Abstract：
:An unmatched, hospital-based case-control study was performed, to determine, whether respiratory syncytial virus (RSV) etiology in hospitalized young children can be predicted clinically. Children under 2 years of age admitted with a lower respiratory tract infection in three hospitals in northern Germany were included (one tertiary and two secondary centers). Cases were children tested positive for RSV by multiplex RT-PCR. One control group consisted of children tested negative for RSV in the multiplex-RT-PCR and a second control group consisted of patients in whom no PCR was done. A weighted backward stepwise logistic regression model was applied for multivariate analysis. RSV-etiology could be predicted with a sensitivity of 72.8% and a specificity of 73.2%. Young age, disease entity--pneumonia or bronchiolitis, center, intercostal retractions, absence of an underlying condition, low level of C-reactive protein, short duration of symptoms (all on admission), prematurity and epidemiologic year were predictive; anatomical infiltrates and wheezing were not. Pathogen specific diagnosis is necessary for individual therapy, allocation in observational studies or treatment trials and for surveillance of airway infections in children, since the positive predictive value is too low for an accurate diagnosis and decision making. Multivariate techniques are effective tools in complex clinical research for deconfounding.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Weigl JA,Puppe W,Schmitt HJdoi
10.1023/a:1024213400297keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
431-9issue
5eissn
0393-2990issn
1573-7284journal_volume
18pub_type
杂志文章abstract：:Influenza related mortality rates have been established in many countries; nevertheless, studies focusing on the Central European population have been rare to date. We assess mortality attributable to influenza by comparing all cause mortality and mortality due to diseases of the circulatory system during influenza ep...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-005-1067-y
更新日期：2005-01-01 00:00:00
abstract：:We studied HBV infection in 34 HIV-2-infected patients followed-up in Marseilles. Ten (29%) patients were chronically-infected with HBV, which represents a three-times higher rate than in HIV-1-infected patients in Europe. HBV occult infection was diagnosed in two patients. HBV genotype E was found in seven patients; ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-006-9039-4
更新日期：2006-01-01 00:00:00
abstract：:This paper describes 188 cases of early breast cancer in which age, menopause status, smoking, and pathological characteristics of the tumor were investigated, as well as status and levels of estrogen and progesterone hormone receptors. Estrogen and progesterone receptor status did not seem to differ between smokers a...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145005
更新日期：1991-07-01 00:00:00
abstract：OBJECTIVES:Associations of cognitive function assessed in adulthood with coronary heart disease (CHD) and stroke might reflect a causal effect or could be explained by residual confounding or a common underlying pathology (atherosclerosis) that links both declines in cognitive function and increased risk of cardiovascu...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-008-9281-z
更新日期：2008-01-01 00:00:00
abstract：:A seroprevalence survey of antibodies to HCV was carried out among 2788 hemodialysis (HD) patients in a region of central Italy. Anti-HCV seroprevalence was 28.6%. A multivariate analysis of risk factors showed a significant association with time on HD, history of blood transfusion and metropolitan area of residence. ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007592912010
更新日期：1999-01-01 00:00:00
abstract：:Mycological, cultural and/or serological studies were performed on 98 patients hospitalized in the Department of Infectious Diseases of the Catholic University in Rome with diagnoses of acquired immune deficiency syndrome (AIDS) or AIDS-related complex (ARC) diseases. The incidence of mycoses was evaluated by retrospe...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00151714
更新日期：1990-12-01 00:00:00
abstract：:The most common diseases affecting middle-aged and elderly subjects in industrialized countries are multigenetic and lifestyle related. Several attempts have been made to study interactions between genes and lifestyle factors, but most such studies lack the power to examine interactions between several genes and sever...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-013-9787-x
更新日期：2013-02-01 00:00:00
abstract：:To systematically review the literature for dementia prediction models for use in the general population and externally validate their performance in a head-to-head comparison. We selected four prediction models for validation: CAIDE, BDSI, ANU-ADRI and DRS. From the Rotterdam Study, 6667 non-demented individuals aged...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-018-0403-y
更新日期：2018-07-01 00:00:00
abstract：:Cytomegalovirus (CMV) infection was one of the most common opportunistic infections in AIDS patients, leading to blindness or life-threatening disease in about 40% of patients in the later stages of AIDS before highly active antiretroviral therapy (HAART). In a retrospective multicenter study we investigated the incid...
journal_title：European journal of epidemiology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1023/a:1007619323939
更新日期：2000-05-01 00:00:00
abstract：:Plans are presented for conducting an epidemiological observational project which will pool the data from nine Italian field studies covering over 70,000 men and women aged 20 to 69 years, belonging to 52 population samples distributed in 13 different regions of the country. The main objective is to produce multivaria...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00209523
更新日期：1993-09-01 00:00:00
abstract：:In the present study data on the incidence of HBV and HCV were used to indicate the prevalence of and trends in risk behavior, assuming that drug users (DUs) who become infected with HBV or HCV are also at risk for infection with HIV. In addition, we determined to that extent the transmission patterns of HIV, HBV and ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00146260
更新日期：1993-05-01 00:00:00
abstract：:Hepatitis B has long been a serious public health problem in Greece. In recent years, a decline in hepatitis B infection is observed ascribable to many factors such as demographic and socioeconomic changes, medical precautions, use of disposable medical equipments, screening of blood donors and vaccination. We studied...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007539517341
更新日期：1999-05-01 00:00:00
abstract：:The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health from fetal life, childhood and young adulthood. This multidis...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-016-0224-9
更新日期：2016-12-01 00:00:00
abstract：:A two-stage cross-sectional study was conducted in a 951-bed acute-care hospital: a first survey designed to determine the profile of patients aged > or = 64 years needing supportive social/health care services, in which 38 patients discharged between June and July, 1992 (group 1) with social/health care problems that...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007420911766
更新日期：1997-12-01 00:00:00
abstract：:A study on the characteristics of alcoholics attending the "Alcoholics in treatment" clubs, a community and family-oriented programme against alcoholism, has been conducted in the Friuli-Venezia Giulia region, Northeastern Italy. A total of 598 individuals (93% of those contacted) completed the questionnaire, 431 (72%...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00146371
更新日期：1992-07-01 00:00:00
abstract：:Various studies have linked different genetic single nucleotide polymorphisms (SNPs) to different blood lipids (BL), but whether these "connections" were identified using cross-sectional or longitudinal (i.e., changes over time) designs has received little attention. Cross-sectional and longitudinal assessments of BL ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-012-9670-1
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:Traumatic brain injuries (TBIs) remain an important public health problem in developed countries. Hospital records were reviewed to ascertain the epidemiology of TBIs in Northeast Italy. METHODS:The annual rates of TBI-associated hospitalisation were estimated by analysing data collected from hospital recor...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1026192020963
更新日期：2003-01-01 00:00:00
abstract：:A case-control study comprised 130 cases affected by chronic lymphocytic leukemia and the same number of individually matched controls, with accidental injuries as a cause of hospitalization. Matching criteria were: sex, age, type of settlement, and area of residence. Both leukemias and all cancers were more frequent ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF01730372
更新日期：1994-04-01 00:00:00
abstract：:EUROCAT Northern Netherlands registers children born with a birth defect in the Northern Netherlands. Data used to be collected via a notification form, which is filled out by the notifier and, if necessary, completed by the general practitioner. To increase the amount of information, EUROCAT started using new methodo...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007656619529
更新日期：2000-04-01 00:00:00
abstract：:This paper studies prostate cancer mortality in Italy from 1950-1979 to evaluate its importance in relation to total cancers, examine the time trend for forecasting future mortality trends, and makes an attempt to interpretate mortality by analyzing demographic and risk factors. In the Authors' opinion findings from c...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00141808
更新日期：1985-06-01 00:00:00
abstract：BACKGROUND:Based on recent epidemiological studies the need for a similar approach towards management of cardiovascular risk factors in type 2 diabetics with different ethnic background can be questioned. We compared the prevalence of cardiovascular risk factors and 10-year absolute risk for a coronary heart disease be...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-004-5193-8
更新日期：2004-01-01 00:00:00
abstract：:A serological survey was performed with M.A.T. on the maintenance staff of water ways and public works and lock keepers to study the occupational hazards of leptospirosis. The target population was 58 professional people, 40 working on French rivers and 18 on a channel in the same western area of France. When we compa...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00144805
更新日期：1992-03-01 00:00:00
abstract：:Substantial evidence supports the role of asbestos in malignant mesothelioma. Clustering for this malignancy among relatives not only suggests genetic susceptibility as a relevant component but also provides a clue to investigate non-occupational sources of exposure. We identified five cases of malignant mesothelioma ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1023032214444
更新日期：2003-01-01 00:00:00
abstract：:According to the 'use it or lose it' hypothesis, a lack of mentally challenging activities might exacerbate the loss of cognitive function. On this basis, retirement has been suggested to increase the risk of cognitive decline, but evidence from studies with long follow-up is lacking. We tested this hypothesis in a co...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-017-0347-7
更新日期：2018-10-01 00:00:00
abstract：:A brief review of the germane literature suggests that the use of artificial intelligence (AI) statistical algorithms in epidemiology has been limited. We discuss the advantages and disadvantages of using AI systems in large-scale sets of epidemiological data to extract inherent, formerly unidentified, and potentially...
journal_title：European journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1007/s10654-006-0005-y
更新日期：2006-01-01 00:00:00
abstract：: ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-018-0461-1
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:A first-aid station was implemented in Falconara Marittima airport (Ancona, Italy). It provided medical emergency care to war victims evacuated from former Yugoslavia in transit for further treatment. MATERIALS AND METHODS:A descriptive analysis of the displaced population arriving at the first-aid station ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007670201028
更新日期：2000-03-01 00:00:00
abstract：:After describing the evolution of mortality from ischaemic cardiopathy (IC) in Spain from 1951 to 1986, which is tending to stabilize in some age groups, and from cerebrovascular accidents (CVA), which is clearly declining, an attempt is made to relate these developments to the prevalence of the main risk factors (hyp...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145318
更新日期：1992-11-01 00:00:00
abstract：:Epidemiological studies have reported that women with osteoporosis present an increased risk of cardiovascular events and that lipid lowering therapy (statins) could be associated with a decreased risk of fracture. We investigated whether women with atherogenic lipid profile have lower lumbar and femoral bone mineral ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-004-1706-8
更新日期：2004-01-01 00:00:00
abstract：:To date, non-pharmacological interventions (NPI) have been the mainstay for controlling the coronavirus disease-2019 (COVID-19) pandemic. While NPIs are effective in preventing health systems overload, these long-term measures are likely to have significant adverse economic consequences. Therefore, many countries are ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-020-00649-w
更新日期：2020-05-01 00:00:00
