当前位置： SCI文献检索 > THROMBOSIS AND HAEMOSTASIS期刊下所有文献 > Prediction of pulmonary embolism extent by clinical findings, D-dimer level and deep vein thrombosis shown by ultrasound.

Prediction of pulmonary embolism extent by clinical findings, D-dimer level and deep vein thrombosis shown by ultrasound.

Abstract：

:Pulmonary embolism (PE) may encompass a wide spectrum of severity. To determine whether clinical findings, D-dimer (DD) concentration, and deep vein thrombosis (DVT) shown by lower-limb venous compression ultrasonography (US) might predict the scintigraphic extent of PE, we studied 104 hemodynamically stable consecutive outpatients with acute PE diagnosed by a high-probability ventilation-perfusion lung scan. Scintigraphic extent of PE was classified into three categories: perfusion defects corresponding to <30%, 30-50%, or >50% of the total lung area. Median respiratory and heart rates were found to be significantly related to the extent of PE. Higher median alveolar-arterial oxygen difference values were observed as the proportion of lung perfusion defects increased (>50% vs. <30%, 6.3 vs. 3.6 kPa, P <.0001). Median plasma DD concentration was 7950 microg/L in patients with >50% perfusion defects compared to 2731 microg/L in those with <30% defects (P = .0001). DD levels above 4000 microg/L were associated to more extensive perfusion defects (>50% vs. <30% defects, OR 30; 95% CI 5.8-155). Finally, a proximal DVT was more likely among patients with larger perfusion defects (>50% vs. <30% defects, OR 4.5; 95% CI 1.5-13.6). In conclusion, clinical signs such as tachypnea and tachycardia, alveolar-arterial oxygen difference, plasma DD concentration, and presence of DVT on US are predictors of a larger PE, as assessed by the extent of perfusion defects on high probability lung scans.

journal_name

Thromb Haemost

journal_title

Thrombosis and haemostasis

authors

Galle C,Papazyan JP,Miron MJ,Slosman D,Bounameaux H,Perrier A

keywords:

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

1156-60

issue

5

eissn

0340-6245

issn

2567-689X

pii

01111156

journal_volume

86

pub_type

杂志文章

相关文献

THROMBOSIS AND HAEMOSTASIS文献大全
  • Homozygous Pro74-->Arg mutation in the platelet glycoprotein Ibbeta gene associated with Bernard-Soulier syndrome.

    abstract：:Bernard-Soulier syndrome (BSS) is an autosomal recessive bleeding disorder due to quantitative or qualitative abnormalities in the glycoprotein (GP) Ib/IX/V complex, the platelet receptor for von Willebrand factor. This complex is composed of four subunits, GPIbalpha, GPIbbeta, GPIX and GPV. We describe here the genet...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Kunishima S,Tomiyama Y,Honda S,Fukunishi M,Hara J,Inoue C,Kamiya T,Saito H

    更新日期：2000-07-01 00:00:00

  • The fast inhibitor of tissue plasminogen activator in plasma during pregnancy.

    abstract：:The novel fast inhibitor to tissue plasminogen activator in plasma has been determined in 20 healthy non-pregnant women, 48 apparently healthy pregnant women and 136 women with risk pregnancies (preeclampsia, suspected fetal growth retardation, thrombosis or previous history of thrombosis, diabetes and others). In hea...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Wiman B,Csemiczky G,Marsk L,Robbe H

    更新日期：1984-10-31 00:00:00

  • Increased plasma levels of plasminogen activator inhibitor-1 and soluble vascular cell adhesion molecule after triacylglycerol infusion in man.

    abstract：:Increased plasma plasminogen activator inhibitor-1 (PAI-1) has been implicated in the development of vascular disease. In type 2 diabetes mellitus high PAI-1 levels are associated with increased plasma concentrations of free fatty acids (FFA) and triacylglycerol indicating an association or a causal relationship. To a...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1160/TH03-07-0457

    authors： Krebs M,Geiger M,Polak K,Vales A,Schmetterer L,Wagner OF,Waldhäusl W,Binder BR,Roden M

    更新日期：2003-09-01 00:00:00

  • Interlaboratory oral anticoagulant quality assessment by the Netherlands Federation of Thrombosis Services.

    abstract：:The 50 laboratories of the Netherlands Federation of Thrombosis Services, covering a population of 9 million and responsible for the laboratory control of approximately 150,000 patients under oral anticoagulation, have participated since 1974 in a voluntary external and internal quality control program. The external p...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： van Dijk-Wierda CA,Hermans J,Loeliger EA,Roos J

    更新日期：1977-06-30 00:00:00

  • Continuous infusion of recombinant factor VIIa for surgery in patients with deficiency of factor VII.

    abstract：:The administration of recombinant activated factor VII (rFVIIa) by continuous infusion has provided a safe and convenient alternative to bolus injections in haemophiliacs with inhibitors, but it has only been reported in a single case with congenital factor VII (FVII) deficiency. The results of 12 consecutive surgical...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1160/TH05-05-0342

    authors： Schulman S,Tjønnfjord GE,Wallensten R,Martinowitz U,Kenet G

    更新日期：2005-12-01 00:00:00

  • The conformational basis of thrombosis.

    abstract：:Antithrombin readily undergoes a spontaneous transition from its active five-stranded form to a six-stranded inactive latent form. The recognition of this change in plasma has been obscured by the immediate linkage of newly formed latent antithrombin to a molecule of active antithrombin to give a dimer with an electro...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：

    authors： Carrell RW,Huntington JA,Mushunje A,Zhou A

    更新日期：2001-07-01 00:00:00

  • Pre- and postoperative state of coagulation and fibrinolysis in plasma of patients with benign and malignant colorectal disease--a preliminary study.

    abstract：:This study was carried out in order to compare the coagulation balance in patients with colorectal cancer before and after surgical removal of tumor with an age matched non-malignancy control group. Furthermore, it was studied whether preoperative coagulation state in cancer patients was correlated to the postoperativ...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章

    doi：

    authors： Iversen LH,Okholm M,Thorlacius-Ussing O

    更新日期：1996-10-01 00:00:00

  • Human carotid artery smooth muscle cells rarely express alpha(v)beta3 integrin at sites of recent plaque rupture.

    abstract：:Fibrin(ogen) is the major matrix ligand for beta3 integrins. If alpha(v)beta3 is the major receptor for fibrin(ogen) on intimal smooth muscle cells, we might expect to see this integrin associated with fibrin(ogen). Eighty-four specimens obtained from endarterectomies of 14 patients were studied. Fibrin was frequently...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Ikari Y,Yee KO,Hatsukami TS,Schwartz SM

    更新日期：2000-08-01 00:00:00

  • Thrombin activatable fibrinolysis inhibitor and its fibrinolytic effect in normal pregnancy.

    abstract：:We investigated changes in both thrombin activatable fibrinolysis inhibitor (TAFI) antigen levels and its functional effect on in vitro fibrinolysis in normal pregnancy. 152 pregnant women and 31 women in the immediate postpartum period were studied, with pregnancy divided into 6 windows at 4 weekly intervals. As TAFI...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH04-06-0387

    authors： Mousa HA,Downey C,Alfirevic Z,Toh CH

    更新日期：2004-11-01 00:00:00

  • Localization and translocation of MMP-2 during aggregation of human platelets.

    abstract：:We have previously shown that human platelets express matrix metalloproteinase-2 (MMP-2) and that the release of this enzyme during platelet activation mediates the ADP- and thromboxane-independent part of aggregation. We have now used immunogold electron microscopy, flow cytometry. Western blot analysis and zymograph...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Sawicki G,Sanders EJ,Salas E,Wozniak M,Rodrigo J,Radomski MW

    更新日期：1998-11-01 00:00:00

  • A comparative study of the effects of adrenoceptor antagonists on platelet aggregation and thromboxane generation.

    abstract：:Platelet aggregation and thromboxane A2 have been implicated in the pathogenesis of several forms of vascular disease. The aim of this study was to determine the effect of a wide range of adrenoceptor antagonists on platelet aggregation, and thromboxane A2 production, from normal human platelet rich plasma in vitro. L...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Greer IA,Walker JJ,McLaren M,Calder AA,Forbes CD

    更新日期：1985-08-30 00:00:00

  • New coagulation factor V gene polymorphisms define a single and infrequent haplotype underlying the factor V Leiden mutation in Mediterranean populations and Indians.

    abstract：:Two novel polymorphisms were identified in the factor V gene by direct sequencing of intronic areas. One of them, located in intron 9, is the marker closest to the Leiden mutation ever described, whereas the other, in intron 16, displays a rare allele invariantly associated to the mutation. Allele-specific amplificati...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Castoldi E,Lunghi B,Mingozzi F,Ioannou P,Marchetti G,Bernardi F

    更新日期：1997-09-01 00:00:00

  • Mice deficient in tissue factor demonstrate attenuated intimal hyperplasia in response to vascular injury and decreased smooth muscle cell migration.

    abstract：:Tissue factor (TF) is the primary initiator of the coagulation cascade and is thought to play a key role in the generation of arterial thrombosis. Recent studies have suggested that TF mediates inflammatory processes in the arterial wall and may be an important regulator of intimal hyperplasia. We have employed geneti...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH04-02-0122

    authors： Pyo RT,Sato Y,Mackman N,Taubman MB

    更新日期：2004-09-01 00:00:00

  • Protean clinical presentation of antiphospholipid-protein antibodies (APA).

    abstract：:Antiphospholipid-protein antibodies (APA) are a family of immunoglobulins which have been defined by varying laboratory test systems. Lupus anticoagulants (LA) and anticardiolipin antibodies (ACA) are the two most prominent members of this family of antibodies. LA are detected utilizing various phospholipid (PL) depen...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：

    authors： Triplett DA

    更新日期：1995-07-01 00:00:00

  • Procoagulant activity and cytokine expression in whole blood cultures from patients with atherosclerosis supplemented with omega-3 fatty acids.

    abstract：:Omega-3 fatty acids (n-3 FA) may reduce atherogenesis and thrombosis. We investigated the effects of n-3 FAs on procoagulant activity and cytokine expression in whole blood cultures from patients with atherosclerosis. Eleven of the 23 included patients had received 5.1 g n-3 FA daily for 6 months (group I) whereas 12 ...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Seljeflot I,Johansen O,Arnesen H,Eggesbø JB,Westvik AB,Kierulf P

    更新日期：1999-04-01 00:00:00

  • Elevated D-dimer level is an independent risk factor for cardiovascular death in out-patients with symptoms compatible with heart failure.

    abstract：:D-dimer, a marker of fibrin turnover, exhibits many interesting properties as a biological marker of thrombosis. Some of the properties of D-dimer might also be used to provide additional information about patients with heart failure. In this study, we evaluate the prognostic information acquired from D-dimer concerni...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH04-05-0278

    authors： Alehagen U,Dahlström U,Lindahl TL

    更新日期：2004-12-01 00:00:00

  • The HR2 haplotype of factor V: effects on factor V levels, normalized activated protein C sensitivity ratios and the risk of venous thrombosis.

    abstract：:We studied the HR2 haplotype of the factor V gene in a case-control study for venous thrombosis including 474 patients with a first deep-vein thrombosis and 474 age- and sex-matched healthy controls (Leiden Thrombophilia Study, LETS). We investigated both the original His1299Arg (A4070G) polymorphism and the Met385Thr...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： de Visser MC,Guasch JF,Kamphuisen PW,Vos HL,Rosendaal FR,Bertina RM

    更新日期：2000-04-01 00:00:00

  • Gain-of-function variant p.Pro2555Arg of von Willebrand factor increases aggregate size through altering stem dynamics.

    abstract：:The multimeric plasma glycoprotein von Willebrand factor (VWF) is best known for recruiting platelets to sites of injury during primary hemostasis. Generally, mutations in the VWF gene lead to loss of hemostatic activity and thus the bleeding disorder von Willebrand Disease. By employing cone and platelet aggregometry...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1055/a-1344-4405

    authors： Huck V,Chen PC,Xu ER,Tischer A,Klemm U,Aponte-Santamaría C,Mess C,Obser T,Kutzki F,König G,Denis C,Gräter F,Wilmanns M,Auton M,Schneider SW,Schneppenheim R,Hennig J,Brehm MA

    更新日期：2020-12-31 00:00:00

  • Effects of cigarette smoking on the ultrastructure of rat thoracic aorta and its ability to produce prostacyclin.

    abstract：:Following exposure of rats to graded doses of fresh cigarette smoke, the aortic endothelium examined by scanning electron microscopy regularly showed alterations. These essentially consisted of areas of blebbing and microvillus-like projections from the luminal surface, and the presence in the majority of cases, of mi...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Pittilo RM,Mackie IJ,Rowles PM,Machin SJ,Woolf N

    更新日期：1982-10-29 00:00:00

  • Interactive Effects of a Combination of the HDAC3 and HDAC9 Genes with Diabetes Mellitus on the Risk of Ischemic Stroke.

    abstract：BACKGROUND AND AIM: Previous studies indicated that the HDAC3 and HDAC9 genes play critical roles in atherosclerosis and ischemic stroke (IS). The purpose of this study was to investigate the association of combined single-nucleotide polymorphisms in the HDAC3 and HDAC9 genes with the susceptibility to IS. METHODS: A ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1055/s-0040-1717116

    authors： Chiou HY,Bai CH,Lien LM,Hu CJ,Jeng JS,Tang SC,Lin HJ,Hsieh YC

    更新日期：2020-09-22 00:00:00

  • Kinetics of the inhibition of tissue factor-factor VIIa by tissue factor pathway inhibitor.

    abstract：:Tissue factor-factor VIIa catalysed activation of factor IX is inhibited by the complex of tissue factor pathway inhibitor (TFPI) and factor Xa. At present, no information is available as to what extent the kinetics of complex formation between TFPI and factor Xa during factor X activation contribute to the overall ra...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Lindhout T,Franssen J,Willems G

    更新日期：1995-09-01 00:00:00

  • Expression and functional characterisation of natural R147W and K150del variants of protein C in the Chinese population.

    abstract：:Protein C is a vitamin K-dependent serine protease zymogen in plasma which upon activation to activated protein C (APC) by thrombin down-regulates the clotting cascade by limited proteolysis of the procoagulant cofactors Va and VIIIa. In addition to its anticoagulant activity, APC also exhibits potent cytoprotective a...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH12-10-0760

    authors： Ding Q,Yang L,Hassanian SM,Rezaie AR

    更新日期：2013-04-01 00:00:00

  • Effect of stabilizing versus destabilizing interactions on plasminogen activator inhibitor-1.

    abstract：:Plasminogen activator inhibitor-1 (PAI-1) is a unique member of the serpin family, as it spontaneously converts into a latent conformation. However, the exact mechanism of this conversion is not known. Previous studies reported that neutralizing monoclonal antibodies as well as reversal or removal of charges on the s3...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Vleugels N,Leys J,Knockaert I,Declerck PJ

    更新日期：2000-11-01 00:00:00

  • Effect of altitude on thrombopoietin and the platelet count in healthy volunteers.

    abstract：:Although there is evidence that altitude increases the platelet count, its effect on the platelet precursor stimulating factor, thrombopoietin (TPO), is unclear. Unlike erythropoietin, TPO appears largely unresponsive to exogenous signals. In a study in 16 healthy volunteers, we report the effects of altitude exposure...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH04-02-0086

    authors： Hartmann S,Krafft A,Huch R,Breymann C

    更新日期：2005-01-01 00:00:00

  • Cultured human mesangial cells produce both type 1 and type 2 plasminogen activator inhibitors.

    abstract：:Cultured human mesangial cells (HMC) derived from normal kidneys have been shown to synthesize tissue-type plasminogen activator (t-PA) and excess amounts of PA inhibitor type 1 (PAI-1). Conflicting results have been obtained concerning the production of urokinase-type PA (u-PA) and efforts to show PA inhibitor 2 (PAI...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Colucci M,Gesualdo L,Montemurro P,Cavallo LG,Conese M,Mascolo E,Ranieri E,Di Paolo S,Schena FP,Semeraro N

    更新日期：1995-12-01 00:00:00

  • Thirty-three novel mutations in the protein C gene. French INSERM network on molecular abnormalities responsible for protein C and protein S.

    abstract：:We analyzed the protein C gene (PROC) with the denaturing gradient gel electrophoresis (DGGE) scanning strategy in a series of 129 patients with suspected protein C (PC) deficiency (93 with low plasma PC levels and 36 with borderline level). At least one sequence variation was found in 104 of the 129 patients. Thirty-...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Alhenc-Gelas M,Gandrille S,Aubry ML,Aiach M

    更新日期：2000-01-01 00:00:00

  • Red blood cell distribution width is associated with poor clinical outcome in acute cerebral infarction.

    abstract：:Increased red blood cell distribution width (RDW), which is a marker of anisocytosis, is associated with mortality and cardiovascular events in the general population and in patients with heart failure or coronary heart disease. We investigated whether RDW in acute cerebral infarction is predictive of functional outco...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH12-03-0165

    authors： Kim J,Kim YD,Song TJ,Park JH,Lee HS,Nam CM,Nam HS,Heo JH

    更新日期：2012-08-01 00:00:00

  • Desmoteplase in acute massive pulmonary thromboembolism.

    abstract：:Alteplase is standard therapy for patients with acute, massive pulmonary embolism. The novel plasminogen activator desmoteplase displays high fibrin specificity and selectivity for fibrinbound plasminogen. In a preclinical model desmoteplase was twice as potent with a shorter lysis time and lower reocclusion rate. We ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：

    authors： Tebbe U,Bramlage P,Graf A,Lechleitner P,Bode C,Riess FC,Clemens N,Al-Rawi Y,Konstantinides S,Goldhaber SZ

    更新日期：2009-03-01 00:00:00

  • Linking Complement Activation, Coagulation, and Neutrophils in Transplant-Associated Thrombotic Microangiopathy.

    abstract：:Transplant-associated thrombotic microangiopathy (TA-TMA) is a severe and life-threatening complication of hematopoietic cell transplantation (HCT) that often coincides with graft-versus-host-disease (GVHD). Although endothelial damage seems to be the common denominator for both disorders, the role of complement syste...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1055/s-0039-1692721

    authors： Gavriilaki E,Chrysanthopoulou A,Sakellari I,Batsis I,Mallouri D,Touloumenidou T,Papalexandri A,Mitsios A,Arampatzioglou A,Ritis K,Brodsky RA,Mitroulis I,Anagnostopoulos A

    更新日期：2019-09-01 00:00:00

  • Reliability of a single beta-thromboglobulin measurement in a diabetic population: importance of PGE1 in anticoagulant mixture. Damad Study Group.

    abstract：:During the collection of samples for plasma beta-thromboglobulin (beta-TG) determination, it is well established that artificially high values can be observed due to in-vitro release. To estimate the reliability of a single beta-TG measurement, blood samples were collected simultaneously from both arms on two separate...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Scarabin PY,Strain L,Ludlam CA,Jones J,Kohner EM

    更新日期：1987-04-07 00:00:00