当前位置： SCI文献检索 > JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY期刊下所有文献 > Rhodiola Inhibits Atrial Arrhythmogenesis in a Heart Failure Model.

Rhodiola Inhibits Atrial Arrhythmogenesis in a Heart Failure Model.

Abstract：

INTRODUCTION:Rhodiola, a popular plant in Tibet, has been proven to decrease arrhythmia. The aim of this study was to elucidate the molecular mechanism and electrophysiological properties of rhodiola in the suppression of atrial fibrillation. METHODS:This study consisted of 3 groups as follows: Group 1: normal control rabbits (n = 5); Group 2: rabbits with heart failure (HF) created by coronary ligation and who received 2 weeks of water orally as a placebo (n = 5); and Group 3: rabbits with HF who received 2 weeks of a rhodiola 270 mg/kg/day treatment orally (n = 5). The monophasic action potential, histology, and real-time polymerase chain reaction (RT-PCR) analysis of ionic channels and PI3K/AKT/eNOS were examined. RESULTS:Compared with the HF group, attenuated atrial fibrosis (35.4 ± 17.4% vs. 16.9 ± 8.4%, P = 0.05) and improved left ventricular (LV) ejection fraction (51.6 ± 3.4% vs. 68.0 ± 0.5%, P = 0.001) were observed in the rhodiola group. The rhodiola group had a shorter ERP (85.3 ± 6.8 vs. 94.3 ± 1.2, P = 0.002), APD90 (89.3 ± 1.5 vs. 112.7 ± 0.7, P < 0.001) in the left atrium (LA), and decreased AF inducibility (0.90 ± 0.04 vs. 0.42 ± 0.04, P < 0.001) compared with the HF group. The mRNA expressions of Kv1.4, Kv1.5, Kv4.3, KvLQT1, Cav1.2, and SERCA2a in the HF LA were up-regulated after rhodiola treatment. The rhodiola-treated HF LA demonstrated higher mRNA expression of PI3K-AKT compared with the HF group. CONCLUSIONS:Rhodiola reversed LA electrical remodeling, attenuated atrial fibrosis and suppressed AF in rabbits with HF. The beneficial electrophysiological effect of rhodiola may be related to upregulation of Kv1.4, Kv1.5, Kv4.3, KvLQT1, Cav1.2, SERCA2a, and activation of PI3K/AKT signaling.

journal_name

J Cardiovasc Electrophysiol

journal_title

Journal of cardiovascular electrophysiology

authors

Liu SH,Hsiao YW,Chong E,Singhal R,Fong MC,Tsai YN,Hsu CP,Chen YC,Chen YJ,Chiou CW,Chiang SJ,Chang SL,Chen SA

doi

10.1111/jce.13026

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

1093-101

issue

9

eissn

1045-3873

issn

1540-8167

journal_volume

27

pub_type

杂志文章

相关文献

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY文献大全
  • Prevalence and significance of exit block during arrhythmias arising in pulmonary veins.

    abstract：INTRODUCTION:Recent studies described the occurrence of conduction block within pulmonary veins. The purpose of this study was to evaluate the prevalence of exit block during arrhythmias that arise in pulmonary veins. METHODS AND RESULTS:Twenty-five patients with atrial tachycardia/fibrillation underwent successful ab...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/j.1540-8167.2000.tb00332.x

    authors： Tse HF,Lau CP,Kou W,Pelosi F,Oral H,Kim M,Michaud GF,Knight BP,Moscucci M,Strickberger SA,Morady F

    更新日期：2000-04-01 00:00:00

  • Long-term functional and neurocognitive recovery in patients who had an acute cerebrovascular event secondary to catheter ablation for atrial fibrillation.

    abstract：INTRODUCTION:Cerebral thromboembolic event (CTE) is a possible complication of pulmonary vein antrum isolation (PVAI). The objective of this study was to report long-term functional and neurocognitive recovery in patients who had a CTE during or within 48 hours of catheter ablation. METHODS AND RESULTS:We screened 3,0...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/j.1540-8167.2009.01650.x

    authors： Patel D,Bailey SM,Furlan AJ,Ching M,Zachaib J,Di Biase L,Mohanty P,Horton RP,Burkhardt JD,Sanchez JE,Zagrodzky JD,Gallinghouse GJ,Schweikert R,Saliba W,Natale A

    更新日期：2010-04-01 00:00:00

  • Narrow irregular QRS tachycardia with AV dissociation: what is the mechanism?

    abstract：:A 39-year-old woman with no structural heart disease and frequent episodes of sudden onset palpitations was referred for the electrophysiological study. During the study, a slightly irregular narrow QRS tachycardia with AV dissociation was repeatedly induced and spontaneously terminated. Apparently, irregular cycles a...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/jce.12026

    authors： Castillo Castillo J,Peñafiel Verdú P,Martínez Sánchez J,García Alberola A

    更新日期：2013-03-01 00:00:00

  • Idiopathic left ventricular tachycardia with left and right bundle branch block configurations.

    abstract：INTRODUCTION:Idiopathic left ventricular tachycardia typically has a right bundle branch block configuration. The purpose of this case report is to demonstrate that idiopathic ventricular tachycardia arising in or near the left posterior fascicle also may have a left bundle branch block configuration. METHODS AND RESU...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/j.1540-8167.1997.tb00810.x

    authors： Zivin A,Goyal R,Daoud E,Man KC,Strickberger SA,Morady F

    更新日期：1997-04-01 00:00:00

  • Management of cardiac implantable electronic device follow-up in COVID-19 pandemic: Lessons learned during Italian lockdown.

    abstract：INTRODUCTION:Remote monitoring (RM) has significantly transformed the standard of care for patients with cardiac electronic implantable devices. It provides easy access to valuable information, such as arrhythmic events, acute decompensation manifestations and device-related issues, without the need of in-person visits...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/jce.14755

    authors： Piro A,Magnocavallo M,Della Rocca DG,Neccia M,Manzi G,Mariani MV,Straito M,Bernardini A,Severino P,Iannucci G,Giunta G,Chimenti C,Natale A,Fedele F,Lavalle C

    更新日期：2020-11-01 00:00:00

  • Implantation techniques and chronic lead parameters of biventricular pacing dual-chamber defibrillators.

    abstract：INTRODUCTION:The aim of this study is to describe implantation techniques and lead performance for biventricular pacing, dual-chamber implantable cardioverter defibrillators (ICDs). METHODS AND RESULTS:A dual-chamber ICD with biventricular pacing was implanted in 87 patients with congestive heart failure (ejection fra...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章,多中心研究

    doi：10.1046/j.1540-8167.2002.00964.x

    authors： Daoud EG,Kalbfleisch SJ,Hummel JD,Weiss R,Augustini RS,Duff SB,Polsinelli G,Castor J,Meta T

    更新日期：2002-10-01 00:00:00

  • Additional gene variants reduce effectiveness of beta-blockers in the LQT1 form of long QT syndrome.

    abstract：INTRODUCTION:Beta-blockers are widely used to prevent the lethal cardiac events associated with the long QT syndrome (LQTS), especially in KCNQ1-related LQTS (LQT1) patients. Some LQT1 patients, however, are refractory to this therapy. METHODS AND RESULTS:Eighteen symptomatic LQTS patients (12 families) were genetical...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1046/j.1540-8167.2004.03212.x

    authors： Kobori A,Sarai N,Shimizu W,Nakamura Y,Murakami Y,Makiyama T,Ohno S,Takenaka K,Ninomiya T,Fujiwara Y,Matsuoka S,Takano M,Noma A,Kita T,Horie M

    更新日期：2004-02-01 00:00:00

  • Late potentials abolition as an additional technique for reduction of arrhythmia recurrence in scar related ventricular tachycardia ablation.

    abstract：RATIONALE:To evaluate the efficacy of radiofrequency ventricular tachycardia (VT) ablation targeting complete late potential (LP) activity. METHODS AND RESULTS:Sixty-four consecutive patients (pts) with recurrent VTs and coronary artery disease or idiopathic dilated cardiomyopathy were evaluated. Fifty patients (47 ma...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/j.1540-8167.2011.02246.x

    authors： Vergara P,Trevisi N,Ricco A,Petracca F,Baratto F,Cireddu M,Bisceglia C,Maccabelli G,Della Bella P

    更新日期：2012-06-01 00:00:00

  • Longstanding persistent accelerated idioatrial rhythm: Benign sinus node-like rhythm or insidious rhythm?

    abstract：INTRODUCTION:Detailed description of longstanding persistent accelerated idioatrial rhythm (AIAR) is lacking. This observational study investigated the clinical manifestations, electrophysiological characteristics, diagnosis, treatment, and prognosis of this unusual arrhythmia. METHODS AND RESULTS:Fifteen patients (11...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/jce.13255

    authors： Liu H,Zhu C,Yang B,Ju W,Chen H,Zhang F,Gu K,Li M,Kojodjojo P,Chen M

    更新日期：2017-08-01 00:00:00

  • Termination of persistent atrial fibrillation during left atrial mapping.

    abstract：:Termination of Persistent AF During Mapping. Complex fractionated atrial electrograms (CFAEs) may represent critical areas for the maintenance of atrial fibrillation (AF). While AF organization and termination have been reported with CFAE ablation, no reports of arrhythmia termination during left atrial mapping exist....

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/j.1540-8167.2011.02079.x

    authors： Tzou WS,Sághy L,Lin D

    更新日期：2011-10-01 00:00:00

  • Droperidol lengthens cardiac repolarization due to block of the rapid component of the delayed rectifier potassium current.

    abstract：INTRODUCTION:Torsades de pointes have been observed during treatment with droperidol, a butyrophenone neuroleptic agent. Our objectives were (1) to characterize the effects of droperidol on cardiac repolarization and (2) to evaluate effects of droperidol on a major time-dependent outward potassium current involved in c...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/j.1540-8167.1999.tb00224.x

    authors： Drolet B,Zhang S,Deschênes D,Rail J,Nadeau S,Zhou Z,January CT,Turgeon J

    更新日期：1999-12-01 00:00:00

  • Interactions between two simultaneous tachycardias within an electrically isolated pulmonary vein.

    abstract：:Pulmonary vein (PV) arrhythmogenicity underlying the maintenance of atrial fibrillation (AF) may be explained by three mechanisms: enhanced automaticity, triggered activity, and reentry. There are only a few reports describing sustained PV tachycardias (PVT) following electrical disconnection from the left atrium, in ...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/j.1540-8167.2006.00713.x

    authors： Rostock T,O'Neill MD,Takahashi Y,Sanders P,Haïssaguerre M

    更新日期：2007-04-01 00:00:00

  • Idiopathic focal ventricular arrhythmias originating from the anterior papillary muscle in the left ventricle.

    abstract：INTRODUCTION:Focal ventricular arrhythmias (VAs) have been reported to arise from the posterior papillary muscle in the left ventricle (LV). We report a distinct subgroup of idiopathic VAs arising from the anterior papillary muscle (APM) in the LV. METHODS AND RESULTS:We studied 432 consecutive patients undergoing cat...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/j.1540-8167.2009.01448.x

    authors： Yamada T,McElderry HT,Okada T,Murakami Y,Doppalapudi H,Yoshida N,Allred JD,Murohara T,Kay GN

    更新日期：2009-08-01 00:00:00

  • Catheter ablation of frequently recurring ventricular fibrillation in a patient after aortic valve repair.

    abstract：:It has been demonstrated that idiopathic ventricular fibrillation (VF) can be triggered by ventricular premature beats (VPBs) arising from the Purkinje fibers. Eliminating these VPBs by radiofrequency catheter ablation prevented VF recurrences. Whether the same pathophysiology and the same treatment option exist in pa...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1046/j.1540-8167.2004.03386.x

    authors： Li YG,Grönefeld G,Israel C,Hohnloser SH

    更新日期：2004-01-01 00:00:00

  • Clinical characteristics and management of periesophageal vagal nerve injury complicating left atrial ablation of atrial fibrillation: lessons from eleven cases.

    abstract：INTRODUCTION:This study aimed to elucidate the clinical characteristics and management of periesophageal vagal nerve injury complicating the ablation of atrial fibrillation (AF). METHODS AND RESULTS:A total of 3,695 patients with drug-resistant AF underwent extensive pulmonary vein isolation at our institution. Either...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/jce.12130

    authors： Kuwahara T,Takahashi A,Takahashi Y,Kobori A,Miyazaki S,Takei A,Fujino T,Okubo K,Takagi K,Fujii A,Takigawa M,Watari Y,Hikita H,Sato A,Aonuma K

    更新日期：2013-08-01 00:00:00

  • Effect of pacing the right ventricular mid-septum tract in patients with permanent atrial fibrillation and low ejection fraction.

    abstract：INTRODUCTION:Permanent right ventricular (RV) pacing leads have been traditionally implanted in the right ventricular apex (RVA). Nowadays, some deleterious effects of RVA pacing have been recognized. The aim of this study was to evaluate the effect of different sites of RV pacing in patients with permanent atrial fibr...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/j.1540-8167.2007.00914.x

    authors： Muto C,Ottaviano L,Canciello M,Carreras G,Calvanese R,Ascione L,Iengo R,Accadia M,Celentano E,Tuccillo B

    更新日期：2007-09-01 00:00:00

  • AV nodal-His-Purkinje reentry: a novel form of tachycardia.

    abstract：INTRODUCTION:Bundle branch reentry (BBR) typically occurs in patients with dilated cardiomyopathy and infra-Hisian conduction system disease. The macroreentrant circuit of BBR is confined to the His-Purkinje system (HPS) and ventricular myocardium. As such, the atrioventricular (AV) node plays no role in the tachycardi...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/j.1540-8167.1995.tb00414.x

    authors： Markowitz SM,Stein KM,Engelstein ED,Lerman BB

    更新日期：1995-05-01 00:00:00

  • Long-Term Results of Radiofrequency Hot Balloon Ablation in Patients With Paroxysmal Atrial Fibrillation: Safety and Rhythm Outcomes.

    abstract：INTRODUCTION:Isolation of pulmonary veins (PVs) and the posterior left atrium (LA) can be safely performed by radiofrequency hot balloon (RHB)-based box isolation. However, data on long-term effects for the treatment of atrial fibrillation (AF) by the use of this method remain limited. METHODS AND RESULTS:We treated 2...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/jce.12820

    authors： Yamaguchi Y,Sohara H,Takeda H,Nakamura Y,Ihara M,Higuchi S,Satake S

    更新日期：2015-12-01 00:00:00

  • Frequency-dependent electrophysiologic effects of d,l-sotalol and quinidine and modulation by beta-adrenergic stimulation.

    abstract：INTRODUCTION:Frequency-dependent electrophysiologic actions of oral quinidine and oral sotalol may be clinically important, but these properties and their modulation by beta-adrenergic sympathetic stimulation have not been determined. METHODS AND RESULTS:The frequency-dependent effects of oral quinidine (n = 17) and o...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/j.1540-8167.1996.tb00505.x

    authors： Sager PT,Behboodikhah M

    更新日期：1996-02-01 00:00:00

  • Gender and seasonally related differences in myocardial recovery and susceptibility to sotalol-induced arrhythmias in isolated rabbit hearts.

    abstract：INTRODUCTION:Gender differences and seasonal variations in cardiac electrophysiology and susceptibility to arrhythmias have been described clinically. The present study was undertaken to determine if there are similar gender and seasonally related differences in the electrophysiology of the rabbit heart. METHODS AND R...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/j.1540-8167.2000.tb00067.x

    authors： Spear JF,Moore EN

    更新日期：2000-08-01 00:00:00

  • Pace-termination and pacing for prevention of atrial tachyarrhythmias: results from a multicenter study with an implantable device for atrial therapy.

    abstract：INTRODUCTION:Patients with bradycardia requiring permanent pacing frequently suffer from additional atrial tachyarrhythmias (ATs). This study evaluated the safety and efficacy of atrial antitachycardia pacing (ATP) and the performance of pacing for AT prevention implemented into a new pacemaker. METHODS AND RESULTS:In...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1046/j.1540-8167.2001.01121.x

    authors： Israel CW,Hügl B,Unterberg C,Lawo T,Kennis I,Hettrick D,Hohnloser SH,AT500 Verification Study Investigators.

    更新日期：2001-10-01 00:00:00

  • Low incidence of left atrial or left atrial appendage thrombus in patients with paroxysmal atrial fibrillation and normal EF who present for pulmonary vein antrum isolation procedure.

    abstract：INTRODUCTION:The incidence of left atrial appendage (LAA) thrombus in patients with paroxysmal atrial fibrillation (PAF) who present for pulmonary vein antrum isolation procedure (PVAI) is unknown. METHODS AND RESULTS:All consecutive patients from January 2000 to June 2004 who underwent a PVAI received a computed tomo...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/j.1540-8167.2007.01070.x

    authors： Khan MN,Usmani A,Noor S,Elayi S,Ching CK,Di Biase L,Patel D,Burkhardt JD,Cummings J,Schweikert R,Saliba W,Natale A

    更新日期：2008-04-01 00:00:00

  • The relationship of bipolar left ventricular pacing stimulus intensity to cardiac depolarization and repolarization in humans with cardiac resynchronization devices.

    abstract：BACKGROUND:Myocardial depolarization can be altered by varying pacing stimulus output. This may have implications on response rates for cardiac resynchronization therapy (CRT). The purpose of our study was to determine the relationship of left ventricular (LV) pacing stimulus intensity to measures of depolarization and...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/j.1540-8167.2008.01378.x

    authors： Theis C,Bavikati VV,Langberg JJ,Lloyd MS

    更新日期：2009-06-01 00:00:00

  • Dual conduction in a Mahaim fiber.

    abstract：:The case of an 8-year-old girl with incessant nonsustained left bundle branch block-like tachycardia refractory to antiarrhythmic drug therapy is reported. Electrophysiologic study revealed the presence of a right-sided accessory atriofascicular pathway. Episodes of nonsustained tachycardia were found to be based upon...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1046/j.1540-8167.2004.04036.x

    authors： Sternick EB,Sosa EA,Scanavacca MI,Wellens HJ

    更新日期：2004-10-01 00:00:00

  • Effects of Age-Related Aortic Root Anatomic Changes on Left Ventricular Outflow Tract Pace-Mapping Morphologies: A Cardiac Magnetic Resonance Imaging Validation Study.

    abstract：INTRODUCTION:Outflow tract ventricular arrhythmias (OT VAs) are common and catheter ablation is an effective treatment option. We sought to investigate the relationship between age-related anatomic aortic root changes and QRS morphology during left ventricular outflow tract (LVOT) pace-mapping using cardiac magnetic re...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/jce.12712

    authors： Maeda S,Chik WW,Han Y,Liang JJ,Squara F,Arkles JS,Sadek MM,Santangeli P,Frankel DS,Zado ES,Takebayashi S,Dixit S,Callans DJ,Marchlinski FE,Lin D

    更新日期：2015-09-01 00:00:00

  • Bipolar ablation with contact force-sensing of swine ventricles shows improved acute lesion features compared to sequential unipolar ablation.

    abstract：INTRODUCTION:Despite technical progress, ventricular tachycardia (VT) recurrence after unipolar ablation remains relatively high (12%-47%). Bipolar ablation has been proposed as an appealing solution that may overcome limitations associated with unipolar ablation settings. We designed an animal study to compare bipolar...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/jce.14407

    authors： Soucek F,Caluori G,Lehar F,Jez J,Pesl M,Wolf J,Wojtaszczyk A,Belaskova S,Starek Z

    更新日期：2020-05-01 00:00:00

  • Mechanical occlusion of the left atrial appendage.

    abstract：INTRODUCTION:Oral anticoagulation therapy reduces significantly the risk of thromboembolism in patients with atrial fibrillation. However, effective oral anticoagulation therapy is not feasible in all patients. The interventional occlusion of the left atrial appendage may reduce the risk of thromboembolism in the latte...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1540-8167.14.s9.11.x

    authors： Omran H,Hardung D,Schmidt H,Hammerstingl C,Lüderitz B

    更新日期：2003-09-01 00:00:00

  • Mechanisms of pacing interventions in atrial fibrillation.

    abstract：:Atrial flutter is due to large single reentrant loops, typically oriented around the caval veins and a line of functional conduction block in between. These reentrant circuits can easily be terminated by properly timed extra beats colliding in the antidromic direction with the reentrant orthodromic wavefront and being...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章,评审

    doi：

    authors： Schoels W,Becker R

    更新日期：1998-08-01 00:00:00

  • Alpha 1-adrenergic blockade and sudden cardiac death.

    abstract：INTRODUCTION:The primary goal of the present study was to test whether selective pharmacologic blockade of alpha 1 receptors, and specifically of the subtype alpha 1a, could prevent ventricular fibrillation (VF) during acute myocardial ischemia. BACKGROUND:The development of new autonomic interventions is of clinical ...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/j.1540-8167.1994.tb01116.x

    authors： Vanoli E,Hull SS Jr,Foreman RD,Ferrari A,Schwartz PJ

    更新日期：1994-01-01 00:00:00

  • Heterogeneous expression of potassium currents and pacemaker currents potentially regulates arrhythmogenesis of pulmonary vein cardiomyocytes.

    abstract：INTRODUCTION:The relationship between the determining factors and beating rates of pulmonary vein (PV) pacemaker cardiomyocytes has not been fully elucidated. The purposes of this study were to compare the electrophysiological characteristics between PV fast and slow pacemaker cardiomyocytes. METHODS:Whole-cell patch ...

    journal_title：Journal of cardiovascular electrophysiology

    pub_type： 杂志文章

    doi：10.1111/j.1540-8167.2009.01480.x

    authors： Chen YC,Pan NH,Cheng CC,Higa S,Chen YJ,Chen SA

    更新日期：2009-09-01 00:00:00