Abstract:
:The initial enthusiasm generated by the discovery of the first susceptibility gene found for melanoma has slightly dampened over recent years. For the majority of melanoma families the underlying gene defect is still not known, so the search for other melanoma genes is continuing. Also, the increased risk of melanoma does not seem to be restricted to mutation carriers, but is present even in non-mutation carriers in melanoma families. The underlying defect of familial melanoma is less straightforward than previously thought; both environmental and hereditary risk modifiers intermingle in a perplexing way. This makes familial melanoma a complex disorder which deserves the close attention of both clinicians and researchers, especially as the opinion on gene testing in familial melanoma has not yet achieved consensus. On the one hand, there is a rising demand from families for genetic testing; on the other hand, there is the clinicians' concern about the value of such testing.
journal_name
Fam Cancerjournal_title
Familial cancerauthors
de Snoo FA,Bergman W,Gruis NAdoi
10.1023/a:1025758527675keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
109-16issue
2eissn
1389-9600issn
1573-7292pii
5120359journal_volume
2pub_type
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