Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease.

abstract：:A recent study has linked the butyrylcholinesterase (BChE) K-variant and the apolipoprotein epsilon4 isoform to late-onset Alzheimer's disease. These findings have been controversial and have led us to examine the differences between wild-type and K-variant BChE in enzyme activity, protein stability, and quaternary st...

journal_title：Journal of neurochemistry

authors： Altamirano CV,Bartels CF,Lockridge O

更新日期：2000-02-01 00:00:00

abstract：:The novel N-methyl-D-aspartate receptor channel ligand (+)-[3H]5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5, 10-imine maleate ([3H]MK-801) has been utilized to label this receptor in human brain tissue. Characteristics of [3H]MK-801 binding to well-washed membranes from 17 control subjects and 16 patients with...

journal_title：Journal of neurochemistry

authors： Procter AW,Wong EH,Stratmann GC,Lowe SL,Bowen DM

更新日期：1989-09-01 00:00:00

abstract：:The mechanism(s) underlying neurodegeneration-associated activation of ERK1/2 remain poorly understood. We report that in cultured rat cortical neurons, whose basal ERK1/2 phosphorylation required NMDA receptors (NMDAR), the neurotoxic DNA intercalating drug cisplatin increased ERK1/2 phosphorylation via NMDAR despite...

journal_title：Journal of neurochemistry

authors： Gozdz A,Vashishta A,Kalita K,Szatmari E,Zheng JJ,Tamiya S,Delamere NA,Hetman M

更新日期：2008-09-01 00:00:00

abstract：:The incorporation of radioactive phosphate into proteins of both normal and regenerating ganglia of the sympathetic nervous system of the rat is reported. The incorporation reactions were carried out in vitro by incubating homogenates of excised ganglia with [gamma-32P]ATP under various conditions. It was found that i...

journal_title：Journal of neurochemistry

authors： Watterson JG,Good R,Moses E,Hearn MT,Austin L

更新日期：1989-06-01 00:00:00

abstract：:Pretreatment of rats with the excitatory amino acid antagonist 2-amino-7-phosphonoheptanoic acid (2-APH; 0.5 mmol/kg, i.p.) protected against insulin-induced clonic seizures. Complete protection was observed in 38% of the rats and partial protection in an additional 50%. Lesioning of the corticostriatal pathway by fro...

journal_title：Journal of neurochemistry

authors： Chapman AG,Engelsen B,Meldrum BS

更新日期：1987-07-01 00:00:00

abstract：:Neurite formation involves coordinated changes between the actin cytoskeleton and the microtubule network. Rho GTPases are clearly implicated in several aspects of neuronal development and function. Indeed, RhoA is a negative regulator of neurite outgrowth and its effector Rho-kinase mediates the Rho-driven neurite re...

journal_title：Journal of neurochemistry

authors： Talens-Visconti R,Peris B,Guerri C,Guasch RM

更新日期：2010-02-01 00:00:00

abstract：:The nerve growth factor (NGF) precursor, proNGF, is implicated in various neuropathological states. ProNGF signals apoptosis by forming a complex with the receptors p75 and sortilin, however, it can also induce neurite growth, proposed to be mediated by the receptor of mature NGF, tyrosine kinase receptor A (TrkA). Th...

journal_title：Journal of neurochemistry

authors： Kalous A,Nangle MR,Anastasia A,Hempstead BL,Keast JR

更新日期：2012-08-01 00:00:00

abstract：:Cystatin C, a well-established biomarker of renal function, has been associated with a protective effect against stroke. However, the potential neuroprotective mechanism of cystatin C in ischemic brain injury remains unclear. Our study hypothesized that cystatin C can ameliorate blood-brain barrier (BBB) disruption by...

journal_title：Journal of neurochemistry

authors： Yang B,Xu J,Chang L,Miao Z,Heang D,Pu Y,Zhou X,Zhang L,Xie H

更新日期：2020-05-01 00:00:00

abstract：:In adult New Zealand white rabbits, the effects of food deprivation and of massive elevations of plasma uridine or thymidine concentrations on CSF and plasma nucleoside and oxypurine concentrations were studied. Nucleoside and oxypurine levels were determined by high performance liquid chromatography using unequivocal...

journal_title：Journal of neurochemistry

authors： Eells JT,Spector R,Huntoon S

更新日期：1984-06-01 00:00:00

abstract：:Prolonged stress affects homeostasis in various organs and induces stress-associated disorders. We examined the cellular changes of pituitary gland under the continuous stress condition using a rat model in which rats were kept in a cage filled with water to a height of 1.5 cm for up to 5 days. Among the pituitary hor...

journal_title：Journal of neurochemistry

authors： Ogawa T,Shishioh-Ikejima N,Konishi H,Makino T,Sei H,Kiryu-Seo S,Tanaka M,Watanabe Y,Kiyama H

更新日期：2009-06-01 00:00:00

abstract：:Differential assembly of N-methyl-D-aspartate (NMDA) receptor subunits determines their functional characteristics. Using in situ hybridization, we found a selective increase of the subunits NR1 and NR2A mRNA at 24 h in ventral motor neurons (VMN) caudal to a standardized spinal cord contusion injury (SCI). Other neur...

journal_title：Journal of neurochemistry

authors： Grossman SD,Wolfe BB,Yasuda RP,Wrathall JR

更新日期：2000-07-01 00:00:00

abstract：:The adenylate cyclase activity of rat hippocampal plasma membranes can be stimulated by vasoactive intestinal polypeptide (VIP). Low concentrations (10(-9) to 19(-7) M) of 5'-guanylyl-imido diphosphate (GppNHp) evoke a transient inhibition of the enzyme, which is followed by stimulation with increasing GppNHp concentr...

journal_title：Journal of neurochemistry

authors： Girardot JM,Kempf J,Cooper DM

更新日期：1983-09-01 00:00:00

abstract：:Prolonged seizures activate members of the Bcl-2 homology domain 3-only sub-group of the Bcl-2 protein family, which are essential for initiation of apoptosis signaling. Bid is a potent pro-apoptotic Bcl-2 homology domain 3-only protein, which upon proteolytic activation translocates to mitochondria to promote activat...

journal_title：Journal of neurochemistry

authors： Engel T,Caballero-Caballero A,Schindler CK,Plesnila N,Strasser A,Prehn JH,Henshall DC

更新日期：2010-10-01 00:00:00

abstract：:At present, treatment for Parkinson's disease (PD) is only symptomatic; therefore, it is important to identify new targets tackling the molecular causes of the disease. We previously found that lymphoblasts from sporadic PD patients display increased activity of the cyclin D3/CDK6/pRb pathway and higher proliferation ...

journal_title：Journal of neurochemistry

authors： Alquézar C,Barrio E,Esteras N,de la Encarnación A,Bartolomé F,Molina JA,Martín-Requero Á

更新日期：2015-06-01 00:00:00

abstract：:The brain-specific protein p42IP4, also called centaurin-alpha1, specifically binds phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P3] and inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4]. Here, we investigate the interaction of p42IP4/centaurin-alpha1 with nardilysin (NRDc), a member of the M16 family of z...

journal_title：Journal of neurochemistry

authors： Stricker R,Chow KM,Walther D,Hanck T,Hersh LB,Reiser G

更新日期：2006-07-01 00:00:00

abstract：:Previous studies have suggested that protein kinase C is important in the regulation of angiotensin II receptors in neuronal cultures, because the C-kinase agonists, phorbol esters, are able to increase the number of these receptors. In the present study, we have further investigated the role of protein kinase C in an...

journal_title：Journal of neurochemistry

authors： Sumners C,Rueth SM,Myers LM,Kalberg CJ,Crews FT,Raizada MK

更新日期：1988-07-01 00:00:00

abstract：:Most biological effects of tissue plasminogen activator (tPA), such as fibrinolysis, are mediated by its protease activity. Recent studies, however, have demonstrated that tPA also has several protease-independent effects such as: neuroprotection, microglial activation, and promoting LTP formation. In order to gain a ...

journal_title：Journal of neurochemistry

authors： Lee HY,Hwang IY,Im H,Koh JY,Kim YH

更新日期：2007-06-01 00:00:00

abstract：:A central role of iron in the pathogenesis of Parkinson's disease (PD), due to its increase in substantia nigra pars compacta dopaminergic neurons and reactive microglia and its capacity to enhance production of toxic reactive oxygen radicals, has been discussed for many years. Recent transcranial ultrasound findings ...

journal_title：Journal of neurochemistry

authors： Berg D,Gerlach M,Youdim MB,Double KL,Zecca L,Riederer P,Becker G

更新日期：2001-10-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a neurotrophic factor essential for maintenance of motor neurons. Loss of this factor produces a phenotype similar to amyotrophic lateral sclerosis (ALS). We recently showed that ALS-producing mutations of Cu/Zn-superoxide dismutase (SOD1) disrupt post-transcriptional regul...

journal_title：Journal of neurochemistry

authors： Li X,Lu L,Bush DJ,Zhang X,Zheng L,Suswam EA,King PH

更新日期：2009-02-01 00:00:00

abstract：:We have characterized the structural properties of heparan sulfates from brain and other tissues after depolymerization with a mixture of three heparin and heparan sulfate lyases from Flavobacterium heparinum. The resulting disaccharides were separated by HPLC and identified by comparison with authentic standards. In ...

journal_title：Journal of neurochemistry

authors： Tekotte H,Engel M,Margolis RU,Margolis RK

更新日期：1994-03-01 00:00:00

abstract：:Excitotoxicity mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors has been proposed to play a major role in the selective death of motor neurons in sporadic amyotrophic lateral sclerosis (ALS), and motor neurons are more vulnerable to AMPA receptor-mediated excitotoxicity than are o...

journal_title：Journal of neurochemistry

authors： Sun H,Kawahara Y,Ito K,Kanazawa I,Kwak S

更新日期：2006-08-01 00:00:00

abstract：:Environment-induced relapse is a major concern in drug addiction because of the strong associations formed between drug reward and environment. Cocaine-conditioned place preference is an ideal experimental tool to examine adaptations in the molecular pathways that are activated upon re-exposure to an environment previ...

journal_title：Journal of neurochemistry

authors： Tropea TF,Kosofsky BE,Rajadhyaksha AM

更新日期：2008-08-01 00:00:00

abstract：:Prostaglandin E2 (PGE2 ) plays crucial roles in managing microglial activation through the prostanoid EP2 receptor, a PGE2 receptor subtype. In this study, we report that PGE2 enhances interferon-γ (IFN-γ)-induced nitric oxide production in microglia. IFN-γ increased the release of nitrite, a metabolite of nitric oxid...

journal_title：Journal of neurochemistry

authors： Nagano T,Nishiyama R,Sanada A,Mutaguchi Y,Ioku A,Umeki H,Kishimoto S,Yamanaka D,Kimura SH,Takemura M

更新日期：2017-02-01 00:00:00

abstract：:The time course of the reduction in brain protein synthesis following transient bilateral ischemia in the gerbil was characterized and compared with changes in a number of metabolites related to brain energy metabolism. The recovery of brain protein synthesis was similar following ischemic periods of 5, 10, or 20 min;...

journal_title：Journal of neurochemistry

authors： Nowak TS Jr,Fried RL,Lust WD,Passonneau JV

更新日期：1985-02-01 00:00:00

abstract：:Mechanical strain in neural tissues can lead to the up-regulation and release of multiple cytokines including interleukin 6 (IL-6). In the retina, the mechanosensitive release of ATP can autostimulate P2X7 receptors on both retinal ganglion cell neurons and optic nerve head astrocytes. Here, we asked whether the purin...

journal_title：Journal of neurochemistry

authors： Lu W,Albalawi F,Beckel JM,Lim JC,Laties AM,Mitchell CH

更新日期：2017-05-01 00:00:00

abstract：:Sympathetic denervation of the iris muscle produces increases in both the breakdown of phosphatidylinositol 4,5-bisphosphate (PIP2) and in muscle contraction in response to norepinephrine (NE). To shed more light on the biochemical basis underlying this supersensitivity we investigated: the effects of NE on PIP2 break...

journal_title：Journal of neurochemistry

authors： Akhtar RA,Abdel-Latif AA

更新日期：1986-01-01 00:00:00

abstract：:The serotonin 5-HT3 receptor, a ligand-gated ion channel, has previously been shown to be present on a subpopulation of brain nerve terminals, where, on activation, the 5-HT3 receptors induce Ca2+ influx. Whereas postsynaptic 5-HT3 receptors induce depolarization, being permeant to Na+ and K+, the basis of presynaptic...

journal_title：Journal of neurochemistry

authors： Rondé P,Nichols RA

更新日期：1998-03-01 00:00:00

abstract：:IMP-GMP 5'-nucleotidase has been purified to homogeneity from total rat brain extracts. This preparation showed a unique band (Mr 54,000 +/- 1,509) in sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The enzyme presented the following properties: optimal pH value, 6.5-6.8; relative velocity measured in the p...

journal_title：Journal of neurochemistry

authors： Marques AF,Teixeira NA,Gambaretto C,Sillero A,Sillero MA

更新日期：1998-09-01 00:00:00

abstract：:We have characterised the induction of the mitogen-inducible form of cyclooxygenase, COX-2, in the rat cerebral cortex in response to excitotoxin injection into the nucleus basalis. This model is associated with intense stimulation of the ascending pathway to the cerebral cortex, seizure activity, and subsequent ipsil...

journal_title：Journal of neurochemistry

authors： Adams J,Collaço-Moraes Y,de Belleroche J

更新日期：1996-01-01 00:00:00

abstract：:The distribution of basal and of H2O2-stimulated cyclooxygenase activity in the primary fractions of rat brain homogenates and in the subfractions of crude mitochondrial fraction was studied. For comparison, the localization of H2O2-generating monoamine oxidase (MAO) as well as that of the mitochondrial marker succina...

journal_title：Journal of neurochemistry

authors： Seregi A,Serfözö P,Mergl Z

更新日期：1983-02-01 00:00:00