XGef mediates early CPEB phosphorylation during Xenopus oocyte meiotic maturation.

abstract：:The serotonin (5-hydroxytryptamine; 5-HT)(2C) receptor is a G protein-coupled receptor (GPCR) exclusively expressed in CNS that has been implicated in numerous brain disorders, including anxio-depressive states. Like many GPCRs, 5-HT(2C) receptors physically interact with a variety of intracellular proteins in additio...

journal_title：Molecular biology of the cell

authors： Labasque M,Reiter E,Becamel C,Bockaert J,Marin P

更新日期：2008-11-01 00:00:00

abstract：:Two widely used hepatoma cell lines, mouse BW1J and human HepG2, express gene products characteristic of fetal hepatocytes, including serum albumin, whereas reporter genes driven by the albumin promoter are expressed at very low levels compared with highly differentiated hepatoma cells. We have investigated the low al...

journal_title：Molecular biology of the cell

authors： Rollier A,DiPersio CM,Cereghini S,Stevens K,Tronche F,Zaret K,Weiss MC

更新日期：1993-01-01 00:00:00

abstract：:Regulator of G protein signaling (RGS) proteins inhibit G protein signaling by activating Galpha GTPase activity, but the mechanisms that regulate RGS activity are not well understood. The mammalian R7 binding protein (R7BP) can interact with all members of the R7 family of RGS proteins, and palmitoylation of R7BP can...

journal_title：Molecular biology of the cell

authors： Porter MY,Koelle MR

更新日期：2010-01-15 00:00:00

abstract：:A chimeric protein (ERaeq) comprised of the invariant chain (Ii) of class II major histocompatability complex (MHC-II) and aequorin was localized in the endoplasmic reticulum (ER) of transfected human embryonal kidney 293 cells. The targeted aequorin resided in the lumen of the ER membrane system, including the nuclea...

journal_title：Molecular biology of the cell

authors： Button D,Eidsath A

更新日期：1996-03-01 00:00:00

abstract：:Proteins establish and maintain a distinct intracellular localization by means of targeting, retention, and retrieval signals, ensuring most proteins reside predominantly in one cellular location. The enzymes involved in the maturation of lamin A present a challenge to this paradigm. Lamin A is first synthesized as a ...

journal_title：Molecular biology of the cell

authors： Barrowman J,Hamblet C,George CM,Michaelis S

更新日期：2008-12-01 00:00:00

abstract：:The nuclear envelope of metazoans disassembles during mitosis and reforms in late anaphase after sister chromatids have well separated. The coordination of these mitotic events is important for genome stability, yet the temporal control of nuclear envelope reassembly is unknown. Although the steps of nuclear formation...

journal_title：Molecular biology of the cell

authors： Tseng LC,Chen RH

更新日期：2011-09-01 00:00:00

abstract：:The protein composition of the plasma membrane is rapidly remodeled in response to changes in nutrient availability or cellular stress. This occurs, in part, through the selective ubiquitylation and endocytosis of plasma membrane proteins, which in the yeast Saccharomyces cerevisiae is mediated by the HECT E3 ubiquiti...

journal_title：Molecular biology of the cell

authors： Baile MG,Guiney EL,Sanford EJ,MacGurn JA,Smolka MB,Emr SD

更新日期：2019-12-01 00:00:00

abstract：:Polalpha is the principal DNA polymerase for initiation of DNA replication and also functions in postinitiation DNA synthesis. In this study, we investigated the cell cycle responses induced by mutations in polalpha+. Germinating spores carrying either a deletion of polalpha+ (polalphaDelta) or a structurally intact b...

journal_title：Molecular biology of the cell

authors： Bhaumik D,Wang TS

更新日期：1998-08-01 00:00:00

abstract：:Most membrane proteins are synthesized on and inserted into the membrane of the endoplasmic reticulum (ER), in eukaryote. The widely conserved ER membrane protein complex (EMC) facilitates the biogenesis of a wide range of membrane proteins. In this study, we investigated the EMC function using Drosophila photorecepto...

journal_title：Molecular biology of the cell

authors： Hiramatsu N,Tago T,Satoh T,Satoh AK

更新日期：2019-11-01 00:00:00

abstract：:Previous work has established that activation of Mos, Mek, and p42 mitogen-activated protein (MAP) kinase can trigger release from G2-phase arrest in Xenopus oocytes and oocyte extracts and can cause Xenopus embryos and extracts to arrest in mitosis. Herein we have found that activation of the MAP kinase cascade can a...

journal_title：Molecular biology of the cell

authors： Walter SA,Guadagno TM,Ferrell JE Jr

更新日期：1997-11-01 00:00:00

abstract：:During interactions with its mammalian host, the pathogenic yeast Candida albicans is exposed to a range of stresses such as superoxide radicals and cationic fluxes. Unexpectedly, a nonbiased screen of transcription factor deletion mutants revealed that the phosphate-responsive transcription factor Pho4 is vital for t...

journal_title：Molecular biology of the cell

authors： Ikeh MA,Kastora SL,Day AM,Herrero-de-Dios CM,Tarrant E,Waldron KJ,Banks AP,Bain JM,Lydall D,Veal EA,MacCallum DM,Erwig LP,Brown AJ,Quinn J

更新日期：2016-09-01 00:00:00

abstract：:Genes occupy preferred spatial positions within interphase cell nuclei. However, positioning patterns are not an innate feature of a locus, and genes can alter their localization in response to physiological and pathological changes. Here we screen the radial positioning patterns of 40 genes in normal, hyperplasic, an...

journal_title：Molecular biology of the cell

authors： Leshner M,Devine M,Roloff GW,True LD,Misteli T,Meaburn KJ

更新日期：2016-01-15 00:00:00

abstract：:The preemptive quality control (pQC) pathway protects cells from acute endoplasmic reticulum (ER) stress by attenuating translocation of nascent proteins despite their targeting to translocons at the ER membrane. Here, we investigate the hypothesis that the DnaJ protein p58(IPK) plays an essential role in this process...

journal_title：Molecular biology of the cell

authors： Rutkowski DT,Kang SW,Goodman AG,Garrison JL,Taunton J,Katze MG,Kaufman RJ,Hegde RS

更新日期：2007-09-01 00:00:00

abstract：:A primary cilium is found on most mammalian cells, where it acts as a cellular antenna for the reception of both mechanical and chemical signals. A variety of diseases are associated with defective ciliogenesis, reflecting the ubiquity of the function of cilia and the number of proteins required for their assembly. Pr...

journal_title：Molecular biology of the cell

authors： Copeland SJ,McRae A,Guarguaglini G,Trinkle-Mulcahy L,Copeland JW

更新日期：2018-07-01 00:00:00

abstract：:A role of Arp2/3 complex in lamellipodia is well established, whereas its roles in filopodia formation remain obscure. We addressed this question in neuronal cells, in which motility is heavily based on filopodia, and we found that Arp2/3 complex is involved in generation of both lamellipodia and filopodia in growth c...

journal_title：Molecular biology of the cell

authors： Korobova F,Svitkina T

更新日期：2008-04-01 00:00:00

abstract：:Episialin (MUC1, PEM, EMA, CA15-3 antigen) is a sialylated, membrane-associated glycoprotein with an extended mucin-like ectodomain. This domain mainly consists of 30-90 homologous 20-amino acid repeats that are rich in O-glycosylation sites (serines and threonines). It is likely that this part forms a polyproline bet...

journal_title：Molecular biology of the cell

authors： Wesseling J,van der Valk SW,Hilkens J

更新日期：1996-04-01 00:00:00

abstract：:The skin's epidermis is a multilayered epithelial tissue and the first line of defense against mechanical stress. Its barrier function depends on an integrated assembly and reorganization of cell-matrix and cell-cell junctions in the basal layer and on different intercellular junctions in suprabasal layers. However, h...

journal_title：Molecular biology of the cell

authors： Noethel B,Ramms L,Dreissen G,Hoffmann M,Springer R,Rübsam M,Ziegler WH,Niessen CM,Merkel R,Hoffmann B

更新日期：2018-09-15 00:00:00

abstract：:Activation of the epidermal growth factor receptor (EGFR) triggers multiple signaling pathways and rapid endocytosis of the epidermal growth factor (EGF)-receptor complexes. To directly visualize the compartmentalization of molecules involved in the major signaling cascade, activation of Ras GTPase, we constructed fus...

journal_title：Molecular biology of the cell

authors： Jiang X,Sorkin A

更新日期：2002-05-01 00:00:00

abstract：:Cell-cell fusion is an intriguing differentiation process, essential for placental development and maturation. A proteomic approach identified a cytoplasmic protein, calponin 3 (CNN3), related to the fusion of BeWo choriocarcinoma cells. CNN3 was expressed in cytotrophoblasts in human placenta. CNN3 gene knockdown pro...

journal_title：Molecular biology of the cell

authors： Shibukawa Y,Yamazaki N,Kumasawa K,Daimon E,Tajiri M,Okada Y,Ikawa M,Wada Y

更新日期：2010-11-15 00:00:00

abstract：:Long-range chromatin interactions between gene loci in the cell nucleus are important for many biological processes, including transcriptional regulation. Previously, we demonstrated that several genes specifically cluster with the astrocyte-specific gene for glial fibrillary acidic protein (Gfap) during astrocyte dif...

journal_title：Molecular biology of the cell

authors： Ito K,Noguchi A,Uosaki Y,Taga T,Arakawa H,Takizawa T

更新日期：2018-01-15 00:00:00

abstract：:The daily phagocytosis of shed photoreceptor outer segments by pigment epithelial cells is critical for the maintenance of the retina. In a subtractive polymerase chain reaction analysis, we found that functional differentiation of human ARPE19 retinal pigment epithelial (RPE) cells is accompanied by up-regulation of ...

journal_title：Molecular biology of the cell

authors： Law AL,Ling Q,Hajjar KA,Futter CE,Greenwood J,Adamson P,Wavre-Shapton ST,Moss SE,Hayes MJ

更新日期：2009-09-01 00:00:00

abstract：:Actin and microtubule dynamics must be precisely coordinated during cell migration, mitosis, and morphogenesis--much of this coordination is mediated by proteins that physically bridge the two cytoskeletal networks. We have investigated the regulation of the Drosophila actin-microtubule cross-linker Short stop (Shot),...

journal_title：Molecular biology of the cell

authors： Applewhite DA,Grode KD,Duncan MC,Rogers SL

更新日期：2013-09-01 00:00:00

abstract：:The actin cytoskeleton is constantly assembling and disassembling. Cells harness the energy of these turnover dynamics to drive cell motility and organize cytoplasm. Although much is known about how cells control actin polymerization, we do not understand how actin filaments depolymerize inside cells. I briefly descri...

journal_title：Molecular biology of the cell

authors： Brieher W

更新日期：2013-08-01 00:00:00

abstract：:The ubiquitin-like hPLIC proteins can associate with proteasomes, and hPLIC overexpression can specifically interfere with ubiquitin-mediated proteolysis (Kleijnen et al., 2000). Because the hPLIC proteins can also interact with certain E3 ubiquitin protein ligases, they may provide a link between the ubiquitination a...

journal_title：Molecular biology of the cell

authors： Kleijnen MF,Alarcon RM,Howley PM

更新日期：2003-09-01 00:00:00

abstract：:Quite a few regulatory proteins, including transcription factors, are normally maintained in a dormant state to be activated after internal or environmental cues. Recently, a novel strategy, requiring proteolytic cleavage, was described for the mobilization of dormant transcription factors. These transcription factors...

journal_title：Molecular biology of the cell

authors： Becker-Herman S,Arie G,Medvedovsky H,Kerem A,Shachar I

更新日期：2005-11-01 00:00:00

abstract：:We have addressed the question of whether or not Golgi fragmentation, as exemplified by that occurring during drug-induced microtubule depolymerization, is accompanied by the separation of Golgi subcompartments one from another. Scattering kinetics of Golgi subcompartments during microtubule disassembly and reassembly...

journal_title：Molecular biology of the cell

authors： Yang W,Storrie B

更新日期：1998-01-01 00:00:00

abstract：:Phosphoinositides (PIs) regulate a myriad of cellular functions including membrane fusion, as exemplified by the yeast vacuole, which uses various PIs at different stages of fusion. In light of this, the effect of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) on vacuole fusion remains unknown. PI(3,5)P2 is made by...

journal_title：Molecular biology of the cell

authors： Miner GE,Sullivan KD,Guo A,Jones BC,Hurst LR,Ellis EC,Starr ML,Fratti RA

更新日期：2019-01-15 00:00:00

abstract：:Outer dynein arms (ODAs) are multiprotein complexes that drive flagellar beating. Based on genetic and biochemical analyses, ODAs preassemble in the cell body and then move into the flagellum by intraflagellar transport (IFT). To study ODA transport in vivo, we expressed the essential intermediate chain 2 tagged with ...

journal_title：Molecular biology of the cell

authors： Dai J,Barbieri F,Mitchell DR,Lechtreck KF

更新日期：2018-10-15 00:00:00

abstract：:Formation and discharge of dense-core secretory vesicles depend on controlled rearrangement of the core proteins during their assembly and dispersal. The ciliate Tetrahymena thermophila offers a simple system in which the mechanisms may be studied. Here we show that most of the core consists of a set of polypeptides d...

journal_title：Molecular biology of the cell

authors： Verbsky JW,Turkewitz AP

更新日期：1998-02-01 00:00:00

abstract：:The Schizosaccharomyces pombe sts1+ gene, identified by supersensitive mutations to a protein kinase inhibitor, staurosporine, was isolated by complementation by the use of a fission yeast genomic library. Nucleotide sequencing shows that the sts1+ gene encodes a 453 amino acid putative membrane-associated protein tha...

journal_title：Molecular biology of the cell

authors： Shimanuki M,Goebl M,Yanagida M,Toda T

更新日期：1992-03-01 00:00:00