Abstract:
:Sulfur mustard (SM) is a highly toxic chemical warfare agent. A satisfactory treatment regimen is not yet available for this toxicant. In a search for an effective antidote against SM, a series of novel S-2(omega-aminoalkylamino)ethyl alkyl/aryl thioethers [H(2)N(CH(2))(n)()NHCH(2)CH(2)SR], where R = alky, alicyclic, aryl, and heterocyclic substituents, have been designed and synthesized as candidate antidotes against SM toxicity. These compounds were screened for their protective efficacy through the oral route against dermally applied sulfur mustard in female mice measured on the basis of percent survival following percutaneous administration of SM. A number of compounds demonstrated significant protection.
journal_name
J Med Chemjournal_title
Journal of medicinal chemistryauthors
Pathak U,Raza SK,Kulkarni AS,Vijayaraghvan R,Kumar P,Jaiswal DKdoi
10.1021/jm030099vkeywords:
subject
Has Abstractpub_date
2004-07-15 00:00:00pages
3817-22issue
15eissn
0022-2623issn
1520-4804journal_volume
47pub_type
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