Long-term survival and residual hazard after in-hospital cardiac arrest.


AIM:The purpose of this study was to determine long-term survival after in-hospital cardiac arrests and to explore if and when the excess mortality risk imposed by the index event reaches that of an age and sex matched general population. METHOD:A retrospective analysis of data from 1,571 in-hospital cardiac arrests between the calendar years 1997 and 2002 inclusive was performed. Two hundred and fifty-nine people survived until hospital discharge, 220 of which were residents in England and included in the study. Kaplan-Meier curves were constructed for the survivors and an age and sex matched comparator population, and survival compared with a one-sample log rank test. Smoothed hazard curves were constructed for the two populations. Differences in outcome from year of index event were also sought. RESULTS:16.5% of patients survived to hospital discharge. Patients continue to experience a mortality rate greater than that of the comparator population during the first 200 days, with overall 70 deaths versus 18.7 as predicted from life tables (p < 0.0001). The hazard is greatest after resuscitation and falls thereafter until about 2 years where it is not very different to that of the comparator population and then subsequently rises. No evidence was found of a difference in the first year survival between patients resuscitated in different calendar years (p > 0.3 for all tests). CONCLUSION:The residual risk to an individual cardiac arrest survivor's life is greatest during the first year of survival, but declines progressively during the first 2 years after the event, subsequently approaching the risk experienced by the general population.






Kalbag A,Kotyra Z,Richards M,Spearpoint K,Brett SJ





Has Abstract


2006-01-01 00:00:00














  • A comparison of European Trauma Registries. The first report from the EuroTARN Group.

    abstract:UNLABELLED:Trauma management systems have grown in response to regional variations in trauma population, geographical conditions and the provisions of care. National Trauma Registries are being established to improve patient outcomes. However international comparisons could provide the potential to record regional perf...


    pub_type: 杂志文章


    authors: Edwards A,Di Bartolomeo S,Chieregato A,Coats T,Della Corte F,Giannoudis P,Gomes E,Groenborg H,Lefering R,Leppaniemi A,Lossius HM,Ortenwal P,Roise O,Rusnak M,Sturms L,Smith M,Bondegaard Thomsen A,Willett K,Woodford M,

    更新日期:2007-11-01 00:00:00

  • Using a smartwatch with real-time feedback improves the delivery of high-quality cardiopulmonary resuscitation by healthcare professionals.

    abstract:AIM:Cardiopulmonary resuscitation (CPR) quality affects survival after cardiac arrest. We aimed to investigate if a smartwatch with real-time feedback can improve CPR quality by healthcare professionals. METHODS:An app providing real-time audiovisual feedback was developed for a smartwatch. Emergency Department (ED) p...


    pub_type: 杂志文章,随机对照试验


    authors: Lu TC,Chang YT,Ho TW,Chen Y,Lee YT,Wang YS,Chen YP,Tsai CL,Ma MH,Fang CC,Lai F,Meischke HW,Turner AM

    更新日期:2019-07-01 00:00:00

  • Medication errors during medical emergencies in a large, tertiary care, academic medical center.

    abstract:PURPOSE:Evaluate the rate, type and severity of medication errors occurring during Medical Emergency Team (MET) care at a large, tertiary-care, academic medical center. METHODS:A prospective, observational evaluation of 50 patients that required MET care was conducted. Data on medication use were collected using a dir...


    pub_type: 杂志文章


    authors: Gokhman R,Seybert AL,Phrampus P,Darby J,Kane-Gill SL

    更新日期:2012-04-01 00:00:00

  • Hospitals with more-active participation in conducting standardized in-situ mock codes have improved survival after in-hospital cardiopulmonary arrest.

    abstract:AIM:The American Heart Association (AHA) and the Institute of Medicine have published a national "call-to-action" to improve survival from in-hospital cardiopulmonary arrest (IHCA). Our aim was to determine if more-active hospital participation in standardized in-situ mock code (ISMC) training is associated with increa...


    pub_type: 杂志文章,多中心研究


    authors: Josey K,Smith ML,Kayani AS,Young G,Kasperski MD,Farrer P,Gerkin R,Theodorou A,Raschke RA

    更新日期:2018-12-01 00:00:00

  • Effect of mattress deflection on CPR quality assessment for older children and adolescents.

    abstract:UNLABELLED:Appropriate chest compression (CC) depth is associated with improved CPR outcome. CCs provided in hospital are often conducted on a compliant mattress. The objective was to quantify the effect of mattress compression on the assessment of CPR quality in children. METHODS:A force and deflection sensor (FDS) w...


    pub_type: 杂志文章


    authors: Nishisaki A,Nysaether J,Sutton R,Maltese M,Niles D,Donoghue A,Bishnoi R,Helfaer M,Perkins GD,Berg R,Arbogast K,Nadkarni V

    更新日期:2009-05-01 00:00:00

  • Primary percutaneous coronary intervention and mild induced hypothermia in comatose survivors of ventricular fibrillation with ST-elevation acute myocardial infarction.

    abstract::Primary percutaneous coronary intervention (PCI) is the preferred reperfusion strategy for ST-elevation acute myocardial infarction (STEMI). In comatose survivors of cardiac arrest, mild induced hypothermia (MIH) improves neurological recovery. In the present study, we investigated feasibility and safety of combining ...


    pub_type: 杂志文章


    authors: Knafelj R,Radsel P,Ploj T,Noc M

    更新日期:2007-08-01 00:00:00

  • Optimal training frequency for acquisition and retention of high-quality CPR skills: A randomized trial.

    abstract:AIM:Spaced training programs employ short, frequent CPR training sessions to improve provider skills. The optimum training frequency for CPR skill acquisition and retention has not been determined. We aimed to determine the training interval associated with the highest quality CPR performance at one year. METHODS:Part...


    pub_type: 杂志文章,随机对照试验


    authors: Anderson R,Sebaldt A,Lin Y,Cheng A

    更新日期:2019-02-01 00:00:00

  • Descriptive analysis of extracorporeal cardiopulmonary resuscitation following out-of-hospital cardiac arrest-An ELSO registry study.

    abstract:AIM:Extracorporeal cardiopulmonary resuscitation (ECPR) is an emerging therapy for refractory cardiac arrest. The purpose of this study was to analyze and report characteristics and outcomes of adult patients treated with ECPR after out-of-hospital cardiac arrest (OHCA) in a large international registry. METHODS:The E...


    pub_type: 杂志文章,多中心研究


    authors: Haas NL,Coute RA,Hsu CH,Cranford JA,Neumar RW

    更新日期:2017-10-01 00:00:00

  • Should predictive scores based on vital signs be used in the same way as those based on laboratory data? A hypothesis generating retrospective evaluation of in-hospital mortality by four different scoring systems.

    abstract:BACKGROUND:few studies have compared the discrimination of predictive scores of in-hospital mortality that used vital signs with those using laboratory results in different patient populations. METHODS:a hypothesis generating retrospective observational cohort study. A score that only used vital signs was compared wit...


    pub_type: 杂志文章


    authors: Kellett J,Murray A

    更新日期:2016-05-01 00:00:00

  • A text message alert system for trained volunteers improves out-of-hospital cardiac arrest survival.

    abstract:AIMS:The survival rate of sudden out-of-hospital cardiac arrests (OHCAs) increases by early notification of Emergency Medical Systems (EMS) and early application of basic life support (BLS) techniques and defibrillation. A Text Message (TM) alert system for trained volunteers in the community was implemented in the Net...


    pub_type: 杂志文章


    authors: Pijls RW,Nelemans PJ,Rahel BM,Gorgels AP

    更新日期:2016-08-01 00:00:00

  • Total hypothermic blood exchange in acute endotoxin shock.

    abstract::It has been reported that total hypothermic blood exchange holds promise for the treatment of septic shock in animals. Since this procedure does not carry any mortality in out laboratory, we studied its effect in an acute septic shock model. After the intravenous injection of endotoxin (10 mg/kg) and blood transfusion...


    pub_type: 杂志文章


    authors: Gollan F,McDermott J

    更新日期:1979-01-01 00:00:00

  • Ivabradine but not propranolol delays the time to onset of ischaemia-induced ventricular fibrillation by preserving myocardial metabolic energy status.

    abstract:OBJECTIVE:Heart rate reduction (HRR) has shown a beneficial impact on the prevention of ventricular fibrillation, which could be explained by increased myocardial blood flow and preservation of mitochondrial structure. Here, we assessed the HRR impact on time to onset of ventricular fibrillation (TOVF) and myocardial m...


    pub_type: 杂志文章


    authors: Vaillant F,Dehina L,Dizerens N,Bui-Xuan B,Tabib A,Lauzier B,Chevalier P,Descotes J,Timour Q

    更新日期:2013-03-01 00:00:00

  • Echocardiographic left ventricular systolic dysfunction early after resuscitation from cardiac arrest does not predict mortality or vasopressor requirements.

    abstract:BACKGROUND/AIMS:Echocardiographic abnormalities are common after resuscitation from cardiac arrest. The association between echocardiographic findings with vasopressor requirements and mortality are not well described. We sought to determine the associations between echocardiographic abnormalities and mortality, vasopr...


    pub_type: 杂志文章


    authors: Jentzer JC,Chonde MD,Shafton A,Abu-Daya H,Chalhoub D,Althouse AD,Rittenberger JC

    更新日期:2016-09-01 00:00:00

  • In hospital cardiac arrest: a role for automatic defibrillation.

    abstract:INTRODUCTION:Sudden cardiac death (SCD) survival decreases by 10% for each minute of delay in defibrillation, however, survival rates of 98% can be achieved when defibrillation is accomplished within 30s of collapse. Recently, a fully automated external cardioverter-defibrillator (AECD) was approved by the FDA for in-h...


    pub_type: 杂志文章


    authors: Cusnir H,Tongia R,Sheka KP,Kavesteen D,Segal RR,Nowakiwskyj VN,Cassera F,Scherer H,Costello D,Valerio L,Yens DP,Shani J,Hollander G

    更新日期:2004-11-01 00:00:00

  • Usefulness of a new rapid bedside troponin T assay in patients with chest pain.

    abstract::We evaluated the usefulness of a rapid, qualitative, bedside immunoassay for cardiac-specific troponin T in patients with chest pain. A concordant result between quantitative troponin T and qualitative troponin T assay was observed in 183 (96%) tests. The sensitivity of the rapid troponin T assay for detecting acute m...


    pub_type: 杂志文章


    authors: Hirschl MM,Lechleitner P,Friedrich G,Sint G,Sterz F,Binder M,Dienstl F,Laggner AN

    更新日期:1996-10-01 00:00:00

  • First aid cooling techniques for heat stroke and exertional hyperthermia: A systematic review and meta-analysis.

    abstract:BACKGROUND:Heat stroke is an emergent condition characterized by hyperthermia (>40 °C/>104 °F) and nervous system dysregulation. There are two primary etiologies: exertional which occurs during physical activity and non-exertional which occurs during extreme heat events without physical exertion. Left untreated, both m...


    pub_type: 杂志文章,评审


    authors: Douma MJ,Aves T,Allan KS,Bendall JC,Berry DC,Chang WT,Epstein J,Hood N,Singletary EM,Zideman D,Lin S,First Aid Task Force of the International Liaison Committee on Resuscitation.

    更新日期:2020-03-01 00:00:00

  • The epidemiology of cardiac arrests in a Sydney hospital.

    abstract:AIM:To examine the epidemiology of cardiac arrest (CA) in New South Wales (NSW), Australia, and a large teaching hospital in Sydney and to identify predictors of survival. METHODS:Data from the 1996/97 NSW inpatient statistics collection were analysed. Logistic regression was used to determine predictors of mortality ...


    pub_type: 杂志文章


    authors: Weerasinghe DP,MacIntyre CR,Rubin GL

    更新日期:2002-04-01 00:00:00

  • Perfluorocarbon induced intra-arrest hypothermia does not improve survival in a swine model of asphyxial cardiac arrest.

    abstract:BACKGROUND:Pulseless electrical activity is an important cause of cardiac arrest. Our purpose was to determine if induction of hypothermia with a cold perfluorocarbon-based total liquid ventilation (TLV) system would improve resuscitation success in a swine model of asphyxial cardiac arrest/PEA. METHODS:Twenty swine w...


    pub_type: 杂志文章


    authors: Albaghdadi AS,Brooks LA,Pretorius AM,Kerber RE

    更新日期:2010-03-01 00:00:00

  • Impact of the direct transfer to percutaneous coronary intervention-capable hospitals on survival to hospital discharge for patients with out-of-hospital cardiac arrest.

    abstract:AIMS:Patients suffering from out-of-hospital cardiac arrest (OHCA) are frequently transported to the closest hospital. Percutaneous coronary intervention (PCI) is often indicated following OHCA. This study's primary objective was to determine the association between being transported to a PCI-capable hospital and survi...


    pub_type: 杂志文章


    authors: Cournoyer A,Notebaert É,de Montigny L,Ross D,Cossette S,Londei-Leduc L,Iseppon M,Lamarche Y,Sokoloff C,Potter BJ,Vadeboncoeur A,Larose D,Morris J,Daoust R,Chauny JM,Piette É,Paquet J,Cavayas YA,de Champlain F,Segal

    更新日期:2018-04-01 00:00:00

  • Prognostic role of EEG identical bursts in patients after cardiac arrest: Multimodal correlation.

    abstract:AIMS:EEG burst-suppression (BS) heralds poor outcome after cardiac arrest (CA). Within this pattern, identical bursts (IB) have been suggested to be absolutely specific, in isolation. We assessed IB prevalence and their added predictive value for poor outcome in a multimodal prognostic approach. METHODS:We retrospecti...


    pub_type: 杂志文章


    authors: Barbella G,Novy J,Marques-Vidal P,Oddo M,Rossetti AO

    更新日期:2020-03-01 00:00:00

  • A modeling approach to the effects of force guided versus depth guided compression during cardiopulmonary resuscitation on different chests and back support surfaces.

    abstract:OBJECTIVES:To validate an existing theoretical model for the mechanics of chest compression (CC) during constant peak force cardiopulmonary resuscitation (CPR) using experimental human and manikin CC data from the literature. Also, to gain insights into the clinical application of force guided CPR. METHODS:The experim...


    pub_type: 杂志文章


    authors: Dellimore KH,Scheffer C

    更新日期:2013-06-01 00:00:00

  • Tracheal rapid ultrasound saline test (T.R.U.S.T.) for confirming correct endotracheal tube depth in children.

    abstract:OBJECTIVE:We evaluated the accuracy of tracheal ultrasonography of a saline-inflated endotracheal tube (ETT) cuff for confirming correct ETT insertion depth. METHODS:We performed a prospective feasibility study of children undergoing endotracheal intubation for surgery. Tracheal ultrasonography at the suprasternal not...


    pub_type: 杂志文章


    authors: Tessaro MO,Salant EP,Arroyo AC,Haines LE,Dickman E

    更新日期:2015-04-01 00:00:00

  • Comparison of sodium bicarbonate with dichloroacetate treatment of hyperlactatemia and lactic acidosis in the ischemic rat.

    abstract::Serum lactic acidosis is characterized by a pH less than 7.25 and lactate greater than 5 mEq. Although sodium bicarbonate (NaHCO3) is standard treatment for this condition, clinical and experimental studies suggest that high doses of NaHCO3 may be ineffectual or even detrimental to brain, cardiovascular, and respirato...


    pub_type: 杂志文章


    authors: Dimlich RV,Biros MH,Widman DW,Kaplan J

    更新日期:1988-01-01 00:00:00

  • Use of an impedance threshold device improves short-term outcomes following out-of-hospital cardiac arrest.

    abstract:INTRODUCTION:An impedance threshold device (ITD) has been developed for the treatment of cardiac arrest to augment circulation to the heart and brain during cardiopulmonary resuscitation (CPR). The ITD has ventilation timing lights that flash at 12 min(-1) to discourage excessive ventilation rates. HYPOTHESIS:Implemen...


    pub_type: 杂志文章


    authors: Thayne RC,Thomas DC,Neville JD,Van Dellen A

    更新日期:2005-10-01 00:00:00

  • Feasibility of bispectral index monitoring to guide early post-resuscitation cardiac arrest triage.

    abstract:INTRODUCTION:Triage after resuscitation from cardiac arrest is hindered by reliable early estimation of brain injury. We evaluated the performance of a triage model based on early bispectral index (BIS) findings and cardiac risk classes. METHODS:Retrospective evaluation of serial patients resuscitated from cardiac arr...


    pub_type: 杂志文章


    authors: Seder DB,Dziodzio J,Smith KA,Hickey P,Bolduc B,Stone P,May T,McCrum B,Fraser GL,Riker RR

    更新日期:2014-08-01 00:00:00

  • Quantitative pupillometry and transcranial Doppler measurements in patients treated with hypothermia after cardiac arrest.

    abstract:BACKGROUND:Predicting outcome after cardiac arrest (CA) is particularly difficult when therapeutic hypothermia (TH) is used. We investigated the performance of quantitative pupillometry and transcranial Doppler (TCD) in this context. METHODS:This prospective observational study included 82 post-CA patients. Quantitati...


    pub_type: 杂志文章


    authors: Heimburger D,Durand M,Gaide-Chevronnay L,Dessertaine G,Moury PH,Bouzat P,Albaladejo P,Payen JF

    更新日期:2016-06-01 00:00:00

  • Comparisons of French and U.S.A. pediatric intensive care units.

    abstract::Consecutive admissions to two pediatric intensive care units (PICUs) in France (n = 93) and the United States (n = 248) were compared using admission demographics, and daily therapeutic and severity of illness data. Analysis of the major demographic characteristics revealed that patients in the French PICU were younge...


    pub_type: 杂志文章


    authors: Davis AL,Pollack MM,Cloup M,Cloup I,Wilkinson JD

    更新日期:1989-04-01 00:00:00

  • Evaluation of out-of-hospital cardiopulmonary resuscitation with resuscitative drugs: a prospective comparative study in Japan.

    abstract:OBJECTIVE:This study aimed at evaluating two emergency medical service systems, one in which emergency life-saving technicians (ELSTs) are allowed to administer epinephrine (adrenaline) to patients with out-of-hospital cardiac arrest and one in which ELSTs are allowed to administer epinephrine, lidocaine, and atropine....


    pub_type: 杂志文章


    authors: Ohshige K,Shimazaki S,Hirasawa H,Nakamura M,Kin H,Fujii C,Okuchi K,Yamamoto Y,Akashi K,Takeda J,Hanyuda T,Tochikubo O

    更新日期:2005-07-01 00:00:00

  • The changes of brain water diffusion and blood flow on diffusion-weighted and perfusion-weighted imaging in a canine model of cardiac arrest.

    abstract:OBJECTIVE:To study the changes of brain water diffusion and cerebral haemodynamics of cortical areas using magnetic resonance imaging (MRI) in canine models of cardiac arrest (CA) and restoration of spontaneous circulation (ROSC). The secondary study objective was to evaluate whether MRI can be used to observe haemodyn...


    pub_type: 杂志文章


    authors: Liu R,Li X,Hu CL,Jiang L,Dai G,Wu GF,Huang GQ,Wei HY,Liao XX

    更新日期:2012-05-01 00:00:00

  • Microcirculatory perfusion and vascular reactivity are altered in post cardiac arrest patients, irrespective of target temperature management to 33 °C vs 36 °C.

    abstract:AIM:In previous reports both microcirculatory alterations and impaired vascular reactivity have been described in post cardiac arrest patients treated with mild therapeutic hypothermia. As of now it is unknown whether these alterations are related to the temperature management or to the cardiac arrest itself. Aim of th...


    pub_type: 杂志文章,随机对照试验


    authors: Koopmans M,Kuiper MA,Endeman H,Veenstra G,Vellinga NA,de Vos R,Boerma EC

    更新日期:2015-01-01 00:00:00