Abstract:
STUDY DESIGN:A 12-week bovine survival study of tethering anterior spine growth that included untethered control subjects. OBJECTIVE:To determine the effects that a flexible cable attached to the anterolateral aspect of the thoracic spine has on spine growth in rapidly growing calves. SUMMARY OF BACKGROUND DATA:The search for a way to correct scoliosis without the use of an arthrodesis continues in an attempt to maintain normal spine mobility. Experience in the hemiepiphyseal stapling of long bones has provided a background rationale for attempting growth modulation in the spine. It is postulated that a mechanical tether to the anterior and lateral growth of the spine in a growing child with scoliosis may allow spontaneous correction of sagittal and coronal plane deformity obviating the need for an arthrodesis. METHODS:Eight calves (age, 3-4 weeks; weight, 47 +/- 4.6 kg) underwent right-side thoracotomies exposing the thoracic spine. Laterally directed anterior vertebral body screws were placed into each body and two vertebrae, either T6 and T7 or T8 and T9, were tethered with a stainless steel cable. After 12 weeks, radiographs were obtained to evaluate the degree of deformity that had developed. In addition, biomechanical testing to determine the range of motion in the tethered and untethered segments was performed. RESULTS:The calves increased their weight 153% during the 12-week postoperative period. The radiographic analysis demonstrated scoliosis of 11.6 degrees +/- 4.8 degrees in the tethered levels, as compared with 0.3 degrees +/- 1.7 degrees in the control segments (P < 0.0001). Similarly, kyphosis developed in the tethered segments (5.1 degrees +/- 5.8 degrees ), as compared with -1.8 degrees +/- 3.1 degrees at the control levels (P = 0.01). There was a significant wedging of the disc in the tethered (6.8 degrees +/- 1.6 degrees ) as compared with the untethered (0.7 degrees +/- 2 degrees ) segments (P < 0.0001). There was a trend toward lower height of the vertebrae on the tethered right side, as compared with the left side in the tethered segments (P = 0.075), whereas no side-to-side difference was noted in the control subjects (P = 0.48). Biomechanical analysis showed that the tether did not affect the range of motion in axial rotation or flexion-extension. However, the tether did restrict lateral bending as compared with that of the control subjects. When the tether was cut, the range of motion returned to levels matching that of the untethered control subjects. CONCLUSIONS:Anterolateral tethering of the spine creates kyphosis and scoliosis in this rapidly growing bovine model. The spinal tether limited motion primarily in lateral flexion. However, total lateral bending motion returned to levels comparable with control motion segments after removal of the tether. This method of spine growth modulation may provide a possible treatment for the correction of spine deformities without arthrodesis in patients who are skeletally immature. The exact mechanisms of growth modulation and the effects of tethering on disc function and integrity are unknown and deserve further study.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Newton PO,Fricka KB,Lee SS,Farnsworth CL,Cox TG,Mahar ATdoi
10.1097/00007632-200204010-00004keywords:
subject
Has Abstractpub_date
2002-04-01 00:00:00pages
689-93issue
7eissn
0362-2436issn
1528-1159pii
00007632-200204010-00004journal_volume
27pub_type
杂志文章相关文献
SPINE文献大全abstract:STUDY DESIGN:New babies with neurologic deficits resulting from intraspinal extension of congenital neuroblastoma is very unusual. Two patients with congenital dumbbell neuroblastoma with paraplegia are described, and 16 other cases are reviewed. OBJECTIVE:To study the clinical features and prognosis of congenital dum...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/00007632-199506000-00019
更新日期:1995-06-01 00:00:00
abstract:STUDY DESIGN:Clinical literature consistently identifies women as more susceptible to trauma-related neck pain, commonly resulting from soft tissue cervical spine injury. Structural gender differences may explain altered response to dynamic loading in women leading to increased soft tissue distortion and greater injury...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e318160462a
更新日期:2008-01-15 00:00:00
abstract:STUDY DESIGN:A prospective series of 15 consecutive adult patients with spinal deformity who underwent endoscopic transthoracic release with simultaneous posterior instrumentation while positioned prone. OBJECTIVES:To describe the technique and clinical results of endoscopic transthoracic release performed with the pa...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200009010-00017
更新日期:2000-09-01 00:00:00
abstract:STUDY DESIGN:This study retrospectively compares the clinical and radiologic outcomes of unilateral transforaminal lumbar interbody fusion (TLIF) with those of transvertebral screw fixation of the lumbosacral spine in high-grade spondylolisthesis. OBJECTIVE:To examine the outcome and perioperative complications of uni...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31817ecc01
更新日期:2008-08-15 00:00:00
abstract:STUDY DESIGN:Biomechanical laboratory research. OBJECTIVE:To compare 4 techniques for vertebral body insufficiency fracture repair by analyzing restoration of height, strength, and stiffness, and quantifying cement leakage. SUMMARY OF BACKGROUND DATA:Current techniques for insufficiency fracture repair, restore prefr...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000224546.29268.d1
更新日期:2006-07-01 00:00:00
abstract::Six cases of spontaneous fracture of the odontoid process in rheumatoid arthritis are presented. Fifty-one patients with atlantoaxial subluxation in rheumatoid arthritis underwent surgery between 1981 and 1990. This included six patients (in 10%) who had subluxation accompanied by fracture of the odontoid without appa...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199210001-00016
更新日期:1992-10-01 00:00:00
abstract:STUDY DESIGN:Case report and biomechanical study. OBJECTIVE:The objectives of this study were to report on a single case of a failed nucleus replacement device and to test the biomechanical properties of the failed device. SUMMARY OF BACKGROUND DATA:The use of spine arthroplasty techniques in the treatment of degener...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181dfbc78
更新日期:2010-10-15 00:00:00
abstract:STUDY DESIGN:Retrospective clinical study. OBJECTIVE:The aim of this study was to evaluate retrospectively the safety and efficacy of 1-stage surgical treatment of 45 consecutive patients, who had progressive congenital spinal deformity associated with split spinal cord malformation (SSCM). SUMMARY OF BACKGROUND DATA...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3182608988
更新日期:2012-12-01 00:00:00
abstract:STUDY DESIGN:A case report of a rare symptomatic, idiopathic, noncommunicating intradural arachnoid cyst (IAC) of the proximal part of the S1 nerve root (NR). OBJECTIVE:To discuss the possible pathophysiology, clinical and magnetic resonance imaging (MRI) presentation, intraoperative findings, and follow-up of IAC of ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181fd679a
更新日期:2011-06-15 00:00:00
abstract:STUDY DESIGN:Translation and psychometric testing. OBJECTIVE:To adapt the neck disability index (NDI) cross-culturally to Arabic language and to investigate the reliability and validity of the Arabic version of NDI in an Arabic-speaking sample with neck pain. SUMMARY OF BACKGROUND DATA:Although largely used, no previ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31828b2d09
更新日期:2013-05-01 00:00:00
abstract::The major objective of this investigation was to study the effectiveness of the physical conditioning program used at the University of Miami Comprehensive Pain and Rehabilitation Center in restoring certain elements of the functional abilities of individuals suffering from chronic low-back pain and to evaluate the ef...
journal_title:Spine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007632-199203000-00012
更新日期:1992-03-01 00:00:00
abstract:STUDY DESIGN:A retrospective multicenter study. OBJECTIVE:To investigate the relationship between the lowest instrumented, stable, and lower end vertebrae in patients with "single overhang" thoracic (main thoracic) curves treated with anterior or posterior spinal fusion. SUMMARY OF BACKGROUND DATA:Previous studies ha...
journal_title:Spine
pub_type: 杂志文章,多中心研究
doi:10.1097/01.brs.0000232799.19179.79
更新日期:2006-09-01 00:00:00
abstract::Various techniques of percutaneous lumbar disc surgery have become popular for treating lumbar disc herniations. There is a vast and increasing body of literature on this topic that consists mainly of retrospective, uncontrolled clinical studies, technical articles, and case reports. A literature analysis revealed two...
journal_title:Spine
pub_type: 杂志文章,评审
doi:
更新日期:1994-12-01 00:00:00
abstract:STUDY DESIGN:Retrospective cohort study. OBJECTIVE:The objective of our study was to evaluate the differential impact of insulin dependence on lumbar surgery outcomes, including surgical and medical complications, total length of hospital stay, nonhome bound discharge, and unplanned readmissions. SUMMARY OF BACKGROUN...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000001359
更新日期:2016-06-01 00:00:00
abstract::Biomechanical models of the spine have traditionally assumed that workplace lifting conditions (weight, posture, motion, etc.) precisely dictate the magnitude of individual muscle forces necessary to maintain a biomechanical balance within the trunk. However, because there are a large number of muscle groups within th...
journal_title:Spine
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract:STUDY DESIGN:Observational longitudinal study. OBJECTIVE:To establish the normal variation over time for active and passive cervical range of motion (ROM) measured with the Flock of Birds electromagnetic tracking system (FOB). SUMMARY OF BACKGROUND DATA:Data about normal variation of cervical ROM over time are scarce...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000155414.03723.3d
更新日期:2005-03-15 00:00:00
abstract::The relationship betewwn compensation and three variables--psychologic disturbance, organic status, and pain report characteristics--was assessed. Patients on compensation were clinically similar to patients not on compensation in the relative frequency of cases of psychologic disturbance and nonorganic findings in ea...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198207000-00010
更新日期:1982-07-01 00:00:00
abstract:STUDY DESIGN:This clinical study examined the association between pulmonary function and thoracic cage deformities in scoliosis. OBJECTIVE:To determine the factors in spinal and thoracic cage deformities that affect pulmonary function in scoliosis. SUMMARY OF BACKGROUND DATA:Pulmonary function in scoliosis has genera...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000251005.31255.25
更新日期:2007-01-01 00:00:00
abstract:STUDY DESIGN:An investigation of mechanical destabilization of the lumbar ovine intervertebral disc (IVD) inducing IVD degeneration (IVDD) as determined by multiparameter outcome measures (magnetic resonance imaging [MRI], IVD composition, biomechanical testing, gene profiling, immunohistochemistry, and immunoblotting)...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31820cd8d5
更新日期:2012-01-01 00:00:00
abstract:STUDY DESIGN:A case report of traumatic atlantooccipital dislocation (AOD) managed by intraarticular-posterior fusion from a posterior approach at the C0-C1 level with preservation of C1-C2 motion. OBJECTIVE:To present a new technique for atlantooccipital fusion with long-term follow-up. SUMMARY OF BACKGROUND DATA:Th...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181c91fa1
更新日期:2010-05-01 00:00:00
abstract:STUDY DESIGN:Retrospective 2:1 propensity score-matched analysis on a national longitudinal database between 2006 and 2010. OBJECTIVE:To compare rates of adverse events, revisions procedure rates, and payment differences in anterior cervical fusion procedures compared with posterior laminectomy and fusion procedures w...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000000872
更新日期:2015-07-01 00:00:00
abstract:STUDY DESIGN:A biomechanical study using multidirectional flexibility testing in a human cadaveric cervical spine model of a flexion-distraction injury. OBJECTIVES:To compare the immediate postoperative stabilizing effect of dynamic and rigid anterior cervical plates and to assess the confounding effects of bone miner...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000152154.57171.92
更新日期:2005-02-01 00:00:00
abstract:STUDY DESIGN:A comparative study of aggrecanases and aggrecan fragmentation profile in the human intervertebral disc at early and advanced stages of disc degeneration. OBJECTIVE:To determine differences in the content of the aggrecanases and the profile of aggrecan fragmentation in early and advanced stages of disc de...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e318158cb85
更新日期:2007-11-01 00:00:00
abstract:STUDY DESIGN:A retrospective radiographic study. OBJECTIVE:To investigate which preoperative radiographic parameters best correlate with the angulation and translation of the lowest instrumented vertebra (LIV) and global coronal balance after posterior spinal pedicle screw fixation for thoracolumbar/lumbar (TL/L) adol...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3182091fba
更新日期:2011-09-15 00:00:00
abstract:STUDY DESIGN:Thirty-five lumbar disc herniations removed at surgery were studied by indirect immunocytochemistry. OBJECTIVES:To localize immunohistochemically both sensory and autonomic nerve terminals in disc herniations. SUMMARY OF BACKGROUND DATA:Using various more or less specific histologic and histochemical met...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199606010-00004
更新日期:1996-06-01 00:00:00
abstract:STUDY DESIGN:A unique case of pseudo-aneurysm of a lumbar artery after injury of the thoracolumbar spine was presented. OBJECTIVE:To describe the exceptional occurrence of pseudo-aneurysm of a lumbar artery after flexion-distraction fracture of thoracolumbar junction and to discuss the mechanism of formation and the t...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181624b93
更新日期:2008-02-01 00:00:00
abstract:STUDY DESIGN:A family-based study. OBJECTIVE:The aim of this study was to identify rare genetic factors predisposing to Modic changes (MCs). SUMMARY OF BACKGROUND DATA:Lumbar disc degeneration (LDD) is one of the contributing factors behind low back pain (LBP). Lumbar MC visualized as bone marrow signal intensity cha...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002049
更新日期:2017-08-15 00:00:00
abstract:STUDY DESIGN:The sheep model was used to investigate the development of disc degeneration after outer anular tearing. OBJECTIVES:The authors determined whether plate fixation promotes healing of peripheral anular tears and thereby minimizes disc degeneration. SUMMARY OF BACKGROUND DATA:A limited outer anular tear (si...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199412150-00010
更新日期:1994-12-15 00:00:00
abstract:STUDY DESIGN:Posterolateral spinal fusion with allogeneic demineralized bone graft-hyaluronan putty in addition to autogenous iliac crest bone graft in a rabbit model. OBJECTIVES:To determine the potential efficacy of demineralized bone graft-hyaluronan putty as a bone graft enhancer. SUMMARY OF BACKGROUND DATA:Autog...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.BRS.0000090828.65638.8C
更新日期:2003-11-01 00:00:00
abstract:STUDY DESIGN:A prospective, nonblinded, multicenter study of outcomes in patients undergoing single-level anterior lumbar discectomy and interbody fusion with InFUSE Bone Graft. OBJECTIVE:To determine the safety and effectiveness of InFUSE Bone Graft applied to an absorbable collagen sponge in anterior lumbar interbod...
journal_title:Spine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/00007632-200211010-00015
更新日期:2002-11-01 00:00:00