Perioperative development of a thrombogenic risk profile in patients with carcinomas of the breast: a cause of increased thrombosis.

Abstract:

:Within the context of a prospective study we investigated the influence of malignant and benign breast disease on the coagulation systems both prior to and after surgery. In addition we also investigated to what extent individual risk factors aid the formation of a thrombophiliac risk profile. Altogether 50 patients with carcinomas of the breast and 12 patients with benign breast disease were included in the study. The coagulation investigations took place prior to surgery and on the 1st, 3rd, 7th and 10th day following the operation. The results have already revealed that prior to surgery a clear activation of the haemostasis takes place among patients with a carcinoma of the breast. When compared to patients with benign breast conditions there was a far greater plasma level of factor VIII vWF, fibrinogen, thrombin-antithrombin III complex, D-dimer fibrin degradation products, tissue-type plasminogen activator and the activity and the antigen of plasminogen activator inhibitor 1. Also during the postoperative period the malignant tumour was a stimulus for additional increased activity of blood coagulation and fibrinolysis. Individual risk factors such as age, menopausal status, obesity and smoking lead to a thrombogenic risk profile which could provide a possible explanation for the observed increased incidence of thrombosis in breast cancer patients. For the clinical work there is a need for intensive pre- and postoperative monitoring in the cases of patients with malignant tumours including angiological examinations, intensive physiotherapy and a risk-adapted prophylactic anticoagulation.

journal_name

Eur J Gynaecol Oncol

authors

Oberhoff C,Rollwagen C,Tauchert AM,Hoffmann O,Winkler UH,Schindler AE

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

560-8

issue

6

eissn

0392-2936

issn

2709-0086

journal_volume

21

pub_type

杂志文章
  • The impact of pretreatment staging laparotomy on survival in locally advanced cervical carcinoma.

    abstract::The purpose of this retrospective study was to determine the effect of pretreatment surgical staging on survival of patients with locally advanced cervical carcinoma. Two hundred and seventy-four women with cervical cancer stages IIB-IVA treated with primary radiotherapy comprised the study group. Eighty-nine patients...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Holcomb K,Abulafia O,Matthews RP,Gabbur N,Lee YC,Buhl A

    更新日期:1999-01-01 00:00:00

  • A study of placental umbilical cord whole blood transfusion in 72 patients with anemia and emaciation in the background of cancer.

    abstract::In the under-resourced world, transfusion to advanced oncological patients involves two major problems, i.e., (a) transfusion transmitted disease, and (b) infrastructural deficiency. Many hospitals cannot cope with the specialized requirements of immunocompromised cancer victims, for instance, leucoreduction, selectiv...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Bhattacharya N

    更新日期:2006-01-01 00:00:00

  • Prognostic value of matrix metalloproteinase-9 (gelatinase-B) expression in epithelial ovarian tumors.

    abstract:PURPOSE OF INVESTIGATION:To determine the expression of matrix metalloproteinase-9 (MMP-9) expression in malignant and borderline ovarian tumors and its correlation to prognosis. METHODS:Forty-five patients with primary epithelial ovarian tumors were enrolled in this retrospective study from 1988 to 2002. Only maligna...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Ozalp S,Tanir HM,Yalcin OT,Kabukcuoglu S,Oner U,Uray M

    更新日期:2003-01-01 00:00:00

  • Diagnostic value of thrombocytosis and high CA 125 level in women with adnexal masses.

    abstract:AIM:The aim of this study was to determine the diagnostic value of thrombocytosis and high CA 125 levels in women with benign and malign adnexal masses. Thrombocytosis (platelet counts > 400 x 10(9)/l) has been identified as a poor prognostic factor in many cancers including certain gynecologic malignant tumors such as...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Atacag T

    更新日期:2012-01-01 00:00:00

  • Hormonal and surgical treatment of endometrial adenocarcinoma.

    abstract::From January 1st 1980 up to December 31st 1986, 93 endometrial adenocarcinomas were treated at the Chair B of the Institute of Gynecology and Obstetrics. Full anatomopathological and hormonal data are available for 81 cases on whom diagnostic and therapeutic protocols were applied. In this selected group, positive lym...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章,评审

    doi:

    authors: D'Addato F,Lanza A,Re A,Valli M,Raspollini M,Caldarola B,Allone T,Proserpio D,Ferraris G

    更新日期:1988-01-01 00:00:00

  • Concurrent cytogenetic and molecular investigations in uterine and ovarian neoplasms.

    abstract::We studied a group of 24 uterine and ovarian neoplasms with the purpose to verify if any correlation could be established between chromosomal abnormalities, loss of heterozigosity (LOH) and microsatellite instability (MIN). Tumor specimens obtained from 24 women (12 affected by ovarian and 12 by uterine neoplasms) wer...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Minelli A,Capra E,Dellavecchia C,Danesino C,Olivieri C,Tateo S,Tenti P,Scappaticci S

    更新日期:1998-01-01 00:00:00

  • The sentinel node biopsy in patients with breast cancer; many controversies remain.

    abstract::The sentinel node procedure has increasingly been used as a diagnostic tool for staging breast cancer. Although many institutes have embraced this procedure, many issues concerning the indications and the technique itself remain unsolved. In this review, several aspects regarding these controversies are discussed from...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Van Rijk MC,Nieweg OE,Oldenburg HS,Rutgers EJ,Kroon BB

    更新日期:2006-01-01 00:00:00

  • Uterine tumors resembling ovarian sex cord tumors: a case report with adenomyosis and complex hyperplasia with atypia.

    abstract::Uterine tumors resembling ovarian sex cord tumors (UTROSCTs) are very rare uterine neoplasms. They mostly behave in a benign fashion but cases were reported with extra-uterine spread. There are less than 50 cases reported in the literature so far according to the present authors' knowledge. We report a case of 45-year...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Tatar B,Yalcin Y,Kursat Bozkurt K,Erdemoglu E,Kapucuoglu N,Erdemoglu E

    更新日期:2016-01-01 00:00:00

  • LDH and LDH isoenzymes in ovarian dysgerminoma.

    abstract::Lactic Dehydrogenase (LDH) serum levels were evaluated in three patients with ovarian dysgerminoma and LDH isoenzymes only in one of them. LDH serum levels were elevated at diagnosis and normal after therapy in all the patients; remained low in two patients in remission, increased in one at the moment of progression. ...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Levato F,Martinello R,Campobasso C,Porto S

    更新日期:1995-01-01 00:00:00

  • Synchronous primary neoplasms of the uterine corpus and the ovary: a case report.

    abstract:OBJECTIVE:To determine the frequency of synchronous primary neoplasia of the ovaries in patients with primary malignant neoplasia of the uterus, and to analyze the clinical and histological characteristics of these cases. MATERIALS AND METHODS:Clinicopathological data from a series of patients treated for primary mali...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Dragoumis K,Zafrakas M,Venizelos I,Kellartzis D,Mikos T,Assimakopoulos E,Bontis J

    更新日期:2004-01-01 00:00:00

  • Specific downregulation of death-associated protein kinase enhances Fas-mediated apoptosis in the human differentiated endometrial adenocarcinoma cell line, HHUA.

    abstract:PURPOSE OF INVESTIGATION:Death-associated protein kinase (DAPK) is a serine/threonine kinase that is well-known as a positive mediator of Fas-mediated apoptosis. Previous reports have shown that DAPK and Fas are expressed in human endometrial adenocarcinoma cells. In this study, we examined the effects of specific down...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Tanaka T,Bai T,Yukawa K

    更新日期:2011-01-01 00:00:00

  • Endometrial carcinoma. Clinical and pathological correlations with survival and surgical treatment.

    abstract::From 1978 to 1985 a total of 151 patients were treated for endometrial carcinoma. Of these, 25 patients underwent extrafascial abdominal hysterectomy and pelvic lymphadenectomy, 25 were treated according to Wertheim procedure and pelvic lymphadenectomy and 32 underwent intrafascial abdominal hysterectomy; 62 women und...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Scotto V,Cirese E,Segatore M,Di Gianfrancesco E,Mazzon I,Crisci G,Miceli E,Masci P,Guidi ML,Sbiroli C

    更新日期:1988-01-01 00:00:00

  • Neoadjuvant chemotherapy in gynecological cancers.

    abstract::Neoadjuvant chemotherapy in gynecological cancers is an approach that is shown to have positive effects on survival. It increases the rate of resectability in ovarian and cervical cancers and thus contributes to survival. However, there are studies reporting that despite increasing operability, the approach does not m...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Ayhan A,Celik H,Dursun P,Salman MC,Yuce K

    更新日期:2006-01-01 00:00:00

  • Peritoneal cytology in patients with stage IB cervical cancer undergoing radical hysterectomy: limited value.

    abstract::Peritoneal cytology, obtained at the start of planned radical hysterectomy in 200 consecutive patients with Stage IB cervical cancer, none of whom had intra-abdominal extension of disease, was positive in only one patient; this patient received no adjuvant treatment and remains disease-free at 48 months. Routine perit...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Patsner B

    更新日期:1992-01-01 00:00:00

  • Hormones and risk of breast cancer.

    abstract::This paper reports the results of a study of 50 menopausal women receiving hormonal replacement therapy. The majority (29) had surgical menopause; their mean age was 45.7 years. It was hypothesized that progestins could equilibrate the effects of the estrogenic stimulation on the mammary and endometrial target tissu...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Onnis A,Marchetti M,Graziottin A

    更新日期:1983-01-01 00:00:00

  • Ovary-preserving tumorectomy for immature teratoma in an adolescent--case report.

    abstract::The authors present a case of a 14-year-old premenarchal girl with a large solid tumor of the left ovary. The rim of normal ovarian tissue was visible around the tumor on ultrasonography scan. Although the levels of two tumor markers, LDH and CA125, were elevated, the authors performed an organ-sparing tumorectomy. Th...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Djukic M,Stankovic Z,Vasiljevic M,Vranes B,Savic D,Djuricic S

    更新日期:2014-01-01 00:00:00

  • Prognostic significance of DNA topoisomerase II-alpha (Ki-S1) immunoexpression in endometrial carcinoma.

    abstract:OBJECTIVE:In order to determine the significance of proliferative activity (PA) in endometrial carcinomas, we analysed the expression of cell cycle-related antigens in routinely processed tissue. MATERIALS AND METHODS:Serial sections of 113 endometrial carcinoma specimens were immunostained with the monoclonal antibod...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Bildrici K,Tel N,Ozalp SS,Yalcin OT,Yilmaz V

    更新日期:2002-01-01 00:00:00

  • Complete remission of recurrent and refractory ovarian cancers using weekly administration of bevacizumab and gemcitabine/oxaliplatin: report of two cases.

    abstract:BACKGROUND:A combination therapy with gemcitabine and oxaliplatin (GEMOX) yielded a moderate activity in platinum-resistant ovarian cancers; however, frequent severe toxicities, such as thrombocytopenia and neurotoxicity, were observed. A certain modification of schedule might therefore facilitate the clinical applicat...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Takano M,Ikeda Y,Kudoh K,Kita T,Sasaki N,Kikuchi Y

    更新日期:2013-01-01 00:00:00

  • Teratomas of the ovary: a clinico-pathological evaluation of 87 patients from one institution during a 10-year period.

    abstract:AIM:To present the classification and diagnostic problems encountered between teratomas and other ovarian tumors as well as with other benign entities diagnosed and treated in our institution. METHODS:We analysed retrospectively the clinical and pathological characteristics of 87 teratomas examined in our hospital dur...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Papadias K,Kairi-Vassilatou E,Kontogiani-Katsaros K,Argeitis J,Kondis-Pafitis A,Greatsas G

    更新日期:2005-01-01 00:00:00

  • Descriptive epidemiology of endometrial hyperplasia in patients with abnormal uterine bleeding.

    abstract:PURPOSE OF INVESTIGATION:To evaluate the prevalence and epidemiologic characteristics of endometrial hyperplasias in women with abnormal uterine bleeding. METHODS:We performed a retrospective analysis on data gained from 294 patients with histologically documented endometrial hyperplasia (with or without atypia), dete...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Anastasiadis PG,Skaphida PG,Koutlaki NG,Galazios GC,Tsikouras PN,Liberis VA

    更新日期:2000-01-01 00:00:00

  • Accuracy of endometrial biopsy with the Cornier pipelle for diagnosis of endometrial cancer and atypical hyperplasia.

    abstract:OBJECTIVE:To establish the accuracy of endometrial biopsy with the Cornier pipelle in the diagnosis of endometrial cancer and atypical endometrial hyperplasia in our milieu. MATERIAL AND METHOD:We reviewed 1,535 anatomopathologic reports on endometrial biopsies taken from outpatients using the Cornier pipelle between ...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Machado F,Moreno J,Carazo M,León J,Fiol G,Serna R

    更新日期:2003-01-01 00:00:00

  • Lymphscintigraphies of the internal mammary ganglion chain: our experience.

    abstract::In this study we have evaluated 301 internal mammary lymphoscintigraphies. The results were compared with the histology of internal mammary lymphoscintigraphies, lymphatic chain and axillary lymph nodes, with the anatomo-pathological stage of the disease, with primary tumor site, and also with patients survival. The i...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Del Castillo RA,Kuschnir E,Figueras S,Ferreyra R

    更新日期:1986-01-01 00:00:00

  • Prolonged stabilization of progressive platinum-refractory ovarian cancer with paclitaxel: brief report.

    abstract::Platinum-based chemotherapy is the standard treatment for ovarian cancer, with response rates of 70-80% and pathologic complete remissions of 20-25%. Salvage therapy with paclitaxel has an established role in patients with platinum-refractory ovarian cancer. In non-randomized trials, high doses have tended to be more ...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Balat O,Kudelka AP,Tunca JC,Edwards CL,Verschraegen C,Kavanagh JJ

    更新日期:1996-01-01 00:00:00

  • Prevalence and types of cervical human papillomavirus among Turkish women and its relationship with demographic factors in a gynecology outpatient clinic.

    abstract:PURPOSE OF INVESTIGATION:The purpose of this study was to determine the prevalence of various human papillomavirus (HPV) types and its relationship with some risk factors among Turkish women. MATERIALS AND METHODS:A total of 673 patients were included in the study. Cervical samples were taken from the patients for rou...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Tunç SY,Onan MA,Turp AB,Kuşvuran ED,Fidan I,Güner H

    更新日期:2016-01-01 00:00:00

  • Sertoli-Leydig cell tumor of the ovary: a clinicopathologic study of 10 cases.

    abstract::Ten patients with Sertoli-Leydig cell tumors of the ovary treated consecutively were analyzed retrospectively for clinicopathological characteristics, treatment modalities and survival. All patients were subjected to a surgical procedure including unilateral salpingoophorectomy (USO) in 5, total abdominal hysterectomy...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Ayhan A,Tuncer ZS,Hakverdi AU,Yüce K,Ayhan A

    更新日期:1996-01-01 00:00:00

  • Female adnexal tumor of probable wolffian origin: clinicopathological, immunohistochemical and cytofluorimetric analyses of a 22-year-old virgin. case report.

    abstract::The term female adnexal tumor of probable Wolffian origin "FATWO" designs this tumor wich arises by the rare persisting remnants of the mesonephric duct (Wolffian duct). About 40 cases have been reported in literature. Few cases of recurrence have been reported, FATWO usually shows no signs of hormonal activity. We re...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Balbi GC,Del Piano L,Labriola D,Visconti S,Monteverde A,Passaro M,Monaco R,Cardone A,Rossiello R,Panariello S,Montone L

    更新日期:2006-01-01 00:00:00

  • An apparently benign vulvar mass: possibly a rare malignancy.

    abstract:BACKGROUND:Vulvar dermatofibrosarcoma is a rare fibrous tumor of intermediate grade malignancy, with a tendency for local recurrence, and rarely metastasizes. Management should be multidisciplinary. This is a report of an apparently benign vulvar mass with delayed diagnosis of vulvar dermatofibrosarcoma. CASE REPORT:A...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Messalli EM,D'Aponte ML,Luise R,Rossiello L,Rotondi M,De Franciscis P

    更新日期:2012-01-01 00:00:00

  • Association of EBV and HPV co-infection with the development of cervical cancer in ethnic Uyghur women.

    abstract:OBJECTIVE:Study on the role of Epstein-Barr virus (EBV) and human papillomavirus (HPV) infection in the development of cervical cancer. MATERIALS AND METHODS:We collected 178 cases of cervical tissue specimens of Uyghur women with cervicitis, cervical intraepithelial neoplasia (CIN I, CIN II-III), and cervical squamou...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Abudoukadeer A,Niyazi M,Aikula A,Kamilijian M,Sulaiman X,Mutailipu A,Abudula A

    更新日期:2015-01-01 00:00:00

  • Laparoscopic surgery and port-site metastases: routine measurements to reduce the risk.

    abstract::More and more malignancies are identified by laparoscopy. Concerns have been risen about the safety of these procedures, especially after the publications on trocar metastases. General laparoscopic techniques should include safety measures in order to reduce the risk of implantation metastasis. ...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Tjalma WA

    更新日期:2003-01-01 00:00:00

  • Possible ways of helping terminal patients.

    abstract::By interview with several women a dramatic problem for the doctors: how to give doomed patients something more than mere medical help. ...

    journal_title:European journal of gynaecological oncology

    pub_type: 杂志文章

    doi:

    authors: Maggioni C,Benzi G,Belloni C,Mangili G,Candiani GB

    更新日期:1984-01-01 00:00:00