterial blood gases during and their dynamic changes after cardiopulmonary resuscitation: A prospective clinical study.

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    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Spindelboeck W,Gemes G,Strasser C,Toescher K,Kores B,Metnitz P,Haas J,Prause G

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    pub_type: 杂志文章


    authors: Herlitz J,Engdahl J,Svensson L,Young M,Angquist KA,Holmberg S

    更新日期:2004-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Moors X,Biesheuvel TH,Cornette J,Van Vledder MG,Veen A,de Quelerij M,Weelink E,Duvekot JJ

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    pub_type: 杂志文章


    authors: Rieke H,Rieke M,Gado SK,Nietert PJ,Field LC,Clark CA,Furse CM,McEvoy MD

    更新日期:2013-11-01 00:00:00

  • Performance of coronary angiography and intervention after out of hospital cardiac arrest.

    abstract:AIMS:Out of Hospital Cardiac Arrest (OHCA) is frequently attributed to coronary artery disease, thus guidelines recommend coronary angiography (CAG) for survivors of OHCA. However, the real-world application of these guidelines is unknown, and we sought to evaluate CAG practices in the contemporary OHCA population. ME...


    pub_type: 杂志文章


    authors: Kearney KE,Maynard C,Smith B,Rea TD,Beatty A,McCabe JM

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    pub_type: 杂志文章


    authors: Ibrahim K,Christoph M,Schmeinck S,Schmieder K,Steiding K,Schoener L,Pfluecke C,Quick S,Mues C,Jellinghaus S,Wunderlich C,Strasser RH,Kolschmann S

    更新日期:2014-05-01 00:00:00

  • Sports activity and paediatric out-of-hospital cardiac arrest at schools in Japan.

    abstract:BACKGROUND:Sudden cardiac death during exercise or sports is an important problem among young athletes and non-athletes. An understanding of the epidemiological features of sports-related out-of-hospital cardiac arrest (OHCA) among children is crucial for planning approaches for prevention and better outcomes of paedia...


    pub_type: 杂志文章


    authors: Sado J,Kiyohara K,Kitamura T,Matsui S,Ayusawa M,Nitta M,Iwami T,Nakata K,Sobue T,Kitamura Y,SPIRITS investigators.

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    pub_type: 杂志文章,评审


    authors: Berré J

    更新日期:1984-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Liberman M,Lavoie A,Mulder D,Sampalis J

    更新日期:1999-09-01 00:00:00

  • Rapid cardiac ultrasound of inpatients suffering PEA arrest performed by nonexpert sonographers.

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    pub_type: 杂志文章


    authors: Niendorff DF,Rassias AJ,Palac R,Beach ML,Costa S,Greenberg M

    更新日期:2005-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Kern KB,Berg RA,Hilwig RW,Larson DF,Gaballa MA

    更新日期:2008-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Baubin MA,Gilly H,Posch A,Schinnerl A,Kroesen GA

    更新日期:1995-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Nelson KL,Mills W Jr,Umbel S,Crosson JE,Shaffner DH,Hunt EA

    更新日期:2007-09-01 00:00:00

  • Emergency cardio-pulmonary bypass in cardiac arrest: seventeen years of experience.

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    pub_type: 杂志文章


    authors: Wallmüller C,Sterz F,Testori C,Schober A,Stratil P,Hörburger D,Stöckl M,Weiser C,Kricanac D,Zimpfer D,Deckert Z,Holzer M

    更新日期:2013-03-01 00:00:00

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    pub_type: 杂志文章


    authors: McCoy JV,Hollenberg SM,Dellinger RP,Arnold RC,Ruoss L,Lotano V,Peters P,Parrillo JE,Trzeciak S

    更新日期:2009-08-01 00:00:00

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    abstract::Prolonged therapeutic hypothermia (32-34 degrees C for 12-24 h) improves the functional outcome of comatose cardiac arrest survivors. It is generally believed that rapidly achieving target temperature optimizes neuroprotection. However, this hypothesis has not been tested systematically. In this study, we compared the...


    pub_type: 杂志文章


    authors: Lawrence EJ,Dentcheva E,Curtis KM,Roberts VL,Siman R,Neumar RW

    更新日期:2005-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Eldor J,Olsha O,Farkas A

    更新日期:1991-04-01 00:00:00