Clinical significance of microvessel density in multiple myeloma patients.

Abstract:

:To investigate the role of angiogenesis in multiple myeloma (MM), bone marrow biopsy from 75 adults with newly diagnosed, untreated MM were evaluated. Microvessels were scored in at least 3 areas ( x 200 fields) of the highest microvessel density in representative sections of each bone marrow specimen using immunohistochemistry for CD34. Prognostic variables were also evaluated for the overall survival. Microvessel counts were significantly higher in patients with MM (n=69.42+/-9.67), compared with control (n=26.81+/-2.85). Microvessel density had a weak correlation with percentage of bone marrow plasma cells. By univariate analysis, age, beta2-microglobulin, serum albumin, serum creatinine, serum calcium, hemoglobin, platelet count, and bone marrow plasma cell percentage were correlated with survival. By multivariate analysis, age, serum albumin, serum creatinine, hemoglobin, platelet count and bone marrow plasma cell percentage were correlated with overall survival, whereas microvessel density was not. In summary, microvessel density in bone marrow of MM is significantly increased compared to control, but was not correlated with overall survival. Further studies regarding angiogeneic molecules are needed to determine the functional role of angiogenesis in MM.

journal_name

J Korean Med Sci

authors

Ahn MJ,Park CK,Choi JH,Lee WM,Lee YY,Choi IY,Kim IS,Lee WS,Ki M

doi

10.3346/jkms.2001.16.1.45

keywords:

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

45-50

issue

1

eissn

1011-8934

issn

1598-6357

journal_volume

16

pub_type

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