Abstract:
OBJECTIVES:We wished to determine whether women with multinodular goitre and spontaneous subclinical hyperthyroidism have decreased bone density. DESIGN AND SUBJECTS:Bone density was measured at the distal and proximal forearm. Data were expressed as Z-scores relative to the mean values out of 125 control subjects matched for age and menopause. The Z-scores of 23 women with subclinical hyperthyroid goitre (TSH < 0.1 mU/l and normal values for FT4 and total T3) and of 54 women with euthyroid goitre were compared. MEASUREMENTS:Bone density was measured by single photon absorptiometry. TSH was measured by IRMA, FT4 by RIA. RESULTS:Relative to the euthyroid goitre subjects the mean +/- SEM Z-scores of both the distal and proximal forearm density were lower (-0.69 +/- 0.17 vs -0.1 +/- 0.18, P < 0.05 and -0.5 +/- 0.18 vs 0.07 +/- 0.18, P < 0.05, respectively). Median (range) FT4 in the subclinical hyperthyroid goitre subjects was significantly higher than euthyroid goitre subjects (15.6 (11-23.2) pmol/l vs 11.9 (8.3-18.3) pmol/l, P < 0.001) although still within the normal range. FT4 correlated inversely with Z-scores of both distal and proximal forearm bone density in the subjects with subclinical hyperthyroidism (r = -0.42, P < 0.05 and r = -0.43, P < 0.05, respectively), but not in the euthyroid goitre subjects. CONCLUSION:These findings indicate that women with untreated multinodular goitre and subclinical hyperthyroidism have reduced bone density in the forearm.
journal_name
Clin Endocrinol (Oxf)journal_title
Clinical endocrinologyauthors
Mudde AH,Reijnders FJ,Kruseman ACdoi
10.1111/j.1365-2265.1992.tb02280.xkeywords:
subject
Has Abstractpub_date
1992-07-01 00:00:00pages
35-9issue
1eissn
0300-0664issn
1365-2265journal_volume
37pub_type
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journal_title:Clinical endocrinology
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journal_title:Clinical endocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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doi:10.1046/j.1365-2265.1998.00533.x
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1993.tb01008.x
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更新日期:2011-09-01 00:00:00
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doi:10.1111/j.1365-2265.1976.tb01985.x
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doi:10.1111/j.1365-2265.1988.tb00249.x
更新日期:1988-07-01 00:00:00
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更新日期:2016-08-01 00:00:00
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doi:10.1111/j.1365-2265.1984.tb00100.x
更新日期:1984-05-01 00:00:00
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更新日期:2002-03-01 00:00:00
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doi:10.1111/j.1365-2265.1989.tb00431.x
更新日期:1989-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1365-2265.2008.03473.x
更新日期:2009-08-01 00:00:00
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1977.tb02005.x
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pub_type: 杂志文章,多中心研究
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更新日期:1994-10-01 00:00:00
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doi:10.1046/j.1365-2265.1998.00329.x
更新日期:1998-04-01 00:00:00
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更新日期:1996-12-01 00:00:00
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journal_title:Clinical endocrinology
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journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/j.1365-2265.1984.tb00089.x
更新日期:1984-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
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更新日期:2003-02-01 00:00:00