Variations in plasma free radicals in patients with venous hypertension with HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides): a clinical, prospective, placebo-controlled, randomized trial.


:The aim of this study was to demonstrate whether HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides), was effective in improving levels of plasma free radicals (PFRs) in patients with chronic venous insufficiency (CVI) and venous microangiopathy. Patients were randomized into the treatment group, which received oral HR (1g sachets, twice daily, for 4 weeks), and a placebo group, which received comparable placebo. Below-knee Sigvaris stockings were used during the study. PFRs were measured with the D-Rom test at the finger and at a vein of the leg in an area of CVI. The mean age of included subjects was 46 years (SD 11) in the treatment group (20 patients; 6 females) and 46.4 (SD 8) in the placebo group (20 patients; 7 females). There were no differences between placebo and treatment groups at inclusion in age and sex distribution and in parameters indicating venous hypertension. The decrease of PFRs levels in the treatment group was significant, both at the finger and in the distal blood taken in areas of CVI. There there were no significant changes in the control group. In areas of venous hypertension, PFRs values were on average higher than at the finger (systemic) level (P < 0.05). In parallel with the progressive decrease in PFRs associated with treatment, the analogue score was significantly decreased at 2 (P < 0.05) and 4 weeks (P < 0.02) in the HR group. No changes were observed in the placebo group. No adverse effects were observed. In conclusion, HR treatment is effective in decreasing both the systemic and local values of PFRs and therefore may have a positive effect on the evolution of CVI.


Cesarone MR,Incandela L,DeSanctis MT,Belcaro G,Dugall M,Acerbi G





Has Abstract


2002-01-01 00:00:00








7 Suppl 1


  • Evolving perspectives on clopidogrel in the treatment of ischemic stroke.

    abstract::Antiplatelet therapy is indicated for the treatment of ischemic stroke or transient ischemic attack (TIA). Aspirin reduces subsequent occlusive vascular events, including recurrent stroke, by about 25%. In such patients, clopidogrel has been evaluated in an effort to further reduce risk. In the Management of Atherothr...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章,评审


    authors: Gorelick P,Sechenova O,Hennekens CH

    更新日期:2006-12-01 00:00:00

  • Hypothesis: atorvastatin has pleiotropic effects that translate into early clinical benefits on cardiovascular disease.

    abstract::The results of numerous long-term, randomized trials show that statins significantly decrease the risks of myocardial infarction, stroke, and vascular death as well as total mortality. The benefits of statins on cardiovascular disease in patients who are not experiencing acute coronary syndromes generally become appar...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章,评审


    authors: Novela C,Hennekens CH

    更新日期:2004-03-01 00:00:00

  • Effect of Digoxin on Ventricular Remodeling and Responsiveness of beta-Adrenoceptors in Chronic Volume Overload.

    abstract::BACKGROUND: Digoxin improves baroreflex function and reduces neurohumoral activation in severe heart failure, but it is uncertain how digoxin affects ventricular remodeling and progression to left ventricular dysfunction. In addition, the effect of digoxin in in vitro beta-adrenoceptor density and function, and contra...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Sullebarger JT,D'Ambra PM,Clark LC,Thanikarry L,Fontanet HL

    更新日期:1998-10-01 00:00:00

  • Different Effects of Volatile and Nonvolatile Anesthetic Agents on Long-Term Survival in an Experimental Model of Hemorrhagic Shock.

    abstract:BACKGROUND:We investigated whether the cardioprotective, volatile gas anesthetic agent, isoflurane, could improve survival and organ function from hemorrhagic shock in an experimental rat model, compared to standard nonvolatile anesthetic agent ketamine/xylazine. METHODS:Sprague Dawley rats (both genders) were randomi...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Dai W,Shi J,Carreno J,Kloner RA

    更新日期:2020-07-01 00:00:00

  • Cardiovascular risk of selective cyclooxygenase-2 inhibitors.

    abstract::Recently, cyclooxygenase-2 (COX-2) inhibitors (coxibs), a class of drugs intended to be painkillers, have created unprecedented controversy because of their cardiovascular risk profile. The controversy has affected the patients, health-care providers, the Food and Drug Administration, and the manufacturers of these ag...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章,评审


    authors: Schrör K,Mehta P,Mehta JL

    更新日期:2005-06-01 00:00:00

  • Dose dependency of fluvastatin pharmacokinetics in serum determined by reversed phase HPLC.

    abstract:BACKGROUND:Fluvastatin is an inhibitor of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, effectively lowering serum cholesterol concentrations. A high-performance liquid chromatography (HPLC) assay was developed that determined the pharmacokinetics of fluvastatin in healthy individuals after administrat...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 临床试验,杂志文章


    authors: Siekmeier R,Lattke P,Mix C,Park JW,Jaross W

    更新日期:2001-04-01 00:00:00

  • Mechanisms of Impaired Endothelial Function Associated With Insulin Resistance.

    abstract::BACKGROUND: The insulin-resistant (IR) syndrome is causally related to hypertension and cardiovascular events; however, the underlying mechanism remains elusive. The current study was designed to determine (1) whether the IR syndrome causes vascular dysfunction and (2) whether insulin resistance alters the activity of...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Miller AW,Hoenig ME,Ujhelyi MR

    更新日期:1998-04-01 00:00:00

  • Novel oral anticoagulants in cardiovascular disease.

    abstract::Nonvalvular atrial fibrillation (AF) confers an increased risk of thromboembolism, with a 5-fold higher risk of ischemic stroke. Oral anticoagulation (OAC) has shown to be highly effective in preventing stroke and mortality compared to placebo and is also used in patients without AF for both treatment and prophylaxis ...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章,评审


    authors: Gallego P,Roldán V,Lip GY

    更新日期:2014-01-01 00:00:00

  • Chronic treatment with qiliqiangxin ameliorates aortic endothelial cell dysfunction in diabetic rats.

    abstract::Qiliqiangxin (QL), a traditional Chinese medicine, has been shown to be beneficial for chronic heart failure. However, whether QL can also improve endothelial cell function in diabetic rats remains unknown. Here, we investigated the effect of QL treatment on endothelial dysfunction by comparing the effect of QL to tha...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Chen F,Wu JL,Fu GS,Mou Y,Hu SJ

    更新日期:2015-03-01 00:00:00

  • Regression of Atherosclerotic Plaques of Cholesterol-Fed Rabbits by Combined Chemotherapy With Paclitaxel and Methotrexate Carried in Lipid Core Nanoparticles.

    abstract::In previous studies, it was demonstrated that lipid core nanoparticles (LDE) resemble the low-density lipoprotein structure and carrying the antiproliferative agent paclitaxel (PTX) strongly reduced atherosclerosis lesions induced in rabbits by cholesterol feeding. Currently, the aim was to verify whether combining LD...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Gomes FLT,Maranhão RC,Tavares ER,Carvalho PO,Higuchi ML,Mattos FR,Pitta FG,Hatab SA,Kalil-Filho R,Serrano CV Jr

    更新日期:2018-11-01 00:00:00

  • Nicorandil, a Nitric Oxide Donor and ATP-Sensitive Potassium Channel Opener, Protects Against Dystrophin-Deficient Cardiomyopathy.

    abstract:BACKGROUND:Dystrophin-deficient cardiomyopathy is a growing clinical problem without targeted treatments. We investigated whether nicorandil promotes cardioprotection in human dystrophin-deficient induced pluripotent stem cell (iPSC)-derived cardiomyocytes and the muscular dystrophy mdx mouse heart. METHODS AND RESULT...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Afzal MZ,Reiter M,Gastonguay C,McGivern JV,Guan X,Ge ZD,Mack DL,Childers MK,Ebert AD,Strande JL

    更新日期:2016-11-01 00:00:00

  • Distinct pharmacologic substrate in lidocaine-sensitive, repetitive atrial tachycardia.

    abstract::Lidocaine-sensitive, repetitive atrial tachycardia is an uncommon arrhythmia. The electrophysiologic substrate is still unknown, and the pharmacologic responses have not been fully explored. The aim of this study was to investigate the effects of intravenous adenosine and verapamil in patients with lidocaine-sensitive...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Chiale PA,Faivelis L,Garro HA,Fernández PA,Herrera Paz JJ,Elizari MV

    更新日期:2012-06-01 00:00:00

  • Therapeutic Implications of COVID-19 for the Interventional Cardiologist.

    abstract::Although COVID-19 is viewed primarily as a respiratory disease, cardiovascular risk factors and disease are prevalent among infected patients and are associated with worse outcomes. In addition, among multiple extra-pulmonary manifestations, there has been an increasing recognition of specific cardiovascular complicat...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Kelham M,Choudry FA,Hamshere S,Beirne AM,Rathod KS,Baumbach A,Ahluwalia A,Mathur A,Jones DA

    更新日期:2020-12-17 00:00:00

  • Separate and combined effects of local and continuous intravenous administration of beta-cyclodextrin tetradecasulfate on intimal hyperplasia after angioplasty in porcine coronary arteries.

    abstract:BACKGROUND:Beta-Cyclodextrin tetradecasulfate binds fibroblast growth factors and possesses anticoagulant properties. This study was designed to assess the separate and combined effects of local intramural delivery and intravenous administration of beta-cyclodextrin tetrade-casulfate on neointimal formation and arteria...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Meneveau NF,Klugherz BD,Chaquor B,Golden MA,Jouille MM,Macarek E,Weisz PB,Wilensky RL

    更新日期:2003-03-01 00:00:00

  • Inhibition of Na+/H+ Exchanger With EMD 87580 does not Confer Greater Cardioprotection Beyond Preconditioning on Ischemia-Reperfusion Injury in Normal Dogs.

    abstract::Postischemic accumulation of intracellular Na+ promotes calcium overload and contributes to cellular necrosis. Cardioprotection afforded by pharmacologic blockade of the sodium-hydrogen exchanger subtype 1 (NHE1) is thought to be more remarkable than that obtained by ischemic conditioning (IC). The window of protectio...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Kingma JG

    更新日期:2018-05-01 00:00:00

  • Prolonged Captopril Therapy in Murine Viral Myocarditis.

    abstract::BACKGROUND: Acute myocarditis can progress to chronic heart muscle disease and cardiomyopathy. In the coxsackievirus B(3) (CB(3)) mouse model of myocarditis, early administration of captopril, an angiotensin-converting enzyme (ACE) inhibitor, ameliorated histopathological changes in inflammation, necrosis, and calcifi...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Reyes MP,Khatib R,Khatib G,Ho KL,Smith F,Kloner RA

    更新日期:1998-01-01 00:00:00

  • Sinus node dysfunction secondary to hyperparathyroidism.

    abstract::We present two patients who were diagnosed with symptomatic sinus node dysfunction in the setting of hypercalcemia secondary to hyperparathyroidism. An extensive review of the literature has not revealed previous reports of this pathologic process. ...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Shah AP,Lopez A,Wachsner RY,Meymandi SK,El-Bialy AK,Ichiuji AM

    更新日期:2004-06-01 00:00:00

  • Sarcoplasmic reticulum adenosine triphosphatase overexpression in the L-type Ca2+ channel mouse results in cardiomyopathy and Ca2+ -induced arrhythmogenesis.

    abstract:BACKGROUND:Overexpression of the L-type voltage-dependent calcium channel alpha(1C)-subunit (L-VDCC OE) in transgenic mice results in adaptive hypertrophy followed by a maladaptive phase associated with a decrease in sarcoplasmic reticulum adenosine triphosphatase (SERCA)2a expression at 8 to 10 months of age. Overexpr...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Rubio M,Bodi I,Fuller-Bicer GA,Hahn HS,Periasamy M,Schwartz A

    更新日期:2005-12-01 00:00:00

  • Persistence of Atrial Fibrillation After Its Induction-Importance of the Duration and Dispersion of Atrial Refractoriness and Electrical Remodeling.

    abstract::BACKGROUND: The electrophysiologic mechanisms of the persistence of atrial fibrillation (AF) after its initiation are not well understood. Therefore, the electrophysiologic characteristics of the right atrium were evaluated in an acute, pacing-induced model of AF in the pig in order to identify parameters associated w...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Rahme MM,Cotter B,Leistad E,Subudhayangkul S,Wadhwa M,Ungab G,Feld GK

    更新日期:1999-04-01 00:00:00

  • Effect of simvastatin/ezetimibe 10/10 mg versus simvastatin 40 mg on serum vitamin D levels.

    abstract:BACKGROUND:Low levels of 25-hydroxyvitamin D (25(OH)VitD) have been recognized as an emerging cardiovascular disease (CVD) risk factor. Statins are reported to increase 25(OH)VitD concentration. Animal studies suggest that ezetimibe is a moderate inhibitor of intestinal 25(OH)VitD absorption, but its effect in humans i...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章,随机对照试验


    authors: Liberopoulos EN,Makariou SE,Moutzouri E,Kostapanos MS,Challa A,Elisaf M

    更新日期:2013-05-01 00:00:00

  • Comparison of the Electromechanical Effects of Vesnarinone and Amrinone in Isolated Dog Purkinje Strands and Ventricular Trabeculae.

    abstract::BACKGROUND: Conventional microelectrode techniques were used to compare the concentration-dependent effects of vesnarinone (0.1-100 µM) and amrinone (1 µM-1 mM) on action potential duration (APD) and developed force in both isolated dog ventricular trabeculae and Purkinje strands. METHODS AND RESULTS: Both drugs incre...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Lathrop DA,Nánási PP,Varró A,Schwartz A

    更新日期:1996-04-01 00:00:00

  • Effect of potassium-channel opener therapy on reperfused infarction in hypertrophied hearts: demonstration of preconditioning by using functional and contrast-enhanced magnetic resonance imaging.

    abstract::Effects of therapy with the potassium-channel opener and vasodilator nicorandil were studied in reperfused infarction of hypertrophied hearts by using magnetic resonance imaging (MRI), hemodynamic measurements, and histochemical staining. Aortic banding was performed on 22 Sprague-Dawley rats to induce left ventricula...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Schalla S,Higgins CB,Chujo M,Saeed M

    更新日期:2004-09-01 00:00:00

  • Ischemic Conditioning Attenuates Platelet-Mediated Thrombosis: A Tale of Reverse Translation.

    abstract::Data obtained in both preclinical models and humans have revealed that the favorable cardiac consequences of ischemic conditioning extend beyond a direct effect on the cardiomyocyte. In the current review, we summarize our as-yet limited understanding of the complex relationships between ischemic conditioning, platele...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章,评审


    authors: Przyklenk K,Whittaker P

    更新日期:2017-09-01 00:00:00

  • Inhibition of Atherosclerosis Progression, Intimal Hyperplasia, and Oxidative Stress by Simvastatin and Ivabradine May Reduce Thoracic Aorta's Stiffness in Hypercholesterolemic Rabbits.

    abstract:AIMS:This study aims to evaluate atherosclerosis, oxidative stress, and arterial stiffness attenuation by simvastatin and ivabradine in hyperlipidemic rabbits. METHODS AND RESULTS:Forty rabbits were randomly divided into 4 groups: atherogenic diet (group C), atherogenic diet plus simvastatin (group S), atherogenic die...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Koniari I,Mavrilas D,Apostolakis E,Papadimitriou E,Papadaki H,Papalois A,Poimenidi E,Xanthopoulou I,Hahalis G,Alexopoulos D

    更新日期:2016-07-01 00:00:00

  • Effects of pre- and postconditioning on arrhythmogenesis in the in vivo rat model.

    abstract::The antiarrhythmic potential of postconditioning in in vivo models remains poorly defined. We compared the effects of pre- and postconditioning on ventricular arrhythmogenesis against controls with and without reperfusion. Wistar rats (n = 40, 269 ± 3 g) subjected to ischemia (30 minutes)--reperfusion (24 hours) were ...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Kolettis TM,Vilaeti AD,Tsalikakis DG,Zoga A,Valenti M,Tzallas AT,Papalois A,Iliodromitis EK

    更新日期:2013-07-01 00:00:00

  • Sulfated polysaccharide fucoidan ameliorates experimental autoimmune myocarditis in rats.

    abstract::Homing of cardiac myosin-specific CD4-positive T cells into the myocardium is the initial pathologic event of experimental autoimmune myocarditis (EAM). Subsequently, various bystander inflammatory cells are recruited into the myocardium crossing vascular endothelial cell walls. Sulfated polysaccharide fucoidan binds ...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Tanaka K,Ito M,Kodama M,Tomita M,Kimura S,Hoyano M,Mitsuma W,Hirono S,Hanawa H,Aizawa Y

    更新日期:2011-03-01 00:00:00

  • Effect of levosimendan and milrinone on regional myocardial ischemia/reperfusion-induced arrhythmias in dogs.

    abstract::Phosphodiesterase inhibitors as inodilators in heart failure are associated with promotion of arrhythmias. Calcium sensitizers have been proposed for the treatment of severe decompensated heart failure. The effect of levosimendan, a calcium sensitizer, and milrinone, a phosphodiesterase inhibitor, on ventricular arrhy...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Papp JG,Pollesello P,Varró AF,Végh AS

    更新日期:2006-06-01 00:00:00

  • Imipramine-induced cardiac depression is responsible for the increase in intracellular magnesium and the activation of ERK 1/2 in rats.

    abstract::Imipramine, an antidepressant drug, can cause potentially lethal cardiotoxic side effects including hypotension, ventricular tachycardia, and decreased cardiac output. This study investigated the mechanism responsible for imipramine-induced cardiac depression in rats. The left ventricular developed pressure (LVDP), ve...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Lee MY,Kim SJ,Kim JS,Kang HS

    更新日期:2010-09-01 00:00:00

  • Safety and efficacy outcomes of preoperative aspirin in patients undergoing coronary artery bypass grafting: a systematic review and meta-analysis.

    abstract:BACKGROUND:The administration of aspirin is traditionally discontinued prior to coronary artery bypass grafting (CABG), given a potential risk of excessive postoperative bleeding. Few studies have previously suggested the benefits of continuing aspirin until the time of surgery. The primary aim of this review is to eva...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章,meta分析,评审


    authors: Ma X,Ma C,Yun Y,Zhang Q,Zheng X

    更新日期:2014-01-01 00:00:00

  • Antiarrhythmic and Arrhythmogenic Actions of Varying Levels of Extracellular Magnesium: Possible Cellular Basis for the Differences in the Efficacy of magnesium and Lidocaine in Torsade de Pointes.

    abstract::BACKGROUND: In recent years, there has been an increasing use of antiarrhythmic drugs that act predominantly by prolonging myocardial repolarization. An inevitable electrophysiologic consequence of these drugs is the development of torsade de pointes as a proarrhythmic reaction. Both intravenous lidocaine and magnesiu...

    journal_title:Journal of cardiovascular pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Takanaka C,Ogunyankin KO,Sarma JS,Singh BN

    更新日期:1997-04-01 00:00:00