In vivo assessment of human visual system connectivity with transcranial electrical stimulation during functional magnetic resonance imaging.

Abstract:

:Functional magnetic resonance imaging (fMRI) was used to investigate local and distant cerebral activation induced by transcranial electrical stimulation in order to noninvasively map functional connectivity in the human visual system. Stimulation with lateromedially directed currents and the anode 4.5 cm dorsally to the inion over the right visual cortex induced phosphenes extending into the contralateral lower quadrant of the visual field. fMRI showed a focal hemodynamic response underneath the anode in extrastriate cortex and distant coactivation in subcortical (lateral geniculate nucleus), cortical visual (striate and extrastriate), and visuomotor areas (frontal and supplementary eye fields). This pattern of activation resembles a network of presumably interconnected visual and visuomotor areas. Analysis of activation sites supplies new information about cerebral correlates of phosphenes and shows that the cortical region underneath the cranial stimulation site is not necessarily the origin of behavioral and/or perceptual effects of transcranial stimulation. We conclude that combining transcranial electrical stimulation of neural tissue with simultaneous fMRI offers the possibility to study noninvasively cerebral connectivity in the human brain.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Brandt SA,Brocke J,Röricht S,Ploner CJ,Villringer A,Meyer BU

doi

10.1006/nimg.2001.0847

keywords:

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

366-75

issue

2

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(01)90847-X

journal_volume

14

pub_type

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