Retinoids in chemoprevention.

Abstract:

:Over several decades, in vitro experimental studies have demonstrated that retinoids effect the process of carcinogenesis and tend towards the alteration of cells back to more normal differentiation. This hypothesis has formed the basis of several chemopreventive studies in breast cancer, cervical cancer, head and neck cancer and lung cancer. Experimental evidence exists to suggest that chemoprevention with retinoids may well have a beneficial effect in patients at high risk of acquiring prostate cancer. None of the studies, however, in any of the cancers have yet been definitive, but opportunities exist with newer retinoids that appear to be able to be given on a long-term basis with minimal toxic side effects, to explore this exciting potential treatment pathway.

journal_name

Eur Urol

journal_title

European urology

authors

Whelan P

doi

10.1159/000019874

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

424-8

issue

5-6

eissn

0302-2838

issn

1873-7560

pii

19874

journal_volume

35

pub_type

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