Genomic analysis of human and mouse TCL1 loci reveals a complex of tightly clustered genes.

abstract：:Within the trimeric HIV-1 envelope (Env) spike, the first and second variable loops (V1V2 region) and the third variable loop (V3) of the gp120 subunit play dual roles in antibody recognition, because they contain neutralization epitopes and also participate in epitope masking. The spatial relationships between V1V2 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu L,Cimbro R,Lusso P,Berger EA

更新日期：2011-12-13 00:00:00

abstract：:Experiments reported here show that some UV-irradiated wild-type T7 phage markers can be rescued efficiently by coinfection with T7 amber mutant phage in a permissive host. Other results show that the segments of a UV-irradiated genome that replicate efficiently are those that also are rescued efficiently during a mar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burck KB,Miller RC Jr

更新日期：1978-12-01 00:00:00

abstract：:Unrestrained 53BP1 activity at DNA double-strand breaks (DSBs) hampers DNA end resection and upsets DSB repair pathway choice. RNF169 acts as a molecular rheostat to limit 53BP1 deposition at DSBs, but how this fine balance translates to DSB repair control remains undefined. In striking contrast to 53BP1, ChIP analyse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： An L,Dong C,Li J,Chen J,Yuan J,Huang J,Chan KM,Yu CH,Huen MSY

更新日期：2018-08-28 00:00:00

abstract：:Disulfide bonds have only rarely been found in intracellular proteins. That pattern is consistent with the chemically reducing environment inside the cells of well-studied organisms. However, recent experiments and new calculations based on genomic data of archaea provide striking contradictions to this pattern. Our r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mallick P,Boutz DR,Eisenberg D,Yeates TO

更新日期：2002-07-23 00:00:00

abstract：:Mutant, but not wild-type p53 binds with high affinity to a variety of MAR-DNA elements (MARs), suggesting that MAR-binding of mutant p53 relates to the dominant-oncogenic activities proposed for mutant p53. MARs recognized by mutant p53 share AT richness and contain variations of an AATATATTT "DNA-unwinding motif," w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Will K,Warnecke G,Wiesmüller L,Deppert W

更新日期：1998-11-10 00:00:00

abstract：:Inadequate resolution is the principal limitation of radiocarbon dating. However, recent work has shown that exact-year precision is attainable if use can be made of past increases in atmospheric radiocarbon concentration or so-called Miyake events. Here, this nascent method is applied to an archaeological site of pre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuitems M,Panin A,Scifo A,Arzhantseva I,Kononov Y,Doeve P,Neocleous A,Dee M

更新日期：2020-06-23 00:00:00

abstract：:We have established a transformation system for Dictyostelium discoideum. The transformation vector contains the protein coding region of the Tn5 neomycin resistance gene fused to the proposed promoter of the Dictyostelium actin 8 gene; the vector also contains a sequence that acts as an autonomously replicating seque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirth KP,Edwards CA,Firtel RA

更新日期：1982-12-01 00:00:00

abstract：:August-Copenhagen-Irish (ACI) rats are unique in that the ovary-intact females develop high incidence of mammary cancers induced solely by hormones upon prolonged exposure to high levels of estrogen alone. Studies have also shown that such prolonged exposure to high-dose estrogen results in human-like aneuploid mammar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blank EW,Wong PY,Lakshmanaswamy R,Guzman R,Nandi S

更新日期：2008-03-04 00:00:00

abstract：:The objective of the present study was to make use of efficient molecular marker systems to reveal genetic relationships in traditional and evolved Basmati (EB) and semidwarf non-Basmati (NB) rice varieties. A subset of three rice groups was analyzed by using 19 simple sequence repeat (SSR) loci and 12 inter-SSR-PCR p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagaraju J,Kathirvel M,Kumar RR,Siddiq EA,Hasnain SE

更新日期：2002-04-30 00:00:00

abstract：:Previous studies have provided evidence that IL-15 expression within human tumors is crucial for optimal antitumor responses; however, the regulation of IL-15 within the tumor microenvironment (TME) is unclear. We report herein, in analyses of mice implanted with various tumor cell lines, soluble IL-15/IL-15Rα complex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santana Carrero RM,Beceren-Braun F,Rivas SC,Hegde SM,Gangadharan A,Plote D,Pham G,Anthony SM,Schluns KS

更新日期：2019-01-08 00:00:00

abstract：:Among yeasts that underwent whole-genome duplication (WGD), Kluyveromyces polysporus represents the lineage most distant from Saccharomyces cerevisiae. By sequencing the K. polysporus genome and comparing it with the S. cerevisiae genome using a likelihood model of gene loss, we show that these species diverged very s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scannell DR,Frank AC,Conant GC,Byrne KP,Woolfit M,Wolfe KH

更新日期：2007-05-15 00:00:00

abstract：:We have developed an approach for deriving and characterizing antigen-receptor (CD3/Ti) signal-transduction mutants. This strategy combines receptor-mediated growth inhibition and fluorescence-activated cell sorting with the Ca2+-indicator indo-1. Despite the expression of structurally normal CD3/Ti complexes, one suc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldsmith MA,Weiss A

更新日期：1987-10-01 00:00:00

abstract：:Cyclotides are plant defense peptides that have been extensively investigated for pharmaceutical and agricultural applications, but key details of their posttranslational biosynthesis have remained elusive. Asparaginyl endopeptidases are crucial in the final stage of the head-to-tail cyclization reaction, but the enzy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rehm FBH,Jackson MA,De Geyter E,Yap K,Gilding EK,Durek T,Craik DJ

更新日期：2019-04-16 00:00:00

abstract：:We describe a single autoregulatory cassette that allows reversible induction of transgene expression in response to tetracycline (tet). This cassette contains all of the necessary components previously described by others on two separate plasmids that are introduced sequentially over a period of months [Gossen, M. & ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hofmann A,Nolan GP,Blau HM

更新日期：1996-05-28 00:00:00

abstract：:By using the maximum likelihood method, we made a genome-wide comparison of the evolutionary rates in the lineages leading to the laboratory strain (S288c) and a wild strain (YJM789) of Saccharomyces cerevisiae and found that genes in the laboratory strain tend to evolve faster than in the wild strain. The pattern of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gu Z,David L,Petrov D,Jones T,Davis RW,Steinmetz LM

更新日期：2005-01-25 00:00:00

abstract：:A genetic analysis is necessary to gain a greater understanding of the complex developmental processes in mammals. Toward this end, an insertional transgenic mouse mutant has been isolated that results in abnormal germ-cell development. This recessive mutation manifests as infertility in both males and females and is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pellas TC,Ramachandran B,Duncan M,Pan SS,Marone M,Chada K

更新日期：1991-10-01 00:00:00

abstract：:We present the sequence of full-length chicken triosephosphate isomerase (D-glyceraldehyde 3-phosphate ketol-isomerase, EC 5.3.1.1) mRNA based on the analysis of cDNA and genomic clones. To isolate cDNA clones encoding the enzyme, we screened a muscle cDNA library with radioactively labeled cDNA made from RNA that had...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Straus D,Gilbert W

更新日期：1985-04-01 00:00:00

abstract：:The severe cooling and the expansion of the ice sheets during the Last Glacial Maximum (LGM), 27,000-19,000 y ago (27-19 ky ago) had a major impact on plant and animal populations, including humans. Changes in human population size and range have affected our genetic evolution, and recent modeling efforts have reaffir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tallavaara M,Luoto M,Korhonen N,Järvinen H,Seppä H

更新日期：2015-07-07 00:00:00

abstract：:Habitat loss and disease are main drivers of global amphibian declines, yet the interaction between them remains largely unexplored. Here we show that paradoxically, habitat loss is negatively associated with occurrence, prevalence, and infection intensity of the chytrid fungus Batrachochytrium dendrobatidis (Bd) in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becker CG,Zamudio KR

更新日期：2011-06-14 00:00:00

abstract：:Rapid North Atlantic cooling events during the last deglaciation caused atmospheric reorganizations on global and regional scales. Their impact on Asian climate has been investigated for monsoonal domains, but remains largely unknown in westerly wind-dominated semiarid regions. Here we generate a dust record from sout...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Safaierad R,Mohtadi M,Zolitschka B,Yokoyama Y,Vogt C,Schefuß E

更新日期：2020-08-04 00:00:00

abstract：:Chemoresistance of cisplatin therapy is related to extensive repair of cisplatin-modified DNA in the nucleus by the nucleotide excision repair (NER). Delivering cisplatin to the mitochondria to attack mitochondrial genome lacking NER machinery can lead to a rationally designed therapy for metastatic, chemoresistant ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marrache S,Pathak RK,Dhar S

更新日期：2014-07-22 00:00:00

abstract：:Midbrain dopamine neurons play central roles in reward processing. It is widely assumed that all dopamine neurons encode the same information. Some evidence, however, suggests functional differences between subgroups of dopamine neurons, particularly with respect to processing nonrewarding, aversive stimuli. To direct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brischoux F,Chakraborty S,Brierley DI,Ungless MA

更新日期：2009-03-24 00:00:00

abstract：:Cytoskeletal filaments assemble into dense parallel, antiparallel, or disordered networks, providing a complex environment for active cargo transport and positioning by molecular motors. The interplay between the network architecture and intrinsic motor properties clearly affects transport properties but remains poorl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richard M,Blanch-Mercader C,Ennomani H,Cao W,De La Cruz EM,Joanny JF,Jülicher F,Blanchoin L,Martin P

更新日期：2019-07-23 00:00:00

abstract：:The complete nucleotide sequences of the cDNAs encoding the heavy- and light-chain variable regions (VH and VL) of myeloma protein W3129, an anti-alpha(1----6)-dextran with a unique combining site, have been determined. The VH region is encoded by a germ-line gene highly homologous to VH441, which also appears to be u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Borden P,Kabat EA

更新日期：1987-04-01 00:00:00

abstract：:Oxidative stress is a ubiquitous threat to all aerobic organisms and has been implicated in numerous pathological conditions such as cancer. Here we demonstrate a pivotal role for E2F1, a cell cycle regulatory transcription factor, in cell tolerance of oxidative stress. Cells lacking E2F1 are hypersensitive to oxidati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graves JD,Lee YJ,Liu K,Li G,Lin FT,Lin WC

更新日期：2020-06-30 00:00:00

abstract：:The bactericidal effects of antibiotics are undoubtedly triggered by target-specific interactions, but there is growing evidence that an important aspect of cytotoxicity results from treatment-induced metabolic perturbations. In this study, we characterized molecular mechanisms whereby trimethoprim treatment results i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giroux X,Su WL,Bredeche MF,Matic I

更新日期：2017-10-24 00:00:00

abstract：:We demonstrate here that yeast killer viruses, previously thought to be transmitted only by cytoplasmic mixing during division, mating, or other induced forms of cell fusion, are capable of extracellular transmission. Viral particles from standard K1 and K2 killer strains were used to inoculate sensitive cells of Sacc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： el-Sherbeini M,Bostian KA

更新日期：1987-06-01 00:00:00

abstract：:We performed label-free observation of molecular dynamics in apoptotic cells by Raman microscopy. Dynamic changes in cytochrome c distribution at the Raman band of 750 cm(-1) were observed after adding an apoptosis inducer to the cells. The comparison of mitochondria fluorescence images and Raman images of cytochrome ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okada M,Smith NI,Palonpon AF,Endo H,Kawata S,Sodeoka M,Fujita K

更新日期：2012-01-03 00:00:00

abstract：:A 6.2-kb full-length clone encoding a distinct protein-tyrosine phosphatase (PTP; EC 3.1.3.48), PTPD1, was isolated from a human skeletal muscle cDNA library. The cDNA encodes a protein of 1174 amino acids with N-terminal sequence homology to the ezrin-band 4.1-merlin-radixin protein family, which also includes the tw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Møller NP,Møller KB,Lammers R,Kharitonenkov A,Sures I,Ullrich A

更新日期：1994-08-02 00:00:00

abstract：:The advent of molecular tension probes for real-time mapping of piconewton forces in living systems has had a major impact on mechanobiology. For example, DNA-based tension probes have revealed roles for mechanics in platelet, B cell, T cell, and fibroblast function. Nonetheless, imaging short-lived forces transmitted...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma R,Kellner AV,Ma VP,Su H,Deal BR,Brockman JM,Salaita K

更新日期：2019-08-20 00:00:00