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Metabolic remodeling in the aging heart.

Abstract：

:The aim of this study was to investigate the effects of aging on the profile of myocardial substrate utilization and cardiac function using a physiological profile of substrates. Hearts from 6-, 15- and 24-month male Wistar rats were perfused in the isovolumic Langendorff mode, with physiological concentrations of 13C labeled palmitate, and either 13C labeled lactate or 13C glucose. 13C-NMR glutamate isotopomer analysis was performed to determine the contribution of the different substrates to oxidative metabolism. Palmitate oxidation was significantly increased and lactate oxidation depressed in the 24-month old, senescent hearts compared to the mature 6-month hearts. This metabolic remodeling was paralleled with a marked decline in cardiac function and efficiency. These results highlight that adaptations in substrate utilization occur during senescence and may contribute to the age-related increase in the incidence of heart failure.

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

Sample J,Cleland JG,Seymour AM

doi

10.1016/j.yjmcc.2005.09.018

keywords:

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

56-63

issue

1

eissn

0022-2828

issn

1095-8584

pii

S0022-2828(05)00312-3

journal_volume

40

pub_type

杂志文章

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