Abstract:
UNLABELLED:Lesion dimension of cryoablation. BACKGROUND:Transvenous catheter cryoablation is a novel technique for treating cardiac arrhythmias. However, the relative importance of temporal application parameters on lesion dimension and clinical efficacy has not been studied. METHODS AND RESULTS:We investigated the effects of (1) application duration: single 2.5 (2.5x1) versus single 5 versus double 2.5 (2.5x2) versus double 5 (5x2) minutes, (2) number of freeze-thaw cycles: single versus double, and (3) electrode contact area: horizontal versus vertical orientation, on the lesion diameter and depth during catheter cryoablation (10F, 6.5-mm tip-electrode, CryoCor, San Diego) in a thigh muscle preparation. A total of 175 lesions (horizontal=90, vertical=85) were created in thigh muscle preparations on 10 swine. The lesion diameter and depth were significantly greater using 2.5x2 and 5x2 application modes as compared with 2.5x1 applications (P<0.05). Horizontal tip-electrode orientation produced larger lesion diameter (P<0.05), but not lesion depth as compared with vertical orientation. Multivariate analysis demonstrated that both tip-electrode orientation and duration of freeze >2.5 minutes were independent predictors for lesion diameter (P<0.001). However, only duration of freeze >2.5 minutes was an independent predictor for lesion depth (P<0.001). CONCLUSIONS:The dimensions of lesions created by catheter cryoablation are affected by mode of cryoablation application and electrode orientation. Increasing the duration of application, employing multiple freeze-thaw cycles at shorter cycle durations, and orienting the catheter to enhance/increase tissue contact can create a larger lesion.
journal_name
J Cardiovasc Electrophysioljournal_title
Journal of cardiovascular electrophysiologyauthors
Tse HF,Ripley KL,Lee KL,Siu CW,Van Vleet JF,Pelkey WL,Lau CPdoi
10.1046/j.1540-8167.2005.40559.xkeywords:
subject
Has Abstractpub_date
2005-02-01 00:00:00pages
201-4issue
2eissn
1045-3873issn
1540-8167pii
JCE40559journal_volume
16pub_type
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更新日期:2011-10-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2005-01-01 00:00:00
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