Abstract:
OBJECTIVE:Inflammation is a frequent histological finding in prostate biopsies, performed on men without prostatic malignancy or clinical prostatitis. We investigated the relationship between morphological parameters of inflammation in prostatic tissue and total serum prostate-specific antigen (PSA) and prostate-specific antigen density (PSAD) levels to determine if subclinical inflammation can cause elevation of PSA and PSAD. METHODS:We reviewed 268 prostate biopsies, performed on 238 men with elevated PSA and/or abnormal digital rectal examination of the prostate. All premalignant and malignant biopsies and cases of clinical prostatitis were excluded. The inflammation in the remaining 145 prostate biopsies was scored for extent of inflammation and aggressiveness of inflammation, using the four-point scale designed by Irani and co-workers. In this prostatic inflammation scoring system, extent of inflammation is graded from 0 up to 3 according to the degree of invasion of inflammatory cells in prostatic tissue. Aggressiveness of inflammation is graded from 0 up to 3 according to the degree of contact or disruption of prostatic glandular epithelium by inflammatory cells. RESULTS:Each of the studied biopsies showed inflammatory cells. Median PSA levels in grades 1, 2 and 3 of extent of inflammation were, respectively, 5.7, 6.8 and 13. 0. Median PSAD levels in these groups were 0.13, 0.16 and 0.33. There was no significant difference between these grades for PSA nor for PSAD. Median PSA levels in grades 0, 1 and 2 of aggressiveness of inflammation were, respectively, 3.9, 5.9 and 8.9. Median PSAD levels in these groups were 0.12, 0.18 and 0.17. For both parameters, there was a significant difference between grades (respectively, p = 0.0028 and p = 0.0330). CONCLUSION:Inflammation of the prostate is a histological finding in almost every set of prostate biopsies, even when there are no signs of clinical prostatitis. This subclinical inflammation can cause PSA elevation. Not the extent of inflammation is of importance, but the disruption of epithelial integrity caused by the inflammatory infiltrate. When confronted with a patient with an elevated PSA level whose prostate biopsies reveal no malignancy but only inflammation, this concept can help in determining the need for quick repeat biopsies.
journal_name
Eur Uroljournal_title
European urologyauthors
Schatteman PH,Hoekx L,Wyndaele JJ,Jeuris W,Van Marck Edoi
10.1159/000020161keywords:
subject
Has Abstractpub_date
2000-04-01 00:00:00pages
404-12issue
4eissn
0302-2838issn
1873-7560pii
20161journal_volume
37pub_type
杂志文章相关文献
EUROPEAN UROLOGY文献大全abstract:UNLABELLED:The response of non-muscle-invasive bladder cancer (NMIBC) to intravesical immunotherapy with bacillus Calmette-Guérin (BCG) depends on adequate stimulation of an immune response. Although BCG has been used for decades, we lack tools to accurately predict response in individual patients. To address this defi...
journal_title:European urology
pub_type: 临床试验,杂志文章
doi:10.1016/j.eururo.2015.06.023
更新日期:2016-02-01 00:00:00
abstract::The quite uncommon case of a girl with two kidneys drained by one single pelvis and one ureter is reported and a review of the literature is presented. ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000473343
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVES:To evaluate serum levels of the carboxy-terminal propeptide of type I procollagen (PICP) and the pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen (ICTP) as possible markers of bone metastases in patients with prostate carcinoma (PCA) patients. METHODS:Levels of PICP and ICTP were me...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000474454
更新日期:1997-01-01 00:00:00
abstract::Over several decades, in vitro experimental studies have demonstrated that retinoids effect the process of carcinogenesis and tend towards the alteration of cells back to more normal differentiation. This hypothesis has formed the basis of several chemopreventive studies in breast cancer, cervical cancer, head and nec...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1159/000019874
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Currently two pretreatment prognostic models with limited accuracy (65-67%) can be used to predict survival in patients with localized renal cell carcinoma (RCC). OBJECTIVE:We set out to develop a more accurate pretreatment model for predicting RCC-specific mortality after nephrectomy for all stages of RCC....
journal_title:European urology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.eururo.2008.07.037
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Laparoscopic cryoablation (LCA) and percutaneous cryoablation (PCA) of small renal masses have gained popularity, but only limited data exist on the complication rates. OBJECTIVES:In this study, we report on postoperative complications associated with LCA and PCA in a single tertiary center experience. DES...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2010.03.035
更新日期:2010-07-01 00:00:00
abstract::Patients diagnosed with locally progressive prostate cancer can be divided into three groups according to the stage of their disease. The first group includes patients with locally progressive cancer presenting initially as either T3 or T4; the second group involves individuals treated curatively who then develop loca...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1159/000474555
更新日期:1997-01-01 00:00:00
abstract:CONTEXT:Nocturia is a common urologic symptom that has been covered in a variety of reported studies in the literature but is not specifically covered in current guidelines. OBJECTIVE:To comprehensively review the literature pertaining to the definition, etiologies, and consequences of nocturia and assess the evidence...
journal_title:European urology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.eururo.2012.07.004
更新日期:2012-11-01 00:00:00
abstract:CONTEXT:Because pelvic lymph node (LN)-positive prostate cancer (PCa) is generally considered a regionally metastatic disease, surgery needs to be better defined. OBJECTIVE:To review the impact of radical prostatectomy (RP) and pelvic lymph node dissection (PLND), possibly in conjunction with a multimodal approach usi...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1016/j.eururo.2013.05.033
更新日期:2014-08-01 00:00:00
abstract::The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial randomized men to usual care or annual prostate-specific antigen (PSA) screening for 6 yr and digital rectal examination for 4 yr. This trial found no difference between the intervention and usual care arms of the study in the primary end point ...
journal_title:European urology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.eururo.2016.01.009
更新日期:2016-07-01 00:00:00
abstract::Prenatal ultrasound has set the stage for new trends in the diagnosis and treatment of many urinary tract malformations, in particular duplication of the renal collecting system with ureterocele. The authors have reviewed their experience with 41 ureteroceles in 7 years. The 36 patients were divided into two groups: t...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000471568
更新日期:1989-01-01 00:00:00
abstract::A new technique for fashioning an ileocecal pouch, applicable for both bladder augmentation and continent urinary diversion, is described. A low pressure reservoir is achieved by antimesenteric longitudinal transsection of ileum and cecum and formation of a pouch from the cecum and two ileal loops. The antireflux proc...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000472481
更新日期:1985-01-01 00:00:00
abstract:CONTEXT:There have been substantial changes in the management of men with metastatic hormone-sensitive prostate cancer (mHSPC) over the past 5 yr, with upfront combination therapies replacing androgen-deprivation therapy (ADT) alone. A range of therapies have entered the space with no clear answer regarding their compa...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1016/j.eururo.2019.09.004
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:The conventional Fuhrman grading system, which categorizes renal cell carcinoma (RCC) with grades I, II, III, and IV, is the most widely used predictor assessment of RCC cancer-specific mortality (CSM). OBJECTIVES:The aim of this study was to test the prognostic ability of simplified Fuhrman grading schemes...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2009.06.008
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Robot-assisted thrombectomy (RAT) for inferior vena cava (IVC) thrombus (RAT-IVCT) is being increasingly reported. However, the techniques and indications for robot-assisted cavectomy (RAC) for IVC thrombus are not well described. OBJECTIVE:To develop a decision-making program and analyze multi-institutiona...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2020.03.020
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the effect of long-term sitting on serum prostate-specific antigen (PSA) levels. METHOD:The serum PSA levels of 50 bus drivers under the age of 45 (mean 37.7) years who worked at least 8 h a day for more than 3 weeks were compared with those of 50 healthy surgeons in sim...
journal_title:European urology
pub_type: 临床试验,杂志文章
doi:10.1159/000020021
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVES:To compare the results of laparoscopic ureteral reimplantation with a previous series of open surgery. MATERIALS AND METHODS:We compared ten patients who underwent laparoscopic vesicopsoas-hitch with (n=4) or without Boari-flap (n=6) technique for ureteral obstructions with ten patients treated by open uret...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2006.08.004
更新日期:2007-02-01 00:00:00
abstract::Although a single ectopic ureter opening into the vagina has frequently been reported in literature, lateralized lumbar pain during sexual intercourse and urinary incontinence after pregnancy due to a single ectopic ureter are uncommon. The etiology and pathogenesis are unknown but some clinical, pathological and embr...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000473017
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVES:Children with neurogenic hyper-reflexive bladder in whom classical therapy with anticholinergic drugs and intermittent catheterization fails are threatened by high intravesical pressure, vesicoureteral reflux, and impairment of kidney function. Surgery, such as bladder augmentation, is often necessary in suc...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/s0302-2838(03)00136-2
更新日期:2003-07-01 00:00:00
abstract:CONTEXT:Use of electronic cigarettes (ECs) is on the rise in most high-income countries. Smoking conventional cigarettes is a known risk factor for urologic malignancy incidence, progression, and mortality, as well as for other urologic health indicators. The potential impact of EC use on urologic health is therefore o...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1016/j.eururo.2016.12.022
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the prognostic role of tumour size in pathological stage T3a renal cell carcinoma (RCC) with fat invasion only and to assess whether this subgroup maintains its relevance over the other pathological stages. METHODS:We retrospectively studied 2113 patients from eight international institutions who...
journal_title:European urology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.eururo.2007.01.106
更新日期:2007-07-01 00:00:00
abstract::Prostatic abscess is a rare but severe disease. Conventional therapy is transurethral resection of the prostatic abscess. Since the advent of transrectal ultrasound (TRUS) a minimal-invasive treatment of prostatic abscess by TRUS-guided perineal drainage under local anesthesia is available. We report on our experience...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000475074
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the technical feasibility, oncological efficacy and intraoperative and postoperative morbidity of laparoscopic radical prostatectomy. METHOD:We describe an original technique of laparoscopic radical prostatectomy performed in 40 patients between 26th January and 12th October, 1998. RESULTS:Radic...
journal_title:European urology
pub_type: 临床试验,杂志文章
doi:10.1159/000019921
更新日期:1999-01-01 00:00:00
abstract::Bladder disorders are important among the various complications of diabetes, both because of their frequency and the severe involvements they can cause to the urinary tract and ultimately to the renal function. Because they are often mild, especially in the first stage, bladder disorders call for early detection and f...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000473221
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:The contact surface area (CSA) of a tumor with adjacent renal parenchyma may determine the complexity and thus the perioperative outcomes of partial nephrectomy (PN). OBJECTIVE:We devised a novel imaging parameter, renal tumor CSA, and correlate it with perioperative outcomes in patients undergoing PN. DES...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2014.03.010
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Open partial nephrectomy (OPN) remains the gold standard for treatment of small renal masses (SRMs). Laparoscopic cryoablation (LCA) has provided encouraging outcomes. Robotic partial nephrectomy (RPN) represents a new promising option but is still under evaluation. OBJECTIVE:Compare the outcomes of RPN and...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2012.01.007
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:This study was undertaken to investigate whether hypermethylation in p16(INK4a) gene promoter could serve as plasma biomarker of bladder cancer. METHODS AND PATIENTS:We examined the p16(INK4a) status using methylation-specific PCR in 86 cancer patients and 49 controls (31 healthy people and 18 patients with ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/s0302-2838(02)00468-2
更新日期:2002-12-01 00:00:00
abstract::Ten cases of prostatic epithelial polyps of the prostatic urethra are reported. The ages of the patients were from 27 to 69 years, with a mean of 44 years. The most common clinical signs were gross hematuria, microhematuria, hematospermia, and dysuria. All specimens, obtained by transurethral resection, had a papillar...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000471544
更新日期:1989-01-01 00:00:00
abstract::A consecutive series of 29 patients (33 pelviureteric units) with urographic signs of altered passage through the pelviureteric junction underwent diuresis renography performed by means of an intravenous injection of 99mTc-diethylenetriamine pentaacetic acid/kg body weight followed by intravenous administration of fru...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000472543
更新日期:1985-01-01 00:00:00
abstract::We report on a case of renal oncocytoma (proximal tubular adenoma) with typical vascular architecture. The vascular supply of the oncocytoma showed a 'spoke-wheel'-like pattern. The typical angiographic features may help to differentiate oncocytomas from hypernephromas and thus diagnose it as such in the preoperative ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000474093
更新日期:1983-01-01 00:00:00