Abstract：
BACKGROUND:A simple and safe method for controlled ablation of esophageal mucosa is not currently available. Therefore, an endoscopic cryotherapy device was developed and its efficacy and safety were assessed in a swine model. METHODS:The device consists of a cryogenic system that delivers cold nitrogen gas via a catheter introduced into the esophagus through the accessory channel of an upper GI endoscope. Esophagoscopy was performed in 20 swine under conscious sedation, and cold nitrogen gas was sprayed on the distal 2 to 3 cm of the esophagus under direct visualization. RESULTS:Freezing of the esophageal mucosa was evidenced by the appearance of a white "cryoburn" with sharply demarcated margins. Hemicircumferential to circumferential freezing of the distal esophagus was achieved in 20 swine by varying the duration of cryoburn from 10 to 60 seconds. Mucosal ablation was noted 2 to 7 days after treatment in 95% of the swine. Complications included 3 esophageal strictures and 1 aspiration pneumonia. CONCLUSIONS:Cryotherapy performed by spraying liquid nitrogen at upper GI endoscopy is a simple technique capable of inducing controlled superficial mucosal necrosis with complete healing in the esophagus. This method warrants further evaluation as a treatment for esophageal lesions including Barrett's esophagus.
journal_name
Gastrointest Endoscjournal_title
Gastrointestinal endoscopyauthors
Johnston CM,Schoenfeld LP,Mysore JV,Dubois Adoi
10.1016/s0016-5107(99)70352-4keywords:
subject
Has Abstractpub_date
1999-07-01 00:00:00pages
86-92issue
1eissn
0016-5107issn
1097-6779pii
S0016-5107(99)70352-4journal_volume
50pub_type
杂志文章abstract：:To investigate the value of 50 mg of topical lidocaine spray in upper gastrointestinal endoscopy, a randomized double-blind placebo-controlled study was undertaken with 50 mg of lidocaine spray as the active treatment. All patients were sedated with diazepam after administration of the spray. Included in the study wer...
journal_title：Gastrointestinal endoscopy
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1993-05-01 00:00:00
abstract：BACKGROUND/AIMS:Intraductal US (IDUS) is an examination of the bile duct by using a thin-caliber ultrasonic probe, yielding real-time, high-quality cross-sectional images. We prospectively evaluated the feasibility and safety of IDUS-directed stone removal without radiocontrast cholangiography (RC) in naïve patients wi...
journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
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journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/s0016-5107(94)70254-3
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pub_type： 杂志文章,随机对照试验
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journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章,多中心研究
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abstract：BACKGROUND:The hemostatic efficacy of mechanical methods of hemostasis, together with epinephrine injection, was compared with that of epinephrine injection alone in bleeding peptic ulcer. METHODS:Ninety patients with a peptic ulcer with active bleeding or a non-bleeding visible vessel were randomly assigned to underg...
journal_title：Gastrointestinal endoscopy
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Gastrointestinal endoscopy
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journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/j.gie.2010.05.029
更新日期：2010-09-01 00:00:00
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journal_title：Gastrointestinal endoscopy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0016-5107(99)70003-9
更新日期：1999-03-01 00:00:00
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journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/j.gie.2010.10.044
更新日期：2011-02-01 00:00:00
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journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/j.gie.2012.02.025
更新日期：2012-06-01 00:00:00
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journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1067/mge.2003.137
更新日期：2003-04-01 00:00:00
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journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
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更新日期：2017-04-01 00:00:00
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journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/s0016-5107(02)70046-1
更新日期：2002-09-01 00:00:00
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journal_title：Gastrointestinal endoscopy
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
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journal_title：Gastrointestinal endoscopy
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journal_title：Gastrointestinal endoscopy
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journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
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更新日期：2020-05-01 00:00:00
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journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/j.gie.2008.08.043
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journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/s0016-5107(95)70013-7
更新日期：1995-12-01 00:00:00
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journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/s0016-5107(03)70038-8
更新日期：2003-06-01 00:00:00
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journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/s0016-5107(96)70158-x
更新日期：1996-09-01 00:00:00
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journal_title：Gastrointestinal endoscopy
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journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章,评审
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journal_title：Gastrointestinal endoscopy
pub_type： 杂志文章
doi：10.1016/s0016-5107(80)73301-1
更新日期：1980-11-01 00:00:00
abstract：BACKGROUND:No objective measure of the level of sedation is universally accepted. However, bispectral index monitoring is currently used to objectively measure sedation levels in several clinical settings. This study compares the temporal relationship of bispectral index levels versus the Observer's Assessment of Alert...
journal_title：Gastrointestinal endoscopy
pub_type： 临床试验,杂志文章
doi：10.1067/mge.2000.107284
更新日期：2000-08-01 00:00:00
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journal_title：Gastrointestinal endoscopy
pub_type： 临床试验,杂志文章
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