Abstract:
:As the mortality rate from breast cancer decreases, the issues facing breast cancer survivors are becoming increasingly important. Survivors of all ages may face physical and psychosocial consequences of their diagnosis and treatments. However, the long-term fertility and menopause-related side-effects of adjuvant therapy uniquely affect younger premenopausal breast cancer survivors. This article provides an evidence-based overview of the reproductive and gynaecological impact of breast cancer therapy for premenopausal women diagnosed with breast cancer. The physical and psychosocial implications of premature menopause are presented. Strategies for preserving fertility in selected patients are also discussed. Recent clinical trials strongly indicate that premenopausal women with oestrogen receptor positive tumours should receive endocrine therapy. The increased use of endocrine therapies in younger women raises important questions regarding patient information needs and treatment decision-making.
journal_name
Intern Med Jjournal_title
Internal medicine journalauthors
Friedlander M,Thewes Bdoi
10.1046/j.1445-5994.2003.00377.xkeywords:
subject
Has Abstractpub_date
2003-08-01 00:00:00pages
372-9issue
8eissn
1444-0903issn
1445-5994pii
377journal_volume
33pub_type
杂志文章,评审abstract:BACKGROUND:Guidelines recommend screening for strongyloidiasis prior to immunosuppression in those at epidemiological risk, as hyperinfection following immunosuppression is often fatal. The uptake of this recommendation is unknown, and we aimed to explore this in our setting. AIMS:Determine the proportion of adult pat...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14991
更新日期:2020-07-20 00:00:00
abstract::We report the first published case of aggressive diffuse large B-cell (non-Hodgkin) lymphoma in a 35-year-old pregnant woman who had Crohn disease and was taking long-term thiopurine therapy: the patient developed placental insufficiency, and there was intrauterine fetal death. ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12957
更新日期:2016-01-01 00:00:00
abstract::Based on the number of new cases (incidence), non-Hodgkin lymphoma is an increasingly common cancer in Australia and many developed countries. Until recently, mortality trends have been stable or slightly increasing. However, since the year 2000, mortality has decreased every year by an average of 5.1% per year (95% c...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2008.01809.x
更新日期:2008-12-01 00:00:00
abstract::More than 177 000 potentially preventable healthcare-associated infections (HAIs) occur per annum in Australia with sizable attributable mortality. Organizational systems to protect against HAI in hospitals in Australia are relatively poorly developed. Awareness and practice of infection control by medical and other h...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2009.02004.x
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:In an era of growing subspecialisation there has been significant research into the role, determinants and outcomes of outpatient referrals but very little on inpatient specialty referrals from general medical units. AIMS:This study aims to describe and compare the rate of specialty referrals from inpatient...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12480
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Glomerular M-type phospholipase A2 receptor (PLA2 R) is important for diagnosing idiopathic membranous nephropathy (IMN). The relation between glomerular PLA2 R expression and response to treatment remains to be explored. AIMS:We conducted the study to explore the positive rate and clinical significance of ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13233
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Off-label use of rituximab in lupus nephritis is reported to be beneficial. While the optimal dose is unknown, the regimen of four intravenous doses of 375 mg/m(2) is commonly employed, despite expense and potential side-effects. AIM:To investigate the response to single-dose rituximab, added to standard co...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13136
更新日期:2016-08-01 00:00:00
abstract::A 75-year-old man of Fijian-Indian extraction complained of a 3-year history of progressive right knee pain and stiffness which were limiting his mobility. On examination, multiple hard nodules were palpable in the popliteal fossa and along the path of the quadriceps tendon. The joint line was not tender, knee flexion...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1046/j.1445-5994.2002.00260.x
更新日期:2002-08-01 00:00:00
abstract::Paradigms for managing acromegaly have undergone major changes in the past two decades. This has been brought about by combining surgical, pharmacological and radiotherapeutic approaches that provide tight biochemical control to reduce mortality to that of the general population. The biochemical targets for treatment ...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2006.01097.x
更新日期:2006-07-01 00:00:00
abstract::Abstract Hyperammonaemic encephalopathy has been infrequently reported after both standard and high-dose chemotherapy for solid and haematological malignancies. It is important to consider this diagnosis for patients with unexplained behaviour changes or encephalopathy and this case report emphasizes this condition an...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2008.01772.x
更新日期:2008-10-01 00:00:00
abstract::Diabetes mellitus (DM) has been found to be associated with cardiovascular disease. The goal of this study is to evaluate the prevalence of asthma in patients with type II DM after adjusting for other comorbid conditions. We used patient treatment files of inpatients' admissions containing discharge diagnosis (Classif...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2009.01976.x
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:There is a high risk of developing venous thromboembolism (VTE) following total knee arthroplasty (TKA). Conventional thromboprophylactic agents have limitations, such as route of administration, the need for monitoring, narrow therapeutic windows and interactions. Apixaban is a new oral anticoagulant with t...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13139
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF), an important and treatable cause of ischaemic stroke, can occur as a sustained or a paroxysmal arrhythmia. Continuous cardiac rhythm monitoring (Holter monitoring) is often performed in stroke patients to identify paroxysmal AF, which is an indication for warfarin anti-coagulation i...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1444-0903.2004.00589.x
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND AND AIM:To identify the underlying heart disease and microbiological pathogen associated with infective endocarditis (IE) in Chinese patients in one university hospital over a 10-year period. METHODS:We recruited 115 adult patients admitted to Peking University First Hospital from 2002 to 2011 who were diag...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12248
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:While medications may prolong life and prevent morbidity in older people, adverse effects of polypharmacy are increasingly recognised. As patients age and become frail, prescribing may be expected to focus more on symptom control and minimise potentially harmful preventive medication use that confer little b...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13526
更新日期:2017-09-01 00:00:00
abstract::Clinician-performed chest ultrasound is rapidly entering clinical practice in the fields of intensive care, respiratory medicine and acute medicine. Ultrasound is clearly useful in the diagnosis and characterisation of pleural diseases. It is also critical in improving the safety of pleural interventions. More recentl...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2012.02816.x
更新日期:2012-08-01 00:00:00
abstract::Carbimazole is a drug that is widely used for hyperthyroid disorders, such as Graves' disease. Agranulocytosis is a rare idiosyncratic adverse reaction to the drug which is potentially fatal. This report describes a patient with a history of successfully treated pyoderma gangrenosum, who developed agranulocytosis 3 we...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2009.02143.x
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:In 2003, chronic obstructive pulmonary disease (COPD) accounted for 46% of the burden of chronic respiratory disease in the Australian community. In the 65-74-year-old age group, COPD was the sixth leading cause of disability for men and the seventh for women. AIMS:To measure the influence of disease severi...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2010.02195.x
更新日期:2010-05-01 00:00:00
abstract::The Australian National Chronic Obstructive Pulmonary Disease (COPD) guidelines recommend that inhaled corticosteroids (ICS) be reserved for patients with a post-bronchodilator forced expiratory volume in 1 s (FEV1 ) less than 50% predicted and those who experience ≥2 exacerbations in 12 months. In total, 707 COPD pat...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13611
更新日期:2017-11-01 00:00:00
abstract::Sleep disturbance during menopause is a common and important complaint faced by many women. There are many factors that may play a role in this problem, including vasomotor symptoms and changing hormone levels, circadian rhythm abnormalities, exacerbation of primary insomnia, mood disorders, coexistent medical conditi...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2012.02723.x
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Pulmonary embolism (PE) is associated with significant morbidity and mortality. PE is a heterogeneous entity that causes a wide variety of clinical presentations, making it imperative to establish which clinical symptoms, signs and biomarkers can influence the pretest probability of PE to aid clinicians and ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13596
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:It is recommended that blood pressure should be measured on a bare upper arm with an appropriately sized cuff. However, in practice, it is more convenient to measure blood pressure on sleeved arms. AIMS:We aim to examine the effect of sleeved arms on the accuracy of blood pressure measurement. METHODS:Pati...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.15071
更新日期:2020-09-25 00:00:00
abstract:AIM:Premature discontinuation of antiplatelet therapy is an independent predictor of late stent thrombosis. We sought to determine the prevalence and predictors of premature discontinuation of antiplatelet therapy after drug-eluting stent implantation among patients in Asia. METHODS:A total of 207 consecutive patients...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2009.02104.x
更新日期:2011-08-01 00:00:00
abstract::Decompressive hemicraniectomy (DHC) has been shown to reduce mortality in malignant middle cerebral artery (MCA) infarction. Our primary objective was to compare 1-year mortality between patients receiving DHC for malignant MCA infarction at our institution based on hospital of origin. We retrospectively reviewed the ...
journal_title:Internal medicine journal
pub_type: 杂志文章,meta分析
doi:10.1111/imj.14050
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Long-term prognosis of acute coronary syndromes (ACS) in human immunodeficiency virus (HIV)-infected patients is unknown. AIMS:To compare outcomes after ACS in HIV-infected and uninfected patients. METHODS:Retrospective observational study. HIV cases were matched with two HIV-uninfected controls for age, s...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14744
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Acute coronary syndromes (ACS) management is now well informed by guidelines extrapolated from clinical trials. However, most of these data have been acquired outside the local context. We sought to describe the current patterns of ACS care in Australia. METHODS:The Acute Coronary Syndrome Prospective Audit...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2007.01435.x
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:High inflammatory bowel disease (IBD) rates have been reported in Australasia, but no state-wide studies have yet been performed. AIM:This study estimates the 1-year incidence and point prevalence of IBD in the state of Tasmania, Australia. It also reports clinical outcomes after 12 months of diagnosis in a...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14111
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Teaching, mentoring and supervision (TMS) are fundamental skills with a specific commitment within the Royal Australasian College of Physicians (RACP) professional practice framework. The new basic training standards include 'use of appropriate educational techniques to facilitate the learning of peers, juni...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14935
更新日期:2020-06-08 00:00:00
abstract::Systemic lupus erythematosus (SLE) has been described as a cause of thrombotic microangiopathy, especially thrombotic thrombocytopenic purpura (TTP). Haemolytic-uraemic syndrome (HUS) is less frequent in SLE. We report a case of such an association during an episode of severe lupus nephritis in a young woman, who was ...
journal_title:Internal medicine journal
pub_type: 信件
doi:10.1111/j.1445-5994.2011.02591.x
更新日期:2012-01-01 00:00:00
abstract::Influenza vaccination is an important preventative health measure. A significant proportion of general medical inpatients meets indications for annual inactivated influenza vaccination (IIV), as recommended by the Australian National Immunisation Programme. This study explores opportunities to provide IIV to eligible ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14275
更新日期:2019-05-01 00:00:00