Abstract:
BACKGROUND:The aim of this prospective, randomized, double-blind study was to evaluate the effects of adding 1 microg/kg clonidine to 20 ml of ropivacaine 0.75% for axillary brachial plexus anesthesia. METHODS:With Ethical Committee approval and written consent, 30 ASA physical status I-II in-patients, undergoing upper extremity orthopedic procedures were randomly allocated to receive axillary brachial plexus block with 20 ml of 0.75% ropivacaine alone (group ropivacaine, n = 15) or 0.75% ropivacaine + 1 microg/kg clonidine (group ropivacaine-clonidine, n = 15). Nerve blocks were placed using a nerve stimulator with the multiple injection technique (stimulation frequency was 2 Hz; stimulation intensity was decreased to < or = 0.5 mA after each muscular twitch; the anesthetic volume was equally divided among arm flexion, arm extension, wrist flexion, and thumb adduction). A blinded observer recorded the time required to achieve surgical block [loss of pinprick sensation in the innervation areas of the hand (C6-C8) with concomitant inability to move the wrist and hand] and first analgesic request. RESULTS:No differences in demography, degree of sedation, peripheral oxygen saturation, and hemodynamic variables were observed between the two groups. Readiness for surgery required 15 min (5-36 min) with 0.75% ropivacaine and 20 min (5-30 min) with the ropivacaine-clonidine mixture. The degree of pain measured at first analgesic request, and consumption of postoperative analgesics were similar in the two groups; while first postoperative analgesic request occurred after 13.8 h (25th-75th percentiles: 9.1-13 h) in the ropivacaine group and 15.2 h (25th-75th percentiles: 10.7-16 h) in the ropivacaine-clonidine group (p = 0.04). CONCLUSIONS:Adding 1 microg/kg clonidine to 20 ml of ropivacaine 0.75% for axillary brachial plexus anesthesia provided a 3 h delay in first analgesic request postoperatively, without clinically relevant effects on the degree of sedation and cardiovascular homeostasis.
journal_name
Minerva Anestesioljournal_title
Minerva anestesiologicaauthors
Casati A,Magistris L,Beccaria P,Cappelleri G,Aldegheri G,Fanelli Gkeywords:
subject
Has Abstractpub_date
2001-05-01 00:00:00pages
407-12issue
5eissn
0375-9393issn
1827-1596journal_volume
67pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:The aim of this study was to investigate the value of serial quantitative (QC) and non-quantitative (NQC) endotracheal aspirate (ETA) surveillance cultures in predicting the causative pathogen of ventilator associated pneumonia (VAP) in patients receiving antibiotic therapy and the factors associated with th...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
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更新日期:2010-08-01 00:00:00
abstract::Cervical vertebral dislocations and fractures require the complete immobility of the neck until an intervention of stabilization of the spinal cord, by surgery or external means, is performed. Endotracheal intubation, which might represent a harmful operation, can become difficult when the stabilization of the spinal ...
journal_title:Minerva anestesiologica
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abstract::Intravenous administration of 400-600 mg/day potassium canrenoate normalised plasma osmolarity and permitted rapid re-establishment of the metabolic picture in 9/12 patients with hyperosmolarity admitted to a resuscitation department for complex physiopathological pictures. The soundness of the drug in this sense is a...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
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更新日期:1979-09-01 00:00:00
abstract::Worldwide about 1 in 1000 adults every year has a sudden cardiac arrest in out-of-hospital. That means 350,000-400,000 persons in the USA alone, 60,000 persons in Italy. Over 70% of times sudden cardiac arrest occurs at home, the remaining 30% in public settings. The chain of survival concept emphasizes four links ass...
journal_title:Minerva anestesiologica
pub_type: 杂志文章,评审
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更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:The aim was to investigate whether tramadol had toxic effect on cerebral neurons and/or spinal cord neurons when it was administered into the cerebrospinal fluid. Due to lipid peroxidation (LPO) and myeloperoxidation (MPO) levels are not specific predictors of neuronal damage, these biochemical markers of ti...
journal_title:Minerva anestesiologica
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
abstract::Regional anaesthesia is useful in day surgery when properly applied. Most commonly used techniques are IVRA, axillary block, local/infiltration plus monitored anaesthesia care. Spinal anaesthesia is also frequently used in DS. Depending on the technique used RA may fasten or prolong discharge when compared to general ...
journal_title:Minerva anestesiologica
pub_type: 杂志文章,评审
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abstract::The swine-origin influenza A (H1N1) virus was responsible for the pandemic infection in 2009. We report a case of encephalitis diagnosed as the H1N1 virus infection in a young child. The H1N1 virus infection can be causative of the encephalitis, as with other influenza virus infections. For patients presenting with in...
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pub_type: 杂志文章
doi:10.23736/S0375-9393.19.13307-X
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abstract:: ...
journal_title:Minerva anestesiologica
pub_type: 评论,信件
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journal_title:Minerva anestesiologica
pub_type: 评论,社论
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pub_type: 杂志文章,已发布勘误
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更新日期:2020-06-01 00:00:00
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journal_title:Minerva anestesiologica
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2015-04-01 00:00:00
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journal_title:Minerva anestesiologica
pub_type: 杂志文章,评审
doi:
更新日期:1999-03-01 00:00:00
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journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
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journal_title:Minerva anestesiologica
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2012-04-01 00:00:00
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journal_title:Minerva anestesiologica
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doi:10.23736/S0375-9393.19.13470-0
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journal_title:Minerva anestesiologica
pub_type: 杂志文章,评审
doi:
更新日期:2000-05-01 00:00:00
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journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:Although esophageal pressure measurement could help clinicians to improve the ventilatory management of acute respiratory distress syndrome (ARDS) patients, it has been mainly used in clinical research. Aim of this study was to compare the measurements of end-expiratory esophageal pressure, end-expiratory tr...
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doi:10.23736/S0375-9393.20.14458-4
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journal_title:Minerva anestesiologica
pub_type: 杂志文章,评审
doi:10.23736/S0375-9393.19.13597-3
更新日期:2019-02-01 00:00:00
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journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
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journal_title:Minerva anestesiologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2000-03-01 00:00:00
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journal_title:Minerva anestesiologica
pub_type: 杂志文章,评审
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更新日期:2006-04-01 00:00:00
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journal_title:Minerva anestesiologica
pub_type: 临床试验,杂志文章
doi:
更新日期:2000-01-01 00:00:00
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journal_title:Minerva anestesiologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1981-05-01 00:00:00
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journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:2007-05-01 00:00:00
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journal_title:Minerva anestesiologica
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:Combined epidural/general anaesthesia might theoretically emphasise the cardiovascular effects of epidural block alone. The goal of the present investigation was to evaluate the incidence of both hypotension and bradycardia during integrated epidural/general anaesthesia in a multicentric, observational study...
journal_title:Minerva anestesiologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1998-07-01 00:00:00
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journal_title:Minerva anestesiologica
pub_type: 临床试验,杂志文章
doi:
更新日期:2000-04-01 00:00:00