Mechanisms of metabolic coronary flow regulation.


:Coronary blood flow is tightly adjusted to the oxygen requirements of the myocardium. The underlying control mechanisms keep coronary venous pO(2) at a rather constant level around 20mm Hg under a variety of physiological conditions. Because coronary flow may increase more than 5-fold during exercise without any signs of under- or overperfusion, coronary flow must be controlled, at least in part, in a feed forward manner. Likely metabolic factors contributing to feed forward control are carbon dioxide and reactive oxygen species. Adaptation of coronary flow to exercise under physiological conditions involves in addition to metabolic control feed forward neuronal and endothelium-dependent control. Under pathological conditions, e.g. vessel stenosis or anemia, or specific environmental conditions, e.g. high altitude exposure, cardiac oxygenation may become critical, especially if oxygen demand is increased during physical exercise. Under such conditions the fall of coronary pO(2) may directly result in opening of oxygen sensitive potassium or closure of calcium channels. Furthermore the fall of pO(2) results in the production of vasoactive metabolites, e.g. adenosine, nitric oxide or prostaglandins, and in proton accumulation. All of these adaptations support a reduction of coronary vessel resistance. This article is part of a Special Issue entitled "Coronoray Blood Flow".


J Mol Cell Cardiol


Deussen A,Ohanyan V,Jannasch A,Yin L,Chilian W




Has Abstract


2012-04-01 00:00:00














  • Inhibitory activity of antibodies against the human atrial 5-HT(4)receptor.

    abstract::Antibodies directed against the second extracellular loop of G protein-coupled receptors have been shown to exert "agonist-like" activities. In order to test the hypothesis that this is a general phenomenon, antibodies were raised in rabbits against a synthetic peptide corresponding to the second extracellular loop of...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Sallé L,Eftekhari P,Aupart M,Cosnay P,Hoebeke J,Argibay JA

    更新日期:2001-03-01 00:00:00

  • Early action potential shortening in hypoxic hearts: role of chloride current(s) mediated by catecholamine release.

    abstract::We tested the hypothesis that the early action potential shortening induced by hypoxia in perfused hearts is attributable to chloride currents activated or modulated by endogenous catecholamine release. Rabbit hearts perfused at 33 degrees C and paced at 2.5-2.8 Hz were used for membrane potential recordings with micr...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Ruiz Petrich E,Ponce Zumino A,Schanne OF

    更新日期:1996-02-01 00:00:00

  • The effects of triiodothyronine on cultured neonatal rat cardiac myocytes.

    abstract::The purpose of this study was to determine whether thyroid hormone could directly affect the phenotypic expression of two isozymic systems [lactate dehydrogenase (LDH) and myosin] and the energy transducing potential of cultured neonatal heart cells. In addition we determined if these biochemical systems developed in ...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Williams HM,Ianuzzo CD

    更新日期:1988-08-01 00:00:00

  • Identification and characterization of proteins in sarcoplasmic reticulum from normal and failing human left ventricles.

    abstract::Monoclonal and polyclonal antibodies to the major sarcoplasmic reticulum proteins of rabbit skeletal and canine cardiac muscle have been used to identify and characterize the corresponding components of human cardiac sarcoplasmic reticulum. The Ca2(+)-transporting ATPase of human cardiac sarcoplasmic reticulum was ide...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Movsesian MA,Leveille C,Krall J,Colyer J,Wang JH,Campbell KP

    更新日期:1990-12-01 00:00:00

  • Isolation of rat cardiac sarcoplasmic reticulum with improved Ca2+ uptake and ryanodine binding.

    abstract::The instability of the oxalate-supported Ca2+ uptake activity of rat cardiac sarcoplasmic reticulum (CSR) in ventricular homogenates most likely accounts for the low specific activity of the rate of oxalate-supported Ca2+ uptake in previously reported fractions of isolated rat CSR. We have found that CSR vesicles with...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Feher JJ,Davis MD

    更新日期:1991-03-01 00:00:00

  • Alterations in ventricular myocyte contraction caused by C-type natriuretic peptide and nitric oxide in eNOS-/- mice.

    abstract::Lack of endothelial nitric oxide synthase (eNOS) may affect the sensitivity of cyclic GMP signaling through soluble guanylyl cyclase (sGC). We hypothesized that in eNOS knockout (eNOS-/-) mice, stimulation of guanylyl cyclase would have enhanced effects inhibiting cardiac contraction. We measured cell shortening and c...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Su J,Tse J,Scholz PM,Weiss HR

    更新日期:2005-12-01 00:00:00

  • Characterization of [3H]U69593 binding sites in the rat heart by receptor binding assays.

    abstract::The binding properties of [3H]U69593, a selective k-ligand, in rat heart homogenates were characterized by direct and displacement receptor binding assays. It was found that there are substantial specific [3H]U69593 binding sites in the rat heart. They were saturable, reversible and stereospecific. Both association an...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Tai KK,Jin WQ,Chan TK,Wong TM

    更新日期:1991-11-01 00:00:00

  • Caspase activation and mitochondrial cytochrome C release during hypoxia-mediated apoptosis of adult ventricular myocytes.

    abstract::Oxygen deprivation for prolonged periods leads to cardiac cell death and ventricular dysfunction. The ability to prevent myocardial cell death would be of significant therapeutic value in maintaining cardiac function after injury. While caspases have been suggested to play a critical role in apoptosis, their involveme...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: de Moissac D,Gurevich RM,Zheng H,Singal PK,Kirshenbaum LA

    更新日期:2000-01-01 00:00:00

  • Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D.

    abstract:RATIONALE:How ischemic postconditioning can inhibit opening of the mitochondrial permeability transition pore (PTP) and subsequent cardiac myocytes death at reperfusion remains unknown. Recent studies have suggested that de-acetylation of cyclophilin D (CyPD) by sirtuin 3 (SIRT3) can modulate its binding to the PTP. O...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Bochaton T,Crola-Da-Silva C,Pillot B,Villedieu C,Ferreras L,Alam MR,Thibault H,Strina M,Gharib A,Ovize M,Baetz D

    更新日期:2015-07-01 00:00:00

  • Extracellular matrix remodeling in atrial fibrosis: mechanisms and implications in atrial fibrillation.

    abstract::Atrial fibrosis has been strongly associated with the presence of heart diseases/arrhythmias, including congestive heart failure (CHF) and atrial fibrillation (AF). Inducibility of AF as a result of atrial fibrosis has been the subject of intense recent investigation since it is the most commonly encountered arrhythmi...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章,评审


    authors: Pellman J,Lyon RC,Sheikh F

    更新日期:2010-03-01 00:00:00

  • Expression and cellular distribution of alpha(v)integrins in beta(1)integrin-deficient embryonic stem cell-derived cardiac cells.

    abstract::beta(1)integrin-deficient (beta(1)-/-) ES cells showed increased differentiation of cardiac cells characterized by reduced adhesion and high beating frequency. Whereas in whole embryoid body outgrowths of beta(1)-/- cells maximum levels of alpha(v), beta(3)and beta(5)integrin mRNA were delayed and transiently upregula...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Guan K,Czyz J,Fürst DO,Wobus AM

    更新日期:2001-03-01 00:00:00

  • Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass.

    abstract::Catecholaminergic polymorphic ventricular tachycardia (CPVT) is linked to mutations in the cardiac ryanodine receptor (RyR2) or calsequestrin. We recently found that the drug flecainide inhibits RyR2 channels and prevents CPVT in mice and humans. Here we compared the effects of flecainide and tetracaine, a known RyR2 ...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Hilliard FA,Steele DS,Laver D,Yang Z,Le Marchand SJ,Chopra N,Piston DW,Huke S,Knollmann BC

    更新日期:2010-02-01 00:00:00

  • Heme oxygenase in diabetes-induced oxidative stress in the heart.

    abstract::Diabetic cardiomyopathy is responsible for substantial morbidity and mortality in the diabetic population. Increased oxidative stress has been associated with the pathogenesis of chronic diabetic complications including cardiomyopathy. Multiple biochemical mechanisms have been proposed to increase oxidative stress in ...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Farhangkhoee H,Khan ZA,Mukherjee S,Cukiernik M,Barbin YP,Karmazyn M,Chakrabarti S

    更新日期:2003-12-01 00:00:00

  • Post-extrasystolic potentiation and the force-frequency relationship: differential augmentation of myocardial contractility in working myocardium from patients with end-stage heart failure.

    abstract::We studied post-extrasystolic potentiation (PESP) and frequency potentiation (FP) of human working myocardium isolated from the ventricles of 10 patients with end-stage heart failure (CHF) and 17 non-failing controls (CTL). The contractility index was peak isometric tension developed in vitro by trabeculae carneae (CT...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Phillips PJ,Gwathmey JK,Feldman MD,Schoen FJ,Grossman W,Morgan JP

    更新日期:1990-01-01 00:00:00

  • NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO.

    abstract::The adenosine A1/A2 adenosine agonist 5'-(N-ethylcarboxamido) adenosine (NECA) and bradykinin both limit infarction when administered at reperfusion in rabbits. This study compares the signal transduction pathways responsible for their anti-infarct effect. Receptor agonists were administered to isolated rabbit hearts ...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Yang XM,Krieg T,Cui L,Downey JM,Cohen MV

    更新日期:2004-03-01 00:00:00

  • Myocardium-targeted delivery of endothelial progenitor cells by ultrasound-mediated microbubble destruction improves cardiac function via an angiogenic response.

    abstract::Application of ultrasound-mediated destruction of microbubbles (US + Bubble) to skeletal muscle creates capillary ruptures leading to leakage of the cell components. We studied whether US + Bubble combined with bone-marrow-derived mononuclear cells (BM-MNCs) infusion enables the targeted delivery of endothelial-lineag...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Zen K,Okigaki M,Hosokawa Y,Adachi Y,Nozawa Y,Takamiya M,Tatsumi T,Urao N,Tateishi K,Takahashi T,Matsubara H

    更新日期:2006-06-01 00:00:00

  • Protein O-linked β-N-acetylglucosamine: a novel effector of cardiomyocyte metabolism and function.

    abstract::The post-translational modification of serine and threonine residues of nuclear and cytoplasmic proteins by the O-linked attachment of the monosaccharide β-N-acetyl-glucosamine (O-GlcNAc) is emerging as an important mechanism for the regulation of numerous biological processes critical for normal cell function. Active...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章,评审


    authors: Darley-Usmar VM,Ball LE,Chatham JC

    更新日期:2012-03-01 00:00:00

  • Changes in mitochondrial matrix free calcium in perfused rat hearts subjected to hypoxia-reoxygenation.

    abstract::Reperfusion or reoxygenation of ischaemic or hypoxic cardiac tissue results in increases in total cell calcium and cell lysis both of which are dependent on mitochondrial function. Although changes which occur during this period of exposure of the tissue to hypoxia predispose the heart to take up calcium on reoxygenat...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Allen SP,Darley-Usmar VM,McCormack JG,Stone D

    更新日期:1993-08-01 00:00:00

  • Alpha-adrenergic receptor agonists stimulate ribosome formation in hearts from enalapril-treated piglets.

    abstract::Hearts from untreated or enalapril-treated piglets were used to measure rates of ribosome formation and total protein synthesis during perfusion as modified Langendorff preparations. Pretreatment of newborn piglets with enalapril maleate (5 mg, once daily for 3 days) resulted in a decreased rate of growth of the left ...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Beinlich CJ,Baker KM,Morgan HE

    更新日期:1993-04-01 00:00:00

  • Functional importance of cardiac enhancer-associated noncoding RNAs in heart development and disease.

    abstract::The key information processing units within gene regulatory networks are enhancers. Enhancer activity is associated with the production of tissue-specific noncoding RNAs, yet the existence of such transcripts during cardiac development has not been established. Using an integrated genomic approach, we demonstrate that...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Ounzain S,Pezzuto I,Micheletti R,Burdet F,Sheta R,Nemir M,Gonzales C,Sarre A,Alexanian M,Blow MJ,May D,Johnson R,Dauvillier J,Pennacchio LA,Pedrazzini T

    更新日期:2014-11-01 00:00:00

  • Moderate calorie restriction improves cardiac remodeling and diastolic dysfunction in the Dahl-SS rat.

    abstract::Caloric restriction extends longevity and reduces the onset of chronic disease in many animal models. Recently, caloric restriction was shown in humans to be associated with lower blood pressure, decreased systemic inflammation, and improved cardiac diastolic parameters. However, the causation and mechanisms of calori...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Seymour EM,Parikh RV,Singer AA,Bolling SF

    更新日期:2006-10-01 00:00:00

  • Inhibition of beta-adrenergic signaling by intracellular AMP is independent of cell-surface adenosine receptors in rat cardiac cells.

    abstract::We report a novel action of intracellular adenosine monophosphate (AMP) to inhibit beta-adrenergic signaling in isolated rat ventricular myocytes. Extracellular application of adenosine or AMP suppressed isoproterenol (Iso)-induced prolongation of action potential duration (APD). This effect was completely abolished b...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Ogura K,Miake J,Sasaki N,Iwai C,Bahrudin U,Li P,Kato M,Iitsuka K,Hirota Y,Koshida T,Yamamoto Y,Inoue Y,Yano A,Adachi M,Igawa O,Kurata Y,Morisaki T,Shiota G,Shirayoshi Y,Haruaki N,Hisatome I

    更新日期:2007-11-01 00:00:00

  • Contractile responses of isolated adult rat and rabbit cardiac myocytes to isoproterenol and calcium.

    abstract::Myocytes were isolated by Langendorff perfusion of rat or rabbit hearts with low calcium solution followed by collagenase and hyaluronidase, or by incubation of chunks of rat ventricular tissue in similar media. Cells were then placed in a bath on a microscope stage, superfused and electrically stimulated. Contraction...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Harding SE,Vescovo G,Kirby M,Jones SM,Gurden J,Poole-Wilson PA

    更新日期:1988-07-01 00:00:00

  • Enrichment of G protein alpha-subunit mRNAS in the AV-conducting system of the mammalian heart.

    abstract::We investigated the expression pattern of the heterotrimeric G proteins Gs alpha, Gi alpha-2 and Go alpha in rat and guinea-pig heart by in situ hybridization. Cryosections were hybridized with single-stranded 35S-cRNA probes complementary to subtype-specific sequences of the respective mRNAs. Hybridization signals we...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Eschenhagen T,Laufs U,Schmitz W,Scholz H,Warnholtz A,Weil J,Schäfer HJ

    更新日期:1995-10-01 00:00:00

  • Increased sodium-calcium exchange current in right ventricular cell hypertrophy induced by simulated high altitude in adult rats.

    abstract::Ventricular hypertrophy is associated with an increase in action potential (AP) duration which is potentially arrhythmogenic. The implication of the Na-Ca exchange current (I(Na-Ca)) in the lengthening of the AP is controversial. The role of this current in the increased duration of the low plateau of the AP in hypert...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Espinosa L,Chouabe C,Morales A,Lachuer J,Georges B,Fatemi M,Terrenoire C,Tourneur Y,Bonvallet R

    更新日期:2000-04-01 00:00:00

  • PICOT is a critical regulator of cardiac hypertrophy and cardiomyocyte contractility.

    abstract::PICOT (PKC-interacting cousin of thioredoxin) was previously shown to inhibit the development of cardiac hypertrophy, concomitant with an increase in cardiomyocyte contractility. To explore the physiological function of PICOT in the hearts, we generated a PICOT-deficient mouse line by using a gene trap approach. PICOT...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Cha H,Kim JM,Oh JG,Jeong MH,Park CS,Park J,Jeong HJ,Park BK,Lee YH,Jeong D,Yang DK,Bernecker OY,Kim DH,Hajjar RJ,Park WJ

    更新日期:2008-12-01 00:00:00

  • Induced pluripotent stem cells as a new strategy for cardiac regeneration and disease modeling.

    abstract::The possibility to induce pluripotency in somatic cells or, even further, to induce cell transdifferentiation through the forced expression of reprogramming factors has offered new, attractive options for cardiovascular regenerative medicine. In fact, recent discoveries have demonstrated that induced pluripotent stem ...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章,评审


    authors: Iglesias-García O,Pelacho B,Prósper F

    更新日期:2013-09-01 00:00:00

  • Longitudinal correlation of biomarkers of cardiac injury, inflammation, and coagulation to outcome in hospitalized COVID-19 patients.

    abstract:BACKGROUND:Cardiac injury, as measured by troponin elevation, has been reported among hospitalized coronavirus disease 2019 (COVID-19) patients and portends a poor prognosis. However, how the dynamics of troponin elevation interplay with inflammation and coagulation biomarkers over time is unknown. We assessed longitud...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Li C,Jiang J,Wang F,Zhou N,Veronese G,Moslehi JJ,Ammirati E,Wang DW

    更新日期:2020-10-01 00:00:00

  • Regulation of L-type calcium channels of vascular smooth muscle cells.

    abstract::Vascular tone is regulated by a variety of neurotransmitters, vasoactive hormones and autacoids, and vasoactive drugs. These actions are mediated, at least in part, by actions on the membrane ion channels, exerted either directly or indirectly. In this article, we described evidence that four different protein kinase ...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章,评审


    authors: Xiong Z,Sperelakis N

    更新日期:1995-01-01 00:00:00

  • Adaptation to chronic hypoxia alters cardiac metabolic response to beta stimulation: novel face of phosphocreatine overshoot phenomenon.

    abstract::The dynamics of the changes in myocardial phosphorylated compound contents (inorganic phosphate: Pi; phosphocreatine: PCr; ATP) induced by 10(-6)M isoprenaline administration was studied, using 31P-NMR spectroscopy, in hearts isolated from rats adapted for three weeks to normobaric hypoxia (10% of oxygen). When compar...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章


    authors: Novel-Chaté V,Aussedat J,Saks VA,Rossi A

    更新日期:1995-08-01 00:00:00