当前位置： SCI文献检索 > CLINICAL NEUROLOGY AND NEUROSURGERY期刊下所有文献 > Is there a difference in risk factors for single and multiple symptomatic lesions in small vessel disease? What is the difference between one and plenty--experience from 201 Serbian patients.

Is there a difference in risk factors for single and multiple symptomatic lesions in small vessel disease? What is the difference between one and plenty--experience from 201 Serbian patients.

Abstract：

OBJECTIVES/PURPOSES:Small vessel disease (SVD) is associated with traditional vascular risk factors (RF). The aim of our study was to determine whether different SVD types, single lacunar infarction (LI) and multiple LI (MLI) with or without white matter lesions (WML), have different RF profiles. PATIENTS AND METHODS:Forty RF parameters were analysed in 201 consecutive patients with magnetic resonance imaging finding of SVD. RESULTS:History of arterial hypertension, higher systolic and mean blood pressure (BP) but also hypotension, and higher plasma homocysteine levels were more frequent in MLI compared to single LI patients (p<0.05). Patients with one LI were younger, more frequently had clinically evident stroke and family history of cardiovascular disease (CVD) (p<0.05). Significant difference between groups was found only in these RF, indicating that similar pathological processes led to both types of SVD. CONCLUSION:Positive correlation with age and family history of CVD necessitates further analyses of other factors, predominantly genetic, as the key to the answer why patients develop different lesions in SVD.

journal_name

Clin Neurol Neurosurg

journal_title

Clinical neurology and neurosurgery

authors

Pavlovic AM,Pekmezovic T,Zidverc-Trajkovic J,Pavlovic DM,Jovanovic Z,Mijajlovic M,Petrovic M,Kostic VS,Sternic N

doi

10.1016/j.clineuro.2005.03.009

keywords:

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

358-62

issue

4

eissn

0303-8467

issn

1872-6968

pii

S0303-8467(05)00060-0

journal_volume

108

pub_type

杂志文章

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