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Positive selection of synonymous mutations in vesicular stomatitis virus.

Abstract：

:Prevailing evolutionary forces are typically deduced from the pattern of differences in synonymous and non-synonymous mutations, under the assumption of neutrality in the absence of amino acid change. We determined the complete sequence of ten vesicular stomatitis virus populations evolving under positive selection. A significant number of the mutations occurred independently in two or more strains, a process known as parallel evolution, and a substantial fraction of the parallel mutations were silent. Parallel evolution was also identified in non-coding regions. These results indicate that silent mutations can significantly contribute to adaptation in RNA viruses, and relative frequencies of synonymous and non-synonymous substitutions may not be useful to resolve their evolutionary history.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Novella IS,Zárate S,Metzgar D,Ebendick-Corpus BE

doi

10.1016/j.jmb.2004.08.003

keywords:

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

1415-21

issue

5

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(04)00969-6

journal_volume

342

pub_type

杂志文章

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