Abstract：
:BACKGROUND: Acute myocarditis can progress to chronic heart muscle disease and cardiomyopathy. In the coxsackievirus B(3) (CB(3)) mouse model of myocarditis, early administration of captopril, an angiotensin-converting enzyme (ACE) inhibitor, ameliorated histopathological changes in inflammation, necrosis, and calcification and reduced heart weight. Late administration of captopril reduced heart weight but did not affect the histological findings. In this study, we investigated the effects of prolonged captopril treatment in the chronic phase of this model. METHODS AND RESULTS: Three-week-old male CD(1) mice were infected with CB(3) and then randomized to receive placebo or captopril starting on day 7 of infection. Captopril, 2 g/L, was given as the drinking water daily for up to 6 months. Autopsies were performed at 6 and 10 months. Heart-to-body weight ratios were obtained, and deaths were tallied. Myocardial fibrosis was graded according to a score system. In addition, picrosirius red stain (PSR) also was used for assessment of collagen deposition. Mean heart weights were similar in both groups. Mean body weight was significantly lower in captopril-treated mice (40.7 g) than in the untreated group (43.6 g) at 6 months (P =.0155), and mortality was higher (8.7 vs 0.87%; P =.009). At 6 months, the mean myocardial fibrosis score in treated mice (0.12) was significantly less than in untreated animals (0.35; P =.035). With PSR, the mean myocardial fibrosis score in the captopril group (1.20) was also significantly less than in the untreated group (1.58; P =.045). At 10 months, fibrosis scores were similar in both groups. CONCLUSIONS: Chronic captopril treatment in CB(3) myocarditis reduces myocardial fibrosis.
journal_name
J Cardiovasc Pharmacol Therjournal_title
Journal of cardiovascular pharmacology and therapeuticsauthors
Reyes MP,Khatib R,Khatib G,Ho KL,Smith F,Kloner RAdoi
10.1177/107424849800300106keywords:
subject
Has Abstractpub_date
1998-01-01 00:00:00pages
43-50issue
1eissn
1074-2484issn
1940-4034pii
S1074248498000054journal_volume
3pub_type
杂志文章abstract：BACKGROUND:Low levels of 25-hydroxyvitamin D (25(OH)VitD) have been recognized as an emerging cardiovascular disease (CVD) risk factor. Statins are reported to increase 25(OH)VitD concentration. Animal studies suggest that ezetimibe is a moderate inhibitor of intestinal 25(OH)VitD absorption, but its effect in humans i...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,随机对照试验
doi：10.1177/1074248412470513
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:Intimal hyperplasia following percutaneous interventional vascular procedures is a major cause of restenosis. Although heparin inhibits intimal hyperplasia, it has not proven clinically useful in part due to an inadequate duration of intramural drug residence. This study was designed to evaluate the efficacy...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/107424840100600407
更新日期：2001-10-01 00:00:00
abstract：INTRODUCTION:Pulmonary hypertension (PH) is a potentially deadly disease for infants and adults with few existing medical interventions and no cure. In PH, increased blood pressure in the pulmonary artery eventually leads to heart failure. Fasudil, an antagonist of Rho-kinase, causes vasodilation leading to decreased s...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248418772814
更新日期：2018-09-01 00:00:00
abstract：:Vascular smooth muscle tone plays a fundamental role in regulating blood pressure, blood flow, microcirculation, and other cardiovascular functions. The cellular and molecular mechanisms by which vascular smooth muscle contractility is regulated are not completely elucidated. Recent studies show that the actin cytoske...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/1074248407313737
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of a pharmacist care program on cardiovascular risks in type 2 diabetic patients. METHODS:A 9-month, prospective, randomized, controlled study was conducted in a public hospital in Hong Kong. Patients in the intervention group had regular drug-counseling sessions with pharmacists in...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,随机对照试验
doi：10.1177/1074248410396216
更新日期：2012-03-01 00:00:00
abstract：:Low-molecular-weight heparins (LMWHs) endure as important drugs for thromboprophylaxis. Although clinical use relies on the subcutaneous (SC) route, our previous studies show that single-dose orally administered LMWHs have antithrombotic activity. Since thromboprophylaxis requires long-term treatment, we examined anti...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248416667601
更新日期：2017-05-01 00:00:00
abstract：:Approximately 40% of heart attack survivors remain at increased risk of recurrent cardiovascular events, despite the current treatment options showing that atherothrombosis is not exclusively a disorder of lipoprotein aggregation in the arterial wall. Clinical and experimental data suggest that inflammation plays an i...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/1074248418778548
更新日期：2018-11-01 00:00:00
abstract：:α-Lipoic acid (LA) has been shown to offer protection against ischemia-reperfusion injury (IRI) in multiple organ systems. N-[(R)-1,2-dithiolane-3-pentanoyl]-L-glutamyl-L-alanine (CMX-2043), a novel analogue of LA, was studied as part of a preclinical development program intended to identify safe and efficacious drug ...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248416640118
更新日期：2016-11-01 00:00:00
abstract：:The results of numerous long-term, randomized trials show that statins significantly decrease the risks of myocardial infarction, stroke, and vascular death as well as total mortality. The benefits of statins on cardiovascular disease in patients who are not experiencing acute coronary syndromes generally become appar...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/107424840400900i109
更新日期：2004-03-01 00:00:00
abstract：:Pulmonary arterial hypertension (PAH) is a progressive disease, which can be potentially fatal. The management of a complex disease like PAH requires a multidisciplinary approach from a team consisting of physicians, nurses, social workers, and pharmacists. Adherence to PAH-specific therapy is one of the key factors i...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/1074248419877409
更新日期：2020-03-01 00:00:00
abstract：:BACKGROUND: Clinical trials have shown that the use of lipid-lowering agents in postmyocardial infarction (MI) patients reduces rates of subsequent coronary events, reduces coronary artery bypass surgery rates, and improves survival. Physician decisions to prescribe lipid-lowering drugs is influenced by a number of pa...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/107424849800300303
更新日期：1998-07-01 00:00:00
abstract：:The aim of this study was to demonstrate whether HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides), was effective in improving levels of plasma free radicals (PFRs) in patients with chronic venous insufficiency (CVI) and venous microangiopathy. Patients were randomized into the treatment group, which received o...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/107424840200700107
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:Patients with coronary artery disease (CAD) should be treated with statins to attain very low cholesterol levels, in order to reduce cardiovascular adverse events. More than 70% of these patients do not reach the appropriate cholesterol goal despite moderate statin doses. However, it is not known whether the...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,随机对照试验
doi：10.1177/1074248413489771
更新日期：2013-09-01 00:00:00
abstract：:Imipramine, an antidepressant drug, can cause potentially lethal cardiotoxic side effects including hypotension, ventricular tachycardia, and decreased cardiac output. This study investigated the mechanism responsible for imipramine-induced cardiac depression in rats. The left ventricular developed pressure (LVDP), ve...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248410366853
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:The administration of aspirin is traditionally discontinued prior to coronary artery bypass grafting (CABG), given a potential risk of excessive postoperative bleeding. Few studies have previously suggested the benefits of continuing aspirin until the time of surgery. The primary aim of this review is to eva...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,meta分析,评审
doi：10.1177/1074248413509026
更新日期：2014-01-01 00:00:00
abstract：:BACKGROUND: The effects of sotalol on the 24-hour profile of the QT interval relative to that of the heart rate (HR) may be helpful in determining the time course of the drug's action in controlling cardiac arhythmias. This has not been previously determined. Thus, the objective of the current study was to evaluate th...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/107424849900400104
更新日期：1999-01-01 00:00:00
abstract：:Cardio-Oncology has blossomed as a new field in cardiovascular medicine, in large part due to new therapies, which may have cardiovascular sequelae. Despite this, anthracyclines still serve as cornerstone therapy for most pediatric cancers, several solid tumors and hematological malignancies. Cardiotoxicity is the mai...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248420968689
更新日期：2021-03-01 00:00:00
abstract：:BACKGROUND: Conventional microelectrode techniques were used to compare the concentration-dependent effects of vesnarinone (0.1-100 µM) and amrinone (1 µM-1 mM) on action potential duration (APD) and developed force in both isolated dog ventricular trabeculae and Purkinje strands. METHODS AND RESULTS: Both drugs incre...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/107424849600100207
更新日期：1996-04-01 00:00:00
abstract：:We present two patients who were diagnosed with symptomatic sinus node dysfunction in the setting of hypercalcemia secondary to hyperparathyroidism. An extensive review of the literature has not revealed previous reports of this pathologic process. ...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/107424840400900209
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Although a gradual increase in heart rate (HR) during dobutamine stress testing (DST) is desired, few data exists regarding whether this is similarly achieved in patients of widely varying body mass index (BMI). Whether difference in BMI contributes to variation in the hemodynamic and symptomatic response to...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248410384709
更新日期：2011-06-01 00:00:00
abstract：:Dronedarone is a new antiarrhythmic drug for patients with nonpermanent atrial fibrillation (AF). A relatively consistent finding in all trials studying dronedarone was a moderate but significant elevation of serum creatinine. Since dronedarone competes for the same organic cation transporter in the distal renal tubul...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248412453873
更新日期：2013-03-01 00:00:00
abstract：PURPOSE:It is known that selective cyclooxygenase 2(COX-2) inhibitors increase mortality in patients with previous myocardial infarction, and it has been suggested that COX-2 plays an important role in cardioprotection against ischemia. The current study was carried out to determine whether COX-2 is involved in the mec...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248410380208
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Myocardial hypertrophy is a common clinical finding leading to heart failure and sudden death. Mitofusin 2 (Mfn2), a hyperplasia suppressor protein, is downregulated in hypertrophic heart. This study examined the role of Mfn2 in myocardial hypertrophy and its potential signal pathway. METHODS...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248410385683
更新日期：2011-06-01 00:00:00
abstract：:Ventricular remodeling is a compensatory response that comprises the processes of apoptosis, muscle cell hypertrophy, and rearrangement of the extracellular matrix fibers connecting the muscles. These processes are associated with transformation of endothelium and/or fibroblasts to myofibroblasts. Neutral matrix metal...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/107424840200700407
更新日期：2002-10-01 00:00:00
abstract：:BACKGROUND: The electrophysiologic mechanisms of the persistence of atrial fibrillation (AF) after its initiation are not well understood. Therefore, the electrophysiologic characteristics of the right atrium were evaluated in an acute, pacing-induced model of AF in the pig in order to identify parameters associated w...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/107424849900400206
更新日期：1999-04-01 00:00:00
abstract：:Qiliqiangxin (QL), a traditional Chinese medicine, has been shown to be beneficial for chronic heart failure. However, whether QL can also improve endothelial cell function in diabetic rats remains unknown. Here, we investigated the effect of QL treatment on endothelial dysfunction by comparing the effect of QL to tha...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248414537705
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Brief periods of reocclusion (postconditioning) during early reperfusion reduce myocardial infarct size. Whether postconditioning has an effect on lethal ventricular arrhythmias independent of infarction in an in-vivo regional ischemia model is unknown. The purpose of this study was to determine if postcondi...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/107424840601100105
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND/AIM:In addition to its cholesterol-lowering effect, atorvastatin (ATV) has been thought to have multiple cardiovascular benefits, including anti-inflammatory and anti-apoptotic properties. The present study was undertaken to determine whether ATV pretreatment could attenuate myocardial apoptosis and inflamma...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248416662348
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:We hypothesized that the cardioprotective effect of angiotensin II (AngII) type 1 receptor (AT(1)R) blockade during in vivo ischemia-reperfusion (IR) might be associated with an increase in AngII type 2 receptor (AT(2)R) protein, as well as 1,4,5-inositol trisphosphate type 2 receptor (IP(3)R) and protein ki...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1054/JCPT.2000.19245
更新日期：2000-10-01 00:00:00
abstract：:Nonvalvular atrial fibrillation (AF) confers an increased risk of thromboembolism, with a 5-fold higher risk of ischemic stroke. Oral anticoagulation (OAC) has shown to be highly effective in preventing stroke and mortality compared to placebo and is also used in patients without AF for both treatment and prophylaxis ...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/1074248413501392
更新日期：2014-01-01 00:00:00
