Abstract:
BACKGROUND:Recent studies highlight the role of duodenal bulb biopsy in the diagnosis of celiac disease. OBJECTIVE:To determine whether a targeted duodenal bulb biopsy in addition to distal duodenal biopsies is the optimal strategy to identify villous atrophy. DESIGN:Prospective cohort study. SETTING:Tertiary-care referral center. PATIENTS:Seventy-seven patients undergoing clinically indicated EGD with duodenal biopsies were recruited. Of these, 28 had newly diagnosed celiac disease and 49 were controls. INTERVENTIONS:At endoscopy, 8 duodenal biopsy specimens were taken: 4 from the second part of the duodenum and 4 quadrantically from the bulb (at the 3-, 6-, 9-, and 12-o'clock positions). MAIN OUTCOME MEASUREMENTS:Increasing the diagnostic yield and detection of the most severe villous atrophy in celiac disease with the addition of a targeted duodenal bulb biopsy. RESULTS:The most severe degree of villous atrophy was detected when distal duodenal biopsy specimens were taken in addition to a duodenal bulb biopsy specimen from either the 9- or 12-o'clock position (96.4% sensitivity; 95% CI, 79.7%-100%). The difference between the 12-o'clock position biopsy and the 3-o'clock position biopsy in detecting the most severe villous atrophy was 92% (24/26) versus 65% (17/26) (P = .02). LIMITATIONS:Small sample and study performed in a tertiary referral center. CONCLUSIONS:This study demonstrates the patchy appearance of villous atrophy that occurs within the duodenum. A targeted duodenal bulb biopsy from either the 9- or 12-o'clock position in addition to distal duodenal biopsies may improve diagnostic yields by detecting the most severe villous atrophy within the duodenum.
journal_name
Gastrointest Endoscjournal_title
Gastrointestinal endoscopyauthors
Kurien M,Evans KE,Hopper AD,Hale MF,Cross SS,Sanders DSdoi
10.1016/j.gie.2012.02.025subject
Has Abstractpub_date
2012-06-01 00:00:00pages
1190-6issue
6eissn
0016-5107issn
1097-6779pii
S0016-5107(12)00190-3journal_volume
75pub_type
杂志文章abstract:BACKGROUND:Endoscopic biliary sphincterotomy (EST) is a well-established procedure for bile duct stone extraction. Bile duct stones can be classified as primary or secondary. However, few data are available on the recurrence of primary and secondary bile duct stones after EST. Therefore risk factors for the recurrence ...
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pub_type: 临床试验,杂志文章,随机对照试验
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