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Sophisticated architecture is required for the sinoatrial node to perform its normal pacemaker function.

Abstract：

:The heart's pacemaker, the sinoatrial node, does not consist of a group of uniform sinoatrial node cells embedded in atrial muscle. Instead, it is a heterogeneous tissue with multiple cell types and a complex structure. Evidence suggests that from the periphery to the center of the sinoatrial node, there is a gradient in action potential shape, pacemaking, ionic current densities, connexin expression, Ca2+ handling, myofilament density, and cell size. This complexity may be necessary for the sinoatrial node to pacemake under diverse conditions, drive the more hyperpolarized atrial muscle, and resist proarrhythmic perturbations.

journal_name

J Cardiovasc Electrophysiol

journal_title

Journal of cardiovascular electrophysiology

authors

Boyett MR,Dobrzynski H,Lancaster MK,Jones SA,Honjo H,Kodama I

doi

10.1046/j.1540-8167.2003.02307.x

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

104-6

issue

1

eissn

1045-3873

issn

1540-8167

journal_volume

14

pub_type

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