Electrophysiological Characteristics, Rhythm, Disturbances and Conduction Discontinuities Under Autonomic Stimulation in the Rat Pulmonary Vein Myocardium.

Abstract:

INTRODUCTION:Despite the importance of neurogenic initiation of rapid firing from pulmonary veins (PVs), the mechanism of autonomic modulation of electrophysiological properties of the PV myocardium to form a substrate for atrial arrhythmia remains poorly understood. METHODS AND RESULTS:A 2-microelectrode technique was used to characterize electrophysiological properties of rat PV myocardium and to explore PV arrhythmogenesis, at baseline, during electrical stimulation and/or under autonomic modulation. PV myocardium was characterized by prolonged action potential duration (APD), high degree of APD alternans, and spontaneous depolarizations. Autonomic stimulation resulted in significantly enhanced APD dispersion within the PV, which dynamically changed over time and was associated with intra-PV and atria-PV conduction blocks and could lead to spontaneous fibrillation-like high-frequency activity. In the distal part of the PV we found an unexcitable area that was characterized by depolarized resting potential (-50 ± 4 mV vs. -75 ± 2 mV vs. PV mouth, P < 0.01). This region could be activated during autonomic stimulation or fast pacing that led to multiple conduction discontinuities (uni- and bi-directional conduction blocks, Wenckebach periodicity, electrotonic modulation conduction block, echo phenomenon) in 17/23 preparations, including those occurring under norepinephrine superfusion (14/17) and during pacing frequency changes (3/17). PV echoes (unstable reentrant circuits) were found in 8/23 preparations. In some experiments, several types of conduction abnormalities were observed. CONCLUSION:The PV myocardium demonstrates distinct electrophysiological characteristics, which could be considerably exaggerated by electrical stimulation and/or autonomic nervous system to dynamically form a functional substrate to support re-entry as well as focal activity.

authors

Egorov YV,Kuz'min VS,Glukhov AV,Rosenshtraukh LV

doi

10.1111/jce.12738

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

1130-9

issue

10

eissn

1045-3873

issn

1540-8167

journal_volume

26

pub_type

杂志文章
  • Psychosocial aspects of patient-activated atrial defibrillation.

    abstract:UNLABELLED:Atrial Defibrillator. INTRODUCTION:The atrial defibrillator empowers patients to cardiovert themselves from atrial arrhythmias at a time that is socially and physically acceptable, thereby preventing hospitalization. The long-term psychosocial effects of repeated use of the patient-activated atrial defibril...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1540-8167.2003.03108.x

    authors: Mitchell AR,Spurrell PA,Boodhoo L,Sulke N

    更新日期:2003-08-01 00:00:00

  • Rotors and spiral waves in atrial fibrillation.

    abstract::Despite many years of research, the mechanisms of atrial fibrillation (AF) are still poorly understood, and we currently are unable to adequately treat most patients with AF. Recently, the demonstration in both human and animal studies that the pulmonary veins (PVs) and the posterior left atrial (LA) wall play a subst...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1540-8167.2003.03136.x

    authors: Jalife J

    更新日期:2003-07-01 00:00:00

  • Drug-induced torsades de pointes and implications for drug development.

    abstract::Torsades de pointes is a potentially lethal arrhythmia that occasionally appears as an adverse effect of pharmacotherapy. Recently developed understanding of the underlying electrophysiology allows better estimation of the drug-induced risks and explains the failures of older approaches through the surface ECG. This a...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1540-8167.2004.03534.x

    authors: Fenichel RR,Malik M,Antzelevitch C,Sanguinetti M,Roden DM,Priori SG,Ruskin JN,Lipicky RJ,Cantilena LR,Independent Academic Task Force.

    更新日期:2004-04-01 00:00:00

  • Atrioventricular nodal reentrant tachycardia requiring ablation on the mitral annulus.

    abstract::We report a case of initial transient success during ablation for typical AV nodal reentrant tachycardia utilizing traditional right-sided approaches, followed by recurrence of the same tachycardia and an ultimately successful ablation on the posteromedial mitral annulus. ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1046/j.1540-8167.2000.01281.x

    authors: Altemose GT,Scott LR,Miller JM

    更新日期:2000-11-01 00:00:00

  • Global P wave duration on the 65-lead ECG: single-site and dual-site pacing in the structurally normal human atrium.

    abstract:INTRODUCTION:Pacing is believed to prevent atrial fibrillation by reducing atrial activation time. Exact correlation between P wave duration (PWD) on surface ECG and endocardial atrial activation time is still unexplored. METHODS AND RESULTS:In 15 patients without structural heart disease (9 women, age 45 +/- 14 years...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1046/j.1540-8167.2002.01240.x

    authors: Gozolits S,Fischer G,Berger T,Hanser F,Abou-Harb M,Tilg B,Pachinger O,Hintringer F,Roithinger FX

    更新日期:2002-12-01 00:00:00

  • Signal transduction in ischemic preconditioning: the role of kinases and mitochondrial K(ATP) channels.

    abstract::Ischemic preconditioning is a phenomenon whereby exposure of the myocardium to a brief episode of ischemia and reperfusion markedly reduces tissue necrosis induced by a subsequent prolonged ischemia. Therefore, it is hoped that elucidation of the mechanism of preconditioning will yield therapeutic strategies capable o...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1540-8167.1999.tb00251.x

    authors: Baines CP,Cohen MV,Downey JM

    更新日期:1999-05-01 00:00:00

  • Assessment of beat-by-beat control of heart rate by the autonomic nervous system: molecular biology technique are necessary, but not sufficient.

    abstract::Vagus nerve activity can change heart rate substantially within one cardiac cycle, and the chronotropic effects decay almost completely within one cardiac cycle after cessation of vagal activity. The ability of the vagus nerves to regulate heart rate beat by beat can be explained in large part by the speed at which th...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.1993.tb01222.x

    authors: Levy MN,Yang T,Wallick DW

    更新日期:1993-04-01 00:00:00

  • Radiofrequency catheter ablation of left ventricular outflow tract tachycardia from the coronary cusp: a new approach to the tachycardia focus.

    abstract:INTRODUCTION:Idiopathic ventricular tachycardia (VT) originating from the left ventricular outflow tract (LVOT) is rare. Previously reported were two cases of LVOT tachycardia which were treated with radiofrequency (RF) catheter ablation through endocardial aortomitral continuity. We report here a case of a repetitive ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.1999.tb01271.x

    authors: Shimoike E,Ohnishi Y,Ueda N,Maruyama T,Kaji Y

    更新日期:1999-07-01 00:00:00

  • Noninvasive electrocardiographic mapping for prediction of tachycardia mechanism and origin of atrial tachycardia following bilateral pulmonary transplantation.

    abstract::This is a case of atrial tachycardia 2 years after pulmonary transplantation. After excluding right atrial involvement, tachycardia origin was located in a scar region medial to the anastomosis of the left inferior pulmonary donor vein. Tachycardia mechanism was microreentry. Noninvasive electrocardiographic mapping p...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.2011.02250.x

    authors: Roten L,Pedersen M,Pascale P,Shah A,Eliautou S,Scherr D,Sacher F,Haïssaguerre M

    更新日期:2012-05-01 00:00:00

  • Contact fluorescence imaging of reentry in monolayers of cultured neonatal rat ventricular myocytes.

    abstract:INTRODUCTION:We present a novel contact fluorescence imaging (CFI) approach to monitor transmembrane potentials in monolayers of cultured neonatal rat ventricular cells. We apply CFI to demonstrate, for the first time, long-term recordings as well as electrical induction and termination of reentrant activity in this in...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.2000.tb00029.x

    authors: Entcheva E,Lu SN,Troppman RH,Sharma V,Tung L

    更新日期:2000-06-01 00:00:00

  • Atrial excitation assuming uniform propagation.

    abstract:INTRODUCTION:We investigated the spread of the excitation wave over the atria following initiation in a given focus in an atrial model containing its overall geometry only, i.e., without atrial bundles. METHODS AND RESULTS:The propagation velocity of the excitation wave was taken to be uniform, and the wall thickness ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1046/j.1540.8167.90307.x

    authors: van Dam PM,van Oosterom A

    更新日期:2003-10-01 00:00:00

  • Rhodiola Inhibits Atrial Arrhythmogenesis in a Heart Failure Model.

    abstract:INTRODUCTION:Rhodiola, a popular plant in Tibet, has been proven to decrease arrhythmia. The aim of this study was to elucidate the molecular mechanism and electrophysiological properties of rhodiola in the suppression of atrial fibrillation. METHODS:This study consisted of 3 groups as follows: Group 1: normal control...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.13026

    authors: Liu SH,Hsiao YW,Chong E,Singhal R,Fong MC,Tsai YN,Hsu CP,Chen YC,Chen YJ,Chiou CW,Chiang SJ,Chang SL,Chen SA

    更新日期:2016-09-01 00:00:00

  • Programmed ventricular stimulation in patients with active vs previous arrhythmic myocarditis.

    abstract:INTRODUCTION:No studies so far addressed the role of invasive programmed ventricular stimulation (PVS) in myocarditis patient's arrhythmic risk stratification. METHODS AND RESULTS:We present a single-center prospective study on 96 consecutive adult patients (44 ± 13 years, 70.1% males) with myocarditis and ventricular...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.14374

    authors: Peretto G,Sala S,Basso C,Della Bella P

    更新日期:2020-03-01 00:00:00

  • Ablation of atrioventricular nodal reentrant tachycardia in tricuspid atresia.

    abstract::A 31-year-old woman with tricuspid atresia and a palliative Waterston shunt presented with intractable poorly tolerated supraventricular tachycardia. Electrophysiologic evaluation was consistent with AV nodal reentrant tachycardia. The fast pathway region was mapped electroanatomically during tachycardia and with cons...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1046/j.1540-8167.2004.03546.x

    authors: Khairy P,Seslar SP,Triedman JK,Cecchin F

    更新日期:2004-06-01 00:00:00

  • Association between epicardial adipose tissue and embolic stroke after catheter ablation of atrial fibrillation.

    abstract:INTRODUCTION:Risk factors of embolic stroke (ES) after atrial fibrillation (AF) ablation have not been fully elucidated especially among the Asian subjects, particularly regarding epicardial adipose tissue (EAT) in cardiac imaging. We aimed to assess the incidence of ES during a long-term follow-up period after AF abla...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/jce.14154

    authors: Ahn J,Shin SY,Shim J,Kim YH,Han SJ,Choi EK,Oh S,Shin JY,Choe JC,Park JS,Lee HW,Oh JH,Choi JH,Lee HC,Cha KS,Hong TJ,Lip GYH,Lim HE

    更新日期:2019-11-01 00:00:00

  • Regional isolation in the right atrium with disruption of intra-atrial conduction after catheter ablation of atrial tachycardia.

    abstract:BACKGROUND:Ablation of atrial tachycardia (AT) that occurs after cardiac surgery or prior ablation often requires complex lesion sets. In combination with the pre-existing atrial scar, these lesion sets may result in inadvertent intra-atrial conduction block. This study reports the phenomenon of incidental isolation of...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.14037

    authors: Markowitz SM,Choi DY,Daian F,Liu CF,Cheung JW,Thomas G,Ip JE,Lerman BB

    更新日期:2019-10-01 00:00:00

  • Adenosine can also improve the conduction between the superior vena cava and right atrium after isolation.

    abstract::A 64-year-old man with atrial tachycardia (AT) 3 years after a superior vena cava (SVC) isolation for atrial fibrillation underwent electrophysiologic testing. SVC mapping with a basket catheter revealed a more frequent activation in the SVC than in either of the atria during the AT and consequently the recovered cond...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.2006.00570.x

    authors: Yamada T,Murakami Y,Plumb VJ,Kay GN

    更新日期:2006-11-01 00:00:00

  • Quatrefoil reentry in myocardium: an optical imaging study of the induction mechanism.

    abstract:INTRODUCTION:The "critical point hypothesis" for induction of ventricular fibrillation has previously been extended to infer the coexistence of four critical points, and hence four simultaneous spiral reentries or a quatrefoil reentry, resulting from only one premature stimulus delivered to the same location as the pac...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.1999.tb00715.x

    authors: Lin SF,Roth BJ,Wikswo JP Jr

    更新日期:1999-04-01 00:00:00

  • Ventricular tachycardia originating from the epicardium identified by intracoronary mapping using a PTCA guidewire.

    abstract::We report a case in which endocardial radiofrequency (RF) ablation guided by unipolar intracoronary mapping using a guidewire was an effective therapy for treating VT originating from an epicardial site of the left ventricle. A 55-year-old man with dilated cardiomyopathy was referred for treatment of refractory sustai...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.2006.00357.x

    authors: Kumagai K,Takahashi A,Yamauchi Y,Aonuma K

    更新日期:2006-06-01 00:00:00

  • Iterative atrial tachycardia originating from the coronary sinus musculature.

    abstract::A case of iterative atrial tachycardia leading to dilated cardiomyopathy is reported. During electrophysiologic study, the tachycardia showed a markedly irregular cycle length associated with changes in atrial activation breakthrough as demonstrated by coronary sinus (CS) recordings and frequently degenerated into sel...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1046/j.1540-8167.2001.01187.x

    authors: Tritto M,Zardini M,De Ponti R,Salerno-Uriarte JA

    更新日期:2001-10-01 00:00:00

  • Insights into the mechanism of sustained ventricular tachycardia after myocardial infarction in a closed chest porcine model using a multielectrode "basket" catheter.

    abstract:INTRODUCTION:Accurate analysis of the arrhythmia substrate is important for successful radiofrequency ablation of sustained ventricular tachycardia (VT) after myocardial infarction (MI). METHODS AND RESULTS:A multielectrode "basket" catheter capable of endocardial recording and pacing was inserted percutaneously into ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.1999.tb00209.x

    authors: Greenspon AJ,Hsu SS,Borge R,Smith MF,Eldar M

    更新日期:1999-11-01 00:00:00

  • Comparison of epicardial cryoablation and irrigated radiofrequency ablation in a Swine infarct model.

    abstract:UNLABELLED:Epicardial Cryoablation in Swine. INTRODUCTION:Cryoablation is an alternative to radiofrequency (RF) energy used in some ablation procedures. Its role and effectiveness compared to irrigated RF in epicardial tissue and epicardial substrates is not yet fully established. METHODS AND RESULTS:Using a swine ch...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.2012.02334.x

    authors: Jauregui-Abularach ME,Campos B,Betensky BP,Michele J,Gerstenfeld EP

    更新日期:2012-09-01 00:00:00

  • Paradoxical effects of interatrial conduction delay in a hypertrophic cardiomyopathy patient in the long-term: time is a great healer.

    abstract::We present a unique case where early proarrhythmic and late antiarrhythmic characteristics of interatrial conduction delay were observed during the long-term progression of HCM. Occurrence of AT constantly increased as the interatrial conduction delay became more prominent, while the P-wave width in sinus rhythm and t...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.2010.01893.x

    authors: Bauernfeind T,Caliskan K,Vletter WB,Ten Cate FJ,Dabiri L,de Groot N,Jordaens L,Szili-Torok T

    更新日期:2011-05-01 00:00:00

  • Bileaflet Mitral Valve Prolapse and Risk of Ventricular Dysrhythmias and Death.

    abstract:INTRODUCTION:Bileaflet mitral valve prolapse (BiMVP) is common among survivors of otherwise unexplained sudden cardiac death, but prognostic implications of BiMVP are unknown. This study evaluated whether patients with BiMVP are at higher risk for ventricular dysrhythmias, ICD placement, or death compared to controls w...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.12914

    authors: Nordhues BD,Siontis KC,Scott CG,Nkomo VT,Ackerman MJ,Asirvatham SJ,Noseworthy PA

    更新日期:2016-04-01 00:00:00

  • Endo-epicardial ablation vs endocardial ablation for the management of ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy: A systematic review and meta-analysis.

    abstract:BACKGROUND:The pathologic process of ARVC (arrhythmogenic right ventricular cardiomyopathy) typically originates in the epicardium or subepicardial layers with progression toward endocardium. However, in the most recent ARVC international task force consensus statement, epicardial ventricular tachycardia (VT) ablation ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.14593

    authors: Romero J,Patel K,Briceno D,Alviz I,Gabr M,Diaz JC,Trivedi C,Mohanty S,Della Rocca D,Al-Ahmad A,Yang R,Rios S,Cerna L,Du X,Tarantino N,Zhang XD,Lakkireddy D,Natale A,Di Biase L

    更新日期:2020-08-01 00:00:00

  • Characteristics of ventricular tachyarrhythmias and their susceptibility to antitachycardia pacing termination in patients with ischemic and nonischemic cardiomyopathy: A patient-level meta-analysis of three large clinical trials.

    abstract:BACKGROUND:Implantable cardioverter defibrillators (ICDs) reduce all-cause mortality among cardiomyopathy patients. Whether or not antitachycardia pacing (ATP) is equally effective in ischemic (ICM) and nonischemic (NICM) cardiomyopathy patients remains poorly understood. We describe the distribution of monomorphic (MV...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.14688

    authors: Cheng A,Joung B,Brown ML,Koehler J,Lexcen DR,Sanders P,Ellenbogen KA

    更新日期:2020-10-01 00:00:00

  • Atrioventricular nodal modification and atrioventricular junctional ablation for control of ventricular rate in atrial fibrillation.

    abstract::Atrial fibrillation results in several structural and functional changes in the heart that lead to worsening ventricular function. Although restoration of sinus rhythm is the ideal goal, it is not always feasible. Pharmacologic therapy is associated with adverse effects and is not always effective. We have reviewed th...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章,评审

    doi:

    authors: Narasimhan C,Blanck Z,Akhtar M

    更新日期:1998-08-01 00:00:00

  • Issues in subgroup analyses and meta-analyses of clinical trials.

    abstract::This commentary discusses two techniques commonly used to analyze clinical trials: subgroup analysis and meta-analysis. Subgroup analysis is used to evaluate the consistency of a treatment across multiple groups, usually within a clinical trial. Subgroup analysis often is used to generate or test an hypothesis about r...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1046/j.1540-8167.14.s9.1.x

    authors: Bigger JT

    更新日期:2003-09-01 00:00:00

  • Catheter ablation of atrial fibrillation in heart failure with reduced ejection fraction.

    abstract::Atrial fibrillation and heart failure are increasing in prevalence, and frequently coexist. Despite the desire to restore sinus rhythm in heart failure patients, large studies comparing rate control to pharmacologic rhythm control have failed to show superiority of either approach. This may in part be due to the ineff...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章,评审

    doi:10.1111/jce.13497

    authors: Malhi N,Hawkins NM,Andrade JG,Krahn AD,Deyell MW

    更新日期:2018-07-01 00:00:00

  • Interaction between the autonomic nervous system and atrial tachyarrhythmias.

    abstract::Atrial tachyarrhythmias are the most common arrhythmias in the general population. The abundant experimental evidence suggests that the autonomic nervous system plays an important role in the occurrence of atrial arrhythmias. However, complex interactions of the autonomic nervous system with the arrhythmogenic substra...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1540-8167.2002.00083.x

    authors: Tai CT,Chiou CW,Chen SA

    更新日期:2002-01-01 00:00:00