Angiotensinogen and angiotensin II type 1 receptor gene polymorphism in patients with autosomal dominant polycystic kidney disease: effect on hypertension and ESRD.

Abstract:

:Autosomal dominant polycystic kidney disease (ADPKD), a common genetic disease, is characterized by the development of hypertension and end stage renal disease. An increase in the activity of the renin-angiotensin system, due to a renal ischemia caused by cyst expansion, contributes to the development of hypertension and renal failure in ADPKD. Recently, the angiotensinogen (AGT) gene, M235T, and angiotensin II type 1 receptor (ATR) gene, A1166C, polymorphisms have been associated with the susceptibility to develop hypertension and renal disease. We hypothesized that the AGT M235T and ATR A1166C polymorphisms could account for some of the variability in the progression of ADPKD. Genotyping was performed in 108 adult patients with ADPKD, and 105 normotensive healthy controls, using PCR and restriction digestion. We analyzed the effects of the AGT M235T and ATR A1166C polymorphisms on hypertension and age at the end stage renal disease (ESRD). Of the 108 patients with ADPKD, 64 (59%) had hypertension and 24 (22%) reached the ESRD. The prevalence of hypertension were; [MM+MT], [TT] genotypes, 60%, 59% (p=1.00); [AA], [AC+CC] genotypes, 60%, 50% respectively (p=0.54). The ages at the onset of ESRD were; [MM+MT], [TT] genotypes, 50 +/- 9 years, 56 +/- 8 years (p=0.07); [AA], [AC+CC] genotypes, 54 +/- 8 years, 52 +/- 14 years, respectively (p=0.07). There were no differences in the prevalence of hypertension and the ages at the ESRD in relation to the AGT M235T and ATR A1166C polymorphisms. We suggest that the AGT and ATR gene polymorphisms would not have an effect on hypertension or the ESRD in ADPKD.

journal_name

Yonsei Med J

journal_title

Yonsei medical journal

authors

Lee KB,Kim UK

doi

10.3349/ymj.2003.44.4.641

keywords:

subject

Has Abstract

pub_date

2003-08-30 00:00:00

pages

641-7

issue

4

eissn

0513-5796

issn

1976-2437

pii

200308641

journal_volume

44

pub_type

杂志文章
  • Low serum vitamin D is associated with anti-thyroid peroxidase antibody in autoimmune thyroiditis.

    abstract:PURPOSE:The association between autoimmune thyroid diseases (AITDs) and vitamin D deficiency is controversial. We aimed to evaluate the relationship between serum 25-hydroxy-vitamin D3 [25(OH)D3] and anti-thyroid antibody levels. MATERIALS AND METHODS:25(OH)D3, anti-thyroid antibodies, and thyroid function measured in...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2014.55.2.476

    authors: Shin DY,Kim KJ,Kim D,Hwang S,Lee EJ

    更新日期:2014-03-01 00:00:00

  • Prospective evaluation of perinatal risk factors for cerebral palsy and delayed development in high risk infants.

    abstract::Prematurity, intrauterine infection and perinatal brain injury have been reported to be significant risk factors of cerebral palsy (CP). We examined the perinatal predictors of cerebral palsy and delayed development (DD) in 184 high risk infants. Thirty-five infants were diagnosed as cerebral palsy and delayed develop...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1999.40.4.363

    authors: Kim JN,Namgung R,Chang W,Oh CH,Shin JC,Park ES,Park CI,Park MS,Park KI,Lee C,Han DG

    更新日期:1999-08-01 00:00:00

  • Manchester Operation: An Effective Treatment for Uterine Prolapse Caused by True Cervical Elongation.

    abstract:PURPOSE:Descent of the uterus is a major etiology of uterine prolapse. However, true cervical elongation can cause uterine prolapse without uterine descent. The aim of study was to investigate the clinical outcomes of Manchester operation in patients with uterine prolapse caused by "true cervical elongation," compared ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2019.60.11.1074

    authors: Park YJ,Kong MK,Lee J,Kim EH,Bai SW

    更新日期:2019-11-01 00:00:00

  • Spontaneous rupture of a functioning adrenocortical carcinoma.

    abstract::Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis, and it can be classified as either a functional or nonfunctional tumor. Affected patients usually present with abdominal pain or with symptoms related to the mass effect or hormonal activity of the tumor. Several cases of spontaneously ruptured n...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2010.51.6.974

    authors: Chung JO,Cho DH,Lee JH,Kwon DD,Chung DJ,Chung MY

    更新日期:2010-11-01 00:00:00

  • A case of life-threatening acute kidney injury with toxic encephalopathy caused by Dioscorea quinqueloba.

    abstract::Some herbal medications induce acute kidney injury. The acute kidney injuries caused by herbal medications are mild and commonly treated by palliative care. A 51-years-old man who drank the juice squeezed from the raw tubers of Dioscorea quinqueloba (D. quinqueloba) was admitted with nausea, vomiting and chilling. He ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2015.56.1.304

    authors: Kang KS,Heo ST

    更新日期:2015-01-01 00:00:00

  • Clinical Implications of Moderate Coronary Stenosis on Coronary Computed Tomography Angiography in Patients with Stable Angina.

    abstract:PURPOSE:The present study investigated the diagnostic accuracy and clinical implications of moderate stenosis (50-69%, Coronary Artery Disease Reporting and Data System, grade 3) on coronary computed tomography angiography (CCTA), compared with invasive coronary angiography (ICA). MATERIALS AND METHODS:Two hundred and...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2018.59.8.937

    authors: Kim C,Hong SJ,Ahn CM,Kim JS,Kim BK,Ko YG,Choi BW,Choi D,Jang Y,Hong MK

    更新日期:2018-10-01 00:00:00

  • A comparison of estrogen and two different doses of calcitonin in ovariectomized rats.

    abstract::The purpose of this study was to investigate the treatment efficacies of salmon calcitonin (SC) and estrogen in a type-I osteoporotic rat model. Sixty, 3-month-old, female Wistar rats were divided into six groups. The first group was used as the control, and the second a sham, the other four were surgically ovariectom...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2003.44.3.508

    authors: Kavuncu V,Sahin S,Baydas G,Ilhan N,Ozercan I,Yasar A,Pekkutucu I,Ilhan N,Ozercan R

    更新日期:2003-06-30 00:00:00

  • Bone morphogenetic protein receptor in the osteogenic differentiation of rat bone marrow stromal cells.

    abstract:PURPOSE:Several signaling pathways have been shown to regulate the lineage commitment and terminal differentiation of bone marrow stromal cells (BMSCs). Bone morphogenetic protein (BMP) signaling has important effects on the process of skeletogenesis. In the present study, we tested the role of bone morphogenetic prote...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2010.51.5.740

    authors: Wang A,Ding X,Sheng S,Yao Z

    更新日期:2010-09-01 00:00:00

  • Radiologic findings of metastatic signet ring cell carcinoma to the breast from stomach.

    abstract::Two Korean women (41 and 23-years of age) presented with painful breast enlargement and redness. The involved breast was confirmed as metastatic signet ring cell carcinoma. Although metastatic signet ring cell carcinoma of the breast shows similar clinical symptoms to inflammatory breast cancer, the difference between...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2000.41.5.669

    authors: Kwak JY,Kim EK,Oh KK

    更新日期:2000-10-01 00:00:00

  • Left Ventricular End-Systolic Volume Can Predict 1-Year Hierarchical Clinical Composite End Point in Patients with Cardiac Resynchronization Therapy.

    abstract:PURPOSE:This study aimed to elucidate which echocardiographic criteria at three time points, for cardiac resynchronization therapy (CRT) response, are accurate in discriminating the hierarchical clinical composite end point (HCCEP). MATERIALS AND METHODS:We included 120 patients (age, 66.1±12.6 years; men, 54.2%) who ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2019.60.1.48

    authors: Uhm JS,Oh J,Cho IJ,Park M,Kim IS,Jin MN,Bae HJ,Yu HT,Kim TH,Pak HN,Lee MH,Joung B,Kang SM

    更新日期:2019-01-01 00:00:00

  • Application of ultrasound-guided trigger point injection for myofascial trigger points in the subscapularis and pectoralis muscles to post-mastectomy patients: a pilot study.

    abstract:PURPOSE:To investigate the therapeutic effectiveness of ultrasound (US)-guided trigger point injection for myofascial trigger points (MTrPs) in the internal rotator muscles of the shoulder in post-mastectomy patients. MATERIALS AND METHODS:This pilot study was a non-controlled, prospective, clinical trial. Nineteen po...

    journal_title:Yonsei medical journal

    pub_type: 临床试验,杂志文章

    doi:10.3349/ymj.2014.55.3.792

    authors: Shin HJ,Shin JC,Kim WS,Chang WH,Lee SC

    更新日期:2014-05-01 00:00:00

  • Difficulty in removal of a femoral intramedullary nail: the geometry of the distal end of the nail.

    abstract::Different difficulties can be encountered during removal of an intramedullary femoral nail depending partly upon the design of the nail but mainly on bone ingrowth. This possibility is higher in younger patients and when nail removal is attempted long after initial insertion. We present a case of difficult nail remova...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2003.44.6.1083

    authors: Bombaci H,Gorgec M

    更新日期:2003-12-30 00:00:00

  • Comparison of natural drainage group and negative drainage groups after total thyroidectomy: prospective randomized controlled study.

    abstract:PURPOSE:The aim of this study was to compare a negative pressure drain with a natural drain in order to determine whether a negative pressure drainage tube causes an increase in the drainage volume. MATERIALS AND METHODS:Sixty-two patients who underwent total thyroidectomy for papillary thyroid carcinoma (PTC) were en...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,随机对照试验

    doi:10.3349/ymj.2013.54.1.204

    authors: Woo SH,Kim JP,Park JJ,Shim HS,Lee SH,Lee HJ,Won SJ,Son HY,Kim RB,Son YI

    更新日期:2013-01-01 00:00:00

  • Randomized Comparison of Strut Coverage between Ticagrelor and Clopidogrel in Acute Myocardial Infarction at 3-Month Optical Coherence Tomography.

    abstract:PURPOSE:This study aimed to compare the effects of ticagrelor and clopidogrel on early neointimal healing assessed with optical coherence tomography (OCT) after drug-eluting stent (DES) implantation in patients with acute myocardial infarction (AMI). MATERIALS AND METHODS:AMI patients were randomly assigned to either ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,随机对照试验

    doi:10.3349/ymj.2018.59.5.624

    authors: Kim C,Kim BK,Hong SJ,Ahn CM,Kim JS,Ko YG,Choi D,Hong MK,Jang Y

    更新日期:2018-07-01 00:00:00

  • Long-Term Outcome and Surveillance Colonoscopy after Successful Endoscopic Treatment of Large Sessile Colorectal Polyps.

    abstract:PURPOSE:Although there is a consensus about the need for surveillance colonoscopy after endoscopic resection, the interval remains controversial for large sessile colorectal polyps. The aim of this study was to evaluate the long-term outcome and the adequate surveillance colonoscopy interval required for sessile and fl...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2016.57.5.1106

    authors: Kim B,Choi AR,Park SJ,Cheon JH,Kim TI,Kim WH,Hong SP

    更新日期:2016-09-01 00:00:00

  • A single center experience of self-bougienage on stricture recurrence after surgery for corrosive esophageal strictures in children.

    abstract:PURPOSE:This study was undertaken to evaluate the long-term treatment of esophageal strictures in children with corrosive esophagitis and to determine the effect of self-bougienage on recurrent strictures. MATERIALS AND METHODS:We reviewed the medical records of nine children that were treated for corrosive esophageal...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2010.51.2.202

    authors: Lee HJ,Lee JH,Seo JM,Lee SK,Choe YH

    更新日期:2010-03-01 00:00:00

  • Parent-reported symptoms of attention deficit hyperactivity disorder in children with intermittent exotropia before and after strabismus surgery.

    abstract:PURPOSE:To investigate the symptoms of attention deficit hyperactivity disorder (ADHD) as reported by parents in children with intermittent exotropia [X(T)] and to determine whether strabismus surgery for X(T) affects ADHD symptoms. MATERIALS AND METHODS:Fifty-one consecutive children undergoing muscle surgery for X(T...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2012.53.4.806

    authors: Chung SA,Chang YH,Rhiu S,Lew H,Lee JB

    更新日期:2012-07-01 00:00:00

  • Identification of differentially expressed genes in papillary thyroid cancers.

    abstract:PURPOSE:Techniques designed to identify differentially expressed genes (DEGs) in tumors have become important in modern pathology. Genefishing technique using the annealing control primer (ACP) system has recently been developed to screen for DEG transcripts. We tried to identify DEGs involved in papillary thyroid canc...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2009.50.1.60

    authors: Lee KY,Huang SM,Li S,Kim JM

    更新日期:2009-02-28 00:00:00

  • Development of a clinical protocol for home hospice care for Koreans.

    abstract::As the Korean government's recognition of the importance of hospice service grows, the government has initiated a variety of hospice services in Korea. Each hospice organization has shown a significant difference in its health care delivery methods, constitution and care content. Developing a clinical protocol is esse...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2005.46.1.8

    authors: Lee WH,Lee CG

    更新日期:2005-02-28 00:00:00

  • Coronary-subclavian steal syndrome presenting with ventricular tachycardia.

    abstract::Coronary-subclavian steal through the left internal mammary graft is a rare cause of myocardial ischemia in patients who have had a coronary bypass surgery. We report a 70-year-old man who presented with sustained monomorphic ventricular tachycardia 5 years after the surgical creation of a left internal mammary to the...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2009.50.6.852

    authors: Kursaklioglu H,Kose S,Iyisoy A,Amasyali B,Celik T,Aytemir K,Isik E

    更新日期:2009-12-31 00:00:00

  • Relationships between serum adiponectin with metabolic syndrome and components of metabolic syndrome in non-diabetic Koreans: ARIRANG study.

    abstract:PURPOSE:Growing evidence suggests that hypoadiponectinemia may play a significant role in the development of metabolic syndrome (MetS). Therefore, the relationships between serum adiponectin with MetS and components of MetS were investigated in non-diabetic samples of drawn from the Koreans general population. MATERIA...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2011.52.2.234

    authors: Koh SB,Yoon J,Kim JY,Yoo BS,Lee SH,Park JK,Choe KH

    更新日期:2011-03-01 00:00:00

  • Effect of long-term hormone therapy on telomere length in postmenopausal women.

    abstract::Telomeres undergo attrition with each cell division, and telomere length is associated with age-related diseases and mortality in the elderly. Estrogen can influence the attrition of telomeres by diverse mechanisms. This is a retrospective case control study that investigated the influence of long-term hormone therapy...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2005.46.4.471

    authors: Lee DC,Im JA,Kim JH,Lee HR,Shim JY

    更新日期:2005-08-31 00:00:00

  • Total Transcanal Endoscopic Facial Nerve Decompression for Traumatic Facial Nerve Palsy.

    abstract::A few approaches can be used to decompress traumatic facial nerve paralysis including the middle cranial fossa approach or transmastoid approach depending on the site of injury. In some specific situation of treating traumatic facial nerve palsy whose injured site was confined from the geniculate ganglion to the secon...

    journal_title:Yonsei medical journal

    pub_type:

    doi:10.3349/ymj.2018.59.3.457

    authors: Kahinga AA,Han JH,Moon IS

    更新日期:2018-05-01 00:00:00

  • Hemodynamical assessment of cavernous hemangioma in cavernous sinus using MR-DSA and conventional DSA.

    abstract::We report a hemodynamical assessment of the blood turnover pattern as well as the imaging of cavernous hemangioma in a cavernous sinus using time-resolved contrast enhanced 2D projection MRA, also known as MR-DSA, and conventional digital subtraction angiography (DSA), before and after radiotherapy. MR-DSA showed very...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2003.44.5.908

    authors: Shim YW,Chung TS,Kang WS,Lee KS,Strecker R,Hennig J

    更新日期:2003-10-30 00:00:00

  • Elevation of Serum Aminotransferase Levels and Future Risk of Death from External Causes: A Prospective Cohort Study in Korea.

    abstract:PURPOSE:The association between liver enzymes and death from external causes has not been examined. We investigated the association between serum aminotransferase levels and external-cause mortality in a large prospective cohort study. MATERIALS AND METHODS:A total of 142,322 subjects of 35-59 years of age who complet...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2015.56.6.1582

    authors: Sohn J,Kang DR,Kim HC,Cho J,Choi YJ,Kim C,Suh I

    更新日期:2015-11-01 00:00:00

  • The expression of folate sensitive fragile sites in patients with bipolar disorder.

    abstract:PURPOSE:Genetic factors are known to be important in the etiology of bipolar disorder (BD). The fragile sites (FSs) are a very interesting subject for the study of clinical disorders. The aim of this study was to evaluate fragile sites seen in patients with bipolar disorder and find a correlation between some fragile s...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2009.50.1.137

    authors: Demirhan O,Tastemir D,Sertdemir Y

    更新日期:2009-02-28 00:00:00

  • Morphological characteristics of the developing human brain during the embryonic period.

    abstract::Many features of the developing nervous system are visible from external observations of intact human embryos. In this study, a photographic atlas from the 4th to the 7th week after ovulation (Carnegie stages 10-18) is provided. The neural folds began to fuse at stage 10, and the rostral and caudal neuropore were clos...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1997.38.1.26

    authors: Yoon H,Shin YS,Lee KC,Park HW

    更新日期:1997-02-01 00:00:00

  • The effect of sodium cromoglycate on the induction of experimental IgA nephropathy.

    abstract::Mesangial IgA nephropathy was experimentally induced in ddY mice by oral and parenteral administration of the poliomyelitis vaccine (POLIO), and we then tried to investigate if IgA deposition could be prevented by the concurrent use of sodium cromoglycate (SCG), which is known to inhibit the local mucosal immune react...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1990.31.1.33

    authors: Jin SY,Choi IJ

    更新日期:1990-03-01 00:00:00

  • Clinical usefulness of magnetic resonance cisternography in patients having hemifacial spasm.

    abstract::To evaluate the usefulness of MR cisternography fourteen patients that had hemifacial spasm and 20 control patients underwent MR cisternography. All the patients with hemifacial spasm had a confirmed vascular compression after surgery. MR cisternography was performed using a 1.5-tesla superconducting MR magnet in whic...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2001.42.4.390

    authors: Lee MS,Kim MS,Hong IS,Whang K,Han YP

    更新日期:2001-08-01 00:00:00

  • Early repolarization and myocardial scar predict poorest prognosis in patients with coronary artery disease.

    abstract:PURPOSE:Recent studies show positive association of early repolarization (ER) with the risk of life-threatening arrhythmias in patients with coronary artery disease (CAD). This study was to investigate the relationships of ER with myocardial scarring and prognosis in patients with CAD. MATERIALS AND METHODS:Of 570 con...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2014.55.4.928

    authors: Lee HY,Mun HS,Wi J,Uhm JS,Shim J,Kim JY,Pak HN,Lee MH,Joung B

    更新日期:2014-07-01 00:00:00