Abstract：
:Inflammation is an essential component of the first phase of anastomotic wound healing, and it is suppressed by corticosteroids. The anti-inflammatory effect of corticosteroids is largely responsible for the impairment of wound healing in bowel anastomosis. It has been reported that local application of granulocyte-macrophage colony-stimulating factor (GM-CSF) improves the healing process in dermal wounds. In the present study, we investigated the effects of locally injected GM-CSF on anastomotic wound healing in long-term corticosteroid treated rats. Eighty male Sprague-Dawley rats were randomized into four groups. (1) control, (2) steroid, (3) steroid + local GM-CSF, (4) steroid + systemic GM-CSF. In groups 2, 3, and 4, methylprednisolone (5 mg/kg) was injected IM daily for 14 days. After 14 days, following anesthesia and laparotomy, colonic anastomosis was performed 3 cm away from the peritoneal reflection. In group 3, 50 mg GM-CSF was injected into the perianastomotic area. In group 4, 50 mg GM-CSF was applied subcutaneously. On postoperative day 3, repeat laparotomies were performed and bursting pressures, hydroxyproline levels, and histopathology examinations were studied. The mean values of bursting pressures and hydroxyproline levels in group 3, treated with steroid + local GM-CSF, were significantly higher than that of the group 2 and group 4 values. In the histopathology examination, the mean score of group 3 was significantly higher than that of groups 2 and 4. Our study indicates that local application of GM-CSF significantly improves the impaired anastomotic wound healing in rats treated with long-term corticosteroid.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Dinc S,Alagol H,Gulcelik MA,Ozbirecikli B,Kuru B,Renda N,Ustun Hdoi
10.1007/s00268-002-6505-3keywords:
subject
Has Abstractpub_date
2002-10-01 00:00:00pages
1208-13issue
10eissn
0364-2313issn
1432-2323journal_volume
26pub_type
杂志文章abstract：:Benign esophageal obstruction is virtually always responsive to dilation therapy. Dilation therapy should, therefore, be the initial approach. The introduction of the Savary-type dilating equipment and of balloon dilation systems are, or will become, standard practice. These systems will increasingly be preferred over...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF01658390
更新日期：1989-03-01 00:00:00
abstract：BACKGROUND:Accurate presurgical assessment is important to anticipate postoperative complications, especially in the growing proportion of elderly cancer patients. We designed a study to define which comorbid conditions at the time of diagnosis predict complications after surgery for colorectal cancer. PATIENTS:A rand...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0711-8
更新日期：2007-01-01 00:00:00
abstract：:The treatment results of mycobacterial cervical lymphadenitis in 69 patients between 1990 and 1993 are reviewed. All patients underwent surgical procedures consisting of total excision or selective nodal dissection for lymphadenopathies and curettage for fluctuant cases, followed by antituberculous chemotherapy applie...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900265
更新日期：1997-06-01 00:00:00
abstract：BACKGROUND:Nodal involvement of papillary thyroid carcinoma (PTC) commonly occurs in the paratracheal region and the internal jugular chain. Lymph node metastasis in the parapharyngeal space (PPS) is rare. In this report, we describe our experience and surgical outcomes of patients with PPS metastasis of PTC. METHODS:...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3321-0
更新日期：2016-02-01 00:00:00
abstract：:Surgical oncology is one of the most frequently studied surgical specialties with regard to disparities in quality of care. There is variation in the care received according to nonclinical factors such as age, race and ethnicity, education, income, and even geographic region. Differences exist with regard to who gets ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9383-x
更新日期：2008-04-01 00:00:00
abstract：:It has been widely acknowledged that exomphalos and gastroschisis are two different clinical entities. Their etiology and pathogenesis, however, remain controversial. Several techniques are available for making a prenatal diagnosis of these as well as many other malformations. Some prenatal treatment is possible, but ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF01658701
更新日期：1993-05-01 00:00:00
abstract：:Axillary dissection in patients with breast cancer is associated with significant morbidity. Because 85% of the patients with a cancer < or = 1 cm have negative axillary nodal status, axillary dissection in these patients is only a staging procedure. A study of the sentinel lymph node (SLN) biopsy has been developed t...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-001-0272-4
更新日期：2002-05-01 00:00:00
abstract：BACKGROUND:New medical therapies available to ulcerative colitis (UC) patients have influenced operative mortality for patients requiring colectomy. We sought to examine trends in treatment and outcome for UC patients treated surgically. METHODS:A review of 36,447 UC patients from the Nationwide Inpatient Sample was p...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0910-9
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:The International Study Group on Pancreatic Fistula (ISGPF) classification scheme has become a useful system for characterizing the clinical impact of pancreatic fistula. We sought to identify predictive factors that predispose patients to fistula, specifically those with clinical relevance (grades B/C), and...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9388-5
更新日期：2008-03-01 00:00:00
abstract：:Frequently, several multiple abdominal reexplorations are needed in patients with acute necrotizing hemorrhagic pancreatitis (ANP) or with persistent intraabdominal sepsis (PIAS). Residual undrained necrotic and septic foci lead to multiple organ failure. To provide wide-open drainage of the abdominal cavity, since 19...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01658968
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Intraoperative cerebral oxygen desaturation was reported to be associated with postoperative cognitive dysfunction in elderly patients. The effect of the anesthesia method on regional cerebral oxygen saturation (rSO(2)) is still a question under debate. The purpose of this study was to compare the effects of...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-012-1676-z
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Molecular diagnostics can allow some patients with indeterminate thyroid nodule cytopathology to avoid diagnostic hemithyroidectomy; however, the testing is costly. We hypothesized that molecular testing with the intention of preventing unnecessary diagnostic hemithyroidectomy would be cost-effective if this...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05177-7
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:We investigated the implications of HER2 amplification in Asian women with small, node-negative breast cancer in low- and middle-income countries (LMCs). METHODS:We reviewed the charts patients treated between 1989 and 2009 with breast conservation therapy for node-negative breast cancers measuring ≤ 2 cm. ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1353-7
更新日期：2012-02-01 00:00:00
abstract：:Gastric cancer is a disease in which the main treatment is surgical extirpation. The modifications introduced in the surgical treatment over the last decades were accompanied by a clear increase of survival, which reaches global values of 61% at 5 years in Japan. One of the reasons that contribute to this improvement ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-001-0228-8
更新日期：2002-03-01 00:00:00
abstract：BACKGROUND:Open surgical cricopharyngeal myotomy(CM) is considered standard of care for Zenker's diverticulum(ZD). Trans-oral CM has been described using a rigid stapling device for two decades; however, this remains problematic for severely kyphotic patients. This problem can be overcome with flexible endoscopy utiliz...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-016-3442-0
更新日期：2016-06-01 00:00:00
abstract：:This retrospective study reports our experience managing 78 patients with adenocarcinoma of the esophagus and gastroesophageal junction operated between January 1982 and December 1996. Altogether 18 patients presented with stage I and II disease, and 60 patients had stage III and IV disease at presentation; 56 patient...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/pl00013179
更新日期：1999-03-01 00:00:00
abstract：BACKGROUND:The decision to proceed to simple underwater seal drainage or apply active suction to the underwater seal after lung resection is mostly based on surgeon preference. The purpose of this study was to test whether routine application of active suction is necessary after lobectomy. PATIENTS AND METHODS:This wa...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-008-9741-3
更新日期：2008-11-01 00:00:00
abstract：BACKGROUND:Pulmonary resection is the best therapeutic option for lung metastases from colorectal cancer (CRC) today. However, recurrences are frequent following pulmonary resection. We aimed to evaluate the recurrence pattern and treatment of initial pulmonary resection for metastases from CRC. METHODS:Data from 76 p...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3006-8
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:Recurrent renal hyperparathyroidism (HPT) is a serious problem after parathyroidectomy (PTx). We evaluated the frequency of graft-dependent recurrent HPT and the clinical outcomes after removal of the autograft. METHODS:Between March 1980 and January 2009, 2660 patients underwent total PTx with forearm auto...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0412-9
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:Radical lymph node dissection (LND) along the bilateral recurrent laryngeal nerve (RLN) is a surgically challenging procedure with a high rate of morbidity. Here, we assessed in a retrospective manner the adequacy of LND along the RLN performed with robot-assisted thoracoscopic esophagectomy (RATE) versus vid...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4179-0
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:The use of the Harmonic Scalpel (HS) for cystic duct ligation began with little data about its efficacy or safety. On the other hand, there is not any literature available about the use of PlasmaKinetic Sealer (PK) for closing the cystic duct in laparoscopic cholecystectomy (LC). Therefore, this study was de...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0819-3
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:The extent to which obesity and genetics determine postoperative complications is incompletely understood. METHODS:We performed a retrospective study using two population cohorts with electronic health record (EHR) data. The first included 736,726 adults with body mass index (BMI) recorded between 1990 and ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05202-9
更新日期：2020-01-01 00:00:00
abstract：:Laparoscopic fundoplication is increasingly used for treating gastro-esophageal reflux disease in children. Mechanical and pharmacological effects may contribute to hemodynamic and respiratory changes during carbon dioxide pneumoperitoneum. The aim of the present study was to evaluate the hemodynamic and respiratory e...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-7695-2
更新日期：2005-05-01 00:00:00
abstract：:Hepatoblastoma is a rare pediatric malignancy that frequently appears in an advanced unresectable stage. Improved resectability and survival rate have been reported with the help of neoadjuvant chemotherapy. Between January 1987 and June 1995 a series of 20 patients were managed with a diagnosis of hepatoblastoma. The...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002680020052
更新日期：2001-02-01 00:00:00
abstract：BACKGROUND:Diabetes mellitus (DM) is a known risk factor for worse outcomes after emergency abdominal surgery (EAS). However, it is unclear if the type of diabetes treatment (insulin or oral agents) has any effect on outcomes after EAS. METHODS:Matched cohort study utilizing the ACS NSQIP database. Patients with DM un...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-016-3469-2
更新日期：2016-07-01 00:00:00
abstract：:Primary hyperparathyroidism was investigated using the presence of basic fibroblast growth factor (bFGF) from the immunohistochemical viewpoint with an anti-bFGF antibody in hyperplastic parathyroid glands of patients with multiple endocrine neoplasia type I (MEN-I) and of patients with non-MEN. The results correspond...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF00299109
更新日期：1994-11-01 00:00:00
abstract：BACKGROUND:Continuous vagal intraoperative neuromonitoring (CIONM) of the recurrent laryngeal nerve (RLN) may reduce the risk of RLN lesions during high-risk endocrine neck surgery such as operation for large goiter potentially requiring transsternal surgery, advanced thyroid cancer, and recurrence. METHODS:Fifty-five...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3368-y
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND AND AIMS:A variety of minimally invasive techniques have been proposed to replace open surgery for the treatment of infected pancreatic necrosis (IPN). In this study, we evaluate the feasibility and safety of the stent-assisted percutaneous endoscopic necrosectomy (SAPEN) procedure. METHODS:Data were collec...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-04878-9
更新日期：2019-04-01 00:00:00
abstract：:Thoracic and thoracoabdominal penetrating wounds are frequently encountered in urban medical centers in the United States. This study was undertaken to determine the clinical characteristics and in hospital outcome of these injuries. This was a longitudinal, nonblinded study using the established standard of care of p...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF03215862
更新日期：2001-09-01 00:00:00
abstract：BACKGROUND:Minimally invasive radio-guided parathyroidectomy (MIRP) has been embraced as an acceptable therapeutic approach to primary hyperparathyroidism. Preoperative sestamibi scanning has facilitated this technique. Here we evaluate the addition of a rapid intraoperative parathyroid hormone (iPTH) assay for patient...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0293-5
更新日期：2006-02-01 00:00:00
