Abstract:
:During the cell cycle, Cdc2-cyclin B kinase abruptly becomes active and triggers the entry into mitosis/meiosis. Recently, it was found that inactive Cdc2-cyclin B is present in aggregates in immature starfish oocytes and becomes disaggregated at the time of its activation during maturation. We discuss a possible scenario in which aggregation of Cdc2-cyclin B dramatically enhances robustness of this activation. In this scenario, only inactive Cdc2-cyclin B can form aggregates, and the aggregates are in equilibrium with inactive Cdc2-cyclin B in solution. During maturation, the hormone-triggered inactivation of Myt1 depletes the soluble inactive Cdc2-cyclin B and the turnover leads to dissolution of the aggregates. This phase change, when coupled with the instability of the signaling network, provides a robust bio-switch.
journal_name
Mol Biol Celljournal_title
Molecular biology of the cellauthors
Slepchenko BM,Terasaki Mdoi
10.1091/mbc.e03-04-0248keywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
4695-706issue
11eissn
1059-1524issn
1939-4586pii
E03-04-0248journal_volume
14pub_type
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