当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Tumor necrosis factor-related apoptosis-inducing ligand induces neuronal death in a murine model of HIV central nervous system infection.

Tumor necrosis factor-related apoptosis-inducing ligand induces neuronal death in a murine model of HIV central nervous system infection.

Abstract：

:HIV-1 infection in the brain induces neuronal apoptosis leading to HIV-associated dementia. To explore the underlying mechanism, we developed a murine model by using human peripheral blood mononuclear cell (PBMC)-transplanted nonobese diabetic (NOD)-severe combined immunodeficiency (SCID) (hu-PBMC-NOD-SCID) mice. Administration of lipopolysaccharide (LPS) to HIV-1-infected hu-PBMC-NOD-SCID mice induced infiltration of HIV-1-infected human cells into the perivascular region of the brain and neuronal apoptosis was found in macrophage (M)-tropic but not T cell (T)-tropic HIV-1-infected brains. The apoptotic neurons were frequently colocalized with the HIV-1-infected macrophages that expressed tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). Administration of a neutralizing antibody against human TRAIL but not human TNF-alpha or Fas ligand (FasL) blocked the neuronal apoptosis in the HIV-1-infected brain. These results strongly suggest a critical contribution of TRAIL expressed on HIV-1-infected macrophages to neuronal apoptosis.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Miura Y,Misawa N,Kawano Y,Okada H,Inagaki Y,Yamamoto N,Ito M,Yagita H,Okumura K,Mizusawa H,Koyanagi Y

doi

10.1073/pnas.2628048100

keywords:

subject

Has Abstract

pub_date

2003-03-04 00:00:00

pages

2777-82

issue

5

eissn

0027-8424

issn

1091-6490

pii

2628048100

journal_volume

100

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer.

    abstract：:p63 inhibits metastasis. Here, we show that p63 (both TAp63 and ΔNp63 isoforms) regulates expression of miR-205 in prostate cancer (PCa) cells, and miR-205 is essential for the inhibitory effects of p63 on markers of epithelial-mesenchymal transition (EMT), such as ZEB1 and vimentin. Correspondingly, the inhibitory ef...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1110977109

    authors： Tucci P,Agostini M,Grespi F,Markert EK,Terrinoni A,Vousden KH,Muller PA,Dötsch V,Kehrloesser S,Sayan BS,Giaccone G,Lowe SW,Takahashi N,Vandenabeele P,Knight RA,Levine AJ,Melino G

    更新日期：2012-09-18 00:00:00

  • Spatial learning with a minislab in the dorsal hippocampus.

    abstract：:We have determined the volume and location of hippocampal tissue required for normal acquisition of a spatial memory task. Ibotenic acid was used to make bilateral symmetric lesions of 20-100% of hippocampal volume. Even a small transverse block (minislab) of the hippocampus (down to 26% of the total) could support sp...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.21.9697

    authors： Moser MB,Moser EI,Forrest E,Andersen P,Morris RG

    更新日期：1995-10-10 00:00:00

  • Propensity for a leucine zipper-like domain of human immunodeficiency virus type 1 gp41 to form oligomers correlates with a role in virus-induced fusion rather than assembly of the glycoprotein complex.

    abstract：:For a number of viruses, oligomerization is a critical component of envelope processing and surface expression. Previously, we reported that a synthetic peptide (DP-107) corresponding to the putative leucine zipper region (aa 553-590) of the transmembrane protein (gp41) of human immunodeficiency virus type 1 (HIV-1) e...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.91.26.12676

    authors： Wild C,Dubay JW,Greenwell T,Baird T Jr,Oas TG,McDanal C,Hunter E,Matthews T

    更新日期：1994-12-20 00:00:00

  • Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site.

    abstract：:Hepatitis A virus (HAV) infects ∼1.4 million people annually and, although there is a vaccine, there are no licensed therapeutic drugs. HAV is unusually stable (making disinfection problematic) and little is known of how it enters cells and releases its RNA. Here we report a potent HAV-specific monoclonal antibody, R1...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1616502114

    authors： Wang X,Zhu L,Dang M,Hu Z,Gao Q,Yuan S,Sun Y,Zhang B,Ren J,Kotecha A,Walter TS,Wang J,Fry EE,Stuart DI,Rao Z

    更新日期：2017-01-24 00:00:00

  • Efficient recovery of infectious vesicular stomatitis virus entirely from cDNA clones.

    abstract：:Infectious vesicular stomatitis virus (VSV), the prototypic nonsegmented negative-strand RNA virus, was recovered from a full-length cDNA clone of the viral genome. Bacteriophage T7 RNA polymerase expressed from a recombinant vaccinia virus was used to drive the synthesis of a genome-length positive-sense transcript o...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.18.8388

    authors： Whelan SP,Ball LA,Barr JN,Wertz GT

    更新日期：1995-08-29 00:00:00

  • Molecular determinants of tissue selectivity in estrogen receptor modulators.

    abstract：:Interaction of the estrogen receptor/ligand complex with a DNA estrogen response element is known to regulate gene transcription. In turn, specific conformations of the receptor-ligand complex have been postulated to influence unique subsets of estrogen-responsive genes resulting in differential modulation and, ultima...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.94.25.14105

    authors： Grese TA,Sluka JP,Bryant HU,Cullinan GJ,Glasebrook AL,Jones CD,Matsumoto K,Palkowitz AD,Sato M,Termine JD,Winter MA,Yang NN,Dodge JA

    更新日期：1997-12-09 00:00:00

  • Structural basis for peptidoglycan binding by peptidoglycan recognition proteins.

    abstract：:Peptidoglycan (PGN) recognition proteins (PGRPs) are pattern-recognition receptors of the innate immune system that bind and, in some cases, hydrolyze bacterial PGNs. We determined the crystal structure, at 2.30-A resolution, of the C-terminal PGN-binding domain of human PGRP-Ialpha in complex with a muramyl tripeptid...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0407856101

    authors： Guan R,Roychowdhury A,Ember B,Kumar S,Boons GJ,Mariuzza RA

    更新日期：2004-12-07 00:00:00

  • Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation.

    abstract：:Saccharomyces cerevisiae Hop2 and Mnd1 are abundant meiosisspecific chromosomal proteins, and mutations in the corresponding genes lead to defects in meiotic recombination and in homologous chromosome interactions during mid-prophase. Analysis of various double mutants suggests that HOP2, MND1, and DMC1 act in the sam...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0404195101

    authors： Chen YK,Leng CH,Olivares H,Lee MH,Chang YC,Kung WM,Ti SC,Lo YH,Wang AH,Chang CS,Bishop DK,Hsueh YP,Wang TF

    更新日期：2004-07-20 00:00:00

  • Genetic changes occurring in established tumors rapidly stimulate new antibody responses.

    abstract：:Cancer patients and tumor-bearing mice possess serum antibodies that recognize antigens expressed by cancer cells at the time of diagnosis. After diagnosis, cancers progress to more aggressive stages, most often by acquiring new genetic changes that can give rise to new proteins, some of which are antigenic. However, ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0930140100

    authors： Spiotto MT,Reth MA,Schreiber H

    更新日期：2003-04-29 00:00:00

  • Adult mouse brain gene expression patterns bear an embryologic imprint.

    abstract：:The current model to explain the organization of the mammalian nervous system is based on studies of anatomy, embryology, and evolution. To further investigate the molecular organization of the adult mammalian brain, we have built a gene expression-based brain map. We measured gene expression patterns for 24 neural ti...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0503357102

    authors： Zapala MA,Hovatta I,Ellison JA,Wodicka L,Del Rio JA,Tennant R,Tynan W,Broide RS,Helton R,Stoveken BS,Winrow C,Lockhart DJ,Reilly JF,Young WG,Bloom FE,Lockhart DJ,Barlow C

    更新日期：2005-07-19 00:00:00

  • On the Fundamental Group of Manifolds of Non-positive Curvature.

    abstract：:We prove theorems on the structure of the fundamental group of a compact riemannian manifold of non-positive curvature. In particular, a conjecture of J. Wolf [J. Differential Geometry, 2, 421-446 (1968)] is proved. ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.67.2.509

    authors： Yau ST

    更新日期：1970-10-01 00:00:00

  • Bis-(3'-5')-cyclic dimeric GMP-linked quorum sensing controls swarming in Vibrio parahaemolyticus.

    abstract：:Movement over and colonization of surfaces are important survival strategies for bacteria, and many find it advantageous to perform these activities as a group, using quorum sensing to sample population size and synchronize behavior. It is puzzling however, that swarming-proficient and virulent strains of Vibrio parah...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1113790108

    authors： Trimble MJ,McCarter LL

    更新日期：2011-11-01 00:00:00

  • Singlet oxygen mediated iron-based Fenton-like catalysis under nanoconfinement.

    abstract：:For several decades, the iron-based Fenton-like catalysis has been believed to be mediated by hydroxyl radicals or high-valent iron-oxo species, while only sporadic evidence supported the generation of singlet oxygen (1O2) in the Haber-Weiss cycle. Herein, we report an unprecedented singlet oxygen mediated Fenton-like...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1819382116

    authors： Yang Z,Qian J,Yu A,Pan B

    更新日期：2019-04-02 00:00:00

  • Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens.

    abstract：:Queuosine (Q) is a complex tRNA modification widespread in eukaryotes and bacteria that contributes to the efficiency and accuracy of protein synthesis. Eukaryotes are not capable of Q synthesis and rely on salvage of the queuine base (q) as a Q precursor. While many bacteria are capable of Q de novo synthesis, salvag...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1909604116

    authors： Yuan Y,Zallot R,Grove TL,Payan DJ,Martin-Verstraete I,Šepić S,Balamkundu S,Neelakandan R,Gadi VK,Liu CF,Swairjo MA,Dedon PC,Almo SC,Gerlt JA,de Crécy-Lagard V

    更新日期：2019-09-17 00:00:00

  • Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans.

    abstract：:Expansion of polyglutamine repeats in several unrelated proteins causes neurodegenerative diseases with distinct but related pathologies. To provide a model system for investigating common pathogenic features, we have examined the behavior of polyglutamine expansions expressed in Caenorhabditis elegans. The expression...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.100107297

    authors： Satyal SH,Schmidt E,Kitagawa K,Sondheimer N,Lindquist S,Kramer JM,Morimoto RI

    更新日期：2000-05-23 00:00:00

  • Direct and synergistic effects of interleukin 11 on murine hemopoiesis in culture.

    abstract：:We have examined the effects of a stromal cell-derived cytokine designated interleukin 11 (IL-11) on the proliferation of murine hemopoietic progenitors in methylcellulose culture. COS cell-conditioned medium containing IL-11 supported formation of granulocyte/macrophage colonies and a small number of multilineage col...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.3.765

    authors： Musashi M,Yang YC,Paul SR,Clark SC,Sudo T,Ogawa M

    更新日期：1991-02-01 00:00:00

  • Isolation and characterization of a human serum cholesteryl ester transfer protein.

    abstract：:Human plasma has been shown to contain an apolipoprotein that mediates the transport of cholesteryl ester from high density lipoprotein (HDL) to very low density lipoprotein (VLDL) or low density lipoprotein (LDL). This activity, confined to the density greater than 1.063 g/ml interval, has been isolated from HDL and ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.75.7.3445

    authors： Chajek T,Fielding CJ

    更新日期：1978-07-01 00:00:00

  • Distant Mimivirus relative with a larger genome highlights the fundamental features of Megaviridae.

    abstract：:Mimivirus, a DNA virus infecting acanthamoeba, was for a long time the largest known virus both in terms of particle size and gene content. Its genome encodes 979 proteins, including the first four aminoacyl tRNA synthetases (ArgRS, CysRS, MetRS, and TyrRS) ever found outside of cellular organisms. The discovery that ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1110889108

    authors： Arslan D,Legendre M,Seltzer V,Abergel C,Claverie JM

    更新日期：2011-10-18 00:00:00

  • Knockin of mutant PIK3CA activates multiple oncogenic pathways.

    abstract：:The phosphatidylinositol 3-kinase subunit PIK3CA is frequently mutated in human cancers. Here we used gene targeting to "knock in" PIK3CA mutations into human breast epithelial cells to identify new therapeutic targets associated with oncogenic PIK3CA. Mutant PIK3CA knockin cells were capable of epidermal growth facto...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0813351106

    authors： Gustin JP,Karakas B,Weiss MB,Abukhdeir AM,Lauring J,Garay JP,Cosgrove D,Tamaki A,Konishi H,Konishi Y,Mohseni M,Wang G,Rosen DM,Denmeade SR,Higgins MJ,Vitolo MI,Bachman KE,Park BH

    更新日期：2009-02-24 00:00:00

  • Structure of a cytochrome P450-redox partner electron-transfer complex.

    abstract：:The crystal structure of the complex between the heme- and FMN-binding domains of bacterial cytochrome P450BM-3, a prototype for the complex between eukaryotic microsomal P450s and P450 reductase, has been determined at 2.03 A resolution. The flavodoxin-like flavin domain is positioned at the proximal face of the heme...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.5.1863

    authors： Sevrioukova IF,Li H,Zhang H,Peterson JA,Poulos TL

    更新日期：1999-03-02 00:00:00

  • Exploring the folding energy landscape of a series of designed consensus tetratricopeptide repeat proteins.

    abstract：:Repeat proteins contain short, tandem arrays of simple structural motifs (20-40 aa). These stack together to form nonglobular structures that are stabilized by short-range interactions from residues close in primary sequence. Unlike globular proteins, they have few, if any, long-range nonlocal stabilizing interactions...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0907455106

    authors： Javadi Y,Main ER

    更新日期：2009-10-13 00:00:00

  • Species interactions limit the occurrence of urban-adapted birds in cities.

    abstract：:Urbanization represents an extreme transformation of more natural systems. Populations of most species decline or disappear with urbanization, and yet some species persist and even thrive in cities. What determines which species persist or thrive in urban habitats? Direct competitive interactions among species can inf...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1809317115

    authors： Martin PR,Bonier F

    更新日期：2018-12-04 00:00:00

  • Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model.

    abstract：:LMB-7 [B3(Fv)-PE38] is a single-chain immunotoxin constructed from the murine monoclonal antibody B3 and a truncated from of Pseudomonas exotoxin PE38. Antibody B3 recognizes a carbohydrate epitope found on solid tumors that frequently invade the intrathecal space and cause neoplastic meningitis. We tested the therape...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.7.2765

    authors： Pastan IH,Archer GE,McLendon RE,Friedman HS,Fuchs HE,Wang QC,Pai LH,Herndon J,Bigner DD

    更新日期：1995-03-28 00:00:00

  • Successful rescue of microsurgically produced homozygous uniparental mouse embryos via production of aggregation chimeras.

    abstract：:Homozygous uniparental mouse embryos, produced by microsurgical removal of the male pronucleus from fertilized eggs and diploidization of the female pronucleus with cytochalasin, were surrounded with blastomeres from normal embryos to produce chimeric embryos. A few of these chimeras developed into viable adults, and ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.83.17.6509

    authors： Anderegg C,Markert CL

    更新日期：1986-09-01 00:00:00

  • Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.

    abstract：:Aire induces ectopic expression of peripheral tissue antigens (PTAs) in thymic medullary epithelial cells, which promotes immunological tolerance. Beginning with a broad screen of histone peptides, we demonstrate that the mechanism by which this single factor controls the transcription of thousands of genes involves r...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0808470105

    authors： Koh AS,Kuo AJ,Park SY,Cheung P,Abramson J,Bua D,Carney D,Shoelson SE,Gozani O,Kingston RE,Benoist C,Mathis D

    更新日期：2008-10-14 00:00:00

  • Elimination of potassium channel expression by antisense oligonucleotides in a pituitary cell line.

    abstract：:The clonal rat pituitary cell line GH4C1 expresses the genes for several voltage-dependent potassium channels including Kv1.5 and Kv1.4. Dexamethasone, a glucocorticoid agonist, induces a slowly inactivating potassium current in these cells but does not alter the amplitude of a rapidly inactivating component of potass...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.13.5955

    authors： Chung S,Saal DB,Kaczmarek LK

    更新日期：1995-06-20 00:00:00

  • Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols.

    abstract：:Development of effective chemopreventive agents against prostate cancer (CaP) for humans requires conclusive evidence of their efficacy in animal models that closely emulates human disease. The autochthonous transgenic adenocarcinoma of the mouse prostate (TRAMP) model, which spontaneously develops metastatic CaP, is ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.171326098

    authors： Gupta S,Hastak K,Ahmad N,Lewin JS,Mukhtar H

    更新日期：2001-08-28 00:00:00

  • A unique role of the DNA fragmentation factor in maintaining genomic stability.

    abstract：:DNA fragmentation is a hallmark of apoptosis (programmed cell death). However, the biological function of apoptotic DNA fragmentation remains unclear. Here, we show that DNA fragmentation factor plays an important role for maintaining genomic stability. Inhibition or loss of the DNA fragmentation factor (DFF)/caspase-...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0507779103

    authors： Yan B,Wang H,Peng Y,Hu Y,Wang H,Zhang X,Chen Q,Bedford JS,Dewhirst MW,Li CY

    更新日期：2006-01-31 00:00:00

  • DEMETER and REPRESSOR OF SILENCING 1 encode 5-methylcytosine DNA glycosylases.

    abstract：:Cytosine methylation is an epigenetic mark that promotes gene silencing and plays important roles in development and genome defense against transposons. Methylation patterns are established and maintained by DNA methyltransferases that catalyze transfer of a methyl group from S-adenosyl-L-methionine to cytosine bases ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0601109103

    authors： Morales-Ruiz T,Ortega-Galisteo AP,Ponferrada-Marín MI,Martínez-Macías MI,Ariza RR,Roldán-Arjona T

    更新日期：2006-05-02 00:00:00

  • Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor.

    abstract：:Mechanisms and signals that regulate transcriptional coactivators are still largely unknown. Here we provide genetic evidence for a repressor that interacts with and regulates the nuclear receptor coactivator PGC-1. Association with the repressor requires a PGC-1 protein interface that is similar to the one used by nu...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.171184698

    authors： Knutti D,Kressler D,Kralli A

    更新日期：2001-08-14 00:00:00