The magnitude of mechanical allodynia in a rodent model of lumbar radiculopathy is dependent on strain and sex.

Abstract:

STUDY DESIGN:This study examined the differences in tactile hypersensitivity across 6 different strains of male mice, and between male and female rats of 3 different strains in a rodent model of low back pain associated with lumbar radiculopathy. OBJECTIVE:We investigated the possibility that differences in tactile allodynia following the same nerve root injury are affected by genotype and sex in rodents. SUMMARY OF BACKGROUND DATA:Low back pain associated with radiculopathy affects countless people throughout the world, encompassing a wide range of individual pain susceptibility. The roles of genetics and sex on differences in nociceptive sensitivities following lumbar nerve root injury have yet to be fully characterized. METHODS:Six strains of mice (BALB/cJ, CBA/J, C57BL/6J, 129P3/J, C3H/HeJ, and C58/J; all males) and male and female Sprague Dawley, Holtzman, and Long-Evans rats underwent a lumbar nerve root injury followed by assessment of tactile allodynia. RESULTS:The most sensitive mouse strains following nerve root injury were: 129P3/J, C58/J, and BALB/cJ; and the less sensitive strains were: C57BL/6J, C3H/HeJ, and CBA/J. Female Sprague Dawley and Long-Evans rats displayed increased hypersensitivity following nerve root injury compared to males. No sex differences were observed in Holtzman rats. CONCLUSIONS:Different mouse strains, and male and female rats that are exposed to identical nerve root injuries have diverse levels of tactile hypersensitivity, supporting the hypothesis that genetic factors and sex play a key role in radicular pain. Our results correlate with data compiled in identical mouse and rat strains after L5-L6 nerve ligation, suggesting that the precise nature of the injury is not relevant to the inheritance of neuropathic symptom sensitivity.

journal_name

Spine (Phila Pa 1976)

journal_title

Spine

authors

LaCroix-Fralish ML,Rutkowski MD,Weinstein JN,Mogil JS,Deleo JA

doi

10.1097/01.brs.0000174122.63291.38

keywords:

subject

Has Abstract

pub_date

2005-08-15 00:00:00

pages

1821-7

issue

16

eissn

0362-2436

issn

1528-1159

pii

00007632-200508150-00005

journal_volume

30

pub_type

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