Abstract:
:Neoplastic meningitis (NM) is a debilitating complication of cancer that occurs when tumour cells infiltrate the leptomeninges. Treatment often includes direct installation of chemotherapy into the cerebrospinal fluid either by lumbar puncture or the use of a ventricular reservoir, radiation therapy, systemic chemotherapy or a combination of these modalities. The current standard chemotherapeutic agents for direct instillation into the cerebrospinal fluid include methotrexate, cytarabine and thiotepa. Other agents, such as topotecan, manfosfamide and IFNs, are undergoing evaluation in clinical trials. Despite active investigation of new therapies, the prognosis for patients with NM remains poor. However, some patients do demonstrate improvement of neurological function and prolongation of survival with treatment. Therefore, careful evaluation and treatment planning is warranted in order to avoid treatment-associated toxicities and to maximise the impact of the treatment on the disease process.
journal_name
Expert Opin Pharmacotherjournal_title
Expert opinion on pharmacotherapyauthors
Armstrong TS,Gilbert MRdoi
10.1517/14656566.5.9.1929keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
1929-35issue
9eissn
1465-6566issn
1744-7666pii
EOP050907journal_volume
5pub_type
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