Abstract:
:The failure of the adult human spinal cord to regenerate following injury is not absolute, but appears to be amenable to therapeutic manipulation. Recent work has shown that the provision of a growth permissive environment by the neutralization of inhibitory influences, or the grafting of fetal tissue, peripheral nerve, Schwann cells, or olfactory ensheathing cells can enhance regeneration in animal models of spinal cord injury. Stem cells are gaining ever-increasing favour as a treatment option for spinal cord injury. The potential of neural stem cells, embryonic stem cells, and bone marrow stromal cells is discussed. Additional treatment options such as pharmacological interventions, functional electrical stimulation and physiotherapy approaches are also explored. Basic science insights are used as a foundation for a discussion of a variety of clinical perspectives including repair of the chronically injured spinal cord, animal models of human spinal cord injuries and clinical trials. A more holistic approach towards spinal cord injury is suggested, one where a hierarchy of needs is recognised and quality of life is paramount. Finally, this review cautions against overly grandiose claims of an imminent miracle cure for human spinal cord injury.
journal_name
NeuroRehabilitationjournal_title
NeuroRehabilitationauthors
Jones DG,Anderson ER,Galvin KAkeywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
339-51issue
4eissn
1053-8135issn
1878-6448journal_volume
18pub_type
杂志文章,评审abstract:BACKGROUND:Gait impairments from a neuromuscular imbalance are crucial issues in cerebral palsy. The purpose of our study was to compare the effects of the assistive tubing gait (ATG) and assistive-resistive tubing gait (ARTG) on improving the vasti and hamstring muscle imbalance during the initial contact to mid-stanc...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-141154
更新日期:2014-01-01 00:00:00
abstract:GOALS AND OBJECTIVES:The main goal of this study is to evaluate the effect of treadmill exercise on the angiogenesis markers in the striatum (ST) of chronic/progressive parkinsonian mice. MATERIALS AND METHODS:Forty 57BL/6 albino mice were randomly divided into four groups. Sedentary control (SC, n=10), exercise contr...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-2010-0574
更新日期:2010-01-01 00:00:00
abstract::Cognitive rehabilitation has evolved to be a common clinical practice, despite questions regarding the scientific basis for its effectiveness. A selective interpretation of existing studies suggests that non-specific treatment factors play an important role in the efficacy of cognitive rehabilitation. Some future dire...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-1997-8103
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:Meta analysis of studies was carried out to examine the effectiveness of functional task training with mental practice on functional performance following stroke. SEARCH STRATEGY:An exhaustive search was conducted using computerized databases such as MEDLINE, PubMed, Cochrane, PsycINFO, and EBSCO (CINAHL). ...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,meta分析
doi:10.3233/NRE-2012-0751
更新日期:2012-01-01 00:00:00
abstract::A significant number of people with multiple sclerosis experience pathological laughing and weeping. This article presents two perspectives on these symptoms. First, the neurological literature is reviewed. Then, the patient's perspective is described in an essay written by a man who lives with pathological laughing a...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-1995-5410
更新日期:1995-01-01 00:00:00
abstract:AIM:The aim of this study was to evaluate the efficacy and safety of radial extracorporeal shock wave therapy (rESWT) in the treatment of spasticity in patients with cerebral palsy. METHODS:Fifteen patients with spastic cerebral palsy, 12 men and 3 women, aged 10-46 years (mean age 31). The 15 patients presented 40 sp...
journal_title:NeuroRehabilitation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3233/NRE-2011-0720
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Systemic inflammation and its impact on rehabilitation for patients with non-traumatic haemorrhagic injury (HBI) sequelae has not yet been adequately documented. OBJECTIVE AND METHODS:We therefore considered 31 patients with HBI, to determine the serum levels of inflammatory markers (C-Reactive Protein, CRP...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-182362
更新日期:2018-04-07 00:00:00
abstract::The management of pain in persons with neurological injuries is challenging and complex. A holistic view and clinical approach are necessary when addressing pain in patients with neurological impairment because interpreting signs and symptoms and deciphering sources of pain is never a straightforward process. This pro...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-208003
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Pisa syndrome (PS) or lateral axial dystonia is often seen in patients with Parkinson's disease (PD). It is characterized by a marked and reversible lateral flexion of the trunk (LFT) more than 10°. OBJECTIVE:To assess the effectiveness of a program of postural exercises and assess the effectiveness in term...
journal_title:NeuroRehabilitation
pub_type: 临床试验,杂志文章
doi:10.3233/NRE-162033
更新日期:2017-01-01 00:00:00
abstract::Praxis is defined as skilled, purposive limb movement. While it has been a consistent finding that lesions of the left cerebral hemisphere result in significantly worse performance on praxis testing than lesions of the right cerebral hemisphere, recently some investigators have proposed that the right hemisphere may a...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-1997-9105
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Balance impairment is a major clinical concern in patients with parkinsonism. Balance training with tetra-ataxiometric posturography (Tetrax) is known to improve balance function through visual biofeedback effects. OBJECTIVE:In this study, we evaluated the effects of balance training with Tetrax in patients...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-192850
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Boxing training including traditional stretching, muscular strength training, and duration training would be considered to be effective for improved functional stretching, dynamic balance, walking speed, and quality of life. OBJECTIVE:We aimed to investigate upper limb function, balance, gait, and quality o...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-161392
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Considering the extensive neural network of the oculomotor subsystems, traumatic brain injury (TBI) could affect oculomotor control and related reading dysfunction. OBJECTIVE:To evaluate comprehensively the effect of oculomotor-based vision rehabilitation (OBVR) in individuals with mTBI. METHODS:Twelve sub...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.3233/NRE-131025
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Children with cerebral palsy show dysfunctional postural control which interferes with their functional performance and daily-life activities. OBJECTIVE:The aim of the study was to identify the effect of a 3D supporting garment on trunk postural control and interjoint coordination during gait in children wi...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-161349
更新日期:2016-06-23 00:00:00
abstract:BACKGROUND:Strength training can increase function in individuals with stroke. However it is unclear which type of strength training is most effective and feasible. OBJECTIVE:To assess the effect and feasibility of an intervention combining eccentric and task-oriented strength training in individuals with chronic stro...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.3233/NRE-171433
更新日期:2017-01-01 00:00:00
abstract::Removal of an indwelling catheter and the initiation of intermittent catheterization (IC) has become a standard urological goal over the past decades. While realistic for men it is more difficult for women, mainly due to their anatomical differences and lack of development of a satisfactory external collection device....
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-1994-4407
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Traumatic brain injury (TBI) remains a silent and global epidemic which creates an aftermath of convoluted dynamics. Despite significant incidence rates and increasing awareness over the long-term catastrophic implications, there remain marked contrasts between acute vs. post-acute rehabilitation processes i...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,评审
doi:10.3233/NRE-192969
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:In a patient with severe hemiplegia, the risk of the knee giving way is high during the early stage of gait exercise with an ankle-foot orthosis. However, use of a knee-ankle-foot orthosis has many problems such as large amount of assistance and compensatory motions. To resolve these problems, we have engage...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-171459
更新日期:2017-01-01 00:00:00
abstract::Twenty five (25) out of 29 patients (86%) with unequivocal memorydisorders who received Memory Compensation Training (MCT) completed both a brief survey regarding their use of memory compensations and the Memory Compensation Questionnaire. Twenty-two (22) of the 25 patients (88%) reported daily use of memory compensat...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::The definitions in the Diagnostic and Statistical Manual-4th Ed.-TR [5] relating to posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) after mechanical accidents do not reflect the range of dysfunctions, the significance of patient differences, and fluctuating intensity, direction, and symptoms with...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,评审
doi:
更新日期:2002-01-01 00:00:00
abstract::The purpose of this study was to determine the degree to which stress-coping variables contribute to quality of life (QOL) among caregivers of individuals with traumatic brain injury (TBI). This study examined the direct effects of the following variables: functional competency, caregiving appraisal, coping, perceived...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-2010-0580
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To evaluate in a preliminary fashion whether several standard cognitive assessments predict treatment outcomes on real-world functional activities following Constraint-Induced Movement therapy (CI therapy) for either the upper extremity (UE) or the lower extremity (LE) for chronic stroke hemiparesis in the ou...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:Although deemed a globally accepted framework, there remains scare evidence on the process and outcome of implementing the International Classification of Functioning, Disability and Health (ICF) within neurorehabilitation. OBJECTIVES:This review briefly explores the existing, broader literature and then ...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,评审
doi:10.3233/NRE-141185
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Good assessment is an essential component of effective patient management. Yet the sheer volume of available assessment instruments presents a barrier for the clinician or researcher to (a) be knowledgeable about suitable measures and (b) keep up-to-date with new measures that are published. In orde...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,评审
doi:10.3233/NRE-130898
更新日期:2013-01-01 00:00:00
abstract::A step-by-step case report describes the rehabilitation program for visual dysfunction of a 52-year-old woman, beginning 2 years post-trauma. Methods to ameliorate such symptoms as diplopia, ocular discomfort, dry eye, inefficient saccadic movement, spasms of accommodation, poor reading comprehension and very limited ...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-1996-6304
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Brain-computer interfaces (BCIs) allow persons with impaired mobility to communicate and interact with the environment, supporting goal-directed thinking and cognitive function. Ideally, a BCI should be able to recognize a user's internal state and adapt to it in real-time, to improve interaction. OBJECTIVE...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,meta分析,评审
doi:10.3233/NRE-151266
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Stroke is the leading cause of adult disability, with walking impairment being a devastating indicator of chronic post-stroke hemiparesis. Limited resources exist for individual treatments; therefore, the delivery of safe group exercise therapy is highly desired. OBJECTIVE:To examine whether the application...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,多中心研究
doi:10.3233/NRE-131035
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Robotic guidance has been shown to facilitate motor skill acquisition, through altered sensorimotor control, in neurologically impaired and healthy populations. OBJECTIVE:To determine if robot-guided practice and online visual feedback availability primarily influences movement planning or online control me...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.3233/NRE-141168
更新日期:2014-01-01 00:00:00
abstract::The corticospinal tract (CST) is the most important neural tract for motor function in the human brain. Therefore, clarification of CST injury would be an important topic in traumatic brain injury (TBI) rehabilitation. In this review, I reviewed diffusion tensor imaging (DTI) studies on CST injuries in terms of etiolo...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,评审
doi:10.3233/NRE-2011-0710
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Gait impairment, balance problems and falls have a negative impact on independence in ADL and quality of life of patients affected by Hereditary Spastic Paraplegia (HSP). Since no pharmacological options are available, treatments rely mostly on rehabilitation therapy, although almost no data on this topic ex...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-141196
更新日期:2015-01-01 00:00:00